Compile Data Set for Download or QSAR

Found 275 hits with Last Name = 'langgard' and Initial = 'm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142416 (US8927738, 2-[2-(2-Furan-3-yl-1H-imidazol-4-yl)-et...) Show SMILES Cc1cnc(C)c2nc(CCc3c[nH]c(n3)-c3ccoc3)nn12 Show InChI InChI=1S/C16H16N6O/c1-10-7-17-11(2)16-20-14(21-22(10)16)4-3-13-8-18-15(19-13)12-5-6-23-9-12/h5-9H,3-4H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50398017 (CHEMBL2180411 | US9018217, 5,8-Dimethyl-2-[2-(1-me...) Show SMILES Cc1ccc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12 Show InChI InChI=1S/C20H21N5/c1-14-9-10-15(2)25-20(14)22-18(23-25)11-12-19-21-17(13-24(19)3)16-7-5-4-6-8-16/h4-10,13H,11-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50398017 (CHEMBL2180411 | US9018217, 5,8-Dimethyl-2-[2-(1-me...) Show SMILES Cc1ccc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12 Show InChI InChI=1S/C20H21N5/c1-14-9-10-15(2)25-20(14)22-18(23-25)11-12-19-21-17(13-24(19)3)16-7-5-4-6-8-16/h4-10,13H,11-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142410 (US8927738, 5,8-Dimethyl-2-[2-(2-thiophen-2-yl-1H-i...) Show SMILES Cc1ccc(C)n2nc(CCc3c[nH]c(n3)-c3cccs3)nc12 Show InChI InChI=1S/C17H17N5S/c1-11-5-6-12(2)22-17(11)20-15(21-22)8-7-13-10-18-16(19-13)14-4-3-9-23-14/h3-6,9-10H,7-8H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.340	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142414 (US8927738, 5,8-Dimethyl-2-[2-(2-thiophen-2-yl-1H-i...) Show SMILES Cc1cnc(C)c2nc(CCc3c[nH]c(n3)-c3cccs3)nn12 Show InChI InChI=1S/C16H16N6S/c1-10-8-17-11(2)16-20-14(21-22(10)16)6-5-12-9-18-15(19-12)13-4-3-7-23-13/h3-4,7-9H,5-6H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142412 (US8927738, 2-[2-(2-Furan-2-yl-1H-imidazol-4-yl)-et...) Show SMILES Cc1ccc(C)n2nc(CCc3c[nH]c(n3)-c3ccco3)nc12 Show InChI InChI=1S/C17H17N5O/c1-11-5-6-12(2)22-17(11)20-15(21-22)8-7-13-10-18-16(19-13)14-4-3-9-23-14/h3-6,9-10H,7-8H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.620	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142415 (US8927738, 5,8-Dimethyl-2-[2-(2-thiazol-2-yl-1H-im...) Show SMILES Cc1cnc(C)c2nc(CCc3c[nH]c(n3)-c3nccs3)nn12 Show InChI InChI=1S/C15H15N7S/c1-9-7-17-10(2)14-20-12(21-22(9)14)4-3-11-8-18-13(19-11)15-16-5-6-23-15/h5-8H,3-4H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.630	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142413 (US8927738, 2-[2-(2-Furan-3-yl-1H-imidazol-4-yl)-et...) Show SMILES Cc1ccc(C)n2nc(CCc3c[nH]c(n3)-c3ccoc3)nc12 Show InChI InChI=1S/C17H17N5O/c1-11-3-4-12(2)22-17(11)20-15(21-22)6-5-14-9-18-16(19-14)13-7-8-23-10-13/h3-4,7-10H,5-6H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM47287 (US9018217, 5,7-Dimethyl-2-[2-(4-phenyl-1-propyl-1H...) Show SMILES CCCn1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C21H24N6/c1-4-12-26-14-18(17-8-6-5-7-9-17)23-20(26)11-10-19-24-21-22-15(2)13-16(3)27(21)25-19/h5-9,13-14H,4,10-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.690	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM47287 (US9018217, 5,7-Dimethyl-2-[2-(4-phenyl-1-propyl-1H...) Show SMILES CCCn1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C21H24N6/c1-4-12-26-14-18(17-8-6-5-7-9-17)23-20(26)11-10-19-24-21-22-15(2)13-16(3)27(21)25-19/h5-9,13-14H,4,10-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.690	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142409 (US8927738, 2-[2-(2-Furan-2-yl-1-methyl-1H-imidazol...) Show SMILES Cc1ccc(C)n2nc(CCc3cn(C)c(n3)-c3ccco3)nc12 Show InChI InChI=1S/C18H19N5O/c1-12-6-7-13(2)23-17(12)20-16(21-23)9-8-14-11-22(3)18(19-14)15-5-4-10-24-15/h4-7,10-11H,8-9H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156359 (US9018217, 8-Ethyl-5-methyl-2-[2-(1-methyl-4-pheny...) Show SMILES CCc1ccc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12 Show InChI InChI=1S/C21H23N5/c1-4-16-11-10-15(2)26-21(16)23-19(24-26)12-13-20-22-18(14-25(20)3)17-8-6-5-7-9-17/h5-11,14H,4,12-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.930	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156359 (US9018217, 8-Ethyl-5-methyl-2-[2-(1-methyl-4-pheny...) Show SMILES CCc1ccc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12 Show InChI InChI=1S/C21H23N5/c1-4-16-11-10-15(2)26-21(16)23-19(24-26)12-13-20-22-18(14-25(20)3)17-8-6-5-7-9-17/h5-11,14H,4,12-13H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.930	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142417 (US8927738, 2-[2-(2-Furan-2-yl-1H-imidazol-4-yl)-et...) Show SMILES Cc1cnc(C)c2nc(CCc3c[nH]c(n3)-c3ccco3)nn12 Show InChI InChI=1S/C16H16N6O/c1-10-8-17-11(2)16-20-14(21-22(10)16)6-5-12-9-18-15(19-12)13-4-3-7-23-13/h3-4,7-9H,5-6H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.970	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50397979 (CHEMBL2180418 | US8927738, 5,8-Dimethyl-2-[2-(1-me...) Show SMILES Cc1cnc(C)c2nc(CCc3cn(C)c(n3)-c3cccs3)nn12 Show InChI InChI=1S/C17H18N6S/c1-11-9-18-12(2)16-20-15(21-23(11)16)7-6-13-10-22(3)17(19-13)14-5-4-8-24-14/h4-5,8-10H,6-7H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM47296 (US9018217, 8-Ethyl-5-methyl-2-(2-(1-methyl-4-pheny...) Show SMILES CCc1cnc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12 Show InChI InChI=1S/C20H22N6/c1-4-15-12-21-14(2)26-20(15)23-18(24-26)10-11-19-22-17(13-25(19)3)16-8-6-5-7-9-16/h5-9,12-13H,4,10-11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142406 (US8927738, 2-[2-(2-Furan-2-yl-1-methyl-1H-imidazol...) Show SMILES Cc1cnc(C)c2nc(CCc3cn(C)c(n3)-c3ccco3)nn12 Show InChI InChI=1S/C17H18N6O/c1-11-9-18-12(2)16-20-15(21-23(11)16)7-6-13-10-22(3)17(19-13)14-5-4-8-24-14/h4-5,8-10H,6-7H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM47296 (US9018217, 8-Ethyl-5-methyl-2-(2-(1-methyl-4-pheny...) Show SMILES CCc1cnc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12 Show InChI InChI=1S/C20H22N6/c1-4-15-12-21-14(2)26-20(15)23-18(24-26)10-11-19-22-17(13-25(19)3)16-8-6-5-7-9-16/h5-9,12-13H,4,10-11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156347 (US9018217, 2-[2-(1-Isobutyl-4-phenyl-1H-imidazol-2...) Show SMILES CC(C)Cn1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C22H26N6/c1-15(2)13-27-14-19(18-8-6-5-7-9-18)24-21(27)11-10-20-25-22-23-16(3)12-17(4)28(22)26-20/h5-9,12,14-15H,10-11,13H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM299447 (US9592230, 5-Methyl-2-{2-[4-phenyl-1-(2-piperidin-...) Show SMILES Cc1cccc2nc(CCc3nc(cn3CCN3CCCCC3)-c3ccccc3)nn12 Show InChI InChI=1S/C25H30N6/c1-20-9-8-12-25-27-23(28-31(20)25)13-14-24-26-22(21-10-4-2-5-11-21)19-30(24)18-17-29-15-6-3-7-16-29/h2,4-5,8-12,19H,3,6-7,13-18H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156347 (US9018217, 2-[2-(1-Isobutyl-4-phenyl-1H-imidazol-2...) Show SMILES CC(C)Cn1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C22H26N6/c1-15(2)13-27-14-19(18-8-6-5-7-9-18)24-21(27)11-10-20-25-22-23-16(3)12-17(4)28(22)26-20/h5-9,12,14-15H,10-11,13H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM47283 (US9018217, 5-Methyl-2-(2-[4-phenyl-1-(2-piperidin-...) Show SMILES Cc1cccc2nc(CCc3nc(cn3CCC3CCCCN3)-c3ccccc3)nn12 Show InChI InChI=1S/C25H30N6/c1-19-8-7-12-25-28-23(29-31(19)25)13-14-24-27-22(20-9-3-2-4-10-20)18-30(24)17-15-21-11-5-6-16-26-21/h2-4,7-10,12,18,21,26H,5-6,11,13-17H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156350 (US9018217, 5,7-Dimethyl-2-{2-[1-(2-morpholin-4-yl-...) Show SMILES Cc1cc(C)n2nc(CCc3nc(cn3CCN3CCOCC3)-c3ccccc3)nc2n1 Show InChI InChI=1S/C24H29N7O/c1-18-16-19(2)31-24(25-18)27-22(28-31)8-9-23-26-21(20-6-4-3-5-7-20)17-30(23)11-10-29-12-14-32-15-13-29/h3-7,16-17H,8-15H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156350 (US9018217, 5,7-Dimethyl-2-{2-[1-(2-morpholin-4-yl-...) Show SMILES Cc1cc(C)n2nc(CCc3nc(cn3CCN3CCOCC3)-c3ccccc3)nc2n1 Show InChI InChI=1S/C24H29N7O/c1-18-16-19(2)31-24(25-18)27-22(28-31)8-9-23-26-21(20-6-4-3-5-7-20)17-30(23)11-10-29-12-14-32-15-13-29/h3-7,16-17H,8-15H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156337 (US9018217, 2-[2-(1-Isobutyl-4-phenyl-1H-imidazol-2...) Show SMILES CC(C)Cn1cc(nc1CCc1nc2cccc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C22H25N5/c1-16(2)14-26-15-19(18-9-5-4-6-10-18)23-21(26)13-12-20-24-22-11-7-8-17(3)27(22)25-20/h4-11,15-16H,12-14H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142411 (US8927738, 5,8-Dimethyl-2-[2-(2-thiazol-2-yl-1H-im...) Show SMILES Cc1ccc(C)n2nc(CCc3c[nH]c(n3)-c3nccs3)nc12 Show InChI InChI=1S/C16H16N6S/c1-10-3-4-11(2)22-15(10)20-13(21-22)6-5-12-9-18-14(19-12)16-17-7-8-23-16/h3-4,7-9H,5-6H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156337 (US9018217, 2-[2-(1-Isobutyl-4-phenyl-1H-imidazol-2...) Show SMILES CC(C)Cn1cc(nc1CCc1nc2cccc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C22H25N5/c1-16(2)14-26-15-19(18-9-5-4-6-10-18)23-21(26)13-12-20-24-22-11-7-8-17(3)27(22)25-20/h4-11,15-16H,12-14H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50398014 (CHEMBL2180414 | US9018217, 5,8-Dimethyl-2-[2-(1-me...) Show SMILES Cc1cnc(C)c2nc(CCc3nc(cn3C)-c3ccccc3)nn12 Show InChI InChI=1S/C19H20N6/c1-13-11-20-14(2)19-22-17(23-25(13)19)9-10-18-21-16(12-24(18)3)15-7-5-4-6-8-15/h4-8,11-12H,9-10H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50398014 (CHEMBL2180414 | US9018217, 5,8-Dimethyl-2-[2-(1-me...) Show SMILES Cc1cnc(C)c2nc(CCc3nc(cn3C)-c3ccccc3)nn12 Show InChI InChI=1S/C19H20N6/c1-13-11-20-14(2)19-22-17(23-25(13)19)9-10-18-21-16(12-24(18)3)15-7-5-4-6-8-15/h4-8,11-12H,9-10H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156352 (US9018217, 8-methoxy-5-methyl-2-(2-(1-methyl-4-phe...) Show SMILES COc1ccc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12 Show InChI InChI=1S/C20H21N5O/c1-14-9-10-17(26-3)20-22-18(23-25(14)20)11-12-19-21-16(13-24(19)2)15-7-5-4-6-8-15/h4-10,13H,11-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156352 (US9018217, 8-methoxy-5-methyl-2-(2-(1-methyl-4-phe...) Show SMILES COc1ccc(C)n2nc(CCc3nc(cn3C)-c3ccccc3)nc12 Show InChI InChI=1S/C20H21N5O/c1-14-9-10-17(26-3)20-22-18(23-25(14)20)11-12-19-21-16(13-24(19)2)15-7-5-4-6-8-15/h4-10,13H,11-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156346 (US9018217, 5,7-Dimethyl-2-{2-[4-phenyl-1-(2-piperi...) Show SMILES Cc1cc(C)n2nc(CCc3nc(cn3CCN3CCCCC3)-c3ccccc3)nc2n1 Show InChI InChI=1S/C25H31N7/c1-19-17-20(2)32-25(26-19)28-23(29-32)11-12-24-27-22(21-9-5-3-6-10-21)18-31(24)16-15-30-13-7-4-8-14-30/h3,5-6,9-10,17-18H,4,7-8,11-16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156346 (US9018217, 5,7-Dimethyl-2-{2-[4-phenyl-1-(2-piperi...) Show SMILES Cc1cc(C)n2nc(CCc3nc(cn3CCN3CCCCC3)-c3ccccc3)nc2n1 Show InChI InChI=1S/C25H31N7/c1-19-17-20(2)32-25(26-19)28-23(29-32)11-12-24-27-22(21-9-5-3-6-10-21)18-31(24)16-15-30-13-7-4-8-14-30/h3,5-6,9-10,17-18H,4,7-8,11-16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156342 (US9018217, 5-Methyl-2-[2-(1-methyl-4-phenyl-1H-imi...) Show SMILES Cc1cc(-c2ccccc2)n2nc(CCc3nc(cn3C)-c3ccccc3)nc2n1 Show InChI InChI=1S/C24H22N6/c1-17-15-21(19-11-7-4-8-12-19)30-24(25-17)27-22(28-30)13-14-23-26-20(16-29(23)2)18-9-5-3-6-10-18/h3-12,15-16H,13-14H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM47278 (US9018217, 1-Methyl-3-(2-[2-[2-(5-methyl-[1,2,4]tr...) Show SMILES CN1CCN(CCn2cc(nc2CCc2nc3cccc(C)n3n2)-c2ccccc2)C1=O Show InChI InChI=1S/C24H27N7O/c1-18-7-6-10-23-26-21(27-31(18)23)11-12-22-25-20(19-8-4-3-5-9-19)17-30(22)16-15-29-14-13-28(2)24(29)32/h3-10,17H,11-16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156333 (US9018217, 5-Methyl-2-[2-(4-phenyl-1H-imidazol-2-y...) Show SMILES Cc1cccc2nc(CCc3nc(c[nH]3)-c3ccccc3)nn12 Show InChI InChI=1S/C18H17N5/c1-13-6-5-9-18-21-17(22-23(13)18)11-10-16-19-12-15(20-16)14-7-3-2-4-8-14/h2-9,12H,10-11H2,1H3,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156342 (US9018217, 5-Methyl-2-[2-(1-methyl-4-phenyl-1H-imi...) Show SMILES Cc1cc(-c2ccccc2)n2nc(CCc3nc(cn3C)-c3ccccc3)nc2n1 Show InChI InChI=1S/C24H22N6/c1-17-15-21(19-11-7-4-8-12-19)30-24(25-17)27-22(28-30)13-14-23-26-20(16-29(23)2)18-9-5-3-6-10-18/h3-12,15-16H,13-14H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM47278 (US9018217, 1-Methyl-3-(2-[2-[2-(5-methyl-[1,2,4]tr...) Show SMILES CN1CCN(CCn2cc(nc2CCc2nc3cccc(C)n3n2)-c2ccccc2)C1=O Show InChI InChI=1S/C24H27N7O/c1-18-7-6-10-23-26-21(27-31(18)23)11-12-22-25-20(19-8-4-3-5-9-19)17-30(22)16-15-29-14-13-28(2)24(29)32/h3-10,17H,11-16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156333 (US9018217, 5-Methyl-2-[2-(4-phenyl-1H-imidazol-2-y...) Show SMILES Cc1cccc2nc(CCc3nc(c[nH]3)-c3ccccc3)nn12 Show InChI InChI=1S/C18H17N5/c1-13-6-5-9-18-21-17(22-23(13)18)11-10-16-19-12-15(20-16)14-7-3-2-4-8-14/h2-9,12H,10-11H2,1H3,(H,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142404 (US8927738, 5,8-Dimethyl-2-[2-(2-thiazol-5-yl-1H-im...) Show SMILES Cc1ccc(C)n2nc(CCc3c[nH]c(n3)-c3cncs3)nc12 Show InChI InChI=1S/C16H16N6S/c1-10-3-4-11(2)22-16(10)20-14(21-22)6-5-12-7-18-15(19-12)13-8-17-9-23-13/h3-4,7-9H,5-6H2,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156348 (US9018217, 2-[2-(1-Isopropyl-4-phenyl-1H-imidazol-...) Show SMILES CC(C)n1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C21H24N6/c1-14(2)26-13-18(17-8-6-5-7-9-17)23-20(26)11-10-19-24-21-22-15(3)12-16(4)27(21)25-19/h5-9,12-14H,10-11H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156348 (US9018217, 2-[2-(1-Isopropyl-4-phenyl-1H-imidazol-...) Show SMILES CC(C)n1cc(nc1CCc1nc2nc(C)cc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C21H24N6/c1-14(2)26-13-18(17-8-6-5-7-9-17)23-20(26)11-10-19-24-21-22-15(3)12-16(4)27(21)25-19/h5-9,12-14H,10-11H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142407 (US8927738, 5,8-Dimethyl-2-[2-(2-thiazol-4-yl-1H-im...) Show SMILES Cc1cnc(C)c2nc(CCc3c[nH]c(n3)-c3cscn3)nn12 Show InChI InChI=1S/C15H15N7S/c1-9-5-16-10(2)15-20-13(21-22(9)15)4-3-11-6-17-14(19-11)12-7-23-8-18-12/h5-8H,3-4H2,1-2H3,(H,17,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142418 (US8927738, 5,8-Dimethyl-2-{2-[1-methyl-2-(5-methyl...) Show SMILES Cc1ccc(o1)-c1nc(CCc2nc3c(C)ncc(C)n3n2)cn1C Show InChI InChI=1S/C18H20N6O/c1-11-9-19-13(3)17-21-16(22-24(11)17)8-6-14-10-23(4)18(20-14)15-7-5-12(2)25-15/h5,7,9-10H,6,8H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142408 (US8927738, 5,8-Dimethyl-2-[2-(2-thiazol-4-yl-1H-im...) Show SMILES Cc1ccc(C)n2nc(CCc3c[nH]c(n3)-c3cscn3)nc12 Show InChI InChI=1S/C16H16N6S/c1-10-3-4-11(2)22-16(10)20-14(21-22)6-5-12-7-17-15(19-12)13-8-23-9-18-13/h3-4,7-9H,5-6H2,1-2H3,(H,17,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156354 (US9018217, 5-Methyl-2-[2-(1-methyl-4-phenyl-1H-imi...) Show SMILES CCCc1cc(C)nc2nc(CCc3nc(cn3C)-c3ccccc3)nn12 Show InChI InChI=1S/C21H24N6/c1-4-8-17-13-15(2)22-21-24-19(25-27(17)21)11-12-20-23-18(14-26(20)3)16-9-6-5-7-10-16/h5-7,9-10,13-14H,4,8,11-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156354 (US9018217, 5-Methyl-2-[2-(1-methyl-4-phenyl-1H-imi...) Show SMILES CCCc1cc(C)nc2nc(CCc3nc(cn3C)-c3ccccc3)nn12 Show InChI InChI=1S/C21H24N6/c1-4-8-17-13-15(2)22-21-24-19(25-27(17)21)11-12-20-23-18(14-26(20)3)16-9-6-5-7-10-16/h5-7,9-10,13-14H,4,8,11-12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142399 (US8927738, 5,8-Dimethyl-2-[2-(2-phenyl-1H-imidazol...) Show SMILES Cc1cnc(C)c2nc(CCc3c[nH]c(n3)-c3ccccc3)nn12 Show InChI InChI=1S/C18H18N6/c1-12-10-19-13(2)18-22-16(23-24(12)18)9-8-15-11-20-17(21-15)14-6-4-3-5-7-14/h3-7,10-11H,8-9H2,1-2H3,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US8927738 (2015) BindingDB Entry DOI: 10.7270/Q2183571
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156334 (US9018217, 2-(1-Isobutyl-4-phenyl-1H-imidazol-2-yl...) Show SMILES CC(C)Cn1cc(nc1SCc1nc2nc(C)cc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C21H24N6S/c1-14(2)11-26-12-18(17-8-6-5-7-9-17)23-21(26)28-13-19-24-20-22-15(3)10-16(4)27(20)25-19/h5-10,12,14H,11,13H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9592230 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KSH
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM156334 (US9018217, 2-(1-Isobutyl-4-phenyl-1H-imidazol-2-yl...) Show SMILES CC(C)Cn1cc(nc1SCc1nc2nc(C)cc(C)n2n1)-c1ccccc1 Show InChI InChI=1S/C21H24N6S/c1-14(2)11-26-12-18(17-8-6-5-7-9-17)23-21(26)28-13-19-24-20-22-15(3)10-16(4)27(20)25-19/h5-10,12,14H,11,13H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9018217 (2015) BindingDB Entry DOI: 10.7270/Q2KW5DS1
					More data for this Ligand-Target Pair

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