Compile Data Set for Download or QSAR

Found 36 hits with Last Name = 'ledgard' and Initial = 'a'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50180524 ((R)-2-(2-methoxyphenyl)-1-((S)-morpholin-2-yl)-1-p...) Show SMILES COc1ccccc1C[C@](O)([C@@H]1CNCCO1)c1ccccc1 Show InChI InChI=1S/C19H23NO3/c1-22-17-10-6-5-7-15(17)13-19(21,16-8-3-2-4-9-16)18-14-20-11-12-23-18/h2-10,18,20-21H,11-14H2,1H3/t18-,19+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity to NET				Bioorg Med Chem Lett 16: 2022-5 (2006) Article DOI: 10.1016/j.bmcl.2005.12.061 BindingDB Entry DOI: 10.7270/Q21J9BJ5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3.37	-48.4	n/a	n/a	n/a	n/a	n/a	7.6	25
Eli Lilly and Company US Patent					Assay Description [3H]-Ketanserin binding experiments are carried out in SPA 96-well format. Membranes used in this assay are prepared from AV-12 cells stably expressi...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50180521 ((R)-2-biphenyl-2-yl-1-(S)-morpholin-2-yl-1-phenyl-...) Show SMILES O[C@@](Cc1ccccc1-c1ccccc1)([C@@H]1CNCCO1)c1ccccc1 Show InChI InChI=1S/C24H25NO2/c26-24(21-12-5-2-6-13-21,23-18-25-15-16-27-23)17-20-11-7-8-14-22(20)19-9-3-1-4-10-19/h1-14,23,25-26H,15-18H2/t23-,24+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity to NET				Bioorg Med Chem Lett 16: 2022-5 (2006) Article DOI: 10.1016/j.bmcl.2005.12.061 BindingDB Entry DOI: 10.7270/Q21J9BJ5
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50180531 ((R)-2-(2-ethoxyphenyl)-1-((S)-morpholin-2-yl)-1-ph...) Show SMILES CCOc1ccccc1C[C@](O)([C@@H]1CNCCO1)c1ccccc1 Show InChI InChI=1S/C20H25NO3/c1-2-23-18-11-7-6-8-16(18)14-20(22,17-9-4-3-5-10-17)19-15-21-12-13-24-19/h3-11,19,21-22H,2,12-15H2,1H3/t19-,20+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity to NET				Bioorg Med Chem Lett 16: 2022-5 (2006) Article DOI: 10.1016/j.bmcl.2005.12.061 BindingDB Entry DOI: 10.7270/Q21J9BJ5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.01	-46.5	n/a	n/a	n/a	n/a	n/a	7.6	25
Eli Lilly and Company US Patent					Assay Description [3H]-Ketanserin binding experiments are carried out in SPA 96-well format. Membranes used in this assay are prepared from AV-12 cells stably expressi...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50180526 ((R)-2-(2-isopropoxyphenyl)-1-((S)-morpholin-2-yl)-...) Show SMILES CC(C)Oc1ccccc1C[C@](O)([C@@H]1CNCCO1)c1ccccc1 Show InChI InChI=1S/C21H27NO3/c1-16(2)25-19-11-7-6-8-17(19)14-21(23,18-9-4-3-5-10-18)20-15-22-12-13-24-20/h3-11,16,20,22-23H,12-15H2,1-2H3/t20-,21+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	7.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity to NET				Bioorg Med Chem Lett 16: 2022-5 (2006) Article DOI: 10.1016/j.bmcl.2005.12.061 BindingDB Entry DOI: 10.7270/Q21J9BJ5
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50180526 ((R)-2-(2-isopropoxyphenyl)-1-((S)-morpholin-2-yl)-...) Show SMILES CC(C)Oc1ccccc1C[C@](O)([C@@H]1CNCCO1)c1ccccc1 Show InChI InChI=1S/C21H27NO3/c1-16(2)25-19-11-7-6-8-17(19)14-21(23,18-9-4-3-5-10-18)20-15-22-12-13-24-20/h3-11,16,20,22-23H,12-15H2,1-2H3/t20-,21+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	7.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity to NET				Bioorg Med Chem Lett 16: 2022-5 (2006) Article DOI: 10.1016/j.bmcl.2005.12.061 BindingDB Entry DOI: 10.7270/Q21J9BJ5
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50180523 ((R)-2-(2-bromophenyl)-1-((S)-morpholin-2-yl)-1-phe...) Show SMILES O[C@@](Cc1ccccc1Br)([C@@H]1CNCCO1)c1ccccc1 Show InChI InChI=1S/C18H20BrNO2/c19-16-9-5-4-6-14(16)12-18(21,15-7-2-1-3-8-15)17-13-20-10-11-22-17/h1-9,17,20-21H,10-13H2/t17-,18+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	11.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity to NET				Bioorg Med Chem Lett 16: 2022-5 (2006) Article DOI: 10.1016/j.bmcl.2005.12.061 BindingDB Entry DOI: 10.7270/Q21J9BJ5
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	20.6	-43.9	n/a	n/a	n/a	n/a	n/a	7.6	25
Eli Lilly and Company US Patent					Assay Description [3H]-Pyrilamine binding experiments are carried out in SPA (scintillation proximity assay) 96-well format. Membranes used in this assay are prepared ...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50180525 ((R)-2-(2-chlorophenyl)-1-((S)-morpholin-2-yl)-1-ph...) Show SMILES O[C@@](Cc1ccccc1Cl)([C@@H]1CNCCO1)c1ccccc1 Show InChI InChI=1S/C18H20ClNO2/c19-16-9-5-4-6-14(16)12-18(21,15-7-2-1-3-8-15)17-13-20-10-11-22-17/h1-9,17,20-21H,10-13H2/t17-,18+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity to NET				Bioorg Med Chem Lett 16: 2022-5 (2006) Article DOI: 10.1016/j.bmcl.2005.12.061 BindingDB Entry DOI: 10.7270/Q21J9BJ5
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50180522 ((R)-1-((S)-morpholin-2-yl)-1-phenyl-2-(2-(trifluor...) Show SMILES O[C@@](Cc1ccccc1SC(F)(F)F)([C@@H]1CNCCO1)c1ccccc1 Show InChI InChI=1S/C19H20F3NO2S/c20-19(21,22)26-16-9-5-4-6-14(16)12-18(24,15-7-2-1-3-8-15)17-13-23-10-11-25-17/h1-9,17,23-24H,10-13H2/t17-,18+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	54.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity to NET				Bioorg Med Chem Lett 16: 2022-5 (2006) Article DOI: 10.1016/j.bmcl.2005.12.061 BindingDB Entry DOI: 10.7270/Q21J9BJ5
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50180524 ((R)-2-(2-methoxyphenyl)-1-((S)-morpholin-2-yl)-1-p...) Show SMILES COc1ccccc1C[C@](O)([C@@H]1CNCCO1)c1ccccc1 Show InChI InChI=1S/C19H23NO3/c1-22-17-10-6-5-7-15(17)13-19(21,16-8-3-2-4-9-16)18-14-20-11-12-23-18/h2-10,18,20-21H,11-14H2,1H3/t18-,19+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	56	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity to NET				Bioorg Med Chem Lett 16: 2022-5 (2006) Article DOI: 10.1016/j.bmcl.2005.12.061 BindingDB Entry DOI: 10.7270/Q21J9BJ5
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	58.8	-41.3	n/a	n/a	n/a	n/a	n/a	7.6	25
Eli Lilly and Company US Patent					Assay Description [3H]-Pyrilamine binding experiments are carried out in SPA (scintillation proximity assay) 96-well format. Membranes used in this assay are prepared ...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	121	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologicall...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	137	-39.2	n/a	n/a	n/a	n/a	n/a	n/a	25
Eli Lilly and Company US Patent					Assay Description [125I]-(±)DOI binding experiments are carried out in SPA 96-well format. Membranes used in this assay are prepared from AV-12 cells stably expressing...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50180527 ((R)-1-((S)-morpholin-2-yl)-1,2-diphenylethanol | C...) Show SMILES O[C@@](Cc1ccccc1)([C@@H]1CNCCO1)c1ccccc1 Show InChI InChI=1S/C18H21NO2/c20-18(16-9-5-2-6-10-16,17-14-19-11-12-21-17)13-15-7-3-1-4-8-15/h1-10,17,19-20H,11-14H2/t17-,18+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	148	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity to NET				Bioorg Med Chem Lett 16: 2022-5 (2006) Article DOI: 10.1016/j.bmcl.2005.12.061 BindingDB Entry DOI: 10.7270/Q21J9BJ5
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50180524 ((R)-2-(2-methoxyphenyl)-1-((S)-morpholin-2-yl)-1-p...) Show SMILES COc1ccccc1C[C@](O)([C@@H]1CNCCO1)c1ccccc1 Show InChI InChI=1S/C19H23NO3/c1-22-17-10-6-5-7-15(17)13-19(21,16-8-3-2-4-9-16)18-14-20-11-12-23-18/h2-10,18,20-21H,11-14H2,1H3/t18-,19+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	156	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity to NET				Bioorg Med Chem Lett 16: 2022-5 (2006) Article DOI: 10.1016/j.bmcl.2005.12.061 BindingDB Entry DOI: 10.7270/Q21J9BJ5
					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50180524 ((R)-2-(2-methoxyphenyl)-1-((S)-morpholin-2-yl)-1-p...) Show SMILES COc1ccccc1C[C@](O)([C@@H]1CNCCO1)c1ccccc1 Show InChI InChI=1S/C19H23NO3/c1-22-17-10-6-5-7-15(17)13-19(21,16-8-3-2-4-9-16)18-14-20-11-12-23-18/h2-10,18,20-21H,11-14H2,1H3/t18-,19+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	161	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity to NET				Bioorg Med Chem Lett 16: 2022-5 (2006) Article DOI: 10.1016/j.bmcl.2005.12.061 BindingDB Entry DOI: 10.7270/Q21J9BJ5
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	328	-37.0	n/a	n/a	n/a	n/a	n/a	n/a	25
Eli Lilly and Company US Patent					Assay Description [125I]-(±)DOI binding experiments are carried out in SPA 96-well format. Membranes used in this assay are prepared from AV-12 cells stably expressing...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	592	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologicall...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>2.06E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologicall...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.78E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologicall...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>3.98E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologicall...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>4.23E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologicall...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>4.57E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologicall...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>5.51E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologicall...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1B (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>5.58E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologicall...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>5.68E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologicall...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
Alpha-2B adrenergic receptor (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>5.76E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologicall...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>5.83E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologicall...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 5A (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>8.81E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologicall...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>8.99E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologicall...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>1.02E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologicall...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
Alpha-1B adrenergic receptor (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>1.47E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologicall...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Activity of compounds on native GABAA receptors is evaluated by monitoring calcium fluxes using a 96 well format FLIPR system (Fluorometric Imaging P...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM255474 (US9481688, 1 | US9481688, 3) Show SMILES Cc1ccc2N=C(N3CCN(CC(C)(C)C(O)=O)CC3)c3cc(Cl)sc3Oc2c1 |t:5| Show InChI InChI=1S/C21H24ClN3O3S/c1-13-4-5-15-16(10-13)28-19-14(11-17(22)29-19)18(23-15)25-8-6-24(7-9-25)12-21(2,3)20(26)27/h4-5,10-11H,6-9,12H2,1-3H3,(H,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologicall...				US Patent US9481688 (2016) BindingDB Entry DOI: 10.7270/Q25D8QRW
					More data for this Ligand-Target Pair