Compile Data Set for Download or QSAR

Found 55 hits with Last Name = 'littler' and Initial = 'bj'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase ATR (Homo sapiens (Human))	BDBM350085 (3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isox...) Show SMILES CNCc1ccc(cc1)-c1cc(on1)-c1nc(cnc1N)-c1ccc(cc1)S(=O)(=O)C(C)C Show InChI InChI=1S/C24H25N5O3S/c1-15(2)33(30,31)19-10-8-18(9-11-19)21-14-27-24(25)23(28-21)22-12-20(29-32-22)17-6-4-16(5-7-17)13-26-3/h4-12,14-15,26H,13H2,1-3H3,(H2,25,27)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	0.148	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt...				US Patent US10822331 (2020) BindingDB Entry DOI: 10.7270/Q2V98C59
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Homo sapiens (Human))	BDBM350085 (3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isox...) Show SMILES CNCc1ccc(cc1)-c1cc(on1)-c1nc(cnc1N)-c1ccc(cc1)S(=O)(=O)C(C)C Show InChI InChI=1S/C24H25N5O3S/c1-15(2)33(30,31)19-10-8-18(9-11-19)21-14-27-24(25)23(28-21)22-12-20(29-32-22)17-6-4-16(5-7-17)13-26-3/h4-12,14-15,26H,13H2,1-3H3,(H2,25,27)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	0.148	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt...				US Patent US10208027 (2019) BindingDB Entry DOI: 10.7270/Q27S7QX5
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Homo sapiens (Human))	BDBM350085 (3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isox...) Show SMILES CNCc1ccc(cc1)-c1cc(on1)-c1nc(cnc1N)-c1ccc(cc1)S(=O)(=O)C(C)C Show InChI InChI=1S/C24H25N5O3S/c1-15(2)33(30,31)19-10-8-18(9-11-19)21-14-27-24(25)23(28-21)22-12-20(29-32-22)17-6-4-16(5-7-17)13-26-3/h4-12,14-15,26H,13H2,1-3H3,(H2,25,27)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt...				US Patent US10208027 (2019) BindingDB Entry DOI: 10.7270/Q27S7QX5
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Homo sapiens (Human))	BDBM350085 (3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isox...) Show SMILES CNCc1ccc(cc1)-c1cc(on1)-c1nc(cnc1N)-c1ccc(cc1)S(=O)(=O)C(C)C Show InChI InChI=1S/C24H25N5O3S/c1-15(2)33(30,31)19-10-8-18(9-11-19)21-14-27-24(25)23(28-21)22-12-20(29-32-22)17-6-4-16(5-7-17)13-26-3/h4-12,14-15,26H,13H2,1-3H3,(H2,25,27)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt...				US Patent US10822331 (2020) BindingDB Entry DOI: 10.7270/Q2V98C59
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Homo sapiens (Human))	BDBM350085 (3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isox...) Show SMILES CNCc1ccc(cc1)-c1cc(on1)-c1nc(cnc1N)-c1ccc(cc1)S(=O)(=O)C(C)C Show InChI InChI=1S/C24H25N5O3S/c1-15(2)33(30,31)19-10-8-18(9-11-19)21-14-27-24(25)23(28-21)22-12-20(29-32-22)17-6-4-16(5-7-17)13-26-3/h4-12,14-15,26H,13H2,1-3H3,(H2,25,27)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt...				US Patent US10822331 (2020) BindingDB Entry DOI: 10.7270/Q2V98C59
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Homo sapiens (Human))	BDBM350085 (3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isox...) Show SMILES CNCc1ccc(cc1)-c1cc(on1)-c1nc(cnc1N)-c1ccc(cc1)S(=O)(=O)C(C)C Show InChI InChI=1S/C24H25N5O3S/c1-15(2)33(30,31)19-10-8-18(9-11-19)21-14-27-24(25)23(28-21)22-12-20(29-32-22)17-6-4-16(5-7-17)13-26-3/h4-12,14-15,26H,13H2,1-3H3,(H2,25,27)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt...				US Patent US10822331 (2020) BindingDB Entry DOI: 10.7270/Q2V98C59
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Homo sapiens (Human))	BDBM350085 (3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isox...) Show SMILES CNCc1ccc(cc1)-c1cc(on1)-c1nc(cnc1N)-c1ccc(cc1)S(=O)(=O)C(C)C Show InChI InChI=1S/C24H25N5O3S/c1-15(2)33(30,31)19-10-8-18(9-11-19)21-14-27-24(25)23(28-21)22-12-20(29-32-22)17-6-4-16(5-7-17)13-26-3/h4-12,14-15,26H,13H2,1-3H3,(H2,25,27)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt...				US Patent US10208027 (2019) BindingDB Entry DOI: 10.7270/Q27S7QX5
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Homo sapiens (Human))	BDBM350085 (3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isox...) Show SMILES CNCc1ccc(cc1)-c1cc(on1)-c1nc(cnc1N)-c1ccc(cc1)S(=O)(=O)C(C)C Show InChI InChI=1S/C24H25N5O3S/c1-15(2)33(30,31)19-10-8-18(9-11-19)21-14-27-24(25)23(28-21)22-12-20(29-32-22)17-6-4-16(5-7-17)13-26-3/h4-12,14-15,26H,13H2,1-3H3,(H2,25,27)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Compounds can be screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays are carried out in a mixt...				US Patent US10208027 (2019) BindingDB Entry DOI: 10.7270/Q27S7QX5
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM161329 (US10087143, Compound 114 | US10738009, Compound 11...) Show SMILES COc1cc(F)ccc1Oc1cc(Cl)c(Cl)cc1C(=O)Nc1cc[nH]c(=O)c1 Show InChI InChI=1S/C19H13Cl2FN2O4/c1-27-17-6-10(22)2-3-15(17)28-16-9-14(21)13(20)8-12(16)19(26)24-11-4-5-23-18(25)7-11/h2-9H,1H3,(H2,23,24,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM161329 (US10087143, Compound 114 | US10738009, Compound 11...) Show SMILES COc1cc(F)ccc1Oc1cc(Cl)c(Cl)cc1C(=O)Nc1cc[nH]c(=O)c1 Show InChI InChI=1S/C19H13Cl2FN2O4/c1-27-17-6-10(22)2-3-15(17)28-16-9-14(21)13(20)8-12(16)19(26)24-11-4-5-23-18(25)7-11/h2-9H,1H3,(H2,23,24,25,26)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM161326 (US10087143, Compound 111 | US10738009, Compound 11...) Show SMILES COc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)C(F)(F)F Show InChI InChI=1S/C21H14F6N2O4/c1-32-17-9-12(22)3-5-15(17)33-16-8-11(20(23,24)21(25,26)27)2-4-14(16)19(31)29-13-6-7-28-18(30)10-13/h2-10H,1H3,(H2,28,29,30,31)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM161326 (US10087143, Compound 111 | US10738009, Compound 11...) Show SMILES COc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)C(F)(F)F Show InChI InChI=1S/C21H14F6N2O4/c1-32-17-9-12(22)3-5-15(17)33-16-8-11(20(23,24)21(25,26)27)2-4-14(16)19(31)29-13-6-7-28-18(30)10-13/h2-10H,1H3,(H2,28,29,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM186571 (US10787472, Compound 1 | US9163042, 1) Show SMILES COc1cc(F)ccc1Oc1cc(Cl)c(Cl)cc1C(=O)Nc1ccn(COP(O)(O)=O)c(=O)c1 Show InChI InChI=1S/C20H16Cl2FN2O8P/c1-31-18-6-11(23)2-3-16(18)33-17-9-15(22)14(21)8-13(17)20(27)24-12-4-5-25(19(26)7-12)10-32-34(28,29)30/h2-9H,10H2,1H3,(H,24,27)(H2,28,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM186571 (US10787472, Compound 1 | US9163042, 1) Show SMILES COc1cc(F)ccc1Oc1cc(Cl)c(Cl)cc1C(=O)Nc1ccn(COP(O)(O)=O)c(=O)c1 Show InChI InChI=1S/C20H16Cl2FN2O8P/c1-31-18-6-11(23)2-3-16(18)33-17-9-15(22)14(21)8-13(17)20(27)24-12-4-5-25(19(26)7-12)10-32-34(28,29)30/h2-9H,10H2,1H3,(H,24,27)(H2,28,29,30)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM161328 (US10087143, Compound 113 | US10738009, Compound 11...) Show SMILES Fc1ccc(Oc2cc(Cl)c(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1 Show InChI InChI=1S/C18H11Cl2FN2O3/c19-14-8-13(18(25)23-11-5-6-22-17(24)7-11)16(9-15(14)20)26-12-3-1-10(21)2-4-12/h1-9H,(H2,22,23,24,25)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM161328 (US10087143, Compound 113 | US10738009, Compound 11...) Show SMILES Fc1ccc(Oc2cc(Cl)c(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1 Show InChI InChI=1S/C18H11Cl2FN2O3/c19-14-8-13(18(25)23-11-5-6-22-17(24)7-11)16(9-15(14)20)26-12-3-1-10(21)2-4-12/h1-9H,(H2,22,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM161294 (US10738009, Compound 79 | US10787472, Compound 5a ...) Show SMILES FC(F)(F)Oc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1 Show InChI InChI=1S/C20H12F6N2O4/c21-19(22,23)11-1-6-15(18(30)28-12-7-8-27-17(29)10-12)16(9-11)31-13-2-4-14(5-3-13)32-20(24,25)26/h1-10H,(H2,27,28,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM161245 (US10087143, Compound 30 | US10738009, Compound 52 ...) Show SMILES COc1cc(F)ccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F Show InChI InChI=1S/C20H14F4N2O4/c1-29-17-9-12(21)3-5-16(17)30-15-4-2-11(20(22,23)24)8-14(15)19(28)26-13-6-7-25-18(27)10-13/h2-10H,1H3,(H2,25,26,27,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM161294 (US10738009, Compound 79 | US10787472, Compound 5a ...) Show SMILES FC(F)(F)Oc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1 Show InChI InChI=1S/C20H12F6N2O4/c21-19(22,23)11-1-6-15(18(30)28-12-7-8-27-17(29)10-12)16(9-11)31-13-2-4-14(5-3-13)32-20(24,25)26/h1-10H,(H2,27,28,29,30)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM161245 (US10087143, Compound 30 | US10738009, Compound 52 ...) Show SMILES COc1cc(F)ccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F Show InChI InChI=1S/C20H14F4N2O4/c1-29-17-9-12(21)3-5-16(17)30-15-4-2-11(20(22,23)24)8-14(15)19(28)26-13-6-7-25-18(27)10-13/h2-10H,1H3,(H2,25,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM161303 (US10087143, Compound 88 | US10738009, Compound 88 ...) Show SMILES Fc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)C(F)(F)F)cc1 Show InChI InChI=1S/C20H12F6N2O3/c21-12-2-4-14(5-3-12)31-16-9-11(19(22,23)20(24,25)26)1-6-15(16)18(30)28-13-7-8-27-17(29)10-13/h1-10H,(H2,27,28,29,30)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM161285 (US10738009, Compound 70 | US10787472, Compound 7a ...) Show SMILES COc1cc(F)ccc1Oc1ccc(Cl)cc1C(=O)Nc1cc[nH]c(=O)c1 Show InChI InChI=1S/C19H14ClFN2O4/c1-26-17-9-12(21)3-5-16(17)27-15-4-2-11(20)8-14(15)19(25)23-13-6-7-22-18(24)10-13/h2-10H,1H3,(H2,22,23,24,25)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM161285 (US10738009, Compound 70 | US10787472, Compound 7a ...) Show SMILES COc1cc(F)ccc1Oc1ccc(Cl)cc1C(=O)Nc1cc[nH]c(=O)c1 Show InChI InChI=1S/C19H14ClFN2O4/c1-26-17-9-12(21)3-5-16(17)27-15-4-2-11(20)8-14(15)19(25)23-13-6-7-22-18(24)10-13/h2-10H,1H3,(H2,22,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM161287 (US10087143, Compound 72 | US10738009, Compound 72 ...) Show SMILES FC(F)(F)Oc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1 Show InChI InChI=1S/C20H12F6N2O4/c21-19(22,23)11-1-6-16(31-13-2-4-14(5-3-13)32-20(24,25)26)15(9-11)18(30)28-12-7-8-27-17(29)10-12/h1-10H,(H2,27,28,29,30)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM161287 (US10087143, Compound 72 | US10738009, Compound 72 ...) Show SMILES FC(F)(F)Oc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1 Show InChI InChI=1S/C20H12F6N2O4/c21-19(22,23)11-1-6-16(31-13-2-4-14(5-3-13)32-20(24,25)26)15(9-11)18(30)28-12-7-8-27-17(29)10-12/h1-10H,(H2,27,28,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM161225 (US10087143, Compound 10 | US10738009, Compound 10 ...) Show SMILES Cc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F Show InChI InChI=1S/C20H14F4N2O3/c1-11-8-13(21)3-5-16(11)29-17-9-12(20(22,23)24)2-4-15(17)19(28)26-14-6-7-25-18(27)10-14/h2-10H,1H3,(H2,25,26,27,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM161225 (US10087143, Compound 10 | US10738009, Compound 10 ...) Show SMILES Cc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F Show InChI InChI=1S/C20H14F4N2O3/c1-11-8-13(21)3-5-16(11)29-17-9-12(20(22,23)24)2-4-15(17)19(28)26-14-6-7-25-18(27)10-14/h2-10H,1H3,(H2,25,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM161246 (US10087143, Compound 106 | US10738009, Compound 10...) Show SMILES Cc1cc(F)ccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F Show InChI InChI=1S/C20H14F4N2O3/c1-11-8-13(21)3-5-16(11)29-17-4-2-12(20(22,23)24)9-15(17)19(28)26-14-6-7-25-18(27)10-14/h2-10H,1H3,(H2,25,26,27,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM161246 (US10087143, Compound 106 | US10738009, Compound 10...) Show SMILES Cc1cc(F)ccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F Show InChI InChI=1S/C20H14F4N2O3/c1-11-8-13(21)3-5-16(11)29-17-4-2-12(20(22,23)24)9-15(17)19(28)26-14-6-7-25-18(27)10-14/h2-10H,1H3,(H2,25,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM161244 (US10087143, Compound 29 | US10738009, Compound 29 ...) Show SMILES Fc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(Cl)c1 Show InChI InChI=1S/C19H11ClF4N2O3/c20-14-8-11(21)2-4-16(14)29-15-3-1-10(19(22,23)24)7-13(15)18(28)26-12-5-6-25-17(27)9-12/h1-9H,(H2,25,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM161244 (US10087143, Compound 29 | US10738009, Compound 29 ...) Show SMILES Fc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(Cl)c1 Show InChI InChI=1S/C19H11ClF4N2O3/c20-14-8-11(21)2-4-16(14)29-15-3-1-10(19(22,23)24)7-13(15)18(28)26-12-5-6-25-17(27)9-12/h1-9H,(H2,25,26,27,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM464394 (N-[1-(chloromethyl)-2-oxo-4-pyridyl]-2-(4-fluoro-2...) Show SMILES Cc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1ccn(CCl)c(=O)c1)C(F)(F)F Show InChI InChI=1S/C21H15ClF4N2O3/c1-12-8-14(23)3-5-17(12)31-18-9-13(21(24,25)26)2-4-16(18)20(30)27-15-6-7-28(11-22)19(29)10-15/h2-10H,11H2,1H3,(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM186572 (US9163042, 2) Show SMILES COc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1ccn(COP(O)(O)=O)c(=O)c1)C(F)(F)C(F)(F)F Show InChI InChI=1S/C22H17F6N2O8P/c1-36-18-9-13(23)3-5-16(18)38-17-8-12(21(24,25)22(26,27)28)2-4-15(17)20(32)29-14-6-7-30(19(31)10-14)11-37-39(33,34)35/h2-10H,11H2,1H3,(H,29,32)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM161235 (US10087143, Compound 20 | US10738009, Compound 20 ...) Show SMILES Cc1cc(F)ccc1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1 Show InChI InChI=1S/C19H14ClFN2O3/c1-11-8-13(21)3-5-16(11)26-17-9-12(20)2-4-15(17)19(25)23-14-6-7-22-18(24)10-14/h2-10H,1H3,(H2,22,23,24,25)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM161283 (US10087143, Compound 68 | US10738009, Compound 68 ...) Show SMILES Cc1cc(F)ccc1Oc1ccc(Cl)cc1C(=O)Nc1cc[nH]c(=O)c1 Show InChI InChI=1S/C19H14ClFN2O3/c1-11-8-13(21)3-5-16(11)26-17-4-2-12(20)9-15(17)19(25)23-14-6-7-22-18(24)10-14/h2-10H,1H3,(H2,22,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM161235 (US10087143, Compound 20 | US10738009, Compound 20 ...) Show SMILES Cc1cc(F)ccc1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1 Show InChI InChI=1S/C19H14ClFN2O3/c1-11-8-13(21)3-5-16(11)26-17-9-12(20)2-4-15(17)19(25)23-14-6-7-22-18(24)10-14/h2-10H,1H3,(H2,22,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM161283 (US10087143, Compound 68 | US10738009, Compound 68 ...) Show SMILES Cc1cc(F)ccc1Oc1ccc(Cl)cc1C(=O)Nc1cc[nH]c(=O)c1 Show InChI InChI=1S/C19H14ClFN2O3/c1-11-8-13(21)3-5-16(11)26-17-4-2-12(20)9-15(17)19(25)23-14-6-7-22-18(24)10-14/h2-10H,1H3,(H2,22,23,24,25)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM161281 (US10087143, Compound 66 | US10738009, Compound 66 ...) Show SMILES Fc1ccc(Oc2ccc(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)c(Cl)c1 Show InChI InChI=1S/C18H11Cl2FN2O3/c19-10-1-3-15(26-16-4-2-11(21)8-14(16)20)13(7-10)18(25)23-12-5-6-22-17(24)9-12/h1-9H,(H2,22,23,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM161281 (US10087143, Compound 66 | US10738009, Compound 66 ...) Show SMILES Fc1ccc(Oc2ccc(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)c(Cl)c1 Show InChI InChI=1S/C18H11Cl2FN2O3/c19-10-1-3-15(26-16-4-2-11(21)8-14(16)20)13(7-10)18(25)23-12-5-6-22-17(24)9-12/h1-9H,(H2,22,23,24,25)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM161243 (US10087143, Compound 28 | US10738009, Compound 28 ...) Show SMILES Cc1ccccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F Show InChI InChI=1S/C20H15F3N2O3/c1-12-4-2-3-5-16(12)28-17-7-6-13(20(21,22)23)10-15(17)19(27)25-14-8-9-24-18(26)11-14/h2-11H,1H3,(H2,24,25,26,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM464410 (US10787472, Compound 15a) Show SMILES COc1cc(NC(=O)c2ccc(cc2F)C(F)(F)F)ccn1 Show InChI InChI=1S/C14H10F4N2O2/c1-22-12-7-9(4-5-19-12)20-13(21)10-3-2-8(6-11(10)15)14(16,17)18/h2-7H,1H3,(H,19,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM161222 (US10087143, Compound 7 | US10738009, Compound 7 | ...) Show SMILES Fc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C19H11F5N2O3/c20-11-2-4-15(14(21)8-11)29-16-7-10(19(22,23)24)1-3-13(16)18(28)26-12-5-6-25-17(27)9-12/h1-9H,(H2,25,26,27,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM161222 (US10087143, Compound 7 | US10738009, Compound 7 | ...) Show SMILES Fc1ccc(Oc2cc(ccc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C19H11F5N2O3/c20-11-2-4-15(14(21)8-11)29-16-7-10(19(22,23)24)1-3-13(16)18(28)26-12-5-6-25-17(27)9-12/h1-9H,(H2,25,26,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM161290 (US10087143, Compound 75 | US10738009, Compound 75 ...) Show SMILES FC(F)(F)Oc1ccccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F Show InChI InChI=1S/C20H12F6N2O4/c21-19(22,23)11-5-6-14(31-15-3-1-2-4-16(15)32-20(24,25)26)13(9-11)18(30)28-12-7-8-27-17(29)10-12/h1-10H,(H2,27,28,29,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM161290 (US10087143, Compound 75 | US10738009, Compound 75 ...) Show SMILES FC(F)(F)Oc1ccccc1Oc1ccc(cc1C(=O)Nc1cc[nH]c(=O)c1)C(F)(F)F Show InChI InChI=1S/C20H12F6N2O4/c21-19(22,23)11-5-6-14(31-15-3-1-2-4-16(15)32-20(24,25)26)13(9-11)18(30)28-12-7-8-27-17(29)10-12/h1-10H,(H2,27,28,29,30)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM161217 (US10087143, Compound 2 | US10738009, Compound 2 | ...) Show SMILES Fc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1 Show InChI InChI=1S/C19H12F4N2O3/c20-12-2-4-14(5-3-12)28-16-6-1-11(19(21,22)23)9-15(16)18(27)25-13-7-8-24-17(26)10-13/h1-10H,(H2,24,25,26,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM161217 (US10087143, Compound 2 | US10738009, Compound 2 | ...) Show SMILES Fc1ccc(Oc2ccc(cc2C(=O)Nc2cc[nH]c(=O)c2)C(F)(F)F)cc1 Show InChI InChI=1S/C19H12F4N2O3/c20-12-2-4-14(5-3-12)28-16-6-1-11(19(21,22)23)9-15(16)18(27)25-13-7-8-24-17(26)10-13/h1-10H,(H2,24,25,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM186574 (US10787472, Compound 10 | US9163042, 10) Show SMILES Cc1cc(F)ccc1Oc1ccc(cc1C(=O)Nc1ccn(COP(O)(O)=O)c(=O)c1)C(F)(F)F Show InChI InChI=1S/C21H17F4N2O7P/c1-12-8-14(22)3-5-17(12)34-18-4-2-13(21(23,24)25)9-16(18)20(29)26-15-6-7-27(19(28)10-15)11-33-35(30,31)32/h2-10H,11H2,1H3,(H,26,29)(H2,30,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Incorporated US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US10787472 (2020) BindingDB Entry DOI: 10.7270/Q2377CSG
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM186574 (US10787472, Compound 10 | US9163042, 10) Show SMILES Cc1cc(F)ccc1Oc1ccc(cc1C(=O)Nc1ccn(COP(O)(O)=O)c(=O)c1)C(F)(F)F Show InChI InChI=1S/C21H17F4N2O7P/c1-12-8-14(22)3-5-17(12)34-18-4-2-13(21(23,24)25)9-16(18)20(29)26-15-6-7-27(19(28)10-15)11-33-35(30,31)32/h2-10H,11H2,1H3,(H,26,29)(H2,30,31,32)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM186575 (US10787472, Compound 13 | US9163042, 13) Show SMILES Cc1cc(F)ccc1Oc1cc(Cl)ccc1C(=O)Nc1ccn(COP(O)(O)=O)c(=O)c1 Show InChI InChI=1S/C20H17ClFN2O7P/c1-12-8-14(22)3-5-17(12)31-18-9-13(21)2-4-16(18)20(26)23-15-6-7-24(19(25)10-15)11-30-32(27,28)29/h2-10H,11H2,1H3,(H,23,26)(H2,27,28,29)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	329	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9163042 (2015) BindingDB Entry DOI: 10.7270/Q21Z4361
					More data for this Ligand-Target Pair

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