Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prothrombin (Homo sapiens (Human)) | BDBM13940 (2-(3-HYDROXY-PYRIDIN-2-YL)-1H-BENZOIMIDAZOLE-5-CAR...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals Corporation | Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... | J Mol Biol 307: 1451-86 (2001) Article DOI: 10.1006/jmbi.2001.4516 BindingDB Entry DOI: 10.7270/Q2FX77PG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM13940 (2-(3-HYDROXY-PYRIDIN-2-YL)-1H-BENZOIMIDAZOLE-5-CAR...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals Corporation | Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... | J Mol Biol 307: 1451-86 (2001) Article DOI: 10.1006/jmbi.2001.4516 BindingDB Entry DOI: 10.7270/Q2FX77PG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120038 (2-{[2-({6-[1-(1-Carboxy-2-phosphono-ethylcarbamoyl...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of EDTA. | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease 1 (Bos taurus (bovine)) | BDBM13940 (2-(3-HYDROXY-PYRIDIN-2-YL)-1H-BENZOIMIDAZOLE-5-CAR...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | 43 | -41.6 | n/a | n/a | n/a | n/a | n/a | 8.0 | 22 |
Axys Pharmaceuticals Corporation | Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... | J Mol Biol 307: 1451-86 (2001) Article DOI: 10.1006/jmbi.2001.4516 BindingDB Entry DOI: 10.7270/Q2FX77PG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine protease 1 (Bos taurus (bovine)) | BDBM13937 (2-(2-HYDROXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMI...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | 65 | -40.6 | n/a | n/a | n/a | n/a | n/a | 8.0 | 22 |
Axys Pharmaceuticals Corporation | Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... | J Mol Biol 307: 1451-86 (2001) Article DOI: 10.1006/jmbi.2001.4516 BindingDB Entry DOI: 10.7270/Q2FX77PG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120023 (2-[(2-{[6-(1-Carboxy-2-phosphono-ethylcarbamoyl)-1...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 73 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120050 (2-({2-[6-(1-Carboxy-2-phosphono-ethylcarbamoyl)-1-...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of EDTA | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120012 (2-{[2-(1H-Benzoimidazol-2-ylmethyl)-3-cyclopropylm...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM13937 (2-(2-HYDROXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMI...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals Corporation | Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... | J Mol Biol 307: 1451-86 (2001) Article DOI: 10.1006/jmbi.2001.4516 BindingDB Entry DOI: 10.7270/Q2FX77PG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120036 (2-{[2-(5-Hydroxy-1H-benzoimidazol-2-ylmethyl)-3-me...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120048 (2-{[2-(5-Methoxy-1H-benzoimidazol-2-ylmethyl)-3-me...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120027 (2-{[3-Methyl-2-(5,6,7-trifluoro-1H-benzoimidazol-2...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50103860 (2-{[2-(5-Carbamoyl-1H-benzoimidazol-2-ylmethyl)-3-...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of EDTA. | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120014 (2-{[2-(5,6-Difluoro-1H-benzoimidazol-2-ylmethyl)-3...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120015 (2-({2-[1-(1H-Benzoimidazol-2-yl)-ethyl]-3-methyl-3...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120047 (2-{[3-Methyl-2-(5-methyl-1H-benzoimidazol-2-ylmeth...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of EDTA. | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120013 (2-{[2-(4,6-Difluoro-1H-benzoimidazol-2-ylmethyl)-3...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120046 (2-({2-[(1H-Benzoimidazol-2-yl)-difluoro-methyl]-3-...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120020 (2-{[2-(4,5-Difluoro-1H-benzoimidazol-2-ylmethyl)-3...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of EDTA. | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120033 (2-[(2-{Difluoro-[6-(1-methoxycarbonyl-2-phosphono-...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 277 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120016 (2-{[2-(5-Fluoro-1H-benzoimidazol-2-ylmethyl)-3-met...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM13937 (2-(2-HYDROXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMI...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | 280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals Corporation | Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... | J Mol Biol 307: 1451-86 (2001) Article DOI: 10.1006/jmbi.2001.4516 BindingDB Entry DOI: 10.7270/Q2FX77PG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120018 (2-{[3-Methyl-2-(4,5,6,7-tetrafluoro-1H-benzoimidaz...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Urokinase-type plasminogen activator (Homo sapiens (Human)) | BDBM13941 (APC-8249 | {amino[2-(2-hydroxy-5-nitrophenyl)-1H-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals Corporation | Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... | J Mol Biol 307: 1451-86 (2001) Article DOI: 10.1006/jmbi.2001.4516 BindingDB Entry DOI: 10.7270/Q2FX77PG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120019 (2-{[3-Methyl-2-(4,6,7-trifluoro-1H-benzoimidazol-2...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120031 (2-{[2-(1H-Benzoimidazol-2-ylmethyl)-3-isobutyl-3H-...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of EDTA. | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120035 (2-{[2-(5-Chloro-1H-benzoimidazol-2-ylmethyl)-3-met...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of EDTA | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease 1 (Bos taurus (bovine)) | BDBM13945 (APC-13140 | [amino(2-{hydroxy[(3-phenoxyphenyl)met...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 380 | -36.3 | n/a | n/a | n/a | n/a | n/a | 7.7 | 22 |
Axys Pharmaceuticals Corporation | Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... | J Mol Biol 307: 1451-86 (2001) Article DOI: 10.1006/jmbi.2001.4516 BindingDB Entry DOI: 10.7270/Q2FX77PG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM13945 (APC-13140 | [amino(2-{hydroxy[(3-phenoxyphenyl)met...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals Corporation | Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... | J Mol Biol 307: 1451-86 (2001) Article DOI: 10.1006/jmbi.2001.4516 BindingDB Entry DOI: 10.7270/Q2FX77PG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120034 (2-{[3-Methyl-2-(5-trifluoromethyl-1H-benzoimidazol...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120051 (2-{[2-(1H-Benzoimidazol-2-ylmethyl)-3-methyl-3H-be...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 450 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120052 (2-({2-[(1H-Benzoimidazol-2-yl)-fluoro-methyl]-3-me...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120042 (2-{[2-(4-Methoxy-1H-benzoimidazol-2-ylmethyl)-3-me...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120030 (2-({2-[Fluoro-(4,6,7-trifluoro-1H-benzoimidazol-2-...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120045 (2-{[2-(1H-Benzoimidazol-2-ylmethyl)-3-(2,2-dimethy...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 610 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120037 (2-({2-[(4,6-Difluoro-1H-benzoimidazol-2-yl)-fluoro...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 660 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM13942 (2-(2-HYDROXY-PHENYL)-1H-INDOLE-5-CARBOXAMIDINE | A...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 740 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals Corporation | Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... | J Mol Biol 307: 1451-86 (2001) Article DOI: 10.1006/jmbi.2001.4516 BindingDB Entry DOI: 10.7270/Q2FX77PG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Urokinase-type plasminogen activator (Homo sapiens (Human)) | BDBM13937 (2-(2-HYDROXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMI...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | 750 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals Corporation | Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... | J Mol Biol 307: 1451-86 (2001) Article DOI: 10.1006/jmbi.2001.4516 BindingDB Entry DOI: 10.7270/Q2FX77PG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120026 (2-[2-({2-[(1H-Benzoimidazol-2-yl)-difluoro-methyl]...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 820 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of EDTA. | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120028 (2-{[2-(1H-Benzoimidazol-2-ylmethyl)-3-(3-methyl-bu...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 870 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Urokinase-type plasminogen activator (Homo sapiens (Human)) | BDBM13942 (2-(2-HYDROXY-PHENYL)-1H-INDOLE-5-CARBOXAMIDINE | A...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 880 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals Corporation | Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... | J Mol Biol 307: 1451-86 (2001) Article DOI: 10.1006/jmbi.2001.4516 BindingDB Entry DOI: 10.7270/Q2FX77PG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease 1 (Bos taurus (bovine)) | BDBM13941 (APC-8249 | {amino[2-(2-hydroxy-5-nitrophenyl)-1H-1...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 940 | -34.1 | n/a | n/a | n/a | n/a | n/a | 6.1 | 22 |
Axys Pharmaceuticals Corporation | Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... | J Mol Biol 307: 1451-86 (2001) Article DOI: 10.1006/jmbi.2001.4516 BindingDB Entry DOI: 10.7270/Q2FX77PG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120038 (2-{[2-({6-[1-(1-Carboxy-2-phosphono-ethylcarbamoyl...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of EDTA. | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Urokinase-type plasminogen activator (Homo sapiens (Human)) | BDBM13939 (2-(2-HYDROXY-5-METHOXY-PHENYL)-1H-BENZOIMIDAZOLE-5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Axys Pharmaceuticals Corporation | Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... | J Mol Biol 307: 1451-86 (2001) Article DOI: 10.1006/jmbi.2001.4516 BindingDB Entry DOI: 10.7270/Q2FX77PG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine protease 1 (Bos taurus (bovine)) | BDBM13937 (2-(2-HYDROXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMI...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | 1.10E+3 | -33.7 | n/a | n/a | n/a | n/a | n/a | 7.0 | 22 |
Axys Pharmaceuticals Corporation | Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... | J Mol Biol 307: 1451-86 (2001) Article DOI: 10.1006/jmbi.2001.4516 BindingDB Entry DOI: 10.7270/Q2FX77PG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120046 (2-({2-[(1H-Benzoimidazol-2-yl)-difluoro-methyl]-3-...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120041 (2-({2-[1-(1H-Benzoimidazol-2-yl)-ethyl]-3-methyl-3...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120049 (2-({2-[(6-Carbamoyl-1H-benzoimidazol-2-yl)-difluor...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120010 (2-({2-[Difluoro-(5-fluoro-1H-benzoimidazol-2-yl)-m...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Genome polyprotein/Non-structural protein 4A (Hepatitis C virus) | BDBM50120021 (2-{[2-(6-Carbamoyl-1H-benzoimidazol-2-ylmethyl)-3-...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Curated by ChEMBL | Assay Description Inhibition of HCV serine protease NS3/NS4A in the presence of Zn | Bioorg Med Chem Lett 12: 3129-33 (2002) BindingDB Entry DOI: 10.7270/Q25D8R64 | |||||||||||
More data for this Ligand-Target Pair |
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