Compile Data Set for Download or QSAR

Found 314 hits with Last Name = 'miller' and Initial = 'nr'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50220541 (CHEMBL392158 | Fallypride | N-(((S)-1-allylpyrroli...) Show SMILES COc1cc(CCCF)cc(C(=O)NC[C@@H]2CCCN2CC=C)c1OC |r| Show InChI InChI=1S/C20H29FN2O3/c1-4-10-23-11-6-8-16(23)14-22-20(24)17-12-15(7-5-9-21)13-18(25-2)19(17)26-3/h4,12-13,16H,1,5-11,14H2,2-3H3,(H,22,24)/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Antagonist activity at dopamine D2 receptor (unknown origin)				Bioorg Med Chem Lett 18: 4467-9 (2008) Article DOI: 10.1016/j.bmcl.2008.07.065 BindingDB Entry DOI: 10.7270/Q25T3K86
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50272063 ((S)-N-((1-allylpyrrolidin-2-yl)methyl)-5-(3-chloro...) Show SMILES COc1cc(CCCCl)cc(C(=O)NC[C@@H]2CCCN2CC=C)c1OC |r| Show InChI InChI=1S/C20H29ClN2O3/c1-4-10-23-11-6-8-16(23)14-22-20(24)17-12-15(7-5-9-21)13-18(25-2)19(17)26-3/h4,12-13,16H,1,5-11,14H2,2-3H3,(H,22,24)/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17.1	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Antagonist activity at dopamine D2 receptor (unknown origin)				Bioorg Med Chem Lett 18: 4467-9 (2008) Article DOI: 10.1016/j.bmcl.2008.07.065 BindingDB Entry DOI: 10.7270/Q25T3K86
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50314594 (CHEMBL1090094 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2c(F)c(F)c(F)c(F)c2F)cc1Cl Show InChI InChI=1S/C19H17ClF5N3O/c1-2-27-5-7-28(8-6-27)12-4-3-10(9-11(12)20)26-19(29)13-14(21)16(23)18(25)17(24)15(13)22/h3-4,9H,2,5-8H2,1H3,(H,26,29)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50231845 (CHEMBL255523 | N-(3-chloro-4-(4-ethylpiperazin-1-y...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)CCC2CCCC2)cc1Cl Show InChI InChI=1S/C20H30ClN3O/c1-2-23-11-13-24(14-12-23)19-9-8-17(15-18(19)21)22-20(25)10-7-16-5-3-4-6-16/h8-9,15-16H,2-7,10-14H2,1H3,(H,22,25)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	441	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat muscarinic M1 receptor				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50314597 (CHEMBL1090097 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2cc(ccc2C(F)(F)F)C(F)(F)F)cc1Cl Show InChI InChI=1S/C21H20ClF6N3O/c1-2-30-7-9-31(10-8-30)18-6-4-14(12-17(18)22)29-19(32)15-11-13(20(23,24)25)3-5-16(15)21(26,27)28/h3-6,11-12H,2,7-10H2,1H3,(H,29,32)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50314590 (2-chloro-N-(3-chloro-4-(4-ethylpiperazin-1-yl)phen...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccccc2Cl)cc1Cl Show InChI InChI=1S/C19H21Cl2N3O/c1-2-23-9-11-24(12-10-23)18-8-7-14(13-17(18)21)22-19(25)15-5-3-4-6-16(15)20/h3-8,13H,2,9-12H2,1H3,(H,22,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	820	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M3 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50314591 (CHEMBL1092460 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccccc2OC)cc1Cl Show InChI InChI=1S/C20H24ClN3O2/c1-3-23-10-12-24(13-11-23)18-9-8-15(14-17(18)21)22-20(25)16-6-4-5-7-19(16)26-2/h4-9,14H,3,10-13H2,1-2H3,(H,22,25)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	820	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50314594 (CHEMBL1090094 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2c(F)c(F)c(F)c(F)c2F)cc1Cl Show InChI InChI=1S/C19H17ClF5N3O/c1-2-27-5-7-28(8-6-27)12-4-3-10(9-11(12)20)26-19(29)13-14(21)16(23)18(25)17(24)15(13)22/h3-4,9H,2,5-8H2,1H3,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50314590 (2-chloro-N-(3-chloro-4-(4-ethylpiperazin-1-yl)phen...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccccc2Cl)cc1Cl Show InChI InChI=1S/C19H21Cl2N3O/c1-2-23-9-11-24(12-10-23)18-8-7-14(13-17(18)21)22-19(25)15-5-3-4-6-16(15)20/h3-8,13H,2,9-12H2,1H3,(H,22,25)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	960	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50275558 (4-(4-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-...) Show SMILES Fc1cccc2n(C3CCN(CC3)C3CCN(CC3)C(=O)Nc3cccc(SC(F)(F)F)c3)c(=O)[nH]c12 Show InChI InChI=1S/C25H27F4N5O2S/c26-20-5-2-6-21-22(20)31-24(36)34(21)18-9-11-32(12-10-18)17-7-13-33(14-8-17)23(35)30-16-3-1-4-19(15-16)37-25(27,28)29/h1-6,15,17-18H,7-14H2,(H,30,35)(H,31,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at dopamine D2 receptor (unknown origin)				Bioorg Med Chem Lett 18: 5443-7 (2008) Article DOI: 10.1016/j.bmcl.2008.09.032 BindingDB Entry DOI: 10.7270/Q29K4B1C
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50263411 (1-[1'-(2-Nitro-benzyl)-[1,4']bipiperidinyl-4-yl]-1...) Show SMILES [O-][N+](=O)c1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C24H29N5O3/c30-24-25-21-6-2-4-8-23(21)28(24)20-11-15-27(16-12-20)19-9-13-26(14-10-19)17-18-5-1-3-7-22(18)29(31)32/h1-8,19-20H,9-17H2,(H,25,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.13E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of dopamine D2 receptor (unknown origin)				Bioorg Med Chem Lett 18: 5439-42 (2008) Article DOI: 10.1016/j.bmcl.2008.09.023 BindingDB Entry DOI: 10.7270/Q2708198
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50314591 (CHEMBL1092460 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccccc2OC)cc1Cl Show InChI InChI=1S/C20H24ClN3O2/c1-3-23-10-12-24(13-11-23)18-9-8-15(14-17(18)21)22-20(25)16-6-4-5-7-19(16)26-2/h4-9,14H,3,10-13H2,1-2H3,(H,22,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50314597 (CHEMBL1090097 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2cc(ccc2C(F)(F)F)C(F)(F)F)cc1Cl Show InChI InChI=1S/C21H20ClF6N3O/c1-2-30-7-9-31(10-8-30)18-6-4-14(12-17(18)22)29-19(32)15-11-13(20(23,24)25)3-5-16(15)21(26,27)28/h3-6,11-12H,2,7-10H2,1H3,(H,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M4 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylch...				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50275559 (4-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-...) Show SMILES Fc1ccc2[nH]c(=O)n(C3CCN(CC3)C3CCN(CC3)C(=O)Nc3cccc(SC(F)(F)F)c3)c2c1 Show InChI InChI=1S/C25H27F4N5O2S/c26-16-4-5-21-22(14-16)34(24(36)31-21)19-8-10-32(11-9-19)18-6-12-33(13-7-18)23(35)30-17-2-1-3-20(15-17)37-25(27,28)29/h1-5,14-15,18-19H,6-13H2,(H,30,35)(H,31,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at dopamine D2 receptor (unknown origin)				Bioorg Med Chem Lett 18: 5443-7 (2008) Article DOI: 10.1016/j.bmcl.2008.09.032 BindingDB Entry DOI: 10.7270/Q29K4B1C
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50263372 (1-[1'-(2-Chloro-benzyl)-[1,4']bipiperidinyl-4-yl]-...) Show SMILES Clc1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C24H29ClN4O/c25-21-6-2-1-5-18(21)17-27-13-9-19(10-14-27)28-15-11-20(12-16-28)29-23-8-4-3-7-22(23)26-24(29)30/h1-8,19-20H,9-17H2,(H,26,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of dopamine D2 receptor (unknown origin)				Bioorg Med Chem Lett 18: 5439-42 (2008) Article DOI: 10.1016/j.bmcl.2008.09.023 BindingDB Entry DOI: 10.7270/Q2708198
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50314593 (CHEMBL1093775 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2cccc(C)c2)cc1Cl Show InChI InChI=1S/C20H24ClN3O/c1-3-23-9-11-24(12-10-23)19-8-7-17(14-18(19)21)22-20(25)16-6-4-5-15(2)13-16/h4-8,13-14H,3,9-12H2,1-2H3,(H,22,25)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50314590 (2-chloro-N-(3-chloro-4-(4-ethylpiperazin-1-yl)phen...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccccc2Cl)cc1Cl Show InChI InChI=1S/C19H21Cl2N3O/c1-2-23-9-11-24(12-10-23)18-8-7-14(13-17(18)21)22-19(25)15-5-3-4-6-16(15)20/h3-8,13H,2,9-12H2,1H3,(H,22,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50275505 (5-chloro-1-(1'-(phenylsulfonyl)-1,4'-bipiperidin-4...) Show SMILES Clc1ccc2n(C3CCN(CC3)C3CCN(CC3)S(=O)(=O)c3ccccc3)c(=O)[nH]c2c1 Show InChI InChI=1S/C23H27ClN4O3S/c24-17-6-7-22-21(16-17)25-23(29)28(22)19-8-12-26(13-9-19)18-10-14-27(15-11-18)32(30,31)20-4-2-1-3-5-20/h1-7,16,18-19H,8-15H2,(H,25,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at dopamine D2 receptor (unknown origin)				Bioorg Med Chem Lett 18: 5443-7 (2008) Article DOI: 10.1016/j.bmcl.2008.09.032 BindingDB Entry DOI: 10.7270/Q29K4B1C
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50314598 (CHEMBL1090759 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1Cl Show InChI InChI=1S/C21H20ClF6N3O/c1-2-30-5-7-31(8-6-30)18-4-3-16(12-17(18)22)29-19(32)13-9-14(20(23,24)25)11-15(10-13)21(26,27)28/h3-4,9-12H,2,5-8H2,1H3,(H,29,32)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50263887 (1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-b...) Show SMILES Cc1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C25H32N4O/c1-19-6-2-3-7-20(19)18-27-14-10-21(11-15-27)28-16-12-22(13-17-28)29-24-9-5-4-8-23(24)26-25(29)30/h2-9,21-22H,10-18H2,1H3,(H,26,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.65E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of dopamine D2 receptor (unknown origin)				Bioorg Med Chem Lett 18: 5439-42 (2008) Article DOI: 10.1016/j.bmcl.2008.09.023 BindingDB Entry DOI: 10.7270/Q2708198
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50263936 (5-Fluoro-1-[1'-(2-trifluoromethyl-benzyl)-[1,4']bi...) Show SMILES Fc1ccc2n(C3CCN(CC3)C3CCN(Cc4ccccc4C(F)(F)F)CC3)c(=O)[nH]c2c1 Show InChI InChI=1S/C25H28F4N4O/c26-18-5-6-23-22(15-18)30-24(34)33(23)20-9-13-32(14-10-20)19-7-11-31(12-8-19)16-17-3-1-2-4-21(17)25(27,28)29/h1-6,15,19-20H,7-14,16H2,(H,30,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.69E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of dopamine D2 receptor (unknown origin)				Bioorg Med Chem Lett 18: 5439-42 (2008) Article DOI: 10.1016/j.bmcl.2008.09.023 BindingDB Entry DOI: 10.7270/Q2708198
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50314597 (CHEMBL1090097 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2cc(ccc2C(F)(F)F)C(F)(F)F)cc1Cl Show InChI InChI=1S/C21H20ClF6N3O/c1-2-30-7-9-31(10-8-30)18-6-4-14(12-17(18)22)29-19(32)15-11-13(20(23,24)25)3-5-16(15)21(26,27)28/h3-6,11-12H,2,7-10H2,1H3,(H,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylch...				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50275557 (5-bromo-1-(1'-(phenylsulfonyl)-1,4'-bipiperidin-4-...) Show SMILES Brc1ccc2n(C3CCN(CC3)C3CCN(CC3)S(=O)(=O)c3ccccc3)c(=O)[nH]c2c1 Show InChI InChI=1S/C23H27BrN4O3S/c24-17-6-7-22-21(16-17)25-23(29)28(22)19-8-12-26(13-9-19)18-10-14-27(15-11-18)32(30,31)20-4-2-1-3-5-20/h1-7,16,18-19H,8-15H2,(H,25,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at dopamine D2 receptor (unknown origin)				Bioorg Med Chem Lett 18: 5443-7 (2008) Article DOI: 10.1016/j.bmcl.2008.09.032 BindingDB Entry DOI: 10.7270/Q29K4B1C
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50314596 (CHEMBL1090096 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Cl Show InChI InChI=1S/C20H21ClF3N3O/c1-2-26-8-10-27(11-9-26)18-7-6-16(13-17(18)21)25-19(28)14-4-3-5-15(12-14)20(22,23)24/h3-7,12-13H,2,8-11H2,1H3,(H,25,28)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50314592 (CHEMBL1092461 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccc(C)cc2)cc1Cl Show InChI InChI=1S/C20H24ClN3O/c1-3-23-10-12-24(13-11-23)19-9-8-17(14-18(19)21)22-20(25)16-6-4-15(2)5-7-16/h4-9,14H,3,10-13H2,1-2H3,(H,22,25)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50231856 (CHEMBL271519 | N-(3-chloro-4-(4-ethylpiperazin-1-y...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccccc2)cc1Cl Show InChI InChI=1S/C19H22ClN3O/c1-2-22-10-12-23(13-11-22)18-9-8-16(14-17(18)20)21-19(24)15-6-4-3-5-7-15/h3-9,14H,2,10-13H2,1H3,(H,21,24)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50314595 (CHEMBL1090095 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccc(OC)cc2)cc1Cl Show InChI InChI=1S/C20H24ClN3O2/c1-3-23-10-12-24(13-11-23)19-9-6-16(14-18(19)21)22-20(25)15-4-7-17(26-2)8-5-15/h4-9,14H,3,10-13H2,1-2H3,(H,22,25)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50314593 (CHEMBL1093775 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2cccc(C)c2)cc1Cl Show InChI InChI=1S/C20H24ClN3O/c1-3-23-9-11-24(12-10-23)19-8-7-17(14-18(19)21)22-20(25)16-6-4-5-15(2)13-16/h4-8,13-14H,3,9-12H2,1-2H3,(H,22,25)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50275503 (5-fluoro-1-(1'-(phenylsulfonyl)-1,4'-bipiperidin-4...) Show SMILES Fc1ccc2n(C3CCN(CC3)C3CCN(CC3)S(=O)(=O)c3ccccc3)c(=O)[nH]c2c1 Show InChI InChI=1S/C23H27FN4O3S/c24-17-6-7-22-21(16-17)25-23(29)28(22)19-8-12-26(13-9-19)18-10-14-27(15-11-18)32(30,31)20-4-2-1-3-5-20/h1-7,16,18-19H,8-15H2,(H,25,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at dopamine D2 receptor (unknown origin)				Bioorg Med Chem Lett 18: 5443-7 (2008) Article DOI: 10.1016/j.bmcl.2008.09.032 BindingDB Entry DOI: 10.7270/Q29K4B1C
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50314598 (CHEMBL1090759 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1Cl Show InChI InChI=1S/C21H20ClF6N3O/c1-2-30-5-7-31(8-6-30)18-4-3-16(12-17(18)22)29-19(32)13-9-14(20(23,24)25)11-15(10-13)21(26,27)28/h3-4,9-12H,2,5-8H2,1H3,(H,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M4 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylch...				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50314592 (CHEMBL1092461 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccc(C)cc2)cc1Cl Show InChI InChI=1S/C20H24ClN3O/c1-3-23-10-12-24(13-11-23)19-9-8-17(14-18(19)21)22-20(25)16-6-4-15(2)5-7-16/h4-9,14H,3,10-13H2,1-2H3,(H,22,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M4 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylch...				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50314594 (CHEMBL1090094 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2c(F)c(F)c(F)c(F)c2F)cc1Cl Show InChI InChI=1S/C19H17ClF5N3O/c1-2-27-5-7-28(8-6-27)12-4-3-10(9-11(12)20)26-19(29)13-14(21)16(23)18(25)17(24)15(13)22/h3-4,9H,2,5-8H2,1H3,(H,26,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M3 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50314596 (CHEMBL1090096 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Cl Show InChI InChI=1S/C20H21ClF3N3O/c1-2-26-8-10-27(11-9-26)18-7-6-16(13-17(18)21)25-19(28)14-4-3-5-15(12-14)20(22,23)24/h3-7,12-13H,2,8-11H2,1H3,(H,25,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M4 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylch...				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50314597 (CHEMBL1090097 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2cc(ccc2C(F)(F)F)C(F)(F)F)cc1Cl Show InChI InChI=1S/C21H20ClF6N3O/c1-2-30-7-9-31(10-8-30)18-6-4-14(12-17(18)22)29-19(32)15-11-13(20(23,24)25)3-5-16(15)21(26,27)28/h3-6,11-12H,2,7-10H2,1H3,(H,29,32)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50314596 (CHEMBL1090096 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Cl Show InChI InChI=1S/C20H21ClF3N3O/c1-2-26-8-10-27(11-9-26)18-7-6-16(13-17(18)21)25-19(28)14-4-3-5-15(12-14)20(22,23)24/h3-7,12-13H,2,8-11H2,1H3,(H,25,28)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M5 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50314597 (CHEMBL1090097 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2cc(ccc2C(F)(F)F)C(F)(F)F)cc1Cl Show InChI InChI=1S/C21H20ClF6N3O/c1-2-30-7-9-31(10-8-30)18-6-4-14(12-17(18)22)29-19(32)15-11-13(20(23,24)25)3-5-16(15)21(26,27)28/h3-6,11-12H,2,7-10H2,1H3,(H,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M3 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50314596 (CHEMBL1090096 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Cl Show InChI InChI=1S/C20H21ClF3N3O/c1-2-26-8-10-27(11-9-26)18-7-6-16(13-17(18)21)25-19(28)14-4-3-5-15(12-14)20(22,23)24/h3-7,12-13H,2,8-11H2,1H3,(H,25,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M3 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM43822 (4-[2-(o-toluoylamino)ethylamino]piperidine-1-carbo...) Show SMILES CCOC(=O)N1CCC(CC1)NCCNC(=O)c1ccccc1C Show InChI InChI=1S/C18H27N3O3/c1-3-24-18(23)21-12-8-15(9-13-21)19-10-11-20-17(22)16-7-5-4-6-14(16)2/h4-7,15,19H,3,8-13H2,1-2H3,(H,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at dopamine D2 receptor				Bioorg Med Chem Lett 21: 6451-5 (2011) Article DOI: 10.1016/j.bmcl.2011.08.084 BindingDB Entry DOI: 10.7270/Q26W9BG8
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50314599 (CHEMBL1093933 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccc(F)c(F)c2)cc1Cl Show InChI InChI=1S/C19H20ClF2N3O/c1-2-24-7-9-25(10-8-24)18-6-4-14(12-15(18)20)23-19(26)13-3-5-16(21)17(22)11-13/h3-6,11-12H,2,7-10H2,1H3,(H,23,26)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50231856 (CHEMBL271519 | N-(3-chloro-4-(4-ethylpiperazin-1-y...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccccc2)cc1Cl Show InChI InChI=1S/C19H22ClN3O/c1-2-22-10-12-23(13-11-22)18-9-8-16(14-17(18)20)21-19(24)15-6-4-3-5-7-15/h3-9,14H,2,10-13H2,1H3,(H,21,24)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at rat muscarinic M1 receptor				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50263887 (1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-b...) Show SMILES Cc1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C25H32N4O/c1-19-6-2-3-7-20(19)18-27-14-10-21(11-15-27)28-16-12-22(13-17-28)29-24-9-5-4-8-23(24)26-25(29)30/h2-9,21-22H,10-18H2,1H3,(H,26,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at dopamine D2 receptor (unknown origin)				Bioorg Med Chem Lett 18: 5443-7 (2008) Article DOI: 10.1016/j.bmcl.2008.09.032 BindingDB Entry DOI: 10.7270/Q29K4B1C
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50314591 (CHEMBL1092460 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccccc2OC)cc1Cl Show InChI InChI=1S/C20H24ClN3O2/c1-3-23-10-12-24(13-11-23)18-9-8-15(14-17(18)21)22-20(25)16-6-4-5-7-19(16)26-2/h4-9,14H,3,10-13H2,1-2H3,(H,22,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M3 receptor expressed in CHO-K1 cells assessed as inhibition of acetylcholine-induced calcium mobilization				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50314592 (CHEMBL1092461 | N-(3-chloro-4-(4-ethylpiperazin-1-...) Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccc(C)cc2)cc1Cl Show InChI InChI=1S/C20H24ClN3O/c1-3-23-10-12-24(13-11-23)19-9-8-17(14-18(19)21)22-20(25)16-6-4-15(2)5-7-16/h4-9,14H,3,10-13H2,1-2H3,(H,22,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Gqi5 chimeric G-protein assessed as inhibition of acetylch...				Bioorg Med Chem Lett 20: 2174-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.041 BindingDB Entry DOI: 10.7270/Q2D50N38
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50263892 (6-Fluoro-1-[1'-(2-methyl-benzyl)-[1,4']bipiperidin...) Show SMILES Cc1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O Show InChI InChI=1S/C25H31FN4O/c1-18-4-2-3-5-19(18)17-28-12-8-21(9-13-28)29-14-10-22(11-15-29)30-24-16-20(26)6-7-23(24)27-25(30)31/h2-7,16,21-22H,8-15,17H2,1H3,(H,27,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of dopamine D2 receptor (unknown origin)				Bioorg Med Chem Lett 18: 5439-42 (2008) Article DOI: 10.1016/j.bmcl.2008.09.023 BindingDB Entry DOI: 10.7270/Q2708198
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50263890 (4-Fluoro-1-[1'-(2-methyl-benzyl)-[1,4']bipiperidin...) Show SMILES Cc1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2cccc(F)c2[nH]c1=O Show InChI InChI=1S/C25H31FN4O/c1-18-5-2-3-6-19(18)17-28-13-9-20(10-14-28)29-15-11-21(12-16-29)30-23-8-4-7-22(26)24(23)27-25(30)31/h2-8,20-21H,9-17H2,1H3,(H,27,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of dopamine D2 receptor (unknown origin)				Bioorg Med Chem Lett 18: 5439-42 (2008) Article DOI: 10.1016/j.bmcl.2008.09.023 BindingDB Entry DOI: 10.7270/Q2708198
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50263893 (4-Fluoro-1-[1'-(2-trifluoromethyl-benzyl)-[1,4']bi...) Show SMILES Fc1cccc2n(C3CCN(CC3)C3CCN(Cc4ccccc4C(F)(F)F)CC3)c(=O)[nH]c12 Show InChI InChI=1S/C25H28F4N4O/c26-21-6-3-7-22-23(21)30-24(34)33(22)19-10-14-32(15-11-19)18-8-12-31(13-9-18)16-17-4-1-2-5-20(17)25(27,28)29/h1-7,18-19H,8-16H2,(H,30,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of dopamine D2 receptor (unknown origin)				Bioorg Med Chem Lett 18: 5439-42 (2008) Article DOI: 10.1016/j.bmcl.2008.09.023 BindingDB Entry DOI: 10.7270/Q2708198
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50263937 (6-Fluoro-1-[1'-(2-trifluoromethyl-benzyl)-[1,4']bi...) Show SMILES Fc1ccc2[nH]c(=O)n(C3CCN(CC3)C3CCN(Cc4ccccc4C(F)(F)F)CC3)c2c1 Show InChI InChI=1S/C25H28F4N4O/c26-18-5-6-22-23(15-18)33(24(34)30-22)20-9-13-32(14-10-20)19-7-11-31(12-8-19)16-17-3-1-2-4-21(17)25(27,28)29/h1-6,15,19-20H,7-14,16H2,(H,30,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of dopamine D2 receptor (unknown origin)				Bioorg Med Chem Lett 18: 5439-42 (2008) Article DOI: 10.1016/j.bmcl.2008.09.023 BindingDB Entry DOI: 10.7270/Q2708198
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50263888 (CHEMBL491209 | Ethyl 4-(2-oxo-2,3-dihydro-1Hbenzo[...) Show SMILES CCOC(=O)N1CCC(CC1)N1CCC(CC1)n1c2ccccc2[nH]c1=O Show InChI InChI=1S/C20H28N4O3/c1-2-27-20(26)23-13-7-15(8-14-23)22-11-9-16(10-12-22)24-18-6-4-3-5-17(18)21-19(24)25/h3-6,15-16H,2,7-14H2,1H3,(H,21,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Inhibition of dopamine D2 receptor (unknown origin)				Bioorg Med Chem Lett 18: 5439-42 (2008) Article DOI: 10.1016/j.bmcl.2008.09.023 BindingDB Entry DOI: 10.7270/Q2708198
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50275560 (4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-...) Show SMILES FC(F)(F)Sc1cccc(NC(=O)N2CCC(CC2)N2CCC(CC2)n2c3ccc(Cl)cc3[nH]c2=O)c1 Show InChI InChI=1S/C25H27ClF3N5O2S/c26-16-4-5-22-21(14-16)31-24(36)34(22)19-8-10-32(11-9-19)18-6-12-33(13-7-18)23(35)30-17-2-1-3-20(15-17)37-25(27,28)29/h1-5,14-15,18-19H,6-13H2,(H,30,35)(H,31,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at dopamine D2 receptor (unknown origin)				Bioorg Med Chem Lett 18: 5443-7 (2008) Article DOI: 10.1016/j.bmcl.2008.09.032 BindingDB Entry DOI: 10.7270/Q29K4B1C
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50275504 (6-fluoro-1-(1'-(phenylsulfonyl)-1,4'-bipiperidin-4...) Show SMILES Fc1ccc2[nH]c(=O)n(C3CCN(CC3)C3CCN(CC3)S(=O)(=O)c3ccccc3)c2c1 Show InChI InChI=1S/C23H27FN4O3S/c24-17-6-7-21-22(16-17)28(23(29)25-21)19-8-12-26(13-9-19)18-10-14-27(15-11-18)32(30,31)20-4-2-1-3-5-20/h1-7,16,18-19H,8-15H2,(H,25,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at dopamine D2 receptor (unknown origin)				Bioorg Med Chem Lett 18: 5443-7 (2008) Article DOI: 10.1016/j.bmcl.2008.09.032 BindingDB Entry DOI: 10.7270/Q29K4B1C
					More data for this Ligand-Target Pair

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