Found 227 hits with Last Name = 'nakatani' and Initial = 'y' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Orexin receptor type 2
(Homo sapiens (Human)) | BDBM50440024
(CHEMBL2425785)Show SMILES COCc1nc(C)ncc1OC[C@]1(C[C@H]1C(=O)Nc1ccc(F)cn1)c1cccc(F)c1 |r| Show InChI InChI=1S/C23H22F2N4O3/c1-14-26-11-20(19(28-14)12-31-2)32-13-23(15-4-3-5-16(24)8-15)9-18(23)22(30)29-21-7-6-17(25)10-27-21/h3-8,10-11,18H,9,12-13H2,1-2H3,(H,27,29,30)/t18-,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co. , Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-orexin-A from human OX2 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis |
J Med Chem 56: 6371-85 (2013)
Article DOI: 10.1021/jm400772t
BindingDB Entry DOI: 10.7270/Q2QF8V91 |
More data for this
Ligand-Target Pair | |
Orexin receptor type 2
(Homo sapiens (Human)) | BDBM50440021
(CHEMBL2425788)Show SMILES COCc1nc(C)ncc1OC[C@]1(C[C@H]1C(=O)Nc1ccc(F)cn1)c1ccccc1 |r| Show InChI InChI=1S/C23H23FN4O3/c1-15-25-12-20(19(27-15)13-30-2)31-14-23(16-6-4-3-5-7-16)10-18(23)22(29)28-21-9-8-17(24)11-26-21/h3-9,11-12,18H,10,13-14H2,1-2H3,(H,26,28,29)/t18-,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co. , Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-orexin-A from human OX2 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis |
J Med Chem 56: 6371-85 (2013)
Article DOI: 10.1021/jm400772t
BindingDB Entry DOI: 10.7270/Q2QF8V91 |
More data for this
Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM50440024
(CHEMBL2425785)Show SMILES COCc1nc(C)ncc1OC[C@]1(C[C@H]1C(=O)Nc1ccc(F)cn1)c1cccc(F)c1 |r| Show InChI InChI=1S/C23H22F2N4O3/c1-14-26-11-20(19(28-14)12-31-2)32-13-23(15-4-3-5-16(24)8-15)9-18(23)22(30)29-21-7-6-17(25)10-27-21/h3-8,10-11,18H,9,12-13H2,1-2H3,(H,27,29,30)/t18-,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co. , Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-orexin-A from human OX1 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis |
J Med Chem 56: 6371-85 (2013)
Article DOI: 10.1021/jm400772t
BindingDB Entry DOI: 10.7270/Q2QF8V91 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50091652
(CHEMBL269503 | PYY | PYY, rat | Peptide YY(PYY)(YP...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O Show InChI InChI=1S/C190H287N53O58/c1-92(2)74-124(166(280)216-114(27-18-66-204-187(195)196)158(272)231-131(83-107-86-203-91-209-107)171(285)230-130(81-105-41-51-111(251)52-42-105)169(283)225-125(75-93(3)4)167(281)232-132(84-143(194)254)172(286)226-127(77-95(7)8)173(287)238-150(96(9)10)180(294)239-151(101(15)247)181(295)222-117(30-21-69-207-190(201)202)156(270)218-119(55-60-142(193)253)161(275)215-116(29-20-68-206-189(199)200)159(273)234-134(186(300)301)82-106-43-53-112(252)54-44-106)227-175(289)135(88-244)235-153(267)97(11)210-164(278)128(79-103-37-47-109(249)48-38-103)229-170(284)129(80-104-39-49-110(250)50-40-104)228-157(271)115(28-19-67-205-188(197)198)217-174(288)136(89-245)236-168(282)126(76-94(5)6)224-163(277)121(58-63-147(260)261)219-162(276)122(59-64-148(262)263)221-179(293)141-34-25-73-243(141)185(299)137(90-246)237-154(268)98(12)211-165(279)133(85-149(264)265)233-160(274)118(56-61-145(256)257)214-144(255)87-208-176(290)138-31-22-70-240(138)182(296)100(14)213-155(269)120(57-62-146(258)259)220-178(292)140-33-24-72-242(140)184(298)123(26-16-17-65-191)223-152(266)99(13)212-177(291)139-32-23-71-241(139)183(297)113(192)78-102-35-45-108(248)46-36-102/h35-54,86,91-101,113-141,150-151,244-252H,16-34,55-85,87-90,191-192H2,1-15H3,(H2,193,253)(H2,194,254)(H,203,209)(H,208,290)(H,210,278)(H,211,279)(H,212,291)(H,213,269)(H,214,255)(H,215,275)(H,216,280)(H,217,288)(H,218,270)(H,219,276)(H,220,292)(H,221,293)(H,222,295)(H,223,266)(H,224,277)(H,225,283)(H,226,286)(H,227,289)(H,228,271)(H,229,284)(H,230,285)(H,231,272)(H,232,281)(H,233,274)(H,234,273)(H,235,267)(H,236,282)(H,237,268)(H,238,287)(H,239,294)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H,264,265)(H,300,301)(H4,195,196,204)(H4,197,198,205)(H4,199,200,206)(H4,201,202,207)/t97-,98-,99-,100-,101+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,150-,151-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Meiji Seika Kaisha, Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 562-70 (2006)
Article DOI: 10.1124/jpet.105.099705
BindingDB Entry DOI: 10.7270/Q25Q4TPT |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50091652
(CHEMBL269503 | PYY | PYY, rat | Peptide YY(PYY)(YP...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O Show InChI InChI=1S/C190H287N53O58/c1-92(2)74-124(166(280)216-114(27-18-66-204-187(195)196)158(272)231-131(83-107-86-203-91-209-107)171(285)230-130(81-105-41-51-111(251)52-42-105)169(283)225-125(75-93(3)4)167(281)232-132(84-143(194)254)172(286)226-127(77-95(7)8)173(287)238-150(96(9)10)180(294)239-151(101(15)247)181(295)222-117(30-21-69-207-190(201)202)156(270)218-119(55-60-142(193)253)161(275)215-116(29-20-68-206-189(199)200)159(273)234-134(186(300)301)82-106-43-53-112(252)54-44-106)227-175(289)135(88-244)235-153(267)97(11)210-164(278)128(79-103-37-47-109(249)48-38-103)229-170(284)129(80-104-39-49-110(250)50-40-104)228-157(271)115(28-19-67-205-188(197)198)217-174(288)136(89-245)236-168(282)126(76-94(5)6)224-163(277)121(58-63-147(260)261)219-162(276)122(59-64-148(262)263)221-179(293)141-34-25-73-243(141)185(299)137(90-246)237-154(268)98(12)211-165(279)133(85-149(264)265)233-160(274)118(56-61-145(256)257)214-144(255)87-208-176(290)138-31-22-70-240(138)182(296)100(14)213-155(269)120(57-62-146(258)259)220-178(292)140-33-24-72-242(140)184(298)123(26-16-17-65-191)223-152(266)99(13)212-177(291)139-32-23-71-241(139)183(297)113(192)78-102-35-45-108(248)46-36-102/h35-54,86,91-101,113-141,150-151,244-252H,16-34,55-85,87-90,191-192H2,1-15H3,(H2,193,253)(H2,194,254)(H,203,209)(H,208,290)(H,210,278)(H,211,279)(H,212,291)(H,213,269)(H,214,255)(H,215,275)(H,216,280)(H,217,288)(H,218,270)(H,219,276)(H,220,292)(H,221,293)(H,222,295)(H,223,266)(H,224,277)(H,225,283)(H,226,286)(H,227,289)(H,228,271)(H,229,284)(H,230,285)(H,231,272)(H,232,281)(H,233,274)(H,234,273)(H,235,267)(H,236,282)(H,237,268)(H,238,287)(H,239,294)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H,264,265)(H,300,301)(H4,195,196,204)(H4,197,198,205)(H4,199,200,206)(H4,201,202,207)/t97-,98-,99-,100-,101+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,150-,151-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Meiji Seika Kaisha, Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 562-70 (2006)
Article DOI: 10.1124/jpet.105.099705
BindingDB Entry DOI: 10.7270/Q25Q4TPT |
More data for this
Ligand-Target Pair | |
Orexin receptor type 2
(Homo sapiens (Human)) | BDBM50440025
(CHEMBL2425784)Show SMILES COc1cc(NC(=O)[C@@H]2C[C@@]2(COc2cnc(C)nc2C)c2cccc(F)c2)ncc1F |r| Show InChI InChI=1S/C23H22F2N4O3/c1-13-20(11-26-14(2)28-13)32-12-23(15-5-4-6-16(24)7-15)9-17(23)22(30)29-21-8-19(31-3)18(25)10-27-21/h4-8,10-11,17H,9,12H2,1-3H3,(H,27,29,30)/t17-,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co. , Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-orexin-A from human OX2 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis |
J Med Chem 56: 6371-85 (2013)
Article DOI: 10.1021/jm400772t
BindingDB Entry DOI: 10.7270/Q2QF8V91 |
More data for this
Ligand-Target Pair | |
Orexin receptor type 2
(Homo sapiens (Human)) | BDBM50440022
(CHEMBL2425787)Show SMILES COc1nc(NC(=O)[C@@H]2C[C@@]2(COc2cnc(C)nc2C)c2cccc(F)c2)ccc1F |r| Show InChI InChI=1S/C23H22F2N4O3/c1-13-19(11-26-14(2)27-13)32-12-23(15-5-4-6-16(24)9-15)10-17(23)21(30)28-20-8-7-18(25)22(29-20)31-3/h4-9,11,17H,10,12H2,1-3H3,(H,28,29,30)/t17-,23+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co. , Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-orexin-A from human OX2 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis |
J Med Chem 56: 6371-85 (2013)
Article DOI: 10.1021/jm400772t
BindingDB Entry DOI: 10.7270/Q2QF8V91 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091652
(CHEMBL269503 | PYY | PYY, rat | Peptide YY(PYY)(YP...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O Show InChI InChI=1S/C190H287N53O58/c1-92(2)74-124(166(280)216-114(27-18-66-204-187(195)196)158(272)231-131(83-107-86-203-91-209-107)171(285)230-130(81-105-41-51-111(251)52-42-105)169(283)225-125(75-93(3)4)167(281)232-132(84-143(194)254)172(286)226-127(77-95(7)8)173(287)238-150(96(9)10)180(294)239-151(101(15)247)181(295)222-117(30-21-69-207-190(201)202)156(270)218-119(55-60-142(193)253)161(275)215-116(29-20-68-206-189(199)200)159(273)234-134(186(300)301)82-106-43-53-112(252)54-44-106)227-175(289)135(88-244)235-153(267)97(11)210-164(278)128(79-103-37-47-109(249)48-38-103)229-170(284)129(80-104-39-49-110(250)50-40-104)228-157(271)115(28-19-67-205-188(197)198)217-174(288)136(89-245)236-168(282)126(76-94(5)6)224-163(277)121(58-63-147(260)261)219-162(276)122(59-64-148(262)263)221-179(293)141-34-25-73-243(141)185(299)137(90-246)237-154(268)98(12)211-165(279)133(85-149(264)265)233-160(274)118(56-61-145(256)257)214-144(255)87-208-176(290)138-31-22-70-240(138)182(296)100(14)213-155(269)120(57-62-146(258)259)220-178(292)140-33-24-72-242(140)184(298)123(26-16-17-65-191)223-152(266)99(13)212-177(291)139-32-23-71-241(139)183(297)113(192)78-102-35-45-108(248)46-36-102/h35-54,86,91-101,113-141,150-151,244-252H,16-34,55-85,87-90,191-192H2,1-15H3,(H2,193,253)(H2,194,254)(H,203,209)(H,208,290)(H,210,278)(H,211,279)(H,212,291)(H,213,269)(H,214,255)(H,215,275)(H,216,280)(H,217,288)(H,218,270)(H,219,276)(H,220,292)(H,221,293)(H,222,295)(H,223,266)(H,224,277)(H,225,283)(H,226,286)(H,227,289)(H,228,271)(H,229,284)(H,230,285)(H,231,272)(H,232,281)(H,233,274)(H,234,273)(H,235,267)(H,236,282)(H,237,268)(H,238,287)(H,239,294)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H,264,265)(H,300,301)(H4,195,196,204)(H4,197,198,205)(H4,199,200,206)(H4,201,202,207)/t97-,98-,99-,100-,101+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,150-,151-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Meiji Seika Kaisha, Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 562-70 (2006)
Article DOI: 10.1124/jpet.105.099705
BindingDB Entry DOI: 10.7270/Q25Q4TPT |
More data for this
Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM50440025
(CHEMBL2425784)Show SMILES COc1cc(NC(=O)[C@@H]2C[C@@]2(COc2cnc(C)nc2C)c2cccc(F)c2)ncc1F |r| Show InChI InChI=1S/C23H22F2N4O3/c1-13-20(11-26-14(2)28-13)32-12-23(15-5-4-6-16(24)7-15)9-17(23)22(30)29-21-8-19(31-3)18(25)10-27-21/h4-8,10-11,17H,9,12H2,1-3H3,(H,27,29,30)/t17-,23+/m0/s1 | PDB
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PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co. , Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-orexin-A from human OX1 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis |
J Med Chem 56: 6371-85 (2013)
Article DOI: 10.1021/jm400772t
BindingDB Entry DOI: 10.7270/Q2QF8V91 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM86732
(3-(5,6,7,8-tetrahydro-9-isopropyl-carbazol-3-yl)-1...)Show SMILES CC(C)n1c2CCCCc2c2cc(NC(=O)N(C)CCc3ccncc3)ccc12 Show InChI InChI=1S/C24H30N4O/c1-17(2)28-22-7-5-4-6-20(22)21-16-19(8-9-23(21)28)26-24(29)27(3)15-12-18-10-13-25-14-11-18/h8-11,13-14,16-17H,4-7,12,15H2,1-3H3,(H,26,29) | KEGG
UniProtKB/SwissProt
antibodypedia
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| PC cid
PC sid
UniChem
| Article
PubMed
| 4.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Meiji Seika Kaisha, Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 562-70 (2006)
Article DOI: 10.1124/jpet.105.099705
BindingDB Entry DOI: 10.7270/Q25Q4TPT |
More data for this
Ligand-Target Pair | |
Orexin receptor type 2
(Homo sapiens (Human)) | BDBM50440023
(CHEMBL2425786)Show SMILES Cc1ncc(OC[C@]2(C[C@H]2C(=O)Nc2ccc(cn2)C#N)c2cccc(F)c2)c(C)n1 |r| Show InChI InChI=1S/C23H20FN5O2/c1-14-20(12-26-15(2)28-14)31-13-23(17-4-3-5-18(24)8-17)9-19(23)22(30)29-21-7-6-16(10-25)11-27-21/h3-8,11-12,19H,9,13H2,1-2H3,(H,27,29,30)/t19-,23+/m0/s1 | PDB
Reactome pathway
KEGG
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PC sid
UniChem
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co. , Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-orexin-A from human OX2 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis |
J Med Chem 56: 6371-85 (2013)
Article DOI: 10.1021/jm400772t
BindingDB Entry DOI: 10.7270/Q2QF8V91 |
More data for this
Ligand-Target Pair | |
Orexin receptor type 2
(Homo sapiens (Human)) | BDBM50440026
(CHEMBL2425783)Show SMILES COc1ccc(cc1F)[C@]1(COc2cnc(C)nc2C)C[C@H]1C(=O)Nc1ccc(F)cn1 |r| Show InChI InChI=1S/C23H22F2N4O3/c1-13-20(11-26-14(2)28-13)32-12-23(15-4-6-19(31-3)18(25)8-15)9-17(23)22(30)29-21-7-5-16(24)10-27-21/h4-8,10-11,17H,9,12H2,1-3H3,(H,27,29,30)/t17-,23+/m0/s1 | PDB
Reactome pathway
KEGG
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PubMed
| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co. , Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-orexin-A from human OX2 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis |
J Med Chem 56: 6371-85 (2013)
Article DOI: 10.1021/jm400772t
BindingDB Entry DOI: 10.7270/Q2QF8V91 |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50002338
((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)Show InChI InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3 | PDB
Reactome pathway
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| DrugBank
Article
PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]-Raclopride from human D2 receptor (unknown origin) expressed in HEK293 cell membranes |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112420
BindingDB Entry DOI: 10.7270/Q2G73JGD |
More data for this
Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM50440021
(CHEMBL2425788)Show SMILES COCc1nc(C)ncc1OC[C@]1(C[C@H]1C(=O)Nc1ccc(F)cn1)c1ccccc1 |r| Show InChI InChI=1S/C23H23FN4O3/c1-15-25-12-20(19(27-15)13-30-2)31-14-23(16-6-4-3-5-7-16)10-18(23)22(29)28-21-9-8-17(24)11-26-21/h3-9,11-12,18H,10,13-14H2,1-2H3,(H,26,28,29)/t18-,23+/m0/s1 | PDB
Reactome pathway
KEGG
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PC sid
UniChem
Similars
| Article
PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co. , Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-orexin-A from human OX1 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis |
J Med Chem 56: 6371-85 (2013)
Article DOI: 10.1021/jm400772t
BindingDB Entry DOI: 10.7270/Q2QF8V91 |
More data for this
Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM50440022
(CHEMBL2425787)Show SMILES COc1nc(NC(=O)[C@@H]2C[C@@]2(COc2cnc(C)nc2C)c2cccc(F)c2)ccc1F |r| Show InChI InChI=1S/C23H22F2N4O3/c1-13-19(11-26-14(2)27-13)32-12-23(15-5-4-6-16(24)9-15)10-17(23)21(30)28-20-8-7-18(25)22(29-20)31-3/h4-9,11,17H,10,12H2,1-3H3,(H,28,29,30)/t17-,23+/m0/s1 | PDB
Reactome pathway
KEGG
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UniChem
Similars
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PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co. , Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-orexin-A from human OX1 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis |
J Med Chem 56: 6371-85 (2013)
Article DOI: 10.1021/jm400772t
BindingDB Entry DOI: 10.7270/Q2QF8V91 |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM86733
(5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1O...)Show SMILES CC1(C)CC(=O)C(C2C3=C(CC(C)(C)CC3=O)Oc3ccccc23)C(=O)C1 |t:8| Show InChI InChI=1S/C23H26O4/c1-22(2)9-14(24)20(15(25)10-22)19-13-7-5-6-8-17(13)27-18-12-23(3,4)11-16(26)21(18)19/h5-8,19-20H,9-12H2,1-4H3 | KEGG
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PubMed
| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Meiji Seika Kaisha, Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 562-70 (2006)
Article DOI: 10.1124/jpet.105.099705
BindingDB Entry DOI: 10.7270/Q25Q4TPT |
More data for this
Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM50440026
(CHEMBL2425783)Show SMILES COc1ccc(cc1F)[C@]1(COc2cnc(C)nc2C)C[C@H]1C(=O)Nc1ccc(F)cn1 |r| Show InChI InChI=1S/C23H22F2N4O3/c1-13-20(11-26-14(2)28-13)32-12-23(15-4-6-19(31-3)18(25)8-15)9-17(23)22(30)29-21-7-5-16(24)10-27-21/h4-8,10-11,17H,9,12H2,1-3H3,(H,27,29,30)/t17-,23+/m0/s1 | PDB
Reactome pathway
KEGG
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antibodypedia
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| CHEMBL
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PC sid
UniChem
Similars
| Article
PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co. , Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-orexin-A from human OX1 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis |
J Med Chem 56: 6371-85 (2013)
Article DOI: 10.1021/jm400772t
BindingDB Entry DOI: 10.7270/Q2QF8V91 |
More data for this
Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM50440023
(CHEMBL2425786)Show SMILES Cc1ncc(OC[C@]2(C[C@H]2C(=O)Nc2ccc(cn2)C#N)c2cccc(F)c2)c(C)n1 |r| Show InChI InChI=1S/C23H20FN5O2/c1-14-20(12-26-15(2)28-14)31-13-23(17-4-3-5-18(24)8-17)9-19(23)22(30)29-21-7-6-16(10-25)11-27-21/h3-8,11-12,19H,9,13H2,1-2H3,(H,27,29,30)/t19-,23+/m0/s1 | PDB
Reactome pathway
KEGG
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PC sid
UniChem
Similars
| Article
PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co. , Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-orexin-A from human OX1 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis |
J Med Chem 56: 6371-85 (2013)
Article DOI: 10.1021/jm400772t
BindingDB Entry DOI: 10.7270/Q2QF8V91 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50002338
((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)Show InChI InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3 | PDB
Reactome pathway
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| Article
PubMed
| 71 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112420
BindingDB Entry DOI: 10.7270/Q2G73JGD |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50002338
((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)Show InChI InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
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CHEMBL
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| Article
PubMed
| 84 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]-Ketanserin from human 5HT2A receptor expressed in CHO-K1 cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112420
BindingDB Entry DOI: 10.7270/Q2G73JGD |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50002338
((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)Show InChI InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3 | PDB
Reactome pathway
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| Article
PubMed
| 181 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112420
BindingDB Entry DOI: 10.7270/Q2G73JGD |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50565002
(CHEMBL4778666)Show SMILES Cl.[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1-[#6]-[#6]-[#7]-1-c2ccc(Br)cc2[Se;v2]c2cc(Br)ccc-12 | PDB
Reactome pathway
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PC sid
UniChem
| Article
PubMed
| 222 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112420
BindingDB Entry DOI: 10.7270/Q2G73JGD |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50565002
(CHEMBL4778666)Show SMILES Cl.[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1-[#6]-[#6]-[#7]-1-c2ccc(Br)cc2[Se;v2]c2cc(Br)ccc-12 | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| 367 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]-Raclopride from human D2 receptor (unknown origin) expressed in HEK293 cell membranes |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112420
BindingDB Entry DOI: 10.7270/Q2G73JGD |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50565001
(CHEMBL4797066)Show SMILES Cl.CN1CCCCC1CCN1c2c(Cl)cc(Cl)cc2Sc2cc(Cl)cc(Cl)c12 | PDB
Reactome pathway
KEGG
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DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 387 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112420
BindingDB Entry DOI: 10.7270/Q2G73JGD |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50565001
(CHEMBL4797066)Show SMILES Cl.CN1CCCCC1CCN1c2c(Cl)cc(Cl)cc2Sc2cc(Cl)cc(Cl)c12 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 639 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]-Raclopride from human D2 receptor (unknown origin) expressed in HEK293 cell membranes |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112420
BindingDB Entry DOI: 10.7270/Q2G73JGD |
More data for this
Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50565000
(CHEMBL4791959) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 688 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]-Raclopride from human D2 receptor (unknown origin) expressed in HEK293 cell membranes |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112420
BindingDB Entry DOI: 10.7270/Q2G73JGD |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50565000
(CHEMBL4791959) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 758 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112420
BindingDB Entry DOI: 10.7270/Q2G73JGD |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50565001
(CHEMBL4797066)Show SMILES Cl.CN1CCCCC1CCN1c2c(Cl)cc(Cl)cc2Sc2cc(Cl)cc(Cl)c12 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112420
BindingDB Entry DOI: 10.7270/Q2G73JGD |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50565001
(CHEMBL4797066)Show SMILES Cl.CN1CCCCC1CCN1c2c(Cl)cc(Cl)cc2Sc2cc(Cl)cc(Cl)c12 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]-Ketanserin from human 5HT2A receptor expressed in CHO-K1 cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112420
BindingDB Entry DOI: 10.7270/Q2G73JGD |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50565000
(CHEMBL4791959) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]-Ketanserin from human 5HT2A receptor expressed in CHO-K1 cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112420
BindingDB Entry DOI: 10.7270/Q2G73JGD |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50565002
(CHEMBL4778666)Show SMILES Cl.[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1-[#6]-[#6]-[#7]-1-c2ccc(Br)cc2[Se;v2]c2cc(Br)ccc-12 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]-Ketanserin from human 5HT2A receptor expressed in CHO-K1 cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112420
BindingDB Entry DOI: 10.7270/Q2G73JGD |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50565000
(CHEMBL4791959) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112420
BindingDB Entry DOI: 10.7270/Q2G73JGD |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50565002
(CHEMBL4778666)Show SMILES Cl.[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1-[#6]-[#6]-[#7]-1-c2ccc(Br)cc2[Se;v2]c2cc(Br)ccc-12 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 2.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112420
BindingDB Entry DOI: 10.7270/Q2G73JGD |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM86732
(3-(5,6,7,8-tetrahydro-9-isopropyl-carbazol-3-yl)-1...)Show SMILES CC(C)n1c2CCCCc2c2cc(NC(=O)N(C)CCc3ccncc3)ccc12 Show InChI InChI=1S/C24H30N4O/c1-17(2)28-22-7-5-4-6-20(22)21-16-19(8-9-23(21)28)26-24(29)27(3)15-12-18-10-13-25-14-11-18/h8-11,13-14,16-17H,4-7,12,15H2,1-3H3,(H,26,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Meiji Seika Kaisha, Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 562-70 (2006)
Article DOI: 10.1124/jpet.105.099705
BindingDB Entry DOI: 10.7270/Q25Q4TPT |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM86733
(5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1O...)Show SMILES CC1(C)CC(=O)C(C2C3=C(CC(C)(C)CC3=O)Oc3ccccc23)C(=O)C1 |t:8| Show InChI InChI=1S/C23H26O4/c1-22(2)9-14(24)20(15(25)10-22)19-13-7-5-6-8-17(13)27-18-12-23(3,4)11-16(26)21(18)19/h5-8,19-20H,9-12H2,1-4H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Meiji Seika Kaisha, Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 562-70 (2006)
Article DOI: 10.1124/jpet.105.099705
BindingDB Entry DOI: 10.7270/Q25Q4TPT |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM86733
(5,5-DIMETHYL-2-(2,3,4,9-TETRAHYDRO-3,3-DIMETHYL-1O...)Show SMILES CC1(C)CC(=O)C(C2C3=C(CC(C)(C)CC3=O)Oc3ccccc23)C(=O)C1 |t:8| Show InChI InChI=1S/C23H26O4/c1-22(2)9-14(24)20(15(25)10-22)19-13-7-5-6-8-17(13)27-18-12-23(3,4)11-16(26)21(18)19/h5-8,19-20H,9-12H2,1-4H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Meiji Seika Kaisha, Ltd.
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 317: 562-70 (2006)
Article DOI: 10.1124/jpet.105.099705
BindingDB Entry DOI: 10.7270/Q25Q4TPT |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142338
(US8933099, 112)Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(C[C@H](C)O)CC2)c1)C(=O)NC |r| Show InChI InChI=1S/C34H41N5O6/c1-4-43-17-18-44-30-21-29-27(12-16-39(29)34(42)35-3)19-31(30)45-28-9-13-36-32(20-28)37-33(41)26-7-5-24(6-8-26)25-10-14-38(15-11-25)22-23(2)40/h5-9,12-13,16,19-21,23,25,40H,4,10-11,14-15,17-18,22H2,1-3H3,(H,35,42)(H,36,37,41)/t23-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142348
(US8933099, 114)Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(C)CC2)c1)C(=O)NC Show InChI InChI=1S/C32H37N5O5/c1-4-40-17-18-41-28-21-27-25(12-16-37(27)32(39)33-2)19-29(28)42-26-9-13-34-30(20-26)35-31(38)24-7-5-22(6-8-24)23-10-14-36(3)15-11-23/h5-9,12-13,16,19-21,23H,4,10-11,14-15,17-18H2,1-3H3,(H,33,39)(H,34,35,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142347
(US8933099, 109)Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(CC(C)(C)O)CC2)c1)C(=O)NC Show InChI InChI=1S/C35H43N5O6/c1-5-44-18-19-45-30-22-29-27(13-17-40(29)34(42)36-4)20-31(30)46-28-10-14-37-32(21-28)38-33(41)26-8-6-24(7-9-26)25-11-15-39(16-12-25)23-35(2,3)43/h6-10,13-14,17,20-22,25,43H,5,11-12,15-16,18-19,23H2,1-4H3,(H,36,42)(H,37,38,41) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142337
(US8933099, 111)Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(C[C@@H](C)O)CC2)c1)C(=O)NC |r| Show InChI InChI=1S/C34H41N5O6/c1-4-43-17-18-44-30-21-29-27(12-16-39(29)34(42)35-3)19-31(30)45-28-9-13-36-32(20-28)37-33(41)26-7-5-24(6-8-26)25-10-14-38(15-11-25)22-23(2)40/h5-9,12-13,16,19-21,23,25,40H,4,10-11,14-15,17-18,22H2,1-3H3,(H,35,42)(H,36,37,41)/t23-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142339
(US8933099, 113)Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(CC)CC2)c1)C(=O)NC Show InChI InChI=1S/C33H39N5O5/c1-4-37-15-11-24(12-16-37)23-6-8-25(9-7-23)32(39)36-31-21-27(10-14-35-31)43-30-20-26-13-17-38(33(40)34-3)28(26)22-29(30)42-19-18-41-5-2/h6-10,13-14,17,20-22,24H,4-5,11-12,15-16,18-19H2,1-3H3,(H,34,40)(H,35,36,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142258
(US8933099, 24)Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCNCC2)c1)C(=O)NC Show InChI InChI=1S/C31H35N5O5/c1-3-39-16-17-40-27-20-26-24(11-15-36(26)31(38)32-2)18-28(27)41-25-10-14-34-29(19-25)35-30(37)23-6-4-21(5-7-23)22-8-12-33-13-9-22/h4-7,10-11,14-15,18-20,22,33H,3,8-9,12-13,16-17H2,1-2H3,(H,32,38)(H,34,35,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor 2
(Homo sapiens (Human)) | BDBM142256
(US8933099, 22 | US9951047, Compound (I))Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCO)CC4)c3)c(OCCOC)cc12 Show InChI InChI=1S/C32H37N5O6/c1-33-32(40)37-14-10-25-19-29(28(21-27(25)37)42-18-17-41-2)43-26-7-11-34-30(20-26)35-31(39)24-5-3-22(4-6-24)23-8-12-36(13-9-23)15-16-38/h3-7,10-11,14,19-21,23,38H,8-9,12-13,15-18H2,1-2H3,(H,33,40)(H,34,35,39) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142325
(US8933099, 91)Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C[C@H](C)O)CC4)c3)c(OCCOC)cc12 |r| Show InChI InChI=1S/C33H39N5O6/c1-22(39)21-37-13-9-24(10-14-37)23-4-6-25(7-5-23)32(40)36-31-19-27(8-12-35-31)44-30-18-26-11-15-38(33(41)34-2)28(26)20-29(30)43-17-16-42-3/h4-8,11-12,15,18-20,22,24,39H,9-10,13-14,16-17,21H2,1-3H3,(H,34,41)(H,35,36,40)/t22-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142333
(US8933099, 103)Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CN(C2)C(C)C)c1)C(=O)NC Show InChI InChI=1S/C32H37N5O5/c1-5-40-14-15-41-28-18-27-24(11-13-37(27)32(39)33-4)16-29(28)42-26-10-12-34-30(17-26)35-31(38)23-8-6-22(7-9-23)25-19-36(20-25)21(2)3/h6-13,16-18,21,25H,5,14-15,19-20H2,1-4H3,(H,33,39)(H,34,35,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor 2
(Homo sapiens (Human)) | BDBM142255
(US8933099, 21)Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C)CC4)c3)c(OCCOC)cc12 Show InChI InChI=1S/C31H35N5O5/c1-32-31(38)36-15-11-24-18-28(27(20-26(24)36)40-17-16-39-3)41-25-8-12-33-29(19-25)34-30(37)23-6-4-21(5-7-23)22-9-13-35(2)14-10-22/h4-8,11-12,15,18-20,22H,9-10,13-14,16-17H2,1-3H3,(H,32,38)(H,33,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142341
(US8933099, 99)Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(CN3CCC[C@H]3CO)s2)c1)C(=O)NC |r| Show InChI InChI=1S/C30H35N5O6S/c1-3-39-13-14-40-25-17-24-20(9-12-35(24)30(38)31-2)15-26(25)41-22-8-10-32-28(16-22)33-29(37)27-7-6-23(42-27)18-34-11-4-5-21(34)19-36/h6-10,12,15-17,21,36H,3-5,11,13-14,18-19H2,1-2H3,(H,31,38)(H,32,33,37)/t21-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142259
(US8933099, 25)Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(CCO)CC2)c1)C(=O)NC Show InChI InChI=1S/C33H39N5O6/c1-3-42-18-19-43-29-22-28-26(11-15-38(28)33(41)34-2)20-30(29)44-27-8-12-35-31(21-27)36-32(40)25-6-4-23(5-7-25)24-9-13-37(14-10-24)16-17-39/h4-8,11-12,15,20-22,24,39H,3,9-10,13-14,16-19H2,1-2H3,(H,34,41)(H,35,36,40) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142359
(US8933099, 125)Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C[C@@H](C)O)CC4)c3)c(OCCCOC)cc12 |r| Show InChI InChI=1S/C34H41N5O6/c1-23(40)22-38-14-10-25(11-15-38)24-5-7-26(8-6-24)33(41)37-32-20-28(9-13-36-32)45-31-19-27-12-16-39(34(42)35-2)29(27)21-30(31)44-18-4-17-43-3/h5-9,12-13,16,19-21,23,25,40H,4,10-11,14-15,17-18,22H2,1-3H3,(H,35,42)(H,36,37,41)/t23-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142257
(US8933099, 23)Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CC4)C(C)C)c3)c(OCCOC)cc12 Show InChI InChI=1S/C33H39N5O5/c1-22(2)37-14-10-24(11-15-37)23-5-7-25(8-6-23)32(39)36-31-20-27(9-13-35-31)43-30-19-26-12-16-38(33(40)34-3)28(26)21-29(30)42-18-17-41-4/h5-9,12-13,16,19-22,24H,10-11,14-15,17-18H2,1-4H3,(H,34,40)(H,35,36,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
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