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Compile Data Set for Download or QSAR

Found 58 hits with Last Name = 'stravodimos' and Initial = 'ga'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen phosphorylase, liver form


(Homo sapiens (Human))
BDBM50148913
PNG
(CHEMBL3770455)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(c[nH]1)-c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C19H20N2O5/c22-9-14-15(23)16(24)17(25)18(26-14)19-20-8-13(21-19)12-6-5-10-3-1-2-4-11(10)7-12/h1-8,14-18,22-25H,9H2,(H,20,21)/t14-,15-,16+,17-,18-/m1/s1
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26n/an/an/an/an/an/an/an/a



University of Thessaly

Curated by ChEMBL


Assay Description
Competitive inhibition of His6-tagged human liver glycogen phosphorylase-a expressed in Escherichia coli BL21 Gold (DE3) assessed as release of inorg...


Eur J Med Chem 123: 737-745 (2016)


Article DOI: 10.1016/j.ejmech.2016.06.049
BindingDB Entry DOI: 10.7270/Q2TT4SXG
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50148913
PNG
(CHEMBL3770455)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(c[nH]1)-c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C19H20N2O5/c22-9-14-15(23)16(24)17(25)18(26-14)19-20-8-13(21-19)12-6-5-10-3-1-2-4-11(10)7-12/h1-8,14-18,22-25H,9H2,(H,20,21)/t14-,15-,16+,17-,18-/m1/s1
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65n/an/an/an/an/an/an/an/a



University of Thessaly

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase-a assessed as release of inorganic phosphate using varying levels of glucose-1-phospha...


Eur J Med Chem 123: 737-745 (2016)


Article DOI: 10.1016/j.ejmech.2016.06.049
BindingDB Entry DOI: 10.7270/Q2TT4SXG
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50241632
PNG
(CHEMBL4101331)
Show SMILES N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1c1nc(c[nH]1)-c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C19H21N3O4/c20-15-17(25)16(24)14(9-23)26-18(15)19-21-8-13(22-19)12-6-5-10-3-1-2-4-11(10)7-12/h1-8,14-18,23-25H,9,20H2,(H,21,22)/t14-,15-,16-,17-,18-/m1/s1
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125n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase-a in presence of varying levels of glucose-1-phosphate and constant concentration of g...


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, liver form


(Homo sapiens (Human))
BDBM50241632
PNG
(CHEMBL4101331)
Show SMILES N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1c1nc(c[nH]1)-c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C19H21N3O4/c20-15-17(25)16(24)14(9-23)26-18(15)19-21-8-13(22-19)12-6-5-10-3-1-2-4-11(10)7-12/h1-8,14-18,23-25H,9,20H2,(H,21,22)/t14-,15-,16-,17-,18-/m1/s1
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143n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Competitive inhibition of 6xHis-tagged human liver glycogen phosphorylase-a expressed in Escherichia coli BL21 Gold (DE3) assessed as release of inor...


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))
BDBM50148915
PNG
(CHEMBL3770514)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(c[nH]1)-c1ccccc1 |r|
Show InChI InChI=1S/C15H18N2O5/c18-7-10-11(19)12(20)13(21)14(22-10)15-16-6-9(17-15)8-4-2-1-3-5-8/h1-6,10-14,18-21H,7H2,(H,16,17)/t10-,11-,12+,13-,14-/m1/s1
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156n/an/an/an/an/an/an/an/a



University of Thessaly

Curated by ChEMBL


Assay Description
Competitive inhibition of His6-tagged human liver glycogen phosphorylase-a expressed in Escherichia coli BL21 Gold (DE3) assessed as release of inorg...


Eur J Med Chem 123: 737-745 (2016)


Article DOI: 10.1016/j.ejmech.2016.06.049
BindingDB Entry DOI: 10.7270/Q2TT4SXG
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))
BDBM50437354
PNG
(CHEMBL2408225)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nnc([nH]1)-c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C18H19N3O5/c22-8-12-13(23)14(24)15(25)16(26-12)18-19-17(20-21-18)11-6-5-9-3-1-2-4-10(9)7-11/h1-7,12-16,22-25H,8H2,(H,19,20,21)/t12-,13-,14+,15-,16-/m1/s1
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172n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Competitive inhibition of human liver glycogen phosphorylase-a assessed as release of inorganic phosphate using varying levels of glucose-1-phosphate...


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50241632
PNG
(CHEMBL4101331)
Show SMILES N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1c1nc(c[nH]1)-c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C19H21N3O4/c20-15-17(25)16(24)14(9-23)26-18(15)19-21-8-13(22-19)12-6-5-10-3-1-2-4-11(10)7-12/h1-8,14-18,23-25H,9,20H2,(H,21,22)/t14-,15-,16-,17-,18-/m1/s1
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191n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase-b in presence of varying levels of glucose-1-phosphate and constant concentration of g...


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50148915
PNG
(CHEMBL3770514)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(c[nH]1)-c1ccccc1 |r|
Show InChI InChI=1S/C15H18N2O5/c18-7-10-11(19)12(20)13(21)14(22-10)15-16-6-9(17-15)8-4-2-1-3-5-8/h1-6,10-14,18-21H,7H2,(H,16,17)/t10-,11-,12+,13-,14-/m1/s1
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226n/an/an/an/an/an/an/an/a



University of Thessaly

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase-a assessed as release of inorganic phosphate using varying levels of glucose-1-phospha...


Eur J Med Chem 123: 737-745 (2016)


Article DOI: 10.1016/j.ejmech.2016.06.049
BindingDB Entry DOI: 10.7270/Q2TT4SXG
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50312225
PNG
(CHEMBL4161353)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(n[nH]1)-c1ccc2cc(ccc2c1)C(O)=O |r|
Show InChI InChI=1S/C19H19N3O7/c23-7-12-13(24)14(25)15(26)16(29-12)18-20-17(21-22-18)10-3-1-9-6-11(19(27)28)4-2-8(9)5-10/h1-6,12-16,23-26H,7H2,(H,27,28)(H,20,21,22)/t12-,13-,14+,15-,16-/m1/s1
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780n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase-a assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of...


Eur J Med Chem 147: 266-278 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.095
BindingDB Entry DOI: 10.7270/Q2J67KF5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50312361
PNG
(CHEMBL4169281)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(n[nH]1)-c1ccc-2c(Cc3ccccc-23)c1 |r|
Show InChI InChI=1S/C21H21N3O5/c25-9-15-16(26)17(27)18(28)19(29-15)21-22-20(23-24-21)11-5-6-14-12(8-11)7-10-3-1-2-4-13(10)14/h1-6,8,15-19,25-28H,7,9H2,(H,22,23,24)/t15-,16-,17+,18-,19-/m1/s1
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840n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase-a assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of...


Eur J Med Chem 147: 266-278 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.095
BindingDB Entry DOI: 10.7270/Q2J67KF5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50313014
PNG
(CHEMBL4172670)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(n[nH]1)-c1ccc(cc1)-c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1S/C21H21N3O7/c25-9-14-15(26)16(27)17(28)18(31-14)20-22-19(23-24-20)12-5-1-10(2-6-12)11-3-7-13(8-4-11)21(29)30/h1-8,14-18,25-28H,9H2,(H,29,30)(H,22,23,24)/t14-,15-,16+,17-,18-/m1/s1
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980n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase-a assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of...


Eur J Med Chem 147: 266-278 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.095
BindingDB Entry DOI: 10.7270/Q2J67KF5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50312361
PNG
(CHEMBL4169281)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(n[nH]1)-c1ccc-2c(Cc3ccccc-23)c1 |r|
Show InChI InChI=1S/C21H21N3O5/c25-9-15-16(26)17(27)18(28)19(29-15)21-22-20(23-24-21)11-5-6-14-12(8-11)7-10-3-1-2-4-13(10)14/h1-6,8,15-19,25-28H,7,9H2,(H,22,23,24)/t15-,16-,17+,18-,19-/m1/s1
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1.19E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase-b assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of...


Eur J Med Chem 147: 266-278 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.095
BindingDB Entry DOI: 10.7270/Q2J67KF5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))
BDBM50437355
PNG
(CHEMBL2408224)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nnc([nH]1)-c1ccccc1 |r|
Show InChI InChI=1S/C14H17N3O5/c18-6-8-9(19)10(20)11(21)12(22-8)14-15-13(16-17-14)7-4-2-1-3-5-7/h1-5,8-12,18-21H,6H2,(H,15,16,17)/t8-,9-,10+,11-,12-/m1/s1
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1.35E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of fibrinogen receptor


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))
BDBM50312361
PNG
(CHEMBL4169281)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(n[nH]1)-c1ccc-2c(Cc3ccccc-23)c1 |r|
Show InChI InChI=1S/C21H21N3O5/c25-9-15-16(26)17(27)18(28)19(29-15)21-22-20(23-24-21)11-5-6-14-12(8-11)7-10-3-1-2-4-13(10)14/h1-6,8,15-19,25-28H,7,9H2,(H,22,23,24)/t15-,16-,17+,18-,19-/m1/s1
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2.02E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase-a assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of g...


Eur J Med Chem 147: 266-278 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.095
BindingDB Entry DOI: 10.7270/Q2J67KF5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50312362
PNG
(CHEMBL4176460)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(n[nH]1)-c1ccc(cc1)-c1ccccc1 |r|
Show InChI InChI=1S/C20H21N3O5/c24-10-14-15(25)16(26)17(27)18(28-14)20-21-19(22-23-20)13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-9,14-18,24-27H,10H2,(H,21,22,23)/t14-,15-,16+,17-,18-/m1/s1
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2.09E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase-a assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of...


Eur J Med Chem 147: 266-278 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.095
BindingDB Entry DOI: 10.7270/Q2J67KF5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))
BDBM50312362
PNG
(CHEMBL4176460)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(n[nH]1)-c1ccc(cc1)-c1ccccc1 |r|
Show InChI InChI=1S/C20H21N3O5/c24-10-14-15(25)16(26)17(27)18(28-14)20-21-19(22-23-20)13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-9,14-18,24-27H,10H2,(H,21,22,23)/t14-,15-,16+,17-,18-/m1/s1
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2.23E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase-a assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of g...


Eur J Med Chem 147: 266-278 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.095
BindingDB Entry DOI: 10.7270/Q2J67KF5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50312362
PNG
(CHEMBL4176460)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(n[nH]1)-c1ccc(cc1)-c1ccccc1 |r|
Show InChI InChI=1S/C20H21N3O5/c24-10-14-15(25)16(26)17(27)18(28-14)20-21-19(22-23-20)13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-9,14-18,24-27H,10H2,(H,21,22,23)/t14-,15-,16+,17-,18-/m1/s1
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2.38E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase-b assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of...


Eur J Med Chem 147: 266-278 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.095
BindingDB Entry DOI: 10.7270/Q2J67KF5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))
BDBM50313014
PNG
(CHEMBL4172670)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(n[nH]1)-c1ccc(cc1)-c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1S/C21H21N3O7/c25-9-14-15(26)16(27)17(28)18(31-14)20-22-19(23-24-20)12-5-1-10(2-6-12)11-3-7-13(8-4-11)21(29)30/h1-8,14-18,25-28H,9H2,(H,29,30)(H,22,23,24)/t14-,15-,16+,17-,18-/m1/s1
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2.67E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase-a assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of g...


Eur J Med Chem 147: 266-278 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.095
BindingDB Entry DOI: 10.7270/Q2J67KF5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50241633
PNG
(CHEMBL4095486)
Show SMILES N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1c1nc(c[nH]1)-c1ccccc1 |r|
Show InChI InChI=1S/C15H19N3O4/c16-11-13(21)12(20)10(7-19)22-14(11)15-17-6-9(18-15)8-4-2-1-3-5-8/h1-6,10-14,19-21H,7,16H2,(H,17,18)/t10-,11-,12-,13-,14-/m1/s1
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2.67E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of fibrinogen receptor


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, liver form


(Homo sapiens (Human))
BDBM50241633
PNG
(CHEMBL4095486)
Show SMILES N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1c1nc(c[nH]1)-c1ccccc1 |r|
Show InChI InChI=1S/C15H19N3O4/c16-11-13(21)12(20)10(7-19)22-14(11)15-17-6-9(18-15)8-4-2-1-3-5-8/h1-6,10-14,19-21H,7,16H2,(H,17,18)/t10-,11-,12-,13-,14-/m1/s1
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2.73E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Competitive inhibition of 6xHis-tagged human liver glycogen phosphorylase-a expressed in Escherichia coli BL21 Gold (DE3) assessed as release of inor...


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50241633
PNG
(CHEMBL4095486)
Show SMILES N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1c1nc(c[nH]1)-c1ccccc1 |r|
Show InChI InChI=1S/C15H19N3O4/c16-11-13(21)12(20)10(7-19)22-14(11)15-17-6-9(18-15)8-4-2-1-3-5-8/h1-6,10-14,19-21H,7,16H2,(H,17,18)/t10-,11-,12-,13-,14-/m1/s1
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3.11E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase-a in presence of varying levels of glucose-1-phosphate and constant concentration of g...


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50312632
PNG
(CHEMBL4164542)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(n[nH]1)-c1cccc2ccccc12 |r|
Show InChI InChI=1S/C18H19N3O5/c22-8-12-13(23)14(24)15(25)16(26-12)18-19-17(20-21-18)11-7-3-5-9-4-1-2-6-10(9)11/h1-7,12-16,22-25H,8H2,(H,19,20,21)/t12-,13-,14+,15-,16-/m1/s1
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3.38E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase-a assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of...


Eur J Med Chem 147: 266-278 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.095
BindingDB Entry DOI: 10.7270/Q2J67KF5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))
BDBM50312225
PNG
(CHEMBL4161353)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(n[nH]1)-c1ccc2cc(ccc2c1)C(O)=O |r|
Show InChI InChI=1S/C19H19N3O7/c23-7-12-13(24)14(25)15(26)16(29-12)18-20-17(21-22-18)10-3-1-9-6-11(19(27)28)4-2-8(9)5-10/h1-6,12-16,23-26H,7H2,(H,27,28)(H,20,21,22)/t12-,13-,14+,15-,16-/m1/s1
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3.88E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase-a assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of g...


Eur J Med Chem 147: 266-278 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.095
BindingDB Entry DOI: 10.7270/Q2J67KF5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50313014
PNG
(CHEMBL4172670)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(n[nH]1)-c1ccc(cc1)-c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1S/C21H21N3O7/c25-9-14-15(26)16(27)17(28)18(31-14)20-22-19(23-24-20)12-5-1-10(2-6-12)11-3-7-13(8-4-11)21(29)30/h1-8,14-18,25-28H,9H2,(H,29,30)(H,22,23,24)/t14-,15-,16+,17-,18-/m1/s1
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4.42E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase-b assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of...


Eur J Med Chem 147: 266-278 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.095
BindingDB Entry DOI: 10.7270/Q2J67KF5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50241634
PNG
(CHEMBL4068103)
Show SMILES N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1c1nc(n[nH]1)-c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C18H20N4O4/c19-13-15(25)14(24)12(8-23)26-16(13)18-20-17(21-22-18)11-6-5-9-3-1-2-4-10(9)7-11/h1-7,12-16,23-25H,8,19H2,(H,20,21,22)/t12-,13-,14-,15-,16-/m1/s1
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4.80E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of ADP-induced platelet aggregation in human platelet-rich plasma


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50312225
PNG
(CHEMBL4161353)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(n[nH]1)-c1ccc2cc(ccc2c1)C(O)=O |r|
Show InChI InChI=1S/C19H19N3O7/c23-7-12-13(24)14(25)15(26)16(29-12)18-20-17(21-22-18)10-3-1-9-6-11(19(27)28)4-2-8(9)5-10/h1-6,12-16,23-26H,7H2,(H,27,28)(H,20,21,22)/t12-,13-,14+,15-,16-/m1/s1
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5.05E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase-b assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of...


Eur J Med Chem 147: 266-278 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.095
BindingDB Entry DOI: 10.7270/Q2J67KF5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50207238
PNG
(Thiohydantoin)
Show SMILES O=C1CNC(=S)N1
Show InChI InChI=1S/C3H4N2OS/c6-2-1-4-3(7)5-2/h1H2,(H2,4,5,6,7)
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5.10E+3n/an/an/an/an/an/an/an/a



University of Thessaly

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase-b in presence of varying glucose-1-phosphate levels and NADP


Eur J Med Chem 123: 737-745 (2016)


Article DOI: 10.1016/j.ejmech.2016.06.049
BindingDB Entry DOI: 10.7270/Q2TT4SXG
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50241634
PNG
(CHEMBL4068103)
Show SMILES N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1c1nc(n[nH]1)-c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C18H20N4O4/c19-13-15(25)14(24)12(8-23)26-16(13)18-20-17(21-22-18)11-6-5-9-3-1-2-4-10(9)7-11/h1-7,12-16,23-25H,8,19H2,(H,20,21,22)/t12-,13-,14-,15-,16-/m1/s1
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5.30E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of fibrinogen receptor


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50241639
PNG
(CHEMBL4081944)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(F)c(=O)[nH]c1=O |r|
Show InChI InChI=1S/C10H13FN2O7/c11-3-1-13(10(19)12-8(3)18)9-7(17)6(16)5(15)4(2-14)20-9/h1,4-7,9,14-17H,2H2,(H,12,18,19)/t4-,5-,6+,7-,9-/m1/s1
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5.50E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase b using glucose-1-phosphate as substrate in presence of constant concentrations of gly...


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, liver form


(Homo sapiens (Human))
BDBM50241634
PNG
(CHEMBL4068103)
Show SMILES N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1c1nc(n[nH]1)-c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C18H20N4O4/c19-13-15(25)14(24)12(8-23)26-16(13)18-20-17(21-22-18)11-6-5-9-3-1-2-4-10(9)7-11/h1-7,12-16,23-25H,8,19H2,(H,20,21,22)/t12-,13-,14-,15-,16-/m1/s1
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7.60E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Competitive inhibition of 6xHis-tagged human liver glycogen phosphorylase-a expressed in Escherichia coli BL21 Gold (DE3) assessed as release of inor...


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))
BDBM50312632
PNG
(CHEMBL4164542)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(n[nH]1)-c1cccc2ccccc12 |r|
Show InChI InChI=1S/C18H19N3O5/c22-8-12-13(23)14(24)15(25)16(26-12)18-19-17(20-21-18)11-7-3-5-9-4-1-2-6-10(9)11/h1-7,12-16,22-25H,8H2,(H,19,20,21)/t12-,13-,14+,15-,16-/m1/s1
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8.91E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase-a assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of g...


Eur J Med Chem 147: 266-278 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.095
BindingDB Entry DOI: 10.7270/Q2J67KF5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50295859
PNG
((2S,3R,4R,5S,6R)-2-(1H-benzo[d]imidazol-2-yl)-6-(h...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc2ccccc2[nH]1 |r|
Show InChI InChI=1S/C13H16N2O5/c16-5-8-9(17)10(18)11(19)12(20-8)13-14-6-3-1-2-4-7(6)15-13/h1-4,8-12,16-19H,5H2,(H,14,15)/t8-,9-,10+,11-,12-/m1/s1
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9.00E+3n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase b using glucose-1-phosphate as substrate in presence of constant concentrations of gly...


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50295859
PNG
((2S,3R,4R,5S,6R)-2-(1H-benzo[d]imidazol-2-yl)-6-(h...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc2ccccc2[nH]1 |r|
Show InChI InChI=1S/C13H16N2O5/c16-5-8-9(17)10(18)11(19)12(20-8)13-14-6-3-1-2-4-7(6)15-13/h1-4,8-12,16-19H,5H2,(H,14,15)/t8-,9-,10+,11-,12-/m1/s1
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9.00E+3n/an/an/an/an/an/an/an/a



University of Thessaly

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase-b in presence of varying levels of glucose-1-phosphate and constant concentration of g...


Eur J Med Chem 123: 737-745 (2016)


Article DOI: 10.1016/j.ejmech.2016.06.049
BindingDB Entry DOI: 10.7270/Q2TT4SXG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50295859
PNG
((2S,3R,4R,5S,6R)-2-(1H-benzo[d]imidazol-2-yl)-6-(h...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc2ccccc2[nH]1 |r|
Show InChI InChI=1S/C13H16N2O5/c16-5-8-9(17)10(18)11(19)12(20-8)13-14-6-3-1-2-4-7(6)15-13/h1-4,8-12,16-19H,5H2,(H,14,15)/t8-,9-,10+,11-,12-/m1/s1
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1.10E+4n/an/an/an/an/an/an/an/a



University of Thessaly

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase-b


Eur J Med Chem 123: 737-745 (2016)


Article DOI: 10.1016/j.ejmech.2016.06.049
BindingDB Entry DOI: 10.7270/Q2TT4SXG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50312632
PNG
(CHEMBL4164542)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(n[nH]1)-c1cccc2ccccc12 |r|
Show InChI InChI=1S/C18H19N3O5/c22-8-12-13(23)14(24)15(25)16(26-12)18-19-17(20-21-18)11-7-3-5-9-4-1-2-6-10(9)11/h1-7,12-16,22-25H,8H2,(H,19,20,21)/t12-,13-,14+,15-,16-/m1/s1
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1.15E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase-b assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of...


Eur J Med Chem 147: 266-278 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.095
BindingDB Entry DOI: 10.7270/Q2J67KF5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50306550
PNG
(1-(beta-D-Glucopyranosyl)-4-(2-naphthyl)-1,2,3-tri...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(nn1)-c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C18H19N3O5/c22-9-14-15(23)16(24)17(25)18(26-14)21-8-13(19-20-21)12-6-5-10-3-1-2-4-11(10)7-12/h1-8,14-18,22-25H,9H2/t14-,15-,16+,17-,18-/m1/s1
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1.60E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of fibrinogen receptor


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50314852
PNG
(CHEMBL4175176)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(n[nH]1)-c1ccc2cc3ccccc3cc2c1 |r|
Show InChI InChI=1S/C22H21N3O5/c26-10-16-17(27)18(28)19(29)20(30-16)22-23-21(24-25-22)14-6-5-13-7-11-3-1-2-4-12(11)8-15(13)9-14/h1-9,16-20,26-29H,10H2,(H,23,24,25)/t16-,17-,18+,19-,20-/m1/s1
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2.00E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase-b assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of...


Eur J Med Chem 147: 266-278 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.095
BindingDB Entry DOI: 10.7270/Q2J67KF5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50241638
PNG
(CHEMBL4090219)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@H](CO)[C@@H]1O)n1cc(F)c(=O)[nH]c1=O |r|
Show InChI InChI=1S/C11H15FN2O7/c12-5-1-14(11(20)13-9(5)19)10-8(18)4(2-15)7(17)6(3-16)21-10/h1,4,6-8,10,15-18H,2-3H2,(H,13,19,20)/t4-,6-,7+,8-,10-/m1/s1
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2.71E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase b using glucose-1-phosphate as substrate in presence of constant concentrations of gly...


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50241635
PNG
(CHEMBL4087784)
Show SMILES N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1c1nc(n[nH]1)-c1ccccc1 |r|
Show InChI InChI=1S/C14H18N4O4/c15-9-11(21)10(20)8(6-19)22-12(9)14-16-13(17-18-14)7-4-2-1-3-5-7/h1-5,8-12,19-21H,6,15H2,(H,16,17,18)/t8-,9-,10-,11-,12-/m1/s1
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3.02E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase-a in presence of varying levels of glucose-1-phosphate and constant concentration of g...


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))
BDBM50241635
PNG
(CHEMBL4087784)
Show SMILES N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1c1nc(n[nH]1)-c1ccccc1 |r|
Show InChI InChI=1S/C14H18N4O4/c15-9-11(21)10(20)8(6-19)22-12(9)14-16-13(17-18-14)7-4-2-1-3-5-7/h1-5,8-12,19-21H,6,15H2,(H,16,17,18)/t8-,9-,10-,11-,12-/m1/s1
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3.08E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Competitive inhibition of 6xHis-tagged human liver glycogen phosphorylase-a expressed in Escherichia coli BL21 Gold (DE3) assessed as release of inor...


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50240802
PNG
(1-N-ACETYL-BETA-D-GLUCOSAMINE | CHEMBL335315 | N-(...)
Show SMILES CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C8H15NO6/c1-3(11)9-8-7(14)6(13)5(12)4(2-10)15-8/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8-/m1/s1
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3.20E+4n/an/an/an/an/an/an/an/a



University of Thessaly

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase-b assessed as release of inorganic phosphate using varying levels of glucose-1-phospha...


Eur J Med Chem 123: 737-745 (2016)


Article DOI: 10.1016/j.ejmech.2016.06.049
BindingDB Entry DOI: 10.7270/Q2TT4SXG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50241635
PNG
(CHEMBL4087784)
Show SMILES N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1c1nc(n[nH]1)-c1ccccc1 |r|
Show InChI InChI=1S/C14H18N4O4/c15-9-11(21)10(20)8(6-19)22-12(9)14-16-13(17-18-14)7-4-2-1-3-5-7/h1-5,8-12,19-21H,6,15H2,(H,16,17,18)/t8-,9-,10-,11-,12-/m1/s1
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3.52E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase-b in presence of varying levels of glucose-1-phosphate and constant concentration of g...


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50295850
PNG
((2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-(5-(naphthale...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1noc(n1)-c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C18H18N2O6/c21-8-12-13(22)14(23)15(24)16(25-12)17-19-18(26-20-17)11-6-5-9-3-1-2-4-10(9)7-11/h1-7,12-16,21-24H,8H2/t12-,13-,14+,15-,16-/m1/s1
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3.80E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase b using glucose-1-phosphate as substrate in presence of constant concentrations of gly...


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50313070
PNG
(CHEMBL4165855)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc(n[nH]1)-c1cccc(c1)-c1ccccc1 |r|
Show InChI InChI=1S/C20H21N3O5/c24-10-14-15(25)16(26)17(27)18(28-14)20-21-19(22-23-20)13-8-4-7-12(9-13)11-5-2-1-3-6-11/h1-9,14-18,24-27H,10H2,(H,21,22,23)/t14-,15-,16+,17-,18-/m1/s1
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6.82E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase-b assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of...


Eur J Med Chem 147: 266-278 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.095
BindingDB Entry DOI: 10.7270/Q2J67KF5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50295860
PNG
((2R,3R,4S,5S,6R)-2-(benzo[d]thiazol-2-yl)-6-(hydro...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc2ccccc2s1 |r|
Show InChI InChI=1S/C13H15NO5S/c15-5-7-9(16)10(17)11(18)12(19-7)13-14-6-3-1-2-4-8(6)20-13/h1-4,7,9-12,15-18H,5H2/t7-,9-,10+,11-,12-/m1/s1
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7.60E+4n/an/an/an/an/an/an/an/a



University of Thessaly

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase-b in presence of varying levels of glucose-1-phosphate and constant concentration of g...


Eur J Med Chem 123: 737-745 (2016)


Article DOI: 10.1016/j.ejmech.2016.06.049
BindingDB Entry DOI: 10.7270/Q2TT4SXG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50313605
PNG
(CHEMBL4161126)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1n[nH]c(n1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r|
Show InChI InChI=1S/C14H18N4O7S/c15-26(23,24)7-3-1-6(2-4-7)13-16-14(18-17-13)12-11(22)10(21)9(20)8(5-19)25-12/h1-4,8-12,19-22H,5H2,(H2,15,23,24)(H,16,17,18)/t8-,9-,10+,11-,12-/m1/s1
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9.82E+4n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase-b assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of...


Eur J Med Chem 147: 266-278 (2018)


Article DOI: 10.1016/j.ejmech.2018.01.095
BindingDB Entry DOI: 10.7270/Q2J67KF5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50241644
PNG
(CHEMBL4075602)
Show SMILES O[C@@H]1CO[C@H]([C@H](O)[C@H]1O)c1nc(c[nH]1)-c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C18H18N2O4/c21-14-9-24-17(16(23)15(14)22)18-19-8-13(20-18)12-6-5-10-3-1-2-4-11(10)7-12/h1-8,14-17,21-23H,9H2,(H,19,20)/t14-,15+,16-,17-/m1/s1
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1.00E+5n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Inhibition of ADP-induced platelet aggregation in human platelet-rich plasma


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50241640
PNG
(CHEMBL4098082)
Show SMILES N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1c1nc2ccccc2[nH]1 |r|
Show InChI InChI=1S/C13H17N3O4/c14-9-11(19)10(18)8(5-17)20-12(9)13-15-6-3-1-2-4-7(6)16-13/h1-4,8-12,17-19H,5,14H2,(H,15,16)/t8-,9-,10-,11-,12-/m1/s1
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1.07E+5n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase-b in presence of varying levels of glucose-1-phosphate and constant concentration of g...


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50306549
PNG
((2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-phenyl-1H-...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)n1cc(nn1)-c1ccccc1 |r|
Show InChI InChI=1S/C14H17N3O5/c18-7-10-11(19)12(20)13(21)14(22-10)17-6-9(15-16-17)8-4-2-1-3-5-8/h1-6,10-14,18-21H,7H2/t10-,11-,12+,13-,14-/m1/s1
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1.51E+5n/an/an/an/an/an/an/an/a



University of Debrecen

Curated by ChEMBL


Assay Description
Competitive inhibition of rabbit muscle glycogen phosphorylase b using glucose-1-phosphate as substrate in presence of constant concentrations of gly...


J Med Chem 60: 9251-9262 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01056
BindingDB Entry DOI: 10.7270/Q2ZC851N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))
BDBM50295860
PNG
((2R,3R,4S,5S,6R)-2-(benzo[d]thiazol-2-yl)-6-(hydro...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1nc2ccccc2s1 |r|
Show InChI InChI=1S/C13H15NO5S/c15-5-7-9(16)10(17)11(18)12(19-7)13-14-6-3-1-2-4-8(6)20-13/h1-4,7,9-12,15-18H,5H2/t7-,9-,10+,11-,12-/m1/s1
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2.29E+5n/an/an/an/an/an/an/an/a



University of Thessaly

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase-b


Eur J Med Chem 123: 737-745 (2016)


Article DOI: 10.1016/j.ejmech.2016.06.049
BindingDB Entry DOI: 10.7270/Q2TT4SXG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
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