Compile Data Set for Download or QSAR

Found 31 hits with Last Name = 'yang' and Initial = 'si'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392710 (Example 4 | US10301291, Compound 10d) Show SMILES N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(NC2CCOCC2)n1 Show InChI InChI=1S/C24H22N6O/c25-11-7-21-16-27-23(19-6-5-17-3-1-2-4-18(17)15-19)30(21)22-8-12-26-24(29-22)28-20-9-13-31-14-10-20/h1-6,8,12,15-16,20H,7,9-10,13-14H2,(H,26,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392734 (Example 34 | US10301291, Compound 15d) Show SMILES O=C(C1CC1)N1CCCC(C1)Nc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2ccccc2c1 Show InChI InChI=1S/C28H27N7O/c29-13-11-24-17-31-26(22-10-7-19-4-1-2-5-21(19)16-22)35(24)25-12-14-30-28(33-25)32-23-6-3-15-34(18-23)27(36)20-8-9-20/h1-2,4-5,7,10,12,14,16-17,20,23H,3,6,8-9,11,15,18H2,(H,30,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392737 (Example 37 | US10301291, Compound 15g) Show SMILES O=C(C1CC1)N1CCCC(C1)Nc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2occc2c1 Show InChI InChI=1S/C26H25N7O2/c27-10-7-21-15-29-24(19-5-6-22-18(14-19)9-13-35-22)33(21)23-8-11-28-26(31-23)30-20-2-1-12-32(16-20)25(34)17-3-4-17/h5-6,8-9,11,13-15,17,20H,1-4,7,12,16H2,(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392728 (Example 28 | US10301291, Compound 14d) Show SMILES N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(NC2CCCNC2)n1 Show InChI InChI=1S/C24H23N7/c25-11-9-21-16-28-23(19-8-7-17-4-1-2-5-18(17)14-19)31(21)22-10-13-27-24(30-22)29-20-6-3-12-26-15-20/h1-2,4-5,7-8,10,13-14,16,20,26H,3,6,9,12,15H2,(H,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392733 (Example 33 | US10301291, Compound 15c) Show SMILES O=C(C1CC1)N1CCCC(C1)Nc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2ccccc2n1 Show InChI InChI=1S/C27H26N8O/c28-13-11-21-16-30-25(23-10-9-18-4-1-2-6-22(18)32-23)35(21)24-12-14-29-27(33-24)31-20-5-3-15-34(17-20)26(36)19-7-8-19/h1-2,4,6,9-10,12,14,16,19-20H,3,5,7-8,11,15,17H2,(H,29,31,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392717 (Example 11 | US10301291, Compound 11e) Show SMILES Clc1ccc(cc1Cl)-c1ncc(CC#N)n1-c1ccnc(NC2CCCCC2)n1 Show InChI InChI=1S/C21H20Cl2N6/c22-17-7-6-14(12-18(17)23)20-26-13-16(8-10-24)29(20)19-9-11-25-21(28-19)27-15-4-2-1-3-5-15/h6-7,9,11-13,15H,1-5,8H2,(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392716 (Example 10 | US10301291, Compound 11d) Show SMILES N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(NC2CCCCC2)n1 Show InChI InChI=1S/C25H24N6/c26-14-12-22-17-28-24(20-11-10-18-6-4-5-7-19(18)16-20)31(22)23-13-15-27-25(30-23)29-21-8-2-1-3-9-21/h4-7,10-11,13,15-17,21H,1-3,8-9,12H2,(H,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392712 (Example 6 | US10301291, Compound 10f) Show SMILES Fc1ccc(cc1C(F)(F)F)-c1ncc(CC#N)n1-c1ccnc(NC2CCOCC2)n1 Show InChI InChI=1S/C21H18F4N6O/c22-17-2-1-13(11-16(17)21(23,24)25)19-28-12-15(3-7-26)31(19)18-4-8-27-20(30-18)29-14-5-9-32-10-6-14/h1-2,4,8,11-12,14H,3,5-6,9-10H2,(H,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392711 (Example 5 | US10301291, Compound 10e) Show SMILES Clc1ccc(cc1Cl)-c1ncc(CC#N)n1-c1ccnc(NC2CCOCC2)n1 Show InChI InChI=1S/C20H18Cl2N6O/c21-16-2-1-13(11-17(16)22)19-25-12-15(3-7-23)28(19)18-4-8-24-20(27-18)26-14-5-9-29-10-6-14/h1-2,4,8,11-12,14H,3,5-6,9-10H2,(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392709 (Example 3 | US10301291, Compound 10c) Show SMILES N#CCc1cnc(-c2ccc3ccccc3n2)n1-c1ccnc(NC2CCOCC2)n1 Show InChI InChI=1S/C23H21N7O/c24-11-7-18-15-26-22(20-6-5-16-3-1-2-4-19(16)28-20)30(18)21-8-12-25-23(29-21)27-17-9-13-31-14-10-17/h1-6,8,12,15,17H,7,9-10,13-14H2,(H,25,27,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392707 (Example 1 | US10301291, Compound 10a) Show SMILES N#CCc1cnc(-c2ccc3OCOc3c2)n1-c1ccnc(NC2CCOCC2)n1 Show InChI InChI=1S/C21H20N6O3/c22-7-3-16-12-24-20(14-1-2-17-18(11-14)30-13-29-17)27(16)19-4-8-23-21(26-19)25-15-5-9-28-10-6-15/h1-2,4,8,11-12,15H,3,5-6,9-10,13H2,(H,23,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392722 (Example 16 | US10301291, Compound 12d) Show SMILES CC(O)CNc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2ccccc2c1 Show InChI InChI=1S/C22H20N6O/c1-15(29)13-26-22-24-11-9-20(27-22)28-19(8-10-23)14-25-21(28)18-7-6-16-4-2-3-5-17(16)12-18/h2-7,9,11-12,14-15,29H,8,13H2,1H3,(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392736 (Example 36 | US10301291, Compound 15f) Show SMILES Fc1ccc(cc1C(F)(F)F)-c1ncc(CC#N)n1-c1ccnc(NC2CCCN(C2)C(=O)C2CC2)n1 Show InChI InChI=1S/C25H23F4N7O/c26-20-6-5-16(12-19(20)25(27,28)29)22-32-13-18(7-9-30)36(22)21-8-10-31-24(34-21)33-17-2-1-11-35(14-17)23(37)15-3-4-15/h5-6,8,10,12-13,15,17H,1-4,7,11,14H2,(H,31,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392735 (Example 35 | US10301291, Compound 15e) Show SMILES Clc1ccc(cc1Cl)-c1ncc(CC#N)n1-c1ccnc(NC2CCCN(C2)C(=O)C2CC2)n1 Show InChI InChI=1S/C24H23Cl2N7O/c25-19-6-5-16(12-20(19)26)22-29-13-18(7-9-27)33(22)21-8-10-28-24(31-21)30-17-2-1-11-32(14-17)23(34)15-3-4-15/h5-6,8,10,12-13,15,17H,1-4,7,11,14H2,(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392732 (Example 32 | US10301291, Compound 15b) Show SMILES O=C(C1CC1)N1CCCC(C1)Nc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2OCCOc2c1 Show InChI InChI=1S/C26H27N7O3/c27-9-7-20-15-29-24(18-5-6-21-22(14-18)36-13-12-35-21)33(20)23-8-10-28-26(31-23)30-19-2-1-11-32(16-19)25(34)17-3-4-17/h5-6,8,10,14-15,17,19H,1-4,7,11-13,16H2,(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392731 (Example 31 | US10301291, Compound 15a) Show SMILES O=C(C1CC1)N1CCCC(C1)Nc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2OCOc2c1 Show InChI InChI=1S/C25H25N7O3/c26-9-7-19-13-28-23(17-5-6-20-21(12-17)35-15-34-20)32(19)22-8-10-27-25(30-22)29-18-2-1-11-31(14-18)24(33)16-3-4-16/h5-6,8,10,12-13,16,18H,1-4,7,11,14-15H2,(H,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392730 (Example 30 | US10301291, Compound 14f) Show SMILES Fc1ccc(cc1C(F)(F)F)-c1ncc(CC#N)n1-c1ccnc(NC2CCCNC2)n1 Show InChI InChI=1S/C21H19F4N7/c22-17-4-3-13(10-16(17)21(23,24)25)19-29-12-15(5-7-26)32(19)18-6-9-28-20(31-18)30-14-2-1-8-27-11-14/h3-4,6,9-10,12,14,27H,1-2,5,8,11H2,(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392719 (Example 13 | US10301291, Compound 12a) Show SMILES CC(O)CNc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2OCOc2c1 Show InChI InChI=1S/C19H18N6O3/c1-12(26)9-23-19-21-7-5-17(24-19)25-14(4-6-20)10-22-18(25)13-2-3-15-16(8-13)28-11-27-15/h2-3,5,7-8,10,12,26H,4,9,11H2,1H3,(H,21,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392720 (Example 14 | US10301291, Compound 12b) Show SMILES CC(O)CNc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2OCCOc2c1 Show InChI InChI=1S/C20H20N6O3/c1-13(27)11-24-20-22-7-5-18(25-20)26-15(4-6-21)12-23-19(26)14-2-3-16-17(10-14)29-9-8-28-16/h2-3,5,7,10,12-13,27H,4,8-9,11H2,1H3,(H,22,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392721 (Example 15 | US10301291, Compound 12c) Show SMILES CC(O)CNc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2ccccc2n1 Show InChI InChI=1S/C21H19N7O/c1-14(29)12-25-21-23-11-9-19(27-21)28-16(8-10-22)13-24-20(28)18-7-6-15-4-2-3-5-17(15)26-18/h2-7,9,11,13-14,29H,8,12H2,1H3,(H,23,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392723 (Example 17 | US10301291, Compound 12e) Show SMILES CC(O)CNc1nccc(n1)-n1c(CC#N)cnc1-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C18H16Cl2N6O/c1-11(27)9-24-18-22-7-5-16(25-18)26-13(4-6-21)10-23-17(26)12-2-3-14(19)15(20)8-12/h2-3,5,7-8,10-11,27H,4,9H2,1H3,(H,22,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392724 (Example 18 | US10301291, Compound 12f) Show SMILES CC(O)CNc1nccc(n1)-n1c(CC#N)cnc1-c1ccc(F)c(c1)C(F)(F)F Show InChI InChI=1S/C19H16F4N6O/c1-11(30)9-27-18-25-7-5-16(28-18)29-13(4-6-24)10-26-17(29)12-2-3-15(20)14(8-12)19(21,22)23/h2-3,5,7-8,10-11,30H,4,9H2,1H3,(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392726 (Example 26 | US10301291, Compound 14b) Show SMILES N#CCc1cnc(-c2ccc3OCCOc3c2)n1-c1ccnc(NC2CCCNC2)n1 Show InChI InChI=1S/C22H23N7O2/c23-7-5-17-14-26-21(15-3-4-18-19(12-15)31-11-10-30-18)29(17)20-6-9-25-22(28-20)27-16-2-1-8-24-13-16/h3-4,6,9,12,14,16,24H,1-2,5,8,10-11,13H2,(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392727 (Example 27 | US10301291, Compound 14c) Show SMILES N#CCc1cnc(-c2ccc3ccccc3n2)n1-c1ccnc(NC2CCCNC2)n1 Show InChI InChI=1S/C23H22N8/c24-11-9-18-15-27-22(20-8-7-16-4-1-2-6-19(16)29-20)31(18)21-10-13-26-23(30-21)28-17-5-3-12-25-14-17/h1-2,4,6-8,10,13,15,17,25H,3,5,9,12,14H2,(H,26,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392729 (Example 29 | US10301291, Compound 14e) Show SMILES Clc1ccc(cc1Cl)-c1ncc(CC#N)n1-c1ccnc(NC2CCCNC2)n1 Show InChI InChI=1S/C20H19Cl2N7/c21-16-4-3-13(10-17(16)22)19-26-12-15(5-7-23)29(19)18-6-9-25-20(28-18)27-14-2-1-8-24-11-14/h3-4,6,9-10,12,14,24H,1-2,5,8,11H2,(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392708 (Example 2 | US10301291, Compound 10b) Show SMILES N#CCc1cnc(-c2ccc3OCCOc3c2)n1-c1ccnc(NC2CCOCC2)n1 Show InChI InChI=1S/C22H22N6O3/c23-7-3-17-14-25-21(15-1-2-18-19(13-15)31-12-11-30-18)28(17)20-4-8-24-22(27-20)26-16-5-9-29-10-6-16/h1-2,4,8,13-14,16H,3,5-6,9-12H2,(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392715 (Example 9 | US10301291, Compound 11c) Show SMILES N#CCc1cnc(-c2ccc3ccccc3n2)n1-c1ccnc(NC2CCCCC2)n1 Show InChI InChI=1S/C24H23N7/c25-14-12-19-16-27-23(21-11-10-17-6-4-5-9-20(17)29-21)31(19)22-13-15-26-24(30-22)28-18-7-2-1-3-8-18/h4-6,9-11,13,15-16,18H,1-3,7-8,12H2,(H,26,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392713 (Example 7 | US10301291, Compound 11a) Show SMILES N#CCc1cnc(-c2ccc3OCOc3c2)n1-c1ccnc(NC2CCCCC2)n1 Show InChI InChI=1S/C22H22N6O2/c23-10-8-17-13-25-21(15-6-7-18-19(12-15)30-14-29-18)28(17)20-9-11-24-22(27-20)26-16-4-2-1-3-5-16/h6-7,9,11-13,16H,1-5,8,14H2,(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392725 (Example 25 | US10301291, Compound 14a) Show SMILES N#CCc1cnc(-c2ccc3OCOc3c2)n1-c1ccnc(NC2CCCNC2)n1 Show InChI InChI=1S/C21H21N7O2/c22-7-5-16-12-25-20(14-3-4-17-18(10-14)30-13-29-17)28(16)19-6-9-24-21(27-19)26-15-2-1-8-23-11-15/h3-4,6,9-10,12,15,23H,1-2,5,8,11,13H2,(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392714 (Example 8 | US10301291, Compound 11b) Show SMILES N#CCc1cnc(-c2ccc3OCCOc3c2)n1-c1ccnc(NC2CCCCC2)n1 Show InChI InChI=1S/C23H24N6O2/c24-10-8-18-15-26-22(16-6-7-19-20(14-16)31-13-12-30-19)29(18)21-9-11-25-23(28-21)27-17-4-2-1-3-5-17/h6-7,9,11,14-15,17H,1-5,8,12-13H2,(H,25,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM392718 (Example 12 | US10301291, Compound 11f) Show SMILES Fc1ccc(cc1C(F)(F)F)-c1ncc(CC#N)n1-c1ccnc(NC2CCCCC2)n1 Show InChI InChI=1S/C22H20F4N6/c23-18-7-6-14(12-17(18)22(24,25)26)20-29-13-16(8-10-27)32(20)19-9-11-28-21(31-19)30-15-4-2-1-3-5-15/h6-7,9,11-13,15H,1-5,8H2,(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...				J Med Chem 52: 1994-2005 (2009) BindingDB Entry DOI: 10.7270/Q20K2BW1
					More data for this Ligand-Target Pair