Found 296 hits with Last Name = 'del rosario' and Initial = 'j' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Placenta growth factor
(Mus musculus) | BDBM50339214
(CHEMBL1689480)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(C)C |r,wU:39.41,4.3,64.68,49.56,2.2,145.161,106.112,132.140,20.21,8.8,wD:56.60,100.108,117.123,99.105,136.149,35.102,30.136,(28.71,-31.85,;27.38,-32.62,;26.04,-31.85,;26.04,-30.32,;24.71,-32.63,;20.77,-34.9,;19.44,-34.12,;18.1,-34.87,;19.46,-32.59,;20.78,-31.84,;20.81,-30.3,;22.14,-29.56,;22.16,-28.02,;20.84,-27.24,;20.86,-25.7,;19.5,-27.99,;19.49,-29.52,;18.13,-31.79,;16.8,-32.55,;16.78,-34.09,;15.46,-31.76,;15.48,-30.23,;14.16,-29.44,;14.02,-27.92,;12.52,-27.58,;11.73,-28.9,;12.74,-30.05,;14.12,-32.54,;14.18,-34.02,;15.53,-34.76,;12.81,-34.79,;12.81,-36.34,;14.15,-37.14,;14.14,-38.71,;15.45,-39.53,;15.45,-41.06,;16.77,-41.84,;16.77,-43.38,;15.44,-44.14,;18.09,-44.15,;18.09,-45.7,;16.74,-46.46,;15.34,-45.83,;14.31,-46.97,;15.08,-48.31,;16.59,-47.99,;19.43,-43.4,;20.74,-44.16,;20.74,-45.7,;22.09,-43.4,;23.55,-43.87,;24.45,-42.64,;23.55,-41.4,;22.1,-41.87,;20.75,-41.12,;19.44,-41.88,;20.75,-39.58,;19.42,-38.82,;18.09,-39.59,;16.75,-38.83,;18.09,-41.13,;22.09,-38.79,;22.07,-37.26,;20.73,-36.51,;23.4,-36.48,;24.73,-37.25,;24.72,-38.79,;26.05,-39.57,;26.04,-41.12,;27.39,-41.91,;28.74,-41.13,;28.75,-39.57,;30.09,-41.91,;31.44,-41.14,;32.78,-41.92,;34.14,-41.14,;34.14,-39.59,;35.48,-41.93,;36.83,-41.15,;38.17,-41.94,;39.52,-41.16,;39.53,-39.61,;40.88,-38.83,;42.22,-39.61,;43.57,-38.83,;43.57,-37.28,;44.92,-39.61,;45.32,-41.11,;46.82,-40.71,;46.42,-39.2,;47.2,-37.86,;38.17,-38.82,;36.83,-39.6,;23.43,-34.93,;24.73,-34.18,;26.05,-34.93,;14.11,-41.84,;14.11,-43.36,;12.79,-41.07,;11.45,-41.84,;11.45,-43.37,;10.13,-44.15,;12.79,-44.14,;10.13,-41.06,;10.13,-39.52,;8.79,-41.84,;7.45,-41.06,;7.45,-39.52,;6.11,-38.75,;4.79,-39.53,;3.46,-38.76,;2.12,-39.53,;.8,-38.77,;2.13,-41.07,;6.11,-41.84,;4.78,-41.07,;6.12,-43.37,;4.8,-44.14,;4.81,-45.7,;3.46,-46.48,;2.11,-45.71,;.77,-46.49,;.78,-48.05,;-.57,-48.83,;2.13,-48.82,;3.47,-48.03,;3.46,-43.38,;2.13,-44.16,;3.46,-41.84,;11.49,-34.02,;10.15,-34.77,;10.15,-36.31,;8.81,-34.01,;7.47,-34.78,;6.16,-34.02,;6.15,-32.49,;4.8,-34.8,;4.82,-36.33,;3.5,-37.12,;2.16,-36.36,;.85,-37.15,;2.14,-34.83,;3.5,-34.03,;3.5,-32.5,;4.84,-31.73,;2.17,-31.72,;2.19,-30.19,;3.52,-29.43,;4.84,-30.2,;6.18,-29.44,;6.19,-27.9,;4.85,-27.13,;3.52,-27.89,;.84,-32.48,;-.49,-31.71,;-1.83,-32.48,;-.49,-30.16,;8.81,-32.48,;7.47,-31.71,;10.13,-31.7,)| Show InChI InChI=1S/C106H146N26O26S2/c1-9-59(6)89-103(155)119-71(19-13-14-39-112-83(137)51-158-52-84(138)117-66-29-22-62(23-30-66)28-36-85(139)132-42-38-86(132)140)93(145)125-79(43-57(2)3)105(157)131-41-16-21-82(131)101(153)124-78(48-68-50-111-56-115-68)97(149)126-81(100(152)130-90(60(7)133)104(156)120-72(20-15-40-113-106(108)109)92(144)121-74(91(107)143)44-64-24-31-69(135)32-25-64)54-160-159-53-80(99(151)123-77(47-67-49-110-55-114-67)96(148)122-76(98(150)129-89)46-65-26-33-70(136)34-27-65)127-102(154)88(58(4)5)128-94(146)73(35-37-87(141)142)118-95(147)75(116-61(8)134)45-63-17-11-10-12-18-63/h10-12,17-18,22-27,29-34,49-50,55-60,71-82,88-90,133,135-136H,9,13-16,19-21,28,35-48,51-54H2,1-8H3,(H2,107,143)(H,110,114)(H,111,115)(H,112,137)(H,116,134)(H,117,138)(H,118,147)(H,119,155)(H,120,156)(H,121,144)(H,122,148)(H,123,151)(H,124,153)(H,125,145)(H,126,149)(H,127,154)(H,128,146)(H,129,150)(H,130,152)(H,141,142)(H4,108,109,113)/t59-,60+,71-,72+,73-,74+,75-,76-,77-,78-,79-,80-,81-,82-,88-,89-,90+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PlGF-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM283216
(4-[2-(4-amino-piperidin-1-yl)-5- (3-fluoro-4-metho...)Show SMILES COc1ccc(cc1F)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1 Show InChI InChI=1S/C24H23F2N5O2/c1-30-23(32)21(14-5-6-20(33-2)19(26)11-14)22(15-3-4-16(13-27)18(25)12-15)29-24(30)31-9-7-17(28)8-10-31/h3-6,11-12,17H,7-10,28H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00978
BindingDB Entry DOI: 10.7270/Q2RJ4P33 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339212
(CHEMBL1689483)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)C(C)(C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)NC(C)(C)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(C)=O)C(C)C |r| Show InChI InChI=1S/C116H168N28O32S2/c1-18-62(6)94-110(171)128-76(28-23-25-44-121-87(149)54-176-55-88(150)127-72-35-30-69(31-36-72)34-40-89(151)144-45-42-90(144)152)99(160)131-78(46-60(2)3)107(168)142-116(15,16)114(175)137-81(50-74-53-119-59-123-74)102(163)135-85(105(166)140-95(66(10)145)111(172)129-77(29-22-24-43-120-67(11)146)106(167)141-115(13,14)113(117)174)57-178-177-56-84(104(165)133-80(49-73-52-118-58-122-73)101(162)132-79(103(164)139-94)47-71-32-37-75(148)38-33-71)136-109(170)93(61(4)5)138-108(169)86(39-41-91(153)154)143(17)112(173)83(48-70-26-20-19-21-27-70)134-98(159)65(9)125-96(157)64(8)126-100(161)82(51-92(155)156)130-97(158)63(7)124-68(12)147/h19-21,26-27,30-33,35-38,52-53,58-66,76-86,93-95,145,148H,18,22-25,28-29,34,39-51,54-57H2,1-17H3,(H2,117,174)(H,118,122)(H,119,123)(H,120,146)(H,121,149)(H,124,147)(H,125,157)(H,126,161)(H,127,150)(H,128,171)(H,129,172)(H,130,158)(H,131,160)(H,132,162)(H,133,165)(H,134,159)(H,135,163)(H,136,170)(H,137,175)(H,138,169)(H,139,164)(H,140,166)(H,141,167)(H,142,168)(H,153,154)(H,155,156)/t62-,63-,64-,65-,66+,76-,77-,78-,79-,80-,81?,82-,83-,84-,85-,86-,93-,94-,95+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM501809
(4-[6-(4-amino-piperidin-1-yl)-4- methyl-5-oxo-3-p...)Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(C#N)c(F)c1 Show InChI InChI=1S/C24H24FN5O/c1-15-3-5-16(6-4-15)22-21(17-7-8-18(14-26)20(25)13-17)28-23(24(31)29(22)2)30-11-9-19(27)10-12-30/h3-8,13,19H,9-12,27H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00978
BindingDB Entry DOI: 10.7270/Q2RJ4P33 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Mus musculus) | BDBM50339209
(CHEMBL1689479)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(C)C |r,wU:4.3,64.68,49.56,2.2,145.161,117.123,99.105,132.140,20.21,8.8,39.41,wD:56.60,100.108,106.112,136.149,35.102,30.136,(16.25,-25.17,;14.91,-25.94,;13.58,-25.18,;13.58,-23.65,;12.25,-25.96,;8.31,-28.23,;6.97,-27.45,;5.63,-28.2,;6.99,-25.91,;8.32,-25.16,;8.34,-23.62,;9.68,-22.88,;9.7,-21.35,;8.38,-20.56,;8.4,-19.02,;7.04,-21.32,;7.02,-22.85,;5.67,-25.12,;4.34,-25.88,;4.32,-27.42,;2.99,-25.09,;3.01,-23.56,;1.69,-22.77,;1.55,-21.25,;.05,-20.91,;-.73,-22.23,;.28,-23.39,;1.66,-25.86,;1.72,-27.35,;3.06,-28.09,;.35,-28.11,;.34,-29.66,;1.68,-30.47,;1.67,-32.03,;2.98,-32.85,;2.98,-34.39,;4.31,-35.17,;4.31,-36.71,;2.97,-37.47,;5.63,-37.48,;5.62,-39.03,;4.28,-39.79,;2.88,-39.16,;1.85,-40.3,;2.61,-41.64,;4.12,-41.32,;6.97,-36.72,;8.28,-37.49,;8.28,-39.03,;9.63,-36.73,;11.08,-37.21,;11.99,-35.97,;11.09,-34.73,;9.63,-35.2,;8.29,-34.44,;6.97,-35.21,;8.29,-32.9,;6.95,-32.14,;5.63,-32.92,;4.29,-32.16,;5.63,-34.46,;9.63,-32.12,;9.61,-30.59,;8.27,-29.83,;10.94,-29.81,;12.27,-30.58,;12.26,-32.12,;13.59,-32.89,;13.58,-34.45,;14.93,-35.23,;16.28,-34.46,;16.28,-32.9,;17.62,-35.24,;18.97,-34.47,;20.32,-35.25,;21.67,-34.47,;21.67,-32.91,;23.02,-35.25,;24.37,-34.48,;25.71,-35.27,;27.06,-34.49,;27.07,-32.93,;28.41,-32.16,;29.76,-32.94,;31.11,-32.16,;31.11,-30.6,;32.46,-32.94,;32.86,-34.44,;34.36,-34.04,;33.96,-32.54,;34.74,-31.19,;25.71,-32.15,;24.37,-32.93,;10.97,-28.26,;12.26,-27.51,;13.59,-28.26,;1.65,-35.17,;1.65,-36.69,;.32,-34.4,;-1.01,-35.17,;-1.01,-36.7,;-2.34,-37.47,;.32,-37.47,;-2.34,-34.38,;-2.34,-32.85,;-3.68,-35.17,;-5.01,-34.38,;-5.02,-32.85,;-6.35,-32.08,;-7.68,-32.86,;-9.01,-32.09,;-10.34,-32.86,;-11.68,-32.09,;-10.34,-34.39,;-6.35,-35.17,;-7.68,-34.4,;-6.34,-36.7,;-7.67,-37.47,;-7.66,-39.03,;-9,-39.81,;-10.35,-39.03,;-11.7,-39.82,;-11.71,-41.38,;-13.04,-42.16,;-10.33,-42.15,;-8.99,-41.36,;-9.01,-36.71,;-10.34,-37.48,;-9.01,-35.17,;-.97,-27.34,;-2.31,-28.09,;-2.31,-29.63,;-3.65,-27.34,;-5,-28.1,;-6.31,-27.35,;-6.32,-25.82,;-7.67,-28.12,;-7.65,-29.66,;-8.97,-30.44,;-10.31,-29.69,;-11.64,-30.47,;-10.32,-28.16,;-8.97,-27.36,;-8.96,-25.83,;-7.63,-25.06,;-10.29,-25.05,;-10.28,-23.51,;-8.94,-22.75,;-7.62,-23.53,;-6.29,-22.76,;-6.28,-21.23,;-7.61,-20.46,;-8.94,-21.22,;-11.63,-25.81,;-12.98,-25.03,;-14.33,-25.81,;-12.98,-23.48,;-3.66,-25.8,;-4.99,-25.03,;-2.33,-25.03,)| Show InChI InChI=1S/C106H146N26O26S2/c1-9-59(6)89-103(155)119-71(19-13-14-39-112-83(137)51-158-52-84(138)117-66-29-22-62(23-30-66)28-36-85(139)132-42-38-86(132)140)93(145)125-79(43-57(2)3)105(157)131-41-16-21-82(131)101(153)124-78(48-68-50-111-56-115-68)97(149)126-81(100(152)130-90(60(7)133)104(156)120-72(20-15-40-113-106(108)109)92(144)121-74(91(107)143)44-64-24-31-69(135)32-25-64)54-160-159-53-80(99(151)123-77(47-67-49-110-55-114-67)96(148)122-76(98(150)129-89)46-65-26-33-70(136)34-27-65)127-102(154)88(58(4)5)128-94(146)73(35-37-87(141)142)118-95(147)75(116-61(8)134)45-63-17-11-10-12-18-63/h10-12,17-18,22-27,29-34,49-50,55-60,71-82,88-90,133,135-136H,9,13-16,19-21,28,35-48,51-54H2,1-8H3,(H2,107,143)(H,110,114)(H,111,115)(H,112,137)(H,116,134)(H,117,138)(H,118,147)(H,119,155)(H,120,156)(H,121,144)(H,122,148)(H,123,151)(H,124,153)(H,125,145)(H,126,149)(H,127,154)(H,128,146)(H,129,150)(H,130,152)(H,141,142)(H4,108,109,113)/t59-,60+,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,88-,89-,90-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PlGF-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM50503504
(CHEMBL4444902 | US10626103, Example 54)Show SMILES CN[C@H]1CCN(C1)C(=O)c1nc(-c2ccc(C#N)c(F)c2)n(c1C)-c1ccc2nn(C)c(Cl)c2c1 |r| Show InChI InChI=1S/C25H23ClFN7O/c1-14-22(25(35)33-9-8-17(13-33)29-2)30-24(15-4-5-16(12-28)20(27)10-15)34(14)18-6-7-21-19(11-18)23(26)32(3)31-21/h4-7,10-11,17,29H,8-9,13H2,1-3H3/t17-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of LSD1 (unknown origin) |
Bioorg Med Chem Lett 29: 103-106 (2019)
Article DOI: 10.1016/j.bmcl.2018.11.001
BindingDB Entry DOI: 10.7270/Q2W95DFG |
More data for this
Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM283129
(4-[2-(4-amino-piperidin-1-yl)-5- (4-methoxyphenyl)...)Show SMILES COc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(cc1)C#N Show InChI InChI=1S/C24H25N5O2/c1-28-23(30)21(17-7-9-20(31-2)10-8-17)22(18-5-3-16(15-25)4-6-18)27-24(28)29-13-11-19(26)12-14-29/h3-10,19H,11-14,26H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00978
BindingDB Entry DOI: 10.7270/Q2RJ4P33 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50079090
(CHEMBL90435 | [(4-{2-[4-((R)-3,10-Dibromo-8-chloro...)Show SMILES OC(=O)CNC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 Show InChI InChI=1S/C29H33Br2ClN4O4/c30-21-12-20-2-1-19-13-22(32)14-23(31)26(19)27(28(20)33-15-21)18-5-9-35(10-6-18)24(37)11-17-3-7-36(8-4-17)29(40)34-16-25(38)39/h12-15,17-18,27H,1-11,16H2,(H,34,40)(H,38,39)/t27-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT). |
J Med Chem 42: 2651-61 (1999)
Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V |
More data for this
Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM283200
(4-[2-(4-amino-piperidin-1-yl)-5-(4- methoxyphenyl)...)Show SMILES COc1ccc(cc1F)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(cc1)C#N Show InChI InChI=1S/C24H24FN5O2/c1-29-23(31)21(17-7-8-20(32-2)19(25)13-17)22(16-5-3-15(14-26)4-6-16)28-24(29)30-11-9-18(27)10-12-30/h3-8,13,18H,9-12,27H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00978
BindingDB Entry DOI: 10.7270/Q2RJ4P33 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50079085
(5-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)Show SMILES OC(=O)c1cncc(c1)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 Show InChI InChI=1S/C33H33Br2ClN4O4/c34-25-13-22-2-1-21-14-26(36)15-27(35)29(21)30(31(22)38-18-25)20-5-9-39(10-6-20)28(41)11-19-3-7-40(8-4-19)32(42)23-12-24(33(43)44)17-37-16-23/h12-20,30H,1-11H2,(H,43,44)/t30-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT). |
J Med Chem 42: 2651-61 (1999)
Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50079075
(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)Show SMILES NC(=O)CNC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 Show InChI InChI=1S/C29H34Br2ClN5O3/c30-21-12-20-2-1-19-13-22(32)14-23(31)26(19)27(28(20)34-15-21)18-5-9-36(10-6-18)25(39)11-17-3-7-37(8-4-17)29(40)35-16-24(33)38/h12-15,17-18,27H,1-11,16H2,(H2,33,38)(H,35,40)/t27-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into His6-H-Ras-CVLS by farnesyl transferase |
J Med Chem 42: 2651-61 (1999)
Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339210
(CHEMBL1689481)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(C)C |r,wU:39.41,4.3,64.68,49.56,2.2,145.161,161.170,106.112,132.140,20.21,8.8,wD:56.60,100.108,117.123,156.165,99.105,136.149,35.102,30.136,166.179,(33.81,-1.12,;32.48,-1.89,;31.15,-1.12,;31.14,.41,;29.82,-1.9,;25.88,-4.17,;24.55,-3.39,;23.21,-4.14,;24.57,-1.86,;25.89,-1.11,;25.92,.43,;27.25,1.17,;27.26,2.71,;25.95,3.49,;25.97,5.03,;24.61,2.74,;24.59,1.21,;23.24,-1.06,;21.91,-1.82,;21.89,-3.36,;20.57,-1.03,;20.59,.5,;19.27,1.29,;19.13,2.81,;17.63,3.15,;16.84,1.83,;17.85,.68,;19.23,-1.81,;19.29,-3.29,;20.64,-4.03,;17.93,-4.05,;17.92,-5.6,;19.26,-6.41,;19.25,-7.97,;20.56,-8.79,;20.56,-10.33,;21.88,-11.11,;21.88,-12.65,;20.55,-13.41,;23.2,-13.41,;23.19,-14.96,;21.85,-15.72,;20.45,-15.09,;19.42,-16.23,;20.19,-17.57,;21.7,-17.25,;24.54,-12.66,;25.85,-13.43,;25.84,-14.96,;27.2,-12.66,;28.65,-13.14,;29.56,-11.91,;28.66,-10.66,;27.2,-11.13,;25.86,-10.38,;24.54,-11.14,;25.86,-8.84,;24.53,-8.08,;23.2,-8.85,;21.86,-8.09,;23.2,-10.39,;27.19,-8.06,;27.18,-6.53,;25.84,-5.77,;28.51,-5.75,;29.84,-6.52,;29.83,-8.06,;31.15,-8.83,;31.15,-10.39,;32.49,-11.17,;33.85,-10.39,;33.85,-8.84,;35.19,-11.18,;36.54,-10.4,;37.88,-11.18,;39.24,-10.41,;39.24,-8.85,;40.58,-11.19,;41.93,-10.41,;43.27,-11.2,;44.62,-10.43,;44.63,-8.87,;45.98,-8.09,;47.32,-8.87,;48.67,-8.1,;48.67,-6.54,;50.02,-8.88,;50.41,-10.38,;51.92,-9.97,;51.52,-8.47,;52.3,-7.13,;43.27,-8.09,;41.93,-8.87,;28.54,-4.2,;29.83,-3.45,;31.16,-4.2,;19.22,-11.1,;19.22,-12.63,;17.9,-10.34,;16.57,-11.1,;16.57,-12.63,;15.24,-13.41,;17.9,-13.4,;15.24,-10.32,;15.24,-8.79,;13.9,-11.1,;12.57,-10.32,;12.56,-8.79,;11.22,-8.02,;9.9,-8.79,;8.57,-8.03,;7.24,-8.8,;5.92,-8.03,;7.24,-10.33,;11.22,-11.1,;9.9,-10.34,;11.23,-12.63,;9.92,-13.4,;9.92,-14.96,;8.58,-15.74,;7.23,-14.97,;5.89,-15.75,;5.89,-17.31,;4.55,-18.09,;7.25,-18.08,;8.59,-17.29,;8.58,-12.64,;7.24,-13.42,;8.58,-11.11,;16.61,-3.28,;15.27,-4.03,;15.27,-5.57,;13.93,-3.28,;12.58,-4.05,;11.27,-3.29,;11.27,-1.76,;9.92,-4.07,;9.94,-5.6,;8.61,-6.38,;7.27,-5.63,;5.97,-6.41,;7.26,-4.1,;8.62,-3.3,;8.62,-1.77,;9.95,-1,;7.29,-.99,;7.3,.54,;8.64,1.3,;9.96,.53,;11.29,1.29,;11.31,2.83,;9.97,3.6,;8.64,2.83,;5.96,-1.75,;4.63,-.98,;4.63,.57,;3.29,-1.75,;3.29,-3.3,;1.95,-.98,;.62,-1.75,;.62,-3.3,;-.72,-.98,;-.72,.57,;-2.05,-1.75,;-3.39,-.98,;-3.39,.57,;-4.73,-1.75,;-4.73,-3.3,;-3.39,-4.07,;-2.05,-3.3,;-3.39,-5.62,;-6.07,-.98,;-7.4,-1.76,;-8.73,-.99,;-7.4,-3.3,;13.92,-1.75,;12.58,-.97,;15.25,-.97,)| Show InChI InChI=1S/C116H161N29O31S2/c1-11-62(6)96-113(173)131-76(21-15-16-41-122-89(150)54-176-55-90(151)129-71-31-24-67(25-32-71)30-38-91(152)145-44-40-92(145)153)102(162)138-85(45-60(2)3)115(175)144-43-18-23-88(144)111(171)137-83(50-73-53-121-59-125-73)107(167)139-87(110(170)143-97(65(9)146)114(174)132-77(22-17-42-123-116(118)119)101(161)133-79(98(117)158)46-69-26-33-74(148)34-27-69)57-178-177-56-86(109(169)136-82(49-72-52-120-58-124-72)106(166)135-81(108(168)142-96)48-70-28-35-75(149)36-29-70)140-112(172)95(61(4)5)141-103(163)78(37-39-93(154)155)130-105(165)80(47-68-19-13-12-14-20-68)134-100(160)64(8)126-99(159)63(7)127-104(164)84(51-94(156)157)128-66(10)147/h12-14,19-20,24-29,31-36,52-53,58-65,76-88,95-97,146,148-149H,11,15-18,21-23,30,37-51,54-57H2,1-10H3,(H2,117,158)(H,120,124)(H,121,125)(H,122,150)(H,126,159)(H,127,164)(H,128,147)(H,129,151)(H,130,165)(H,131,173)(H,132,174)(H,133,161)(H,134,160)(H,135,166)(H,136,169)(H,137,171)(H,138,162)(H,139,167)(H,140,172)(H,141,163)(H,142,168)(H,143,170)(H,154,155)(H,156,157)(H4,118,119,123)/t62-,63-,64-,65+,76-,77+,78-,79+,80-,81-,82-,83-,84-,85-,86-,87-,88-,95-,96-,97+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM50503514
(CHEMBL4522607 | US10626103, Example 55)Show SMILES CN[C@@H]1CCCN(C1)C(=O)c1nc(-c2ccc(C#N)c(F)c2)n(c1C)-c1ccc2nn(C)c(Cl)c2c1 |r| Show InChI InChI=1S/C26H25ClFN7O/c1-15-23(26(36)34-10-4-5-18(14-34)30-2)31-25(16-6-7-17(13-29)21(28)11-16)35(15)19-8-9-22-20(12-19)24(27)33(3)32-22/h6-9,11-12,18,30H,4-5,10,14H2,1-3H3/t18-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of LSD1 (unknown origin) |
Bioorg Med Chem Lett 29: 103-106 (2019)
Article DOI: 10.1016/j.bmcl.2018.11.001
BindingDB Entry DOI: 10.7270/Q2W95DFG |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM14457
((+)-4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo...)Show SMILES [O-][n+]1ccc(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)cc1 |r| Show InChI InChI=1S/C26H24Br2ClN3O2/c27-20-12-19-2-1-18-13-21(29)14-22(28)24(18)25(26(19)30-15-20)17-5-7-31(8-6-17)23(33)11-16-3-9-32(34)10-4-16/h3-4,9-10,12-15,17,25H,1-2,5-8,11H2/t25-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Schering-Plough Research Institute
| Assay Description
FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate... |
J Med Chem 41: 4890-902 (1998)
Article DOI: 10.1021/jm980462b
BindingDB Entry DOI: 10.7270/Q2ZS2TRS |
More data for this
Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM501778
(4-[6-(4-aminopiperidin-1-yl)-4- methyl-3-(4-methy...)Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)c(=O)n1C)-c1ccc(cc1)C#N Show InChI InChI=1S/C24H25N5O/c1-16-3-7-19(8-4-16)22-21(18-9-5-17(15-25)6-10-18)27-23(24(30)28(22)2)29-13-11-20(26)12-14-29/h3-10,20H,11-14,26H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00978
BindingDB Entry DOI: 10.7270/Q2RJ4P33 |
More data for this
Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM50554230
(CHEMBL4748670)Show SMILES [H][C@]12CCN[C@@]1([H])CCN(C2)c1ncc(-c2ccc(C)cc2)c(n1)-c1ccc(cc1)C#N |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00978
BindingDB Entry DOI: 10.7270/Q2RJ4P33 |
More data for this
Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM283128
(4-(2-(4-aminopiperidin-1-yl)- 1-methyl-6-oxo-5-p-t...)Show SMILES Cc1ccc(cc1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(cc1)C#N Show InChI InChI=1S/C24H25N5O/c1-16-3-7-18(8-4-16)21-22(19-9-5-17(15-25)6-10-19)27-24(28(2)23(21)30)29-13-11-20(26)12-14-29/h3-10,20H,11-14,26H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00978
BindingDB Entry DOI: 10.7270/Q2RJ4P33 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50079079
(1-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)Show SMILES Clc1cc(Br)c2[C@@H](C3CCN(CC3)C(=O)CC3CCN(CC3)C(=O)Cn3cncn3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C30H33Br2ClN6O2/c31-23-12-22-2-1-21-13-24(33)14-25(32)28(21)29(30(22)35-15-23)20-5-9-37(10-6-20)26(40)11-19-3-7-38(8-4-19)27(41)16-39-18-34-17-36-39/h12-15,17-20,29H,1-11,16H2/t29-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT). |
J Med Chem 42: 2651-61 (1999)
Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM14461
((+)-4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo...)Show SMILES [O-][n+]1ccc(CC(=O)N2CCN(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)cc1 |r| Show InChI InChI=1S/C25H23Br2ClN4O2/c26-19-12-18-2-1-17-13-20(28)14-21(27)23(17)25(24(18)29-15-19)31-9-7-30(8-10-31)22(33)11-16-3-5-32(34)6-4-16/h3-6,12-15,25H,1-2,7-11H2/t25-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
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Schering-Plough Research Institute
| Assay Description
FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate... |
J Med Chem 41: 4890-902 (1998)
Article DOI: 10.1021/jm980462b
BindingDB Entry DOI: 10.7270/Q2ZS2TRS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM14459
((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)Show SMILES NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 |r| Show InChI InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1 | PDB
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Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT). |
J Med Chem 42: 2651-61 (1999)
Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM14459
((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)Show SMILES NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 |r| Show InChI InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1 | PDB
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Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Farnesyl protein transferase |
J Med Chem 42: 2125-35 (1999)
Article DOI: 10.1021/jm990030g
BindingDB Entry DOI: 10.7270/Q2ZS2VP9 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM14459
((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)Show SMILES NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 |r| Show InChI InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1 | PDB
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Schering-Plough Research Institute
| Assay Description
FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate... |
J Med Chem 41: 4890-902 (1998)
Article DOI: 10.1021/jm980462b
BindingDB Entry DOI: 10.7270/Q2ZS2TRS |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50079074
(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)Show SMILES CNC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 Show InChI InChI=1S/C28H33Br2ClN4O2/c1-32-28(37)35-8-4-17(5-9-35)12-24(36)34-10-6-18(7-11-34)26-25-19(14-22(31)15-23(25)30)2-3-20-13-21(29)16-33-27(20)26/h13-18,26H,2-12H2,1H3,(H,32,37)/t26-/m1/s1 | PDB
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Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT). |
J Med Chem 42: 2651-61 (1999)
Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V |
More data for this
Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM50554231
(CHEMBL4796870)Show SMILES Cc1ccc(cc1)-c1cnc(C[C@H]2CCNC2)nc1-c1ccc(cc1)C#N |r| | PDB
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TBA
| Assay Description
Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00978
BindingDB Entry DOI: 10.7270/Q2RJ4P33 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339191
(CHEMBL1689460)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC(=O)COCC(=O)Nc1ccc(CCC(=O)N2CCC2=O)cc1 |r| Show InChI InChI=1S/C107H157N25O25S3/c1-58(2)46-79-107(156)131-43-23-31-82(131)102(151)122-77(49-68-52-111-57-113-68)97(146)124-80(100(149)118-73(30-19-22-42-110)95(144)127-88(59(3)4)103(152)119-74(39-45-158-11)93(142)116-72(29-18-21-41-109)94(143)126-84(136)54-157-53-83(135)115-67-35-32-64(33-36-67)34-37-85(137)132-44-38-86(132)138)55-159-160-56-81(125-104(153)89(60(5)6)128-99(148)78(50-87(139)140)121-96(145)75(114-63(10)134)47-65-24-13-12-14-25-65)101(150)117-71(28-17-20-40-108)92(141)120-76(48-66-51-112-70-27-16-15-26-69(66)70)98(147)129-90(61(7)8)105(154)130-91(62(9)133)106(155)123-79/h12-16,24-27,32-33,35-36,51-52,57-62,71-82,88-91,112,133H,17-23,28-31,34,37-50,53-56,108-110H2,1-11H3,(H,111,113)(H,114,134)(H,115,135)(H,116,142)(H,117,150)(H,118,149)(H,119,152)(H,120,141)(H,121,145)(H,122,151)(H,123,155)(H,124,146)(H,125,153)(H,127,144)(H,128,148)(H,129,147)(H,130,154)(H,139,140)(H,126,136,143)/t62-,71+,72+,73+,74+,75+,76+,77+,78+,79+,80+,81+,82+,88+,89+,90+,91+/m1/s1 | PDB
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Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50079089
(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)Show SMILES CS(=O)(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 Show InChI InChI=1S/C27H32Br2ClN3O3S/c1-37(35,36)33-10-4-17(5-11-33)12-24(34)32-8-6-18(7-9-32)26-25-19(14-22(30)15-23(25)29)2-3-20-13-21(28)16-31-27(20)26/h13-18,26H,2-12H2,1H3/t26-/m1/s1 | PDB
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Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT). |
J Med Chem 42: 2651-61 (1999)
Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50079084
(CHEMBL432573 | [(4-{2-[4-((R)-3,10-Dibromo-8-chlor...)Show SMILES CCOC(=O)CNC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 Show InChI InChI=1S/C31H37Br2ClN4O4/c1-2-42-27(40)18-36-31(41)38-9-5-19(6-10-38)13-26(39)37-11-7-20(8-12-37)29-28-21(15-24(34)16-25(28)33)3-4-22-14-23(32)17-35-30(22)29/h14-17,19-20,29H,2-13,18H2,1H3,(H,36,41)/t29-/m1/s1 | PDB
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Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT). |
J Med Chem 42: 2651-61 (1999)
Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V |
More data for this
Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM50503507
(CHEMBL4451607 | US10626103, Example 53)Show SMILES Cc1c(nc(-c2ccc(C#N)c(F)c2)n1-c1ccc2nn(C)c(Cl)c2c1)C(=O)N1CCC[C@@H](N)C1 |r| Show InChI InChI=1S/C25H23ClFN7O/c1-14-22(25(35)33-9-3-4-17(29)13-33)30-24(15-5-6-16(12-28)20(27)10-15)34(14)18-7-8-21-19(11-18)23(26)32(2)31-21/h5-8,10-11,17H,3-4,9,13,29H2,1-2H3/t17-/m1/s1 | PDB
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Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of LSD1 (unknown origin) |
Bioorg Med Chem Lett 29: 103-106 (2019)
Article DOI: 10.1016/j.bmcl.2018.11.001
BindingDB Entry DOI: 10.7270/Q2W95DFG |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4
(Homo sapiens (Human)) | BDBM285038
(4-(5-ethylsulfonyl-2-propoxyphenyl)-2-methyl- 6-(1...)Show SMILES CCCOc1ccc(cc1-c1cn(C)c(=O)c2ccc(cc12)-c1cnn(C)c1)S(=O)(=O)CC Show InChI InChI=1S/C25H27N3O4S/c1-5-11-32-24-10-8-19(33(30,31)6-2)13-22(24)23-16-27(3)25(29)20-9-7-17(12-21(20)23)18-14-26-28(4)15-18/h7-10,12-16H,5-6,11H2,1-4H3 | PDB
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Celgene Quanticel Research
Curated by ChEMBL
| Assay Description
Inhibition of BRD4-BD1 in human Raji cells assessed as downregulation of MYC gene expression by PCR method |
Bioorg Med Chem Lett 28: 1811-1816 (2018)
Article DOI: 10.1016/j.bmcl.2018.04.016
BindingDB Entry DOI: 10.7270/Q20Z75WN |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4
(Homo sapiens (Human)) | BDBM50158627
(CHEMBL3787482 | US10023592, Example 81)Show SMILES CCOc1ccc(cc1-c1cn(C)c(=O)c2ccc(cc12)-c1cnn(C)c1)S(=O)(=O)CC Show InChI InChI=1S/C24H25N3O4S/c1-5-31-23-10-8-18(32(29,30)6-2)12-21(23)22-15-26(3)24(28)19-9-7-16(11-20(19)22)17-13-25-27(4)14-17/h7-15H,5-6H2,1-4H3 | PDB
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Celgene Quanticel Research
Curated by ChEMBL
| Assay Description
Inhibition of BRD4-BD1 in human Raji cells assessed as downregulation of MYC gene expression by PCR method |
Bioorg Med Chem Lett 28: 1811-1816 (2018)
Article DOI: 10.1016/j.bmcl.2018.04.016
BindingDB Entry DOI: 10.7270/Q20Z75WN |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50079073
(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)Show SMILES CN(C)C(=O)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 Show InChI InChI=1S/C30H35Br2ClN4O3/c1-35(2)29(39)30(40)37-9-5-18(6-10-37)13-25(38)36-11-7-19(8-12-36)27-26-20(15-23(33)16-24(26)32)3-4-21-14-22(31)17-34-28(21)27/h14-19,27H,3-13H2,1-2H3/t27-/m1/s1 | PDB
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Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT). |
J Med Chem 42: 2651-61 (1999)
Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50079083
(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)Show SMILES [O-][n+]1cccc(c1)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 Show InChI InChI=1S/C32H33Br2ClN4O3/c33-25-15-23-4-3-22-16-26(35)17-27(34)29(22)30(31(23)36-18-25)21-7-12-37(13-8-21)28(40)14-20-5-10-38(11-6-20)32(41)24-2-1-9-39(42)19-24/h1-2,9,15-21,30H,3-8,10-14H2/t30-/m1/s1 | PDB
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Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Hras Farnesyl protein transferase(FPT) |
J Med Chem 42: 2651-61 (1999)
Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50079091
(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)Show SMILES NC(=O)CN1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 Show InChI InChI=1S/C28H33Br2ClN4O2/c29-21-12-20-2-1-19-13-22(31)14-23(30)26(19)27(28(20)33-15-21)18-5-9-35(10-6-18)25(37)11-17-3-7-34(8-4-17)16-24(32)36/h12-15,17-18,27H,1-11,16H2,(H2,32,36)/t27-/m1/s1 | PDB
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Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into His6-H-Ras-CVLS by farnesyl transferase |
J Med Chem 42: 2651-61 (1999)
Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50079076
(5-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)Show SMILES NC(=O)c1cncc(c1)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 Show InChI InChI=1S/C33H34Br2ClN5O3/c34-25-13-22-2-1-21-14-26(36)15-27(35)29(21)30(31(22)39-18-25)20-5-9-40(10-6-20)28(42)11-19-3-7-41(8-4-19)33(44)24-12-23(32(37)43)16-38-17-24/h12-20,30H,1-11H2,(H2,37,43)/t30-/m1/s1 | PDB
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Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT). |
J Med Chem 42: 2651-61 (1999)
Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM14473
((-)-1-(8-Chloro-3,7-dibromo-6,11-dihydro-5H-benzo-...)Show SMILES [O-][n+]1ccc(CC(=O)N2CCN(CC2)[C@H]2c3ccc(Cl)c(Br)c3CCc3cc(Br)cnc23)cc1 |r| Show InChI InChI=1S/C25H23Br2ClN4O2/c26-18-14-17-1-2-19-20(3-4-21(28)23(19)27)25(24(17)29-15-18)31-11-9-30(10-12-31)22(33)13-16-5-7-32(34)8-6-16/h3-8,14-15,25H,1-2,9-13H2/t25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
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| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Schering-Plough Research Institute
| Assay Description
FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate... |
J Med Chem 41: 4890-902 (1998)
Article DOI: 10.1021/jm980462b
BindingDB Entry DOI: 10.7270/Q2ZS2TRS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50079070
(1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-be...)Show SMILES [O-][n+]1ccc(cc1)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 Show InChI InChI=1S/C32H33Br2ClN4O3/c33-25-16-24-2-1-23-17-26(35)18-27(34)29(23)30(31(24)36-19-25)21-5-11-37(12-6-21)28(40)15-20-3-9-38(10-4-20)32(41)22-7-13-39(42)14-8-22/h7-8,13-14,16-21,30H,1-6,9-12,15H2/t30-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
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| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Hras Farnesyl protein transferase(FPT) |
J Med Chem 42: 2651-61 (1999)
Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM14467
((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)Show SMILES NC(=O)N1CCC(CC(=O)N2CCN(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 |r| Show InChI InChI=1S/C26H30Br2ClN5O2/c27-19-12-18-2-1-17-13-20(29)14-21(28)23(17)25(24(18)31-15-19)33-9-7-32(8-10-33)22(35)11-16-3-5-34(6-4-16)26(30)36/h12-16,25H,1-11H2,(H2,30,36)/t25-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Schering-Plough Research Institute
| Assay Description
FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate... |
J Med Chem 41: 4890-902 (1998)
Article DOI: 10.1021/jm980462b
BindingDB Entry DOI: 10.7270/Q2ZS2TRS |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM14469
((-)-4-(8-Chloro-3,7-dibromo-6,11-dihydro-5H-benzo-...)Show SMILES [O-][n+]1ccc(CC(=O)N2CCC(CC2)[C@H]2c3ccc(Cl)c(Br)c3CCc3cc(Br)cnc23)cc1 |r| Show InChI InChI=1S/C26H24Br2ClN3O2/c27-19-14-18-1-2-21-20(3-4-22(29)25(21)28)24(26(18)30-15-19)17-7-9-31(10-8-17)23(33)13-16-5-11-32(34)12-6-16/h3-6,11-12,14-15,17,24H,1-2,7-10,13H2/t24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Schering-Plough Research Institute
| Assay Description
FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate... |
J Med Chem 41: 4890-902 (1998)
Article DOI: 10.1021/jm980462b
BindingDB Entry DOI: 10.7270/Q2ZS2TRS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50079086
(3-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)Show SMILES Clc1cc(Br)c2[C@@H](C3CCN(CC3)C(=O)CC3CCN(CC3)C(=O)CC#N)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C29H31Br2ClN4O2/c30-22-14-21-2-1-20-15-23(32)16-24(31)27(20)28(29(21)34-17-22)19-6-11-36(12-7-19)26(38)13-18-4-9-35(10-5-18)25(37)3-8-33/h14-19,28H,1-7,9-13H2/t28-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
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PC sid
UniChem
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Similars
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| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Hras Farnesyl protein transferase(FPT) |
J Med Chem 42: 2651-61 (1999)
Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50079077
(2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro...)Show SMILES NC(=O)C(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 Show InChI InChI=1S/C28H31Br2ClN4O3/c29-20-12-19-2-1-18-13-21(31)14-22(30)24(18)25(26(19)33-15-20)17-5-9-34(10-6-17)23(36)11-16-3-7-35(8-4-16)28(38)27(32)37/h12-17,25H,1-11H2,(H2,32,37)/t25-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT). |
J Med Chem 42: 2651-61 (1999)
Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V |
More data for this
Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM301089
(4-[2-(4-aminopiperidin-1-yl)-5-(4- methylphenyl)py...)Show SMILES Cc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1 Show InChI InChI=1S/C23H23N5/c1-16-2-6-18(7-3-16)21-15-26-23(28-12-10-20(25)11-13-28)27-22(21)19-8-4-17(14-24)5-9-19/h2-9,15,20H,10-13,25H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00978
BindingDB Entry DOI: 10.7270/Q2RJ4P33 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339211
(CHEMBL1689482)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc2ccc(CCC(=O)N3CCC3=O)cc2)NC1=O)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(C)=O)C(C)C |r,wU:8.8,39.41,4.3,64.68,49.56,2.2,146.162,162.171,175.184,106.112,132.140,20.21,wD:56.60,100.108,117.123,157.166,99.105,136.149,167.180,35.102,30.136,(38.18,-23.64,;36.84,-24.41,;35.51,-23.65,;35.5,-22.12,;34.18,-24.43,;30.24,-26.69,;28.91,-25.91,;27.57,-26.67,;28.93,-24.38,;30.25,-23.63,;30.28,-22.09,;31.61,-21.35,;31.63,-19.82,;30.31,-19.03,;30.33,-17.49,;28.97,-19.79,;28.96,-21.32,;27.6,-23.59,;26.28,-24.35,;26.26,-25.88,;24.93,-23.56,;24.95,-22.03,;23.63,-21.24,;23.49,-19.72,;22,-19.37,;21.21,-20.7,;22.22,-21.85,;23.6,-24.33,;23.65,-25.82,;25,-26.56,;22.29,-26.58,;22.28,-28.13,;23.62,-28.93,;23.61,-30.5,;24.92,-31.32,;24.92,-32.86,;26.24,-33.64,;26.24,-35.17,;24.91,-35.93,;27.57,-35.94,;27.56,-37.49,;26.21,-38.25,;24.82,-37.62,;23.78,-38.76,;24.55,-40.1,;26.06,-39.78,;28.91,-35.19,;30.21,-35.95,;30.21,-37.49,;31.56,-35.19,;33.01,-35.66,;33.92,-34.43,;33.02,-33.19,;31.56,-33.66,;30.22,-32.91,;28.91,-33.67,;30.22,-31.37,;28.89,-30.61,;27.56,-31.38,;26.23,-30.62,;27.57,-32.92,;31.56,-30.58,;31.54,-29.05,;30.2,-28.3,;32.87,-28.28,;34.2,-29.05,;34.19,-30.59,;35.51,-31.36,;35.51,-32.91,;36.86,-33.7,;38.21,-32.92,;38.21,-31.37,;39.56,-33.7,;40.9,-32.93,;42.25,-33.71,;43.6,-32.93,;43.6,-31.38,;44.95,-33.72,;46.29,-32.94,;47.63,-33.73,;48.99,-32.96,;48.99,-31.4,;50.34,-30.62,;51.68,-31.4,;53.03,-30.62,;53.03,-29.07,;54.38,-31.4,;54.77,-32.9,;56.28,-32.5,;55.88,-31,;56.66,-29.65,;47.63,-30.62,;46.29,-31.39,;32.9,-26.73,;34.2,-25.98,;35.52,-26.73,;23.59,-33.63,;23.59,-35.15,;22.26,-32.86,;20.93,-33.63,;20.93,-35.16,;19.6,-35.94,;22.26,-35.93,;19.6,-32.85,;19.6,-31.32,;18.26,-33.63,;16.93,-32.85,;16.93,-31.32,;15.59,-30.55,;14.27,-31.32,;12.94,-30.55,;11.6,-31.33,;10.28,-30.56,;11.61,-32.86,;15.59,-33.63,;14.26,-32.87,;15.6,-35.16,;14.28,-35.93,;14.29,-37.49,;12.94,-38.27,;11.59,-37.5,;10.25,-38.28,;10.26,-39.84,;8.91,-40.62,;11.61,-40.61,;12.95,-39.82,;12.94,-35.17,;11.61,-35.95,;12.94,-33.64,;20.97,-25.81,;19.63,-26.56,;19.63,-28.1,;18.29,-25.8,;16.95,-26.57,;15.64,-25.82,;15.63,-24.29,;14.28,-26.59,;14.3,-28.12,;12.98,-28.91,;11.63,-28.16,;10.33,-28.94,;11.62,-26.62,;12.98,-25.83,;11.48,-25.42,;12.98,-24.3,;14.32,-23.53,;11.65,-23.52,;11.66,-21.98,;13,-21.22,;14.32,-22,;15.65,-21.24,;15.67,-19.7,;14.33,-18.93,;13,-19.69,;10.32,-24.28,;8.99,-23.51,;8.99,-21.96,;7.65,-24.28,;7.65,-25.82,;6.32,-23.51,;4.98,-24.28,;4.98,-25.83,;3.64,-23.51,;3.64,-21.96,;2.31,-24.28,;.98,-23.51,;.98,-21.96,;-.37,-24.28,;-.37,-25.83,;.98,-26.6,;2.32,-25.82,;.98,-28.14,;-1.7,-23.51,;-3.04,-24.25,;-3.06,-25.8,;-4.37,-23.46,;-4.35,-21.93,;-5.71,-24.22,;-7.03,-23.44,;-8.37,-24.2,;-7.02,-21.9,;18.28,-24.27,;16.95,-23.5,;19.61,-23.5,)| Show InChI InChI=1S/C120H168N30O32S2/c1-13-64(6)99-116(178)134-79(23-17-18-43-126-92(155)56-182-57-93(156)133-74-33-26-70(27-34-74)32-40-94(157)150-46-42-95(150)158)106(168)142-86(47-62(2)3)119(181)149-45-20-25-91(149)114(176)140-84(52-76-55-125-61-129-76)109(171)143-89(112(174)147-100(68(10)151)117(179)135-80(24-19-44-127-120(122)123)105(167)136-81(101(121)163)48-72-28-35-77(153)36-29-72)59-184-183-58-88(111(173)139-83(51-75-54-124-60-128-75)108(170)138-82(110(172)146-99)49-73-30-37-78(154)38-31-73)144-115(177)98(63(4)5)145-113(175)90(39-41-96(159)160)148(12)118(180)87(50-71-21-15-14-16-22-71)141-104(166)67(9)131-102(164)66(8)132-107(169)85(53-97(161)162)137-103(165)65(7)130-69(11)152/h14-16,21-22,26-31,33-38,54-55,60-68,79-91,98-100,151,153-154H,13,17-20,23-25,32,39-53,56-59H2,1-12H3,(H2,121,163)(H,124,128)(H,125,129)(H,126,155)(H,130,152)(H,131,164)(H,132,169)(H,133,156)(H,134,178)(H,135,179)(H,136,167)(H,137,165)(H,138,170)(H,139,173)(H,140,176)(H,141,166)(H,142,168)(H,143,171)(H,144,177)(H,145,175)(H,146,172)(H,147,174)(H,159,160)(H,161,162)(H4,122,123,127)/t64-,65-,66-,67-,68+,79-,80+,81+,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,98-,99-,100+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4
(Homo sapiens (Human)) | BDBM285038
(4-(5-ethylsulfonyl-2-propoxyphenyl)-2-methyl- 6-(1...)Show SMILES CCCOc1ccc(cc1-c1cn(C)c(=O)c2ccc(cc12)-c1cnn(C)c1)S(=O)(=O)CC Show InChI InChI=1S/C25H27N3O4S/c1-5-11-32-24-10-8-19(33(30,31)6-2)13-22(24)23-16-27(3)25(29)20-9-7-17(12-21(20)23)18-14-26-28(4)15-18/h7-10,12-16H,5-6,11H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
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| Article
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research
Curated by ChEMBL
| Assay Description
Inhibition of His-tagged human BRD4-BD1 using H4K5acK8acK12acK16ac as substrate preincubated for 30 mins followed by substrate addition measured afte... |
Bioorg Med Chem Lett 28: 1811-1816 (2018)
Article DOI: 10.1016/j.bmcl.2018.04.016
BindingDB Entry DOI: 10.7270/Q20Z75WN |
More data for this
Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM50503503
(CHEMBL4548929 | US10626103, Example 22)Show SMILES Cc1c(nc(-c2ccc(C#N)c(F)c2)n1-c1ccc2nn(C)cc2c1)C(=O)N1CC[C@H](N)C1 |r| Show InChI InChI=1S/C24H22FN7O/c1-14-22(24(33)31-8-7-18(27)13-31)28-23(15-3-4-16(11-26)20(25)10-15)32(14)19-5-6-21-17(9-19)12-30(2)29-21/h3-6,9-10,12,18H,7-8,13,27H2,1-2H3/t18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of LSD1 (unknown origin) |
Bioorg Med Chem Lett 29: 103-106 (2019)
Article DOI: 10.1016/j.bmcl.2018.11.001
BindingDB Entry DOI: 10.7270/Q2W95DFG |
More data for this
Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM50503493
(CHEMBL4448358 | US10626103, Example 23)Show SMILES Cc1c(nc(-c2ccc(C#N)c(F)c2)n1-c1ccc2n(C)ncc2c1)C(=O)N1CCC[C@@H](N)C1 |r| Show InChI InChI=1S/C25H24FN7O/c1-15-23(25(34)32-9-3-4-19(28)14-32)30-24(16-5-6-17(12-27)21(26)11-16)33(15)20-7-8-22-18(10-20)13-29-31(22)2/h5-8,10-11,13,19H,3-4,9,14,28H2,1-2H3/t19-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of LSD1 (unknown origin) |
Bioorg Med Chem Lett 29: 103-106 (2019)
Article DOI: 10.1016/j.bmcl.2018.11.001
BindingDB Entry DOI: 10.7270/Q2W95DFG |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM14477
((-)-4-[2-[4-(3,7-Dibromo-8-chloro-6,11-dihydro-5Hb...)Show SMILES NC(=O)N1CCC(CC(=O)N2CCN(CC2)[C@H]2c3ccc(Cl)c(Br)c3CCc3cc(Br)cnc23)CC1 |r| Show InChI InChI=1S/C26H30Br2ClN5O2/c27-18-14-17-1-2-19-20(3-4-21(29)23(19)28)25(24(17)31-15-18)33-11-9-32(10-12-33)22(35)13-16-5-7-34(8-6-16)26(30)36/h3-4,14-16,25H,1-2,5-13H2,(H2,30,36)/t25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Schering-Plough Research Institute
| Assay Description
FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate... |
J Med Chem 41: 4890-902 (1998)
Article DOI: 10.1021/jm980462b
BindingDB Entry DOI: 10.7270/Q2ZS2TRS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50079072
(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H...)Show SMILES NS(=O)(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1 Show InChI InChI=1S/C26H31Br2ClN4O3S/c27-20-12-19-2-1-18-13-21(29)14-22(28)24(18)25(26(19)31-15-20)17-5-7-32(8-6-17)23(34)11-16-3-9-33(10-4-16)37(30,35)36/h12-17,25H,1-11H2,(H2,30,35,36)/t25-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Hras Farnesyltransferase (FPT). |
J Med Chem 42: 2651-61 (1999)
Article DOI: 10.1021/jm990059k
BindingDB Entry DOI: 10.7270/Q2ST7P2V |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM14463
((+)-4-(3-Bromo-8,10-dichloro-6,11-dihydro-5H-benzo...)Show SMILES [O-][n+]1ccc(CC(=O)N2CCN(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Cl)c23)cc1 |r| Show InChI InChI=1S/C25H23BrCl2N4O2/c26-19-12-18-2-1-17-13-20(27)14-21(28)23(17)25(24(18)29-15-19)31-9-7-30(8-10-31)22(33)11-16-3-5-32(34)6-4-16/h3-6,12-15,25H,1-2,7-11H2/t25-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <3.80 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Schering-Plough Research Institute
| Assay Description
FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate... |
J Med Chem 41: 4890-902 (1998)
Article DOI: 10.1021/jm980462b
BindingDB Entry DOI: 10.7270/Q2ZS2TRS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50077853
(1-[4-(3,10-Dibromo-8-chloro-5,6-dihydro-benzo[5,6]...)Show SMILES [#8-]-[n+]1ccc(-[#6]-[#6](=O)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2/c3ncc(Br)cc3-[#6]-[#6]-c3cc(Cl)cc(Br)c-23)cc1 Show InChI InChI=1S/C26H22Br2ClN3O2/c27-20-12-19-2-1-18-13-21(29)14-22(28)24(18)25(26(19)30-15-20)17-5-7-31(8-6-17)23(33)11-16-3-9-32(34)10-4-16/h3-4,9-10,12-15H,1-2,5-8,11H2 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Farnesyl protein transferase |
J Med Chem 42: 2125-35 (1999)
Article DOI: 10.1021/jm990030g
BindingDB Entry DOI: 10.7270/Q2ZS2VP9 |
More data for this
Ligand-Target Pair | |
Placenta growth factor
(Homo sapiens (Human)) | BDBM50339193
(CHEMBL1689463)Show SMILES CSCC[C@H](NC(=O)[C@H](CCCCNC(=O)COCC(=O)Nc1ccc(CCC(=O)N2CCC2=O)cc1)NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(C)=O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N1)C(N)=O |r| Show InChI InChI=1S/C102H144N24O26S3/c1-54(2)41-75-102(151)125-38-20-27-78(125)98(147)118-72(44-64-48-105-53-109-64)92(141)120-76(96(145)114-69(25-16-18-36-106-58(8)128)90(139)113-68(89(138)112-67(88(104)137)35-40-153-10)26-17-19-37-107-80(131)49-152-50-81(132)111-63-31-28-60(29-32-63)30-33-82(133)126-39-34-83(126)134)51-154-155-52-77(121-99(148)85(55(3)4)122-95(144)74(46-84(135)136)117-91(140)70(110-59(9)129)42-61-21-12-11-13-22-61)97(146)116-73(45-79(103)130)93(142)115-71(43-62-47-108-66-24-15-14-23-65(62)66)94(143)123-86(56(5)6)100(149)124-87(57(7)127)101(150)119-75/h11-15,21-24,28-29,31-32,47-48,53-57,67-78,85-87,108,127H,16-20,25-27,30,33-46,49-52H2,1-10H3,(H2,103,130)(H2,104,137)(H,105,109)(H,106,128)(H,107,131)(H,110,129)(H,111,132)(H,112,138)(H,113,139)(H,114,145)(H,115,142)(H,116,146)(H,117,140)(H,118,147)(H,119,150)(H,120,141)(H,121,148)(H,122,144)(H,123,143)(H,124,149)(H,135,136)/t57-,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77+,78+,85+,86+,87+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human PlGF-1-VEGFR-1 interaction by ELISA |
J Med Chem 54: 1256-65 (2011)
Article DOI: 10.1021/jm101226k
BindingDB Entry DOI: 10.7270/Q2BK1CN1 |
More data for this
Ligand-Target Pair | |
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