Found 7 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50262420
(7-Phenyl-1-(5-(pyridin-2-yl)-1,3,4-thiadiazol-2-yl...)Show InChI InChI=1S/C20H21N3OS/c24-18(14-7-2-1-4-10-16-11-5-3-6-12-16)20-23-22-19(25-20)17-13-8-9-15-21-17/h3,5-6,8-9,11-13,15H,1-2,4,7,10,14H2 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | 9.0 | n/a |
Institute for Chemical Biology
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH expressed in Escherichia coli at pH 9.0 |
J Med Chem 51: 4392-403 (2008)
Article DOI: 10.1021/jm800136b BindingDB Entry DOI: 10.7270/Q26D5TW3 |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50262420
(7-Phenyl-1-(5-(pyridin-2-yl)-1,3,4-thiadiazol-2-yl...)Show InChI InChI=1S/C20H21N3OS/c24-18(14-7-2-1-4-10-16-11-5-3-6-12-16)20-23-22-19(25-20)17-13-8-9-15-21-17/h3,5-6,8-9,11-13,15H,1-2,4,7,10,14H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Chemical Biology
Curated by ChEMBL
| Assay Description Inhibition of human recombinant FAAH expressed in african green monkey COS7 cells |
J Med Chem 51: 4392-403 (2008)
Article DOI: 10.1021/jm800136b BindingDB Entry DOI: 10.7270/Q26D5TW3 |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50262420
(7-Phenyl-1-(5-(pyridin-2-yl)-1,3,4-thiadiazol-2-yl...)Show InChI InChI=1S/C20H21N3OS/c24-18(14-7-2-1-4-10-16-11-5-3-6-12-16)20-23-22-19(25-20)17-13-8-9-15-21-17/h3,5-6,8-9,11-13,15H,1-2,4,7,10,14H2 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Chemical Biology
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH expressed in Escherichia coli |
J Med Chem 51: 4392-403 (2008)
Article DOI: 10.1021/jm800136b BindingDB Entry DOI: 10.7270/Q26D5TW3 |
More data for this Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50262420
(7-Phenyl-1-(5-(pyridin-2-yl)-1,3,4-thiadiazol-2-yl...)Show InChI InChI=1S/C20H21N3OS/c24-18(14-7-2-1-4-10-16-11-5-3-6-12-16)20-23-22-19(25-20)17-13-8-9-15-21-17/h3,5-6,8-9,11-13,15H,1-2,4,7,10,14H2 | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Chemical Biology
Curated by ChEMBL
| Assay Description Inhibition of rat FAAH expressed in Escherichia coli |
J Med Chem 51: 4392-403 (2008)
Article DOI: 10.1021/jm800136b BindingDB Entry DOI: 10.7270/Q26D5TW3 |
More data for this Ligand-Target Pair | |
Liver carboxylesterase 1
(Homo sapiens (Human)) | BDBM50262420
(7-Phenyl-1-(5-(pyridin-2-yl)-1,3,4-thiadiazol-2-yl...)Show InChI InChI=1S/C20H21N3OS/c24-18(14-7-2-1-4-10-16-11-5-3-6-12-16)20-23-22-19(25-20)17-13-8-9-15-21-17/h3,5-6,8-9,11-13,15H,1-2,4,7,10,14H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Chemical Biology
Curated by ChEMBL
| Assay Description Inhibition of TGH |
J Med Chem 51: 4392-403 (2008)
Article DOI: 10.1021/jm800136b BindingDB Entry DOI: 10.7270/Q26D5TW3 |
More data for this Ligand-Target Pair | |
Diacylglycerol lipase-alpha
(Homo sapiens (Human)) | BDBM50262420
(7-Phenyl-1-(5-(pyridin-2-yl)-1,3,4-thiadiazol-2-yl...)Show InChI InChI=1S/C20H21N3OS/c24-18(14-7-2-1-4-10-16-11-5-3-6-12-16)20-23-22-19(25-20)17-13-8-9-15-21-17/h3,5-6,8-9,11-13,15H,1-2,4,7,10,14H2 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description Inhibition of full-length human DAGLalpha expressed in HEK293T cell membranes using para-nitrophenylbutyrate by colorimetric assay |
J Med Chem 58: 9742-53 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01627 BindingDB Entry DOI: 10.7270/Q2D50QZ9 |
More data for this Ligand-Target Pair | |
Neutral cholesterol ester hydrolase 1
(Homo sapiens (Human)) | BDBM50262420
(7-Phenyl-1-(5-(pyridin-2-yl)-1,3,4-thiadiazol-2-yl...)Show InChI InChI=1S/C20H21N3OS/c24-18(14-7-2-1-4-10-16-11-5-3-6-12-16)20-23-22-19(25-20)17-13-8-9-15-21-17/h3,5-6,8-9,11-13,15H,1-2,4,7,10,14H2 | KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Chemical Biology
Curated by ChEMBL
| Assay Description Inhibition of KIAA1363 hydrolase |
J Med Chem 51: 4392-403 (2008)
Article DOI: 10.1021/jm800136b BindingDB Entry DOI: 10.7270/Q26D5TW3 |
More data for this Ligand-Target Pair | |