Found 172 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| 8.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Technology Sydney
Curated by ChEMBL
| Assay Description Competitive inhibition of mushroom tyrosinase assessed as inhibition of L-DOPA oxidase activity at 5 uM active compound by Lineweaver-Burk plot analy... |
Bioorg Med Chem Lett 25: 1753-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.02.060 BindingDB Entry DOI: 10.7270/Q2T72K42 |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 1 [N65D,S176D,K211T,P277A,P406L]
(Agaricus bisporus (Mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| 1.22E+4 | n/a | 2.75E+4 | n/a | n/a | n/a | n/a | 6.8 | n/a |
University of Technology Sydney
| Assay Description The mushroom tyrosinase inhibition activity of hydroxy naphthylchalcone compounds was measured using L-DOPA as substrate. The activity assay used 3 m... |
Bioorg Chem 63: 116-22 (2015)
Article DOI: 10.1016/j.bioorg.2015.10.003 BindingDB Entry DOI: 10.7270/Q2MS3RH3 |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| 1.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Technology Sydney
Curated by ChEMBL
| Assay Description Competitive inhibition of mushroom tyrosinase polyphenol oxidase activity using L-DOPA as substrate by Dixon plot analysis |
Bioorg Med Chem Lett 25: 5495-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.071 BindingDB Entry DOI: 10.7270/Q2N018C4 |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| 1.49E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bahirji Smarak Mahavidyalaya
Curated by ChEMBL
| Assay Description Competitive inhibition of mushroom tyrosinase diphenolase activity assessed as L-DOPA conversion to dopachrome by Lineweaver-Burk plot analysis |
Bioorg Med Chem 21: 2772-7 (2013)
Article DOI: 10.1016/j.bmc.2012.12.053 BindingDB Entry DOI: 10.7270/Q2G44T6G |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Catholic University of C£rdoba
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase diphenolase activity |
Bioorg Med Chem 19: 3474-82 (2011)
Article DOI: 10.1016/j.bmc.2011.04.025 BindingDB Entry DOI: 10.7270/Q22Z18DZ |
More data for this Ligand-Target Pair | |
D-amino-acid oxidase
(Sus scrofa (pig)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johns Hopkins University
Curated by ChEMBL
| Assay Description Competitive inhibition of pig kidney DAAO using D-Alanine as substrate by Michaelis-Menten plot analysis |
Bioorg Med Chem Lett 23: 3910-3 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.062 BindingDB Entry DOI: 10.7270/Q2K35W2G |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| 2.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
King Saud University
Curated by ChEMBL
| Assay Description Inhibition of mashroom tyrosinase |
Bioorg Med Chem 18: 4042-8 (2010)
Article DOI: 10.1016/j.bmc.2010.04.021 BindingDB Entry DOI: 10.7270/Q2FJ2GZ8 |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Catholic University of C£rdoba
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase assessed as inhibition constant for compound-free enzyme using as L-tyrosine substrate by spectrophotometric analys... |
Bioorg Med Chem 19: 3474-82 (2011)
Article DOI: 10.1016/j.bmc.2011.04.025 BindingDB Entry DOI: 10.7270/Q22Z18DZ |
More data for this Ligand-Target Pair | |
Tyrosinase
(Homo sapiens (Human)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | KEGG
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| Article PubMed
| 3.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Univ. Grenoble-Alpes/CNRS
Curated by ChEMBL
| Assay Description Inhibition of recombinant human tyrosinase expressed in baculovirus infected Sf9 cells assessed as diphenolase activity using L-DOPA as substrate by ... |
ACS Med Chem Lett 8: 55-60 (2017)
Article DOI: 10.1021/acsmedchemlett.6b00369 BindingDB Entry DOI: 10.7270/Q24F1SQN |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| 5.83E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Seoul National University
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase assessed as oxidation of L-DOPA |
Bioorg Med Chem Lett 19: 5586-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.08.041 BindingDB Entry DOI: 10.7270/Q2DF6R8S |
More data for this Ligand-Target Pair | |
Tyrosinase
(Mus musculus (Mouse)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| 5.50E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Chinese University of Hong Kong
Curated by ChEMBL
| Assay Description Inhibition of tyrosinase in mouse Melan-a cells assessed as decrease in L-DOPA Vmax at 120 uM by Lineweaver-Burk plot |
J Nat Prod 77: 1270-4 (2014)
Article DOI: 10.1021/np4008798 BindingDB Entry DOI: 10.7270/Q2MK6FFJ |
More data for this Ligand-Target Pair | |
Tyrosinase
(Homo sapiens (Human)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | KEGG
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| | n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| | n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Tyrosinase
(Homo sapiens (Human)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | KEGG
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| | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | PDB MMDB
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| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johns Hopkins University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DAAO expressed in HEK293 cell lysate assessed as D-Serine conversion to H2O2 after 20 mins by spectrophotometric anal... |
Bioorg Med Chem Lett 23: 3910-3 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.062 BindingDB Entry DOI: 10.7270/Q2K35W2G |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Utsunomiya University
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase |
Bioorg Med Chem Lett 18: 5252-4 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.053 BindingDB Entry DOI: 10.7270/Q2VX0GBZ |
More data for this Ligand-Target Pair | |
Tyrosinase
(Homo sapiens (Human)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | KEGG
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| Article PubMed
| n/a | n/a | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Utsunomiya University
Curated by ChEMBL
| Assay Description Inhibition of Tyrosinase |
Eur J Med Chem 46: 1374-81 (2011)
Article DOI: 10.1016/j.ejmech.2011.01.065 BindingDB Entry DOI: 10.7270/Q20V8D41 |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 8.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Cagliari
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase after 10 mins by L-DOPA oxidation assay |
Bioorg Med Chem Lett 20: 6138-40 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.018 BindingDB Entry DOI: 10.7270/Q2N87BSC |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | 9.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Agriculture and Technology
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as dopachrome formation after 5 mins by spectrophotometry |
Bioorg Med Chem Lett 24: 122-5 (2014)
Article DOI: 10.1016/j.bmcl.2013.11.063 BindingDB Entry DOI: 10.7270/Q2NZ8BMD |
More data for this Ligand-Target Pair | |
Tyrosinase
(Homo sapiens (Human)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | KEGG
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| Article PubMed
| n/a | n/a | 9.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Agriculture and Technology
Curated by ChEMBL
| Assay Description Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis |
Bioorg Med Chem 23: 6650-8 (2015)
Article DOI: 10.1016/j.bmc.2015.09.014 BindingDB Entry DOI: 10.7270/Q2DR2X9W |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 9.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University Putra Malaysia
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase preincubated for 5 mins before addition of L-DOPA measured after 10 mins |
Bioorg Med Chem Lett 20: 3755-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.067 BindingDB Entry DOI: 10.7270/Q290240T |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 9.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of mushroom tyrosinase assessed as reduction in dopachrome formation using L-DOPA as substrate by ELISA |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112480 BindingDB Entry DOI: 10.7270/Q2WW7NGF |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 9.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Cagliari
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosine kinase assessed as oxidation of 0.25 mM L-3,4-dihydroxyphenylalanine |
Bioorg Med Chem Lett 19: 36-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.020 BindingDB Entry DOI: 10.7270/Q2445MB2 |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 9.96E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Athens
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase using L-DOPA as substrate after 10 mins |
Bioorg Med Chem Lett 22: 5523-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.029 BindingDB Entry DOI: 10.7270/Q29C7199 |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pretoria
Curated by ChEMBL
| Assay Description Antibacterial activity against D-alanyl-D-alanine ligase from Streptococcus faecalis (ATCC 8043) |
J Nat Prod 81: 49-56 (2018)
Article DOI: 10.1021/acs.jnatprod.7b00564 BindingDB Entry DOI: 10.7270/Q2H70JBS |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as dopaquinone production after 5 mins by microplate reader analysis |
Bioorg Med Chem Lett 25: 2702-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.052 BindingDB Entry DOI: 10.7270/Q26M38KR |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Nacional de Co£?rdoba
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase preincubated for 10 mins before addition of 1.7 mM L-tyrosine measured after 20 mins by spectrophotometric method |
J Nat Prod 74: 158-62 (2011)
Article DOI: 10.1021/np1004664 BindingDB Entry DOI: 10.7270/Q2416XB4 |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Utsunomiya University
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase using TBC as substrate by spectrophotometric method |
Bioorg Med Chem Lett 29: 313-316 (2019)
Article DOI: 10.1016/j.bmcl.2018.11.029 BindingDB Entry DOI: 10.7270/Q22V2KCK |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.12E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Technology Sydney
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase assessed as reduction in L-DOPA oxidase activity using L-DOPA substrate at 5 uM by Dixon plot |
Bioorg Med Chem Lett 25: 4085-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.08.033 BindingDB Entry DOI: 10.7270/Q2P270ZQ |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokkaido University
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase |
Bioorg Med Chem 15: 2396-402 (2007)
Article DOI: 10.1016/j.bmc.2007.01.017 BindingDB Entry DOI: 10.7270/Q2R78DWH |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokushima
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase |
Bioorg Med Chem Lett 20: 7393-6 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.040 BindingDB Entry DOI: 10.7270/Q26110KT |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Gyeongsang National University
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase using L-tyrosine as substrate preincubated for 10 mins with substrate followed by enzyme addition measured after 15... |
Bioorg Med Chem 22: 1115-20 (2014)
Article DOI: 10.1016/j.bmc.2013.12.047 BindingDB Entry DOI: 10.7270/Q2222XQ8 |
More data for this Ligand-Target Pair | |
Polymerase acidic protein
(Hepatitis C virus) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | PDB MMDB
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UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California San Diego
Curated by ChEMBL
| Assay Description Inhibition of 8-histidine tagged influenza virus H1N1 N-terminal PA endonuclease expressed in Escherichia coli BL21 cells using single-stranded 5'-FA... |
J Med Chem 59: 6444-54 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00628 BindingDB Entry DOI: 10.7270/Q2W95DPM |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of KwaZulu Natal
Curated by ChEMBL
| Assay Description Inhibition of diphenolase activity of mushroom tyrosinase pre-incubated for 30 mins before L-DOPA substrate addition and measured after 1 min by spec... |
Eur J Med Chem 142: 179-212 (2017)
Article DOI: 10.1016/j.ejmech.2017.07.033 BindingDB Entry DOI: 10.7270/Q2DR2Z6Z |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang Gongshang University
Curated by ChEMBL
| Assay Description Inhibition of monophenolase activity of mushroom tyrosinase using L-tyrosine as substrate incubated for 10 mins by UV-Visible spectrophotometric anal... |
Bioorg Med Chem Lett 26: 3103-8 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.006 BindingDB Entry DOI: 10.7270/Q2JM2CJ8 |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.25E+4 | n/a | n/a | n/a | n/a | n/a | 30 |
Gyeongsang National University
| Assay Description Mushroom tyrosinase using either L-DOPA or L-tyrosine as substrate. In spectrophotometric experiments, enzyme activity was monitored by dopachrome f... |
J Enzyme Inhib Med Chem 23: 922-30 (2008)
Article DOI: 10.1080/14756360701810207 BindingDB Entry DOI: 10.7270/Q2P849G3 |
More data for this Ligand-Target Pair | |
Polymerase acidic protein
(Hepatitis C virus) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | PDB MMDB
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Patents
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| Article PubMed
| n/a | n/a | 1.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California San Diego
Curated by ChEMBL
| Assay Description Inhibition of 8-histidine tagged influenza virus H1N1 N-terminal PA endonuclease expressed in Escherichia coli BL21 cells using single-stranded 5'-FA... |
J Med Chem 59: 6444-54 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00628 BindingDB Entry DOI: 10.7270/Q2W95DPM |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoshi University
Curated by ChEMBL
| Assay Description Inhibition of mushroom tyrosinase using L-tyrosine as substrate by spectrophotometry |
Bioorg Med Chem 22: 3994-4000 (2014)
Article DOI: 10.1016/j.bmc.2014.05.073 BindingDB Entry DOI: 10.7270/Q2XW4MG6 |
More data for this Ligand-Target Pair | |
Tyrosinase
(Homo sapiens (Human)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | KEGG
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Similars
| Article PubMed
| n/a | n/a | 1.28E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of Tyrosinase (unknown origin) using tyrosine as substrate incubated for 20 mins followed by substrate addition and measured every 10 mins... |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115873 BindingDB Entry DOI: 10.7270/Q2571GMT |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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Patents
Similars
| Article PubMed
| n/a | n/a | 1.32E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Gyeongsang National University
Curated by ChEMBL
| Assay Description Inhibition of monophenolase activity of mushroom tyrosinase using L-tyrosine as substrate preincubated with substrate for 10 mins followed by protein... |
Bioorg Med Chem 24: 153-9 (2016)
Article DOI: 10.1016/j.bmc.2015.11.040 BindingDB Entry DOI: 10.7270/Q2RN39PT |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 1
(Agaricus bisporus (White button mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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Patents
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| US Patent
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | 6.8 | n/a |
PIERRE FABRE DERMO-COSMETIQUE
US Patent
| Assay Description Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos... |
US Patent US9422261 (2016)
BindingDB Entry DOI: 10.7270/Q2PG1QMS |
More data for this Ligand-Target Pair | |
Polyphenol oxidase 2
(Agaricus bisporus (Common mushroom)) | BDBM50031467
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 | UniProtKB/SwissProt
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Patents
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| Article PubMed
| n/a | n/a | 1.53E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Gyeongsang National University
Curated by ChEMBL
| Assay Description Inhibition of monophenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-Tyrosine substrate by UV-Vis spectr... |
Bioorg Med Chem 27: 2499-2507 (2019)
Article DOI: 10.1016/j.bmc.2019.03.013 BindingDB Entry DOI: 10.7270/Q2PV6PTR |
More data for this Ligand-Target Pair | |