Compile Data Set for Download or QSAR

Found 68 hits Enz. Inhib. hit(s) with Target = 'Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115]'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482162 (N-[3-(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimid...) Show SMILES COc1ccc(cc1Cl)S(=O)(=O)Nc1cccc(-c2cn(C(C)C)c3ncnc(N)c23)c1F Show InChI InChI=1S/C22H21ClFN5O3S/c1-12(2)29-10-15(19-21(25)26-11-27-22(19)29)14-5-4-6-17(20(14)24)28-33(30,31)13-7-8-18(32-3)16(23)9-13/h4-12,28H,1-3H3,(H2,25,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482228 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES COc1ccc(cc1Br)S(=O)(=O)Nc1cccc(-c2cn(C)c3ncnc(N)c23)c1F Show InChI InChI=1S/C20H17BrFN5O3S/c1-27-9-13(17-19(23)24-10-25-20(17)27)12-4-3-5-15(18(12)22)26-31(28,29)11-6-7-16(30-2)14(21)8-11/h3-10,26H,1-2H3,(H2,23,24,25)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482164 (N-{3-[4-Amino-7-(1-methyl-piperidin-4-yl)-7H-pyrro...) Show SMILES COc1ccc(cc1Cl)S(=O)(=O)Nc1cccc(-c2cn(C3CCN(C)CC3)c3ncnc(N)c23)c1F Show InChI InChI=1S/C25H26ClFN6O3S/c1-32-10-8-15(9-11-32)33-13-18(22-24(28)29-14-30-25(22)33)17-4-3-5-20(23(17)27)31-37(34,35)16-6-7-21(36-2)19(26)12-16/h3-7,12-15,31H,8-11H2,1-2H3,(H2,28,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482166 (N-{3-[4-Amino-7-(1-isopropyl-piperidin-4-yl)-7H-py...) Show SMILES COc1ccc(cc1Cl)S(=O)(=O)Nc1cccc(-c2cn(C3CCN(CC3)C(C)C)c3ncnc(N)c23)c1F Show InChI InChI=1S/C27H30ClFN6O3S/c1-16(2)34-11-9-17(10-12-34)35-14-20(24-26(30)31-15-32-27(24)35)19-5-4-6-22(25(19)29)33-39(36,37)18-7-8-23(38-3)21(28)13-18/h4-8,13-17,33H,9-12H2,1-3H3,(H2,30,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482167 (N-[3-(4-Amino-1-methyl-1H-pyrazolo[3,4-d]pyrimidin...) Show SMILES COc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cccc(-c2nn(C)c3ncnc(N)c23)c1F Show InChI InChI=1S/C19H15ClF2N6O3S/c1-28-19-15(18(23)24-8-25-19)17(26-28)9-4-3-5-12(16(9)22)27-32(29,30)14-6-10(20)13(31-2)7-11(14)21/h3-8,27H,1-2H3,(H2,23,24,25)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM580481 (US11491158, Cmpd 13) Show SMILES Cn1cc(-c2cccc(NS(=O)(=O)c3cccc(Cl)c3)c2F)c2c(N)ncnc12 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482183 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES COc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cccc(-c2cn(C)c3ncnc(N)c23)c1F Show InChI InChI=1S/C20H16ClF2N5O3S/c1-28-8-11(17-19(24)25-9-26-20(17)28)10-4-3-5-14(18(10)23)27-32(29,30)16-6-12(21)15(31-2)7-13(16)22/h3-9,27H,1-2H3,(H2,24,25,26)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482186 (2,3-Dihydro-benzofuran-5-sulfonic acid [3-(4-amino...) Show SMILES Cn1cc(-c2cccc(NS(=O)(=O)c3ccc4OCCc4c3)c2F)c2c(N)ncnc12 Show InChI InChI=1S/C21H18FN5O3S/c1-27-10-15(18-20(23)24-11-25-21(18)27)14-3-2-4-16(19(14)22)26-31(28,29)13-5-6-17-12(9-13)7-8-30-17/h2-6,9-11,26H,7-8H2,1H3,(H2,23,24,25)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482161 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES COc1ccc(cc1Cl)S(=O)(=O)Nc1cccc(-c2cn(C)c3ncnc(N)c23)c1F Show InChI InChI=1S/C20H17ClFN5O3S/c1-27-9-13(17-19(23)24-10-25-20(17)27)12-4-3-5-15(18(12)22)26-31(28,29)11-6-7-16(30-2)14(21)8-11/h3-10,26H,1-2H3,(H2,23,24,25)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482196 (N-{3-[4-Amino-7-(1-methyl-piperidin-4-yl)-7H-pyrro...) Show SMILES COc1ccc(cc1C)S(=O)(=O)Nc1cccc(-c2cn(C3CCN(C)CC3)c3ncnc(N)c23)c1F Show InChI InChI=1S/C26H29FN6O3S/c1-16-13-18(7-8-22(16)36-3)37(34,35)31-21-6-4-5-19(24(21)27)20-14-33(17-9-11-32(2)12-10-17)26-23(20)25(28)29-15-30-26/h4-8,13-15,17,31H,9-12H2,1-3H3,(H2,28,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482200 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES COc1cc(F)c(cc1C)S(=O)(=O)Nc1cccc(-c2cn(C)c3ncnc(N)c23)c1F Show InChI InChI=1S/C21H19F2N5O3S/c1-11-7-17(14(22)8-16(11)31-3)32(29,30)27-15-6-4-5-12(19(15)23)13-9-28(2)21-18(13)20(24)25-10-26-21/h4-10,27H,1-3H3,(H2,24,25,26)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482201 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES Cn1cc(-c2cccc(NS(=O)(=O)c3cc(F)c(Br)cc3F)c2F)c2c(N)ncnc12 Show InChI InChI=1S/C19H13BrF3N5O2S/c1-28-7-10(16-18(24)25-8-26-19(16)28)9-3-2-4-14(17(9)23)27-31(29,30)15-6-12(21)11(20)5-13(15)22/h2-8,27H,1H3,(H2,24,25,26)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482207 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES Cc1cc(ccc1Br)S(=O)(=O)Nc1cccc(-c2cn(C)c3ncnc(N)c23)c1F Show InChI InChI=1S/C20H17BrFN5O2S/c1-11-8-12(6-7-15(11)21)30(28,29)26-16-5-3-4-13(18(16)22)14-9-27(2)20-17(14)19(23)24-10-25-20/h3-10,26H,1-2H3,(H2,23,24,25)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482217 (N-{3-[4-Amino-7-(1-methyl-piperidin-4-yl)-7H-pyrro...) Show SMILES CN1CCC(CC1)n1cc(-c2cccc(NS(=O)(=O)c3ccc(Cl)c(Cl)c3)c2F)c2c(N)ncnc12 Show InChI InChI=1S/C24H23Cl2FN6O2S/c1-32-9-7-14(8-10-32)33-12-17(21-23(28)29-13-30-24(21)33)16-3-2-4-20(22(16)27)31-36(34,35)15-5-6-18(25)19(26)11-15/h2-6,11-14,31H,7-10H2,1H3,(H2,28,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482219 (N-{3-[4-Amino-7-(1-methyl-piperidin-4-yl)-7H-pyrro...) Show SMILES COc1cc(F)c(cc1C)S(=O)(=O)Nc1cccc(-c2cn(C3CCN(C)CC3)c3ncnc(N)c23)c1F Show InChI InChI=1S/C26H28F2N6O3S/c1-15-11-22(19(27)12-21(15)37-3)38(35,36)32-20-6-4-5-17(24(20)28)18-13-34(16-7-9-33(2)10-8-16)26-23(18)25(29)30-14-31-26/h4-6,11-14,16,32H,7-10H2,1-3H3,(H2,29,30,31)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482163 (N-[3-(4-Amino-7-(1-methyl-piperidin-4-yl)-7H-pyrro...) Show SMILES COc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cccc(-c2cn(C3CCN(C)CC3)c3ncnc(N)c23)c1F Show InChI InChI=1S/C25H25ClF2N6O3S/c1-33-8-6-14(7-9-33)34-12-16(22-24(29)30-13-31-25(22)34)15-4-3-5-19(23(15)28)32-38(35,36)21-10-17(26)20(37-2)11-18(21)27/h3-5,10-14,32H,6-9H2,1-2H3,(H2,29,30,31)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482161 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES COc1ccc(cc1Cl)S(=O)(=O)Nc1cccc(-c2cn(C)c3ncnc(N)c23)c1F Show InChI InChI=1S/C20H17ClFN5O3S/c1-27-9-13(17-19(23)24-10-25-20(17)27)12-4-3-5-15(18(12)22)26-31(28,29)11-6-7-16(30-2)14(21)8-11/h3-10,26H,1-2H3,(H2,23,24,25)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482165 (N-{3-[4-Amino-7-(1-cyclopropyl-piperidin-4-yl)-7H-...) Show SMILES COc1ccc(cc1Cl)S(=O)(=O)Nc1cccc(-c2cn(C3CCN(CC3)C3CC3)c3ncnc(N)c23)c1F Show InChI InChI=1S/C27H28ClFN6O3S/c1-38-23-8-7-18(13-21(23)28)39(36,37)33-22-4-2-3-19(25(22)29)20-14-35(27-24(20)26(30)31-15-32-27)17-9-11-34(12-10-17)16-5-6-16/h2-4,7-8,13-17,33H,5-6,9-12H2,1H3,(H2,30,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482170 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES COc1ccc(cc1C)S(=O)(=O)Nc1cccc(-c2cn(C)c3ncnc(N)c23)c1F Show InChI InChI=1S/C21H20FN5O3S/c1-12-9-13(7-8-17(12)30-3)31(28,29)26-16-6-4-5-14(19(16)22)15-10-27(2)21-18(15)20(23)24-11-25-21/h4-11,26H,1-3H3,(H2,23,24,25)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482177 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES Cn1cc(-c2cccc(NS(=O)(=O)c3ccc(cc3)[N+]([O-])=O)c2F)c2c(N)ncnc12 Show InChI InChI=1S/C19H15FN6O4S/c1-25-9-14(16-18(21)22-10-23-19(16)25)13-3-2-4-15(17(13)20)24-31(29,30)12-7-5-11(6-8-12)26(27)28/h2-10,24H,1H3,(H2,21,22,23)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482181 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES Cn1cc(-c2cccc(NS(=O)(=O)c3ccc(Br)cc3F)c2F)c2c(N)ncnc12 Show InChI InChI=1S/C19H14BrF2N5O2S/c1-27-8-12(16-18(23)24-9-25-19(16)27)11-3-2-4-14(17(11)22)26-30(28,29)15-6-5-10(20)7-13(15)21/h2-9,26H,1H3,(H2,23,24,25)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482184 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES Cn1cc(-c2cccc(NS(=O)(=O)c3ccc(Cl)c(Cl)c3)c2F)c2c(N)ncnc12 Show InChI InChI=1S/C19H14Cl2FN5O2S/c1-27-8-12(16-18(23)24-9-25-19(16)27)11-3-2-4-15(17(11)22)26-30(28,29)10-5-6-13(20)14(21)7-10/h2-9,26H,1H3,(H2,23,24,25)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482185 (N-[2-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES Cn1cc(-c2cccc(NS(=O)(=O)c3cc(Cl)cc(Cl)c3)c2F)c2c(N)ncnc12 Show InChI InChI=1S/C19H14Cl2FN5O2S/c1-27-8-14(16-18(23)24-9-25-19(16)27)13-3-2-4-15(17(13)22)26-30(28,29)12-6-10(20)5-11(21)7-12/h2-9,26H,1H3,(H2,23,24,25)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482187 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES CCOc1ccc(cc1C)S(=O)(=O)Nc1cccc(-c2cn(C)c3ncnc(N)c23)c1F Show InChI InChI=1S/C22H22FN5O3S/c1-4-31-18-9-8-14(10-13(18)2)32(29,30)27-17-7-5-6-15(20(17)23)16-11-28(3)22-19(16)21(24)25-12-26-22/h5-12,27H,4H2,1-3H3,(H2,24,25,26)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482188 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES COc1c(C)cc(cc1C)S(=O)(=O)Nc1cccc(-c2cn(C)c3ncnc(N)c23)c1F Show InChI InChI=1S/C22H22FN5O3S/c1-12-8-14(9-13(2)20(12)31-4)32(29,30)27-17-7-5-6-15(19(17)23)16-10-28(3)22-18(16)21(24)25-11-26-22/h5-11,27H,1-4H3,(H2,24,25,26)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482190 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES Cn1cc(-c2cccc(NS(=O)(=O)c3cc(F)c(F)c(F)c3)c2F)c2c(N)ncnc12 Show InChI InChI=1S/C19H13F4N5O2S/c1-28-7-11(15-18(24)25-8-26-19(15)28)10-3-2-4-14(16(10)22)27-31(29,30)9-5-12(20)17(23)13(21)6-9/h2-8,27H,1H3,(H2,24,25,26)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482191 (5-Bromo-6-chloro-pyridine-3-sulfonic acid [3-(4-am...) Show SMILES Cn1cc(-c2cccc(NS(=O)(=O)c3cnc(Cl)c(Br)c3)c2F)c2c(N)ncnc12 Show InChI InChI=1S/C18H13BrClFN6O2S/c1-27-7-11(14-17(22)24-8-25-18(14)27)10-3-2-4-13(15(10)21)26-30(28,29)9-5-12(19)16(20)23-6-9/h2-8,26H,1H3,(H2,22,24,25)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482170 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES COc1ccc(cc1C)S(=O)(=O)Nc1cccc(-c2cn(C)c3ncnc(N)c23)c1F Show InChI InChI=1S/C21H20FN5O3S/c1-12-9-13(7-8-17(12)30-3)31(28,29)26-16-6-4-5-14(19(16)22)15-10-27(2)21-18(15)20(23)24-11-25-21/h4-11,26H,1-3H3,(H2,23,24,25)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482194 (N-{3-[4-Amino-7-(tetrahydro-pyran-4-yl)-7H-pyrrolo...) Show SMILES COc1ccc(cc1C)S(=O)(=O)Nc1cccc(-c2cn(C3CCOCC3)c3ncnc(N)c23)c1F Show InChI InChI=1S/C25H26FN5O4S/c1-15-12-17(6-7-21(15)34-2)36(32,33)30-20-5-3-4-18(23(20)26)19-13-31(16-8-10-35-11-9-16)25-22(19)24(27)28-14-29-25/h3-7,12-14,16,30H,8-11H2,1-2H3,(H2,27,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482195 (N-{3-[4-Amino-7-(tetrahydro-pyran-4-yl)-7H-pyrrolo...) Show SMILES COc1ccc(cc1Cl)S(=O)(=O)Nc1cccc(-c2cn(C3CCOCC3)c3ncnc(N)c23)c1F Show InChI InChI=1S/C24H23ClFN5O4S/c1-34-20-6-5-15(11-18(20)25)36(32,33)30-19-4-2-3-16(22(19)26)17-12-31(14-7-9-35-10-8-14)24-21(17)23(27)28-13-29-24/h2-6,11-14,30H,7-10H2,1H3,(H2,27,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482197 (N-{3-[4-Amino-7-(1-cyclopropyl-piperidin-4-yl)-7H-...) Show SMILES COc1ccc(cc1C)S(=O)(=O)Nc1cccc(-c2cn(C3CCN(CC3)C3CC3)c3ncnc(N)c23)c1F Show InChI InChI=1S/C28H31FN6O3S/c1-17-14-20(8-9-24(17)38-2)39(36,37)33-23-5-3-4-21(26(23)29)22-15-35(28-25(22)27(30)31-16-32-28)19-10-12-34(13-11-19)18-6-7-18/h3-5,8-9,14-16,18-19,33H,6-7,10-13H2,1-2H3,(H2,30,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482198 (N-{3-[4-Amino-7-(1-isopropyl-piperidin-4-yl)-7H-py...) Show SMILES COc1ccc(cc1C)S(=O)(=O)Nc1cccc(-c2cn(C3CCN(CC3)C(C)C)c3ncnc(N)c23)c1F Show InChI InChI=1S/C28H33FN6O3S/c1-17(2)34-12-10-19(11-13-34)35-15-22(25-27(30)31-16-32-28(25)35)21-6-5-7-23(26(21)29)33-39(36,37)20-8-9-24(38-4)18(3)14-20/h5-9,14-17,19,33H,10-13H2,1-4H3,(H2,30,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482199 (N-{3-[4-Amino-7-(1-ethyl-piperidin-4-yl)-7H-pyrrol...) Show SMILES CCN1CCC(CC1)n1cc(-c2cccc(NS(=O)(=O)c3ccc(OC)c(C)c3)c2F)c2c(N)ncnc12 Show InChI InChI=1S/C27H31FN6O3S/c1-4-33-12-10-18(11-13-33)34-15-21(24-26(29)30-16-31-27(24)34)20-6-5-7-22(25(20)28)32-38(35,36)19-8-9-23(37-3)17(2)14-19/h5-9,14-16,18,32H,4,10-13H2,1-3H3,(H2,29,30,31)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482202 (5-Chloro-thiophene-2-sulfonic acid [3-(4-amino-7-m...) Show SMILES Cn1cc(-c2cccc(NS(=O)(=O)c3ccc(Cl)s3)c2F)c2c(N)ncnc12 Show InChI InChI=1S/C17H13ClFN5O2S2/c1-24-7-10(14-16(20)21-8-22-17(14)24)9-3-2-4-11(15(9)19)23-28(25,26)13-6-5-12(18)27-13/h2-8,23H,1H3,(H2,20,21,22)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482203 (5-Bromo-thiophene-2-sulfonic acid [3-(4-amino-7-me...) Show SMILES Cn1cc(-c2cccc(NS(=O)(=O)c3ccc(Br)s3)c2F)c2c(N)ncnc12 Show InChI InChI=1S/C17H13BrFN5O2S2/c1-24-7-10(14-16(20)21-8-22-17(14)24)9-3-2-4-11(15(9)19)23-28(25,26)13-6-5-12(18)27-13/h2-8,23H,1H3,(H2,20,21,22)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482206 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES Cn1cc(-c2cccc(NS(=O)(=O)c3ccc(Br)c(c3)C(F)(F)F)c2F)c2c(N)ncnc12 Show InChI InChI=1S/C20H14BrF4N5O2S/c1-30-8-12(16-18(26)27-9-28-19(16)30)11-3-2-4-15(17(11)22)29-33(31,32)10-5-6-14(21)13(7-10)20(23,24)25/h2-9,29H,1H3,(H2,26,27,28)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482210 (N-{3-[4-Amino-1-(1-methyl-piperidin-4-yl)-1H-pyraz...) Show SMILES COc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cccc(-c2nn(C3CCN(C)CC3)c3ncnc(N)c23)c1F Show InChI InChI=1S/C24H24ClF2N7O3S/c1-33-8-6-13(7-9-33)34-24-20(23(28)29-12-30-24)22(31-34)14-4-3-5-17(21(14)27)32-38(35,36)19-10-15(25)18(37-2)11-16(19)26/h3-5,10-13,32H,6-9H2,1-2H3,(H2,28,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482211 (N-[3-(4-Amino-1-piperidin-4-yl-1H-pyrazolo[3,4-d]p...) Show SMILES COc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cccc(-c2nn(C3CCNCC3)c3ncnc(N)c23)c1F Show InChI InChI=1S/C23H22ClF2N7O3S/c1-36-17-10-15(25)18(9-14(17)24)37(34,35)32-16-4-2-3-13(20(16)26)21-19-22(27)29-11-30-23(19)33(31-21)12-5-7-28-8-6-12/h2-4,9-12,28,32H,5-8H2,1H3,(H2,27,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482212 (N-[3-(4-Amino-1-piperidin-4-yl-1H-pyrazolo[3,4-d]p...) Show SMILES COc1ccc(cc1Cl)S(=O)(=O)Nc1cccc(-c2nn(C3CCNCC3)c3ncnc(N)c23)c1F Show InChI InChI=1S/C23H23ClFN7O3S/c1-35-18-6-5-14(11-16(18)24)36(33,34)31-17-4-2-3-15(20(17)25)21-19-22(26)28-12-29-23(19)32(30-21)13-7-9-27-10-8-13/h2-6,11-13,27,31H,7-10H2,1H3,(H2,26,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482213 (N-[3-(4-Amino-7-piperidin-4-yl-7H-pyrrolo[2,3-d]py...) Show SMILES COc1ccc(cc1C)S(=O)(=O)Nc1cccc(-c2cn(C3CCNCC3)c3ncnc(N)c23)c1F Show InChI InChI=1S/C25H27FN6O3S/c1-15-12-17(6-7-21(15)35-2)36(33,34)31-20-5-3-4-18(23(20)26)19-13-32(16-8-10-28-11-9-16)25-22(19)24(27)29-14-30-25/h3-7,12-14,16,28,31H,8-11H2,1-2H3,(H2,27,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482218 (N-{3-[4-Amino-7-(1-methyl-piperidin-4-yl)-7H-pyrro...) Show SMILES CN1CCC(CC1)n1cc(-c2cccc(NS(=O)(=O)c3ccc(Br)cc3F)c2F)c2c(N)ncnc12 Show InChI InChI=1S/C24H23BrF2N6O2S/c1-32-9-7-15(8-10-32)33-12-17(21-23(28)29-13-30-24(21)33)16-3-2-4-19(22(16)27)31-36(34,35)20-6-5-14(25)11-18(20)26/h2-6,11-13,15,31H,7-10H2,1H3,(H2,28,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482221 (N-[3-(4-Amino-7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-5...) Show SMILES CCn1cc(-c2cccc(NS(=O)(=O)c3cc(Cl)c(OC)cc3F)c2F)c2c(N)ncnc12 Show InChI InChI=1S/C21H18ClF2N5O3S/c1-3-29-9-12(18-20(25)26-10-27-21(18)29)11-5-4-6-15(19(11)24)28-33(30,31)17-7-13(22)16(32-2)8-14(17)23/h4-10,28H,3H2,1-2H3,(H2,25,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482223 (5-Bromo-thiophene-2-sulfonic acid {3-[4-amino-7-(1...) Show SMILES CN1CCC(CC1)n1cc(-c2cccc(NS(=O)(=O)c3ccc(Br)s3)c2F)c2c(N)ncnc12 Show InChI InChI=1S/C22H22BrFN6O2S2/c1-29-9-7-13(8-10-29)30-11-15(19-21(25)26-12-27-22(19)30)14-3-2-4-16(20(14)24)28-34(31,32)18-6-5-17(23)33-18/h2-6,11-13,28H,7-10H2,1H3,(H2,25,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482224 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES COc1cc(c(F)cc1Cl)S(=O)(=O)Nc1cccc(-c2cn(C)c3ncnc(N)c23)c1F Show InChI InChI=1S/C20H16ClF2N5O3S/c1-28-8-11(17-19(24)25-9-26-20(17)28)10-4-3-5-14(18(10)23)27-32(29,30)16-7-15(31-2)12(21)6-13(16)22/h3-9,27H,1-2H3,(H2,24,25,26)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482226 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES Cn1cc(-c2cccc(NS(=O)(=O)c3ccc(Cl)cc3F)c2F)c2c(N)ncnc12 Show InChI InChI=1S/C19H14ClF2N5O2S/c1-27-8-12(16-18(23)24-9-25-19(16)27)11-3-2-4-14(17(11)22)26-30(28,29)15-6-5-10(20)7-13(15)21/h2-9,26H,1H3,(H2,23,24,25)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482227 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES COc1ccc(cc1C#N)S(=O)(=O)Nc1cccc(-c2cn(C)c3ncnc(N)c23)c1F Show InChI InChI=1S/C21H17FN6O3S/c1-28-10-15(18-20(24)25-11-26-21(18)28)14-4-3-5-16(19(14)22)27-32(29,30)13-6-7-17(31-2)12(8-13)9-23/h3-8,10-11,27H,1-2H3,(H2,24,25,26)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482172 (N-[3-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1cccc(-c2cn(C)c3ncnc(N)c23)c1F Show InChI InChI=1S/C20H18FN5O3S/c1-26-10-15(17-19(22)23-11-24-20(17)26)14-4-3-5-16(18(14)21)25-30(27,28)13-8-6-12(29-2)7-9-13/h3-11,25H,1-2H3,(H2,22,23,24)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	105	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482225 (6-Methoxy-pyridine-3-sulfonic acid [3-(4-amino-7-m...) Show SMILES COc1ccc(cn1)S(=O)(=O)Nc1cccc(-c2cn(C)c3ncnc(N)c23)c1F Show InChI InChI=1S/C19H17FN6O3S/c1-26-9-13(16-18(21)23-10-24-19(16)26)12-4-3-5-14(17(12)20)25-30(27,28)11-6-7-15(29-2)22-8-11/h3-10,25H,1-2H3,(H2,21,23,24)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	105	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482222 (N-{3-[4-Amino-7-(tetrahydro-pyran-4-yl)-7H-pyrrolo...) Show SMILES COc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cccc(-c2cn(C3CCOCC3)c3ncnc(N)c23)c1F Show InChI InChI=1S/C24H22ClF2N5O4S/c1-35-19-10-17(26)20(9-16(19)25)37(33,34)31-18-4-2-3-14(22(18)27)15-11-32(13-5-7-36-8-6-13)24-21(15)23(28)29-12-30-24/h2-4,9-13,31H,5-8H2,1H3,(H2,28,29,30)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	105	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair
Eukaryotic translation initiation factor 2-alpha kinase 3 [540-1115] (Homo sapiens (Human))	BDBM482220 (N-[3-(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimid...) Show SMILES COc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cccc(-c2cn(C(C)C)c3ncnc(N)c23)c1F Show InChI InChI=1S/C22H20ClF2N5O3S/c1-11(2)30-9-13(19-21(26)27-10-28-22(19)30)12-5-4-6-16(20(12)25)29-34(31,32)18-7-14(23)17(33-3)8-15(18)24/h4-11,29H,1-3H3,(H2,26,27,28)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	105	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The biochemical activity of compounds was determined by incubation with PERK recombinant enzyme (cytoplasmic domain corresponding to residues 540-111...				Citation and Details BindingDB Entry DOI: 10.7270/Q2C2518M
					More data for this Ligand-Target Pair

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