BindingDB PrimarySearch

Found 109 hits Enz. Inhib. hit(s) with Target = 'Gamma-aminobutyric acid receptor subunit rho-1'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50211642 (CHEMBL397209 \| Methyl(1,2,3,6-tetrahydropyridinium...) Show SMILES CP(O)(=O)C1=CCNCC1 \|t:4\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	2.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GABAc rho-1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...				ACS Med Chem Lett 2: 11-16 (2011) Article DOI: 10.1021/ml1001344 BindingDB Entry DOI: 10.7270/Q2FX79QR
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50211642 (CHEMBL397209 \| Methyl(1,2,3,6-tetrahydropyridinium...) Show SMILES CP(O)(=O)C1=CCNCC1 \|t:4\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	2.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at GABAC rho1 receptor (unknown origin)				ACS Med Chem Lett 4: 402-7 (2013) Article DOI: 10.1021/ml300476v BindingDB Entry DOI: 10.7270/Q27H1KXG
The University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM24189 (3-aminopropylphosphinic derivative, (R)-4 \| 3-amin...) Show SMILES CP(O)(O)CC(=O)CN Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GABAc rho1 receptor expressed in Xenopus laevis oocytes at -60mV by two-electrode voltage clamp method				Bioorg Med Chem Lett 18: 402-4 (2008) Article DOI: 10.1016/j.bmcl.2007.10.019 BindingDB Entry DOI: 10.7270/Q2TT4RTQ
The University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50032973 (((Z)-3-Amino-propenyl)-methyl-phosphinic acid \| 3-...) Show SMILES CP(O)(=O)CCC=N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50492303 (CHEMBL2398121) Show SMILES NC1CC=C(C1)C(O)=O \|c:3\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GABAA rho1 receptor expressed in Xenopus laevis assessed as inhibition of GABA-induced chloride current prod...				J Med Chem 56: 5626-30 (2013) Article DOI: 10.1021/jm4006548 BindingDB Entry DOI: 10.7270/Q20K2CHH
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50492306 (CHEMBL2398115) Show SMILES NC1CC=C(C1)C(N)=O \|c:3\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GABAA rho1 receptor expressed in Xenopus laevis assessed as inhibition of GABA-induced chloride current prod...				J Med Chem 56: 5626-30 (2013) Article DOI: 10.1021/jm4006548 BindingDB Entry DOI: 10.7270/Q20K2CHH
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50428278 (CHEMBL446306) Show SMILES CCCCP(O)(=O)C1=C[C@@H](N)CC1 \|r,t:7\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by two electrode ...				ACS Med Chem Lett 4: 402-7 (2013) Article DOI: 10.1021/ml300476v BindingDB Entry DOI: 10.7270/Q27H1KXG
The University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50240386 (5-amino-4-oxopentanoic acid \| 5-aminolevulinic aci...) Show SMILES NCC(=O)CCC(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.29E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50492304 (CHEMBL2398120) Show SMILES NC1CC=C(C1)C(=O)NO \|c:3\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.29E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GABAA rho1 receptor expressed in Xenopus laevis assessed as inhibition of GABA-induced chloride current prod...				J Med Chem 56: 5626-30 (2013) Article DOI: 10.1021/jm4006548 BindingDB Entry DOI: 10.7270/Q20K2CHH
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50374650 (CHEMBL257443) Show SMILES C[C@H](CCN)C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GABAc rho1 receptor expressed in Xenopus laevis oocytes at -60mV by two-electrode voltage clamp method				Bioorg Med Chem Lett 18: 402-4 (2008) Article DOI: 10.1016/j.bmcl.2007.10.019 BindingDB Entry DOI: 10.7270/Q2TT4RTQ
The University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM24189 (3-aminopropylphosphinic derivative, (R)-4 \| 3-amin...) Show SMILES CP(O)(O)CC(=O)CN Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.71E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GABAc rho1 receptor expressed in Xenopus laevis oocytes at -60mV by two-electrode voltage clamp method				Bioorg Med Chem Lett 18: 402-4 (2008) Article DOI: 10.1016/j.bmcl.2007.10.019 BindingDB Entry DOI: 10.7270/Q2TT4RTQ
The University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50336851 (3-(aminomethyl)-1-oxo-1-hydroxy-phospholane \| CHEM...) Show SMILES NCC1CCP(O)(O)=C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.99E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GABAc rho-1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...				ACS Med Chem Lett 2: 11-16 (2011) Article DOI: 10.1021/ml1001344 BindingDB Entry DOI: 10.7270/Q2FX79QR
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50336850 (3-(guanido)-1-oxo-1-hydroxy-phospholane \| CHEMBL16...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.97E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GABAc rho-1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...				ACS Med Chem Lett 2: 11-16 (2011) Article DOI: 10.1021/ml1001344 BindingDB Entry DOI: 10.7270/Q2FX79QR
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50428276 (CHEMBL2337487) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.86E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current preincubated for ...				ACS Med Chem Lett 4: 402-7 (2013) Article DOI: 10.1021/ml300476v BindingDB Entry DOI: 10.7270/Q27H1KXG
The University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50032982 ((3-Amino-propyl)-butyl-phosphinic acid \| 3-aminopr...) Show SMILES CCCCP(O)(=O)CCCN Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GABAc rho-1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...				ACS Med Chem Lett 2: 11-16 (2011) Article DOI: 10.1021/ml1001344 BindingDB Entry DOI: 10.7270/Q2FX79QR
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50032982 ((3-Amino-propyl)-butyl-phosphinic acid \| 3-aminopr...) Show SMILES CCCCP(O)(=O)CCCN Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50428275 (CHEMBL2337889) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.65E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current preincubated for ...				ACS Med Chem Lett 4: 402-7 (2013) Article DOI: 10.1021/ml300476v BindingDB Entry DOI: 10.7270/Q27H1KXG
The University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50492305 (CHEMBL2398122) Show SMILES CONC(=O)C1=CCC(N)C1 \|t:5\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.15E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GABAA rho1 receptor expressed in Xenopus laevis assessed as inhibition of GABA-induced chloride current prod...				J Med Chem 56: 5626-30 (2013) Article DOI: 10.1021/jm4006548 BindingDB Entry DOI: 10.7270/Q20K2CHH
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50525195 (CHEMBL4586460) Show SMILES C[C@@H]1SC(N)=N[C@@H]1CC(O)=O \|r,c:4\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Antagonist activity at recombinant human GABA-A rho-1 receptor transiently expressed in human tsA201 cells incubated for 30 mins and measured up to 9...				J Med Chem 62: 5797-5809 (2019) Article DOI: 10.1021/acs.jmedchem.9b00026 BindingDB Entry DOI: 10.7270/Q2D2222H
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50243876 (CHEMBL447036 \| trans-3-Amino-cyclobutyl(methyl)pho...) Show SMILES CP(O)(O)C1=C[C@H](N)C1 \|r,t:4\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50243875 (CHEMBL451118 \| cis-3-Amino-cyclobutyl(methyl)phosp...) Show SMILES CP(O)(O)C1=C[C@@H](N)C1 \|r,t:4\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50428276 (CHEMBL2337487) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.03E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by two electrode ...				ACS Med Chem Lett 4: 402-7 (2013) Article DOI: 10.1021/ml300476v BindingDB Entry DOI: 10.7270/Q27H1KXG
The University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50492302 (CHEMBL2398114) Show SMILES NC1CC=C(C1)C(=O)NOCC=C \|c:3\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.15E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GABAA rho1 receptor expressed in Xenopus laevis assessed as inhibition of GABA-induced chloride current prod...				J Med Chem 56: 5626-30 (2013) Article DOI: 10.1021/jm4006548 BindingDB Entry DOI: 10.7270/Q20K2CHH
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50428275 (CHEMBL2337889) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.48E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by two electrode ...				ACS Med Chem Lett 4: 402-7 (2013) Article DOI: 10.1021/ml300476v BindingDB Entry DOI: 10.7270/Q27H1KXG
The University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50492299 (CHEMBL2398123) Show SMILES CCONC(=O)C1=CCC(N)C1 \|t:6\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.53E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GABAA rho1 receptor expressed in Xenopus laevis assessed as inhibition of GABA-induced chloride current prod...				J Med Chem 56: 5626-30 (2013) Article DOI: 10.1021/jm4006548 BindingDB Entry DOI: 10.7270/Q20K2CHH
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50428277 (CHEMBL2337486) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.93E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current preincubated for ...				ACS Med Chem Lett 4: 402-7 (2013) Article DOI: 10.1021/ml300476v BindingDB Entry DOI: 10.7270/Q27H1KXG
The University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50428277 (CHEMBL2337486) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.81E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by two electrode ...				ACS Med Chem Lett 4: 402-7 (2013) Article DOI: 10.1021/ml300476v BindingDB Entry DOI: 10.7270/Q27H1KXG
The University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50525193 (CHEMBL4455221) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Antagonist activity at recombinant human GABA-A rho-1 receptor transiently expressed in human tsA201 cells incubated for 30 mins and measured up to 9...				J Med Chem 62: 5797-5809 (2019) Article DOI: 10.1021/acs.jmedchem.9b00026 BindingDB Entry DOI: 10.7270/Q2D2222H
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50525186 (CHEMBL4566832) Show SMILES CC1(CC(O)=O)CSC(N)=N1 \|c:9\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Antagonist activity at recombinant human GABA-A rho-1 receptor transiently expressed in human tsA201 cells incubated for 30 mins and measured up to 9...				J Med Chem 62: 5797-5809 (2019) Article DOI: 10.1021/acs.jmedchem.9b00026 BindingDB Entry DOI: 10.7270/Q2D2222H
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50492301 (CHEMBL2398116) Show SMILES CNC(=O)C1=CCC(N)C1 \|t:4\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.08E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GABAA rho1 receptor expressed in Xenopus laevis assessed as inhibition of GABA-induced chloride current prod...				J Med Chem 56: 5626-30 (2013) Article DOI: 10.1021/jm4006548 BindingDB Entry DOI: 10.7270/Q20K2CHH
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50492300 (CHEMBL2398117) Show SMILES CCCNC(=O)C1=CCC(N)C1 \|t:6\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.70E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GABAA rho1 receptor expressed in Xenopus laevis assessed as inhibition of GABA-induced chloride current prod...				J Med Chem 56: 5626-30 (2013) Article DOI: 10.1021/jm4006548 BindingDB Entry DOI: 10.7270/Q20K2CHH
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50241194 ((1S,2R)-2-(aminomethyl)cyclopropanecarboxylic acid...) Show SMILES NC[C@@H]1C[C@@H]1C(O)=O \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>8.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50374649 (CHEMBL257442) Show SMILES N[C@H]1C[C@H]1C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.90E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GABAc rho1 receptor expressed in Xenopus laevis oocytes at -60mV by two-electrode voltage clamp method				Bioorg Med Chem Lett 18: 402-4 (2008) Article DOI: 10.1016/j.bmcl.2007.10.019 BindingDB Entry DOI: 10.7270/Q2TT4RTQ
The University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50026410 (CHEBI:16974 \| Imidazole acetic acid) Show SMILES OC(=O)Cc1c[nH]cn1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at recombinant human GABA-A rho-1 receptor transiently expressed in human tsA201 cells incubated for 30 mins and measured up to 90 s...				J Med Chem 62: 5797-5809 (2019) Article DOI: 10.1021/acs.jmedchem.9b00026 BindingDB Entry DOI: 10.7270/Q2D2222H
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50087271 ((E)-4-Amino-but-2-enoic acid (TACA) \| 4-Amino-but-...) Show SMILES NC\C=C\C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	440	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Partial agonist activity against human rho-1 subunit GABA-C receptor expressed in Xenopus oocytes				J Med Chem 43: 1427-47 (2000) BindingDB Entry DOI: 10.7270/Q2PZ59HT
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50087269 ((cis)-2-Aminomethyl-cyclopropanecarboxylic acid \| ...) Show SMILES NCC1CC1C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	6.80E+4	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Full agonist activity against human rho-1 subunit GABA-C receptor expressed in Xenopus oocytes				J Med Chem 43: 1427-47 (2000) BindingDB Entry DOI: 10.7270/Q2PZ59HT
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM24183 (4-amino-n-[2,3-3H]butyric acid \| 4-aminobutanoic a...) Show SMILES NCCCC(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	270	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50052792 (CHEBI:7035 \| Muscimol) Show SMILES NCc1cc(O)no1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	700	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50032955 (1,2,3,6-Tetrahydro-pyridine-4-carboxylic acid \| 1,...) Show SMILES OC(=O)C1=CCNCC1 \|t:3\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.90E+4	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50052794 (CHEMBL3322871) Show SMILES CCc1nc(N)ccc1C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50052795 (CHEMBL3322872) Show SMILES CCCCc1nc(N)ccc1C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50052797 (CHEMBL3322876) Show SMILES CCc1cc(N)ncc1C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50052798 (CHEMBL3322877) Show SMILES CCCCc1cc(N)ncc1C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50052799 (CHEMBL3322882) Show SMILES NC1=NCC(CC1)C(O)=O \|t:1\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50052801 (CHEMBL3322886) Show SMILES NC1=NCC(CN1)C(O)=O \|t:1\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8.10E+3	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM24183 (4-amino-n-[2,3-3H]butyric acid \| 4-aminobutanoic a...) Show SMILES NCCCC(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	269	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50052792 (CHEBI:7035 \| Muscimol) Show SMILES NCc1cc(O)no1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	692	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50032955 (1,2,3,6-Tetrahydro-pyridine-4-carboxylic acid \| 1,...) Show SMILES OC(=O)C1=CCNCC1 \|t:3\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.89E+4	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50052794 (CHEMBL3322871) Show SMILES CCc1nc(N)ccc1C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	<1.00E+6	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50052795 (CHEMBL3322872) Show SMILES CCCCc1nc(N)ccc1C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	<1.00E+6	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assay				Eur J Med Chem 84: 404-16 (2014) Article DOI: 10.1016/j.ejmech.2014.07.039 BindingDB Entry DOI: 10.7270/Q2QV3P4Z
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair

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