BindingDB PrimarySearch

Found 8 hits Enz. Inhib. hit(s) with Target = 'HTH-type transcriptional regulator MgrA'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
HTH-type transcriptional regulator MgrA (Staphylococcus aureus)	BDBM11979 (5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...) Show SMILES OC(=O)c1cc(Cc2ccc(O)c(c2)C(O)=O)ccc1O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Nottingham Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus Newman His6-tagged MgrA expressed in Escherichia coli BL21(DE3) using 5'-6-F-TAAACAACAAGTTGTCCAAA-3' as substrate...				J Med Chem 56: 1389-404 (2013) Article DOI: 10.1021/jm3014635 BindingDB Entry DOI: 10.7270/Q2BV7J0M
University of Nottingham Curated by ChEMBL					More data for this Ligand-Target Pair
HTH-type transcriptional regulator MgrA (Staphylococcus aureus)	BDBM11979 (5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...) Show SMILES OC(=O)c1cc(Cc2ccc(O)c(c2)C(O)=O)ccc1O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	7.4	7.7
The University of Chicago					Assay Description A fluorescence anisotropy (FA)-based biochemical assay that monitors MgrA-DNA binding. To determine the binding affinity of MgrA to the labeled DNA,...				Chem Biol 18: 1032-41 (2011) Article DOI: 10.1016/j.chembiol.2011.05.014 BindingDB Entry DOI: 10.7270/Q2CN72DF
The University of Chicago					More data for this Ligand-Target Pair
HTH-type transcriptional regulator MgrA (Staphylococcus aureus)	BDBM81554 (MgrA inhibitor, 3) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	7.4	3.6
The University of Chicago					Assay Description A fluorescence anisotropy (FA)-based biochemical assay that monitors MgrA-DNA binding. To determine the binding affinity of MgrA to the labeled DNA,...				Chem Biol 18: 1032-41 (2011) Article DOI: 10.1016/j.chembiol.2011.05.014 BindingDB Entry DOI: 10.7270/Q2CN72DF
The University of Chicago					More data for this Ligand-Target Pair
HTH-type transcriptional regulator MgrA (Staphylococcus aureus)	BDBM81554 (MgrA inhibitor, 3) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Nottingham Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus Newman His6-tagged MgrA expressed in Escherichia coli BL21(DE3) using 5'-6-F-TAAACAACAAGTTGTCCAAA-3' as substrate...				J Med Chem 56: 1389-404 (2013) Article DOI: 10.1021/jm3014635 BindingDB Entry DOI: 10.7270/Q2BV7J0M
University of Nottingham Curated by ChEMBL					More data for this Ligand-Target Pair
HTH-type transcriptional regulator MgrA (Staphylococcus aureus)	BDBM81553 (MgrA inhibitor, 2) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Nottingham Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus Newman His6-tagged MgrA expressed in Escherichia coli BL21(DE3) using 5'-6-F-TAAACAACAAGTTGTCCAAA-3' as substrate...				J Med Chem 56: 1389-404 (2013) Article DOI: 10.1021/jm3014635 BindingDB Entry DOI: 10.7270/Q2BV7J0M
University of Nottingham Curated by ChEMBL					More data for this Ligand-Target Pair
HTH-type transcriptional regulator MgrA (Staphylococcus aureus)	BDBM81553 (MgrA inhibitor, 2) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	7.4	2.7
The University of Chicago					Assay Description A fluorescence anisotropy (FA)-based biochemical assay that monitors MgrA-DNA binding. To determine the binding affinity of MgrA to the labeled DNA,...				Chem Biol 18: 1032-41 (2011) Article DOI: 10.1016/j.chembiol.2011.05.014 BindingDB Entry DOI: 10.7270/Q2CN72DF
The University of Chicago					More data for this Ligand-Target Pair
HTH-type transcriptional regulator MgrA (Staphylococcus aureus)	BDBM81555 (MgrA inhibitor, 4) Show SMILES Cc1ccc(C)n1[C@@H](CC(O)=O)c1ccsc1 \|r\| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Nottingham Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus Newman His6-tagged MgrA expressed in Escherichia coli BL21(DE3) using 5'-6-F-TAAACAACAAGTTGTCCAAA-3' as substrate...				J Med Chem 56: 1389-404 (2013) Article DOI: 10.1021/jm3014635 BindingDB Entry DOI: 10.7270/Q2BV7J0M
University of Nottingham Curated by ChEMBL					More data for this Ligand-Target Pair
HTH-type transcriptional regulator MgrA (Staphylococcus aureus)	BDBM81555 (MgrA inhibitor, 4) Show SMILES Cc1ccc(C)n1[C@@H](CC(O)=O)c1ccsc1 \|r\| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a	7.4	3.5
The University of Chicago					Assay Description A fluorescence anisotropy (FA)-based biochemical assay that monitors MgrA-DNA binding. To determine the binding affinity of MgrA to the labeled DNA,...				Chem Biol 18: 1032-41 (2011) Article DOI: 10.1016/j.chembiol.2011.05.014 BindingDB Entry DOI: 10.7270/Q2CN72DF
The University of Chicago					More data for this Ligand-Target Pair