Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Peptidoglycan D,D-transpeptidase FtsI (Pseudomonas aeruginosa) | BDBM50240480 ((2S,3S)-3-({(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 68.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 3 | Antimicrob Agents Chemother 51: 2621-4 (2007) Article DOI: 10.1128/aac.00029-07 BindingDB Entry DOI: 10.7270/Q2VH5RN2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptidoglycan D,D-transpeptidase FtsI (Pseudomonas aeruginosa) | BDBM50240426 ((2S,5R,6R)-6-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazi...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 166 | n/a | n/a | n/a | n/a | 7.2 | 25 |
University of Oxford | Assay Description An appropriate amount of enzyme (4uM) was pre-incubated with the (5R)- or 5(S)-penicilloic acid in the assay buffer (50mM HEPES-NaOH buffer (pH 7.2) ... | ACS Chem Biol 8: 2112-6 (2013) Article DOI: 10.1021/cb400200h BindingDB Entry DOI: 10.7270/Q2VT1QRK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptidoglycan D,D-transpeptidase FtsI (Pseudomonas aeruginosa) | BDBM50420259 (CEFTAZIDIME) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 182 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 3 | Antimicrob Agents Chemother 51: 2621-4 (2007) Article DOI: 10.1128/aac.00029-07 BindingDB Entry DOI: 10.7270/Q2VH5RN2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptidoglycan D,D-transpeptidase FtsI (Pseudomonas aeruginosa) | BDBM50378857 (CEFTOBIPROLE | Zeftera | Zevtera) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 187 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 3 | Antimicrob Agents Chemother 51: 2621-4 (2007) Article DOI: 10.1128/aac.00029-07 BindingDB Entry DOI: 10.7270/Q2VH5RN2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptidoglycan D,D-transpeptidase FtsI (Pseudomonas aeruginosa) | BDBM50350470 (CEFEPIME | Maxipime) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 208 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 3 | Antimicrob Agents Chemother 51: 2621-4 (2007) Article DOI: 10.1128/aac.00029-07 BindingDB Entry DOI: 10.7270/Q2VH5RN2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptidoglycan D,D-transpeptidase FtsI (Pseudomonas aeruginosa) | BDBM50213266 (CHEBI:471744 | Imipenem | MK-0787) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 334 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 3 | Antimicrob Agents Chemother 51: 2621-4 (2007) Article DOI: 10.1128/aac.00029-07 BindingDB Entry DOI: 10.7270/Q2VH5RN2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptidoglycan D,D-transpeptidase FtsI (Pseudomonas aeruginosa) | BDBM50538667 (CHEMBL4634190) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of Pseudomonas aeruginosa PBP3 assessed as reduction in fluorescence intensity using Bocillin-protein as fluorescent substrate preincubate... | Citation and Details Article DOI: 10.1016/j.ejmech.2021.113436 BindingDB Entry DOI: 10.7270/Q2X92G5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptidoglycan D,D-transpeptidase FtsI (Pseudomonas aeruginosa) | BDBM50538667 (CHEMBL4634190) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Louis Stokes Cleveland Department of Veterans Affairs Medical Center Curated by ChEMBL | Assay Description Inhibition of Pseudomonas aeruginosa PBP3 assessed as reduction in fluorescence intensity of bocillin labeled protein pre-incubated for 20 mins befor... | J Med Chem 63: 5990-6002 (2020) Article DOI: 10.1021/acs.jmedchem.0c00255 BindingDB Entry DOI: 10.7270/Q25142S5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptidoglycan D,D-transpeptidase FtsI (Pseudomonas aeruginosa) | BDBM50578473 (CHEMBL4872152) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of Pseudomonas aeruginosa PBP3 assessed as reduction in fluorescence intensity using Bocillin-protein as fluorescent substrate preincubate... | Citation and Details Article DOI: 10.1016/j.ejmech.2021.113436 BindingDB Entry DOI: 10.7270/Q2X92G5W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptidoglycan D,D-transpeptidase FtsI (Pseudomonas aeruginosa) | BDBM104100 ((5S)-PA | (5S)-Penicilloic acid) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.26E+5 | n/a | n/a | n/a | n/a | 7.2 | 25 |
University of Oxford | Assay Description An appropriate amount of enzyme (4uM) was pre-incubated with the (5R)- or 5(S)-penicilloic acid in the assay buffer (50mM HEPES-NaOH buffer (pH 7.2) ... | ACS Chem Biol 8: 2112-6 (2013) Article DOI: 10.1021/cb400200h BindingDB Entry DOI: 10.7270/Q2VT1QRK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptidoglycan D,D-transpeptidase FtsI (Pseudomonas aeruginosa) | BDBM104099 ((5R)-PA | (5R)-Penicilloic acid) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.96E+5 | n/a | n/a | n/a | n/a | 7.2 | 25 |
University of Oxford | Assay Description An appropriate amount of enzyme (4uM) was pre-incubated with the (5R)- or 5(S)-penicilloic acid in the assay buffer (50mM HEPES-NaOH buffer (pH 7.2) ... | ACS Chem Biol 8: 2112-6 (2013) Article DOI: 10.1021/cb400200h BindingDB Entry DOI: 10.7270/Q2VT1QRK | |||||||||||
More data for this Ligand-Target Pair |