BindingDB PrimarySearch

Found 10 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase VRK1'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Serine/threonine-protein kinase VRK1 (Homo sapiens (Human))	BDBM25017 (2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Estadual de Campinas (UNICAMP) Curated by ChEMBL					Assay Description Inhibition of full length wild-type VRK1 (unknown origin) expressed in insect cells using ULight-Histone 3-Thr3 peptide as substrate incubated for 30...				ACS Med Chem Lett 10: 1266-1271 (2019) Article DOI: 10.1021/acsmedchemlett.9b00082 BindingDB Entry DOI: 10.7270/Q2BP061J
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase VRK1 (Homo sapiens (Human))	BDBM50502749 (CHEMBL4435359) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Estadual de Campinas (UNICAMP) Curated by ChEMBL					Assay Description Inhibition of full length wild-type VRK1 (unknown origin) expressed in insect cells using ULight-Histone 3-Thr3 peptide as substrate incubated for 30...				ACS Med Chem Lett 10: 1266-1271 (2019) Article DOI: 10.1021/acsmedchemlett.9b00082 BindingDB Entry DOI: 10.7270/Q2BP061J
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase VRK1 (Homo sapiens (Human))	BDBM50502748 (CHEMBL4436323) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Estadual de Campinas (UNICAMP) Curated by ChEMBL					Assay Description Inhibition of full length wild-type VRK1 (unknown origin) expressed in insect cells using ULight-Histone 3-Thr3 peptide as substrate incubated for 30...				ACS Med Chem Lett 10: 1266-1271 (2019) Article DOI: 10.1021/acsmedchemlett.9b00082 BindingDB Entry DOI: 10.7270/Q2BP061J
					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase VRK1 (Homo sapiens (Human))	BDBM50502751 (CHEMBL4452098) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	674	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Estadual de Campinas (UNICAMP) Curated by ChEMBL					Assay Description Inhibition of full length wild-type VRK1 (unknown origin) expressed in insect cells using ULight-Histone 3-Thr3 peptide as substrate incubated for 30...				ACS Med Chem Lett 10: 1266-1271 (2019) Article DOI: 10.1021/acsmedchemlett.9b00082 BindingDB Entry DOI: 10.7270/Q2BP061J
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase VRK1 (Homo sapiens (Human))	BDBM3175 (3-[1-[3-(Amidinothio)propyl]-3-indolyl]-4-(1-methy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	743	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of human VRK1 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate by [gamma-33P]-ATP assay				Eur J Med Chem 161: 456-467 (2019) Article DOI: 10.1016/j.ejmech.2018.10.052 BindingDB Entry DOI: 10.7270/Q2W380MT
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase VRK1 (Homo sapiens (Human))	BDBM50519662 (CHEMBL4438748) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human VRK1 in presence of 10 uM ATP by radiometric analysis				J Med Chem 62: 10691-10710 (2019) Article DOI: 10.1021/acs.jmedchem.9b01143 BindingDB Entry DOI: 10.7270/Q2MC93FG
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase VRK1 (Homo sapiens (Human))	BDBM50001733 (CHEMBL3133821) Show SMILES Oc1cccc(Nc2ccnc3[nH]c4ccccc4c23)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Martin-Luther University Halle-Wittenberg Curated by ChEMBL					Assay Description Inhibition of human VRK1				Bioorg Med Chem Lett 24: 1948-51 (2014) Article DOI: 10.1016/j.bmcl.2014.03.002 BindingDB Entry DOI: 10.7270/Q2TM7CN0
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase VRK1 (Homo sapiens (Human))	BDBM50135286 (CHEMBL3745885) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of human VRK1 using [KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK] as substrate				Bioorg Med Chem 24: 521-44 (2016) Article DOI: 10.1016/j.bmc.2015.11.045 BindingDB Entry DOI: 10.7270/Q24Q7WT8
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase VRK1 (Homo sapiens (Human))	BDBM50331612 (CHEMBL1290072 \| N-(4-methoxybenzyl)benzofuro[2,3-b...) Show SMILES COc1ccc(CNc2ccnc3oc4ccccc4c23)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.29E+5	n/a	n/a	n/a	n/a	n/a	n/a
Martin Luther University Halle-Wittenberg Curated by ChEMBL					Assay Description Inhibition of human VRK1				Bioorg Med Chem Lett 20: 6915-9 (2010) Article DOI: 10.1016/j.bmcl.2010.10.004 BindingDB Entry DOI: 10.7270/Q2GF0TQS
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase VRK1 (Homo sapiens (Human))	BDBM50502749 (CHEMBL4435359) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a
Universidade Estadual de Campinas (UNICAMP) Curated by ChEMBL					Assay Description Binding affinity to recombinant full length N-terminal His-tagged VRK1 (unknown origin) (1 to 396 residues) expressed in Escherichia coli BL 21 DE3-R...				ACS Med Chem Lett 10: 1266-1271 (2019) Article DOI: 10.1021/acsmedchemlett.9b00082 BindingDB Entry DOI: 10.7270/Q2BP061J
					More data for this Ligand-Target Pair