Compile Data Set for Download or QSAR

Found 22 hits Enz. Inhib. hit(s) with Target = 'Potassium channel subfamily K member 10'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium channel subfamily K member 10 (Homo sapiens (Human))	BDBM25759 (CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...) Show SMILES COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12 Show InChI InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Clermont Auvergne Curated by ChEMBL					Assay Description Inhibition of of TREK2 (unknown origin) expressed in HEK293 cells assessed as reduction in channel currents				J Med Chem 59: 5149-57 (2016) Article DOI: 10.1021/acs.jmedchem.5b00671 BindingDB Entry DOI: 10.7270/Q2319XSS
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Homo sapiens (Human))	BDBM25759 (CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...) Show SMILES COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12 Show InChI InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Clermont Auvergne Curated by ChEMBL					Assay Description Inhibition of of TREK2 (unknown origin) expressed in oocytes assessed as reduction in channel currents				J Med Chem 59: 5149-57 (2016) Article DOI: 10.1021/acs.jmedchem.5b00671 BindingDB Entry DOI: 10.7270/Q2319XSS
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Rattus norvegicus)	BDBM50174835 (4'-(4-toluenesulfonamido)-4-hydroxychalcone | 4'-(...) Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)C(=O)\C=C\c1ccc(O)cc1 Show InChI InChI=1S/C22H19NO4S/c1-16-2-13-21(14-3-16)28(26,27)23-19-9-7-18(8-10-19)22(25)15-6-17-4-11-20(24)12-5-17/h2-15,23-24H,1H3/b15-6+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Gyeongsang National University Curated by ChEMBL					Assay Description Inhibition of rat TREK2 channel -mediated current expressed in HEK293 at 60 mV holding potential by patch clamp method				Bioorg Med Chem Lett 20: 4237-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.033 BindingDB Entry DOI: 10.7270/Q25Q4ZXM
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Rattus norvegicus)	BDBM50482294 (CHEMBL1170811) Show SMILES COc1ccc(\C=C\C(=O)c2ccc(NS(=O)(=O)c3ccc(C)cc3)cc2)cc1 Show InChI InChI=1S/C23H21NO4S/c1-17-3-14-22(15-4-17)29(26,27)24-20-10-8-19(9-11-20)23(25)16-7-18-5-12-21(28-2)13-6-18/h3-16,24H,1-2H3/b16-7+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Gyeongsang National University Curated by ChEMBL					Assay Description Inhibition of rat TREK2 channel -mediated current expressed in HEK293 at 60 mV holding potential by patch clamp method				Bioorg Med Chem Lett 20: 4237-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.033 BindingDB Entry DOI: 10.7270/Q25Q4ZXM
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Rattus norvegicus)	BDBM50482296 (CHEMBL1169729) Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)C(=O)\C=C\c1ccccc1 Show InChI InChI=1S/C22H19NO3S/c1-17-7-14-21(15-8-17)27(25,26)23-20-12-10-19(11-13-20)22(24)16-9-18-5-3-2-4-6-18/h2-16,23H,1H3/b16-9+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Gyeongsang National University Curated by ChEMBL					Assay Description Inhibition of rat TREK2 channel -mediated current expressed in HEK293 at 60 mV holding potential by patch clamp method				Bioorg Med Chem Lett 20: 4237-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.033 BindingDB Entry DOI: 10.7270/Q25Q4ZXM
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Homo sapiens (Human))	BDBM50546011 (CHEMBL4741659) Show SMILES OC(=O)c1cc(sc1NC(=O)c1ccc(SC(F)(F)F)cc1)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of human TREK2 by thallium flux mobilization assay				Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Homo sapiens (Human))	BDBM50546001 (CHEMBL4776102) Show SMILES OC(=O)c1cc(Cl)ccc1NC(=O)c1ccc(SC(F)(F)F)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of human TREK2 by thallium flux mobilization assay				Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Homo sapiens (Human))	BDBM50546002 (CHEMBL4747631) Show SMILES OC(=O)c1ccc(Br)cc1NC(=O)c1ccc(SC(F)(F)F)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of human TREK2 by thallium flux mobilization assay				Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Homo sapiens (Human))	BDBM50546003 (CHEMBL4759642) Show SMILES OC(=O)c1cc(Br)ccc1NC(=O)c1ccc(SC(F)(F)F)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of human TREK2 by thallium flux mobilization assay				Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Homo sapiens (Human))	BDBM50546004 (CHEMBL4759521) Show SMILES OC(=O)c1cc(Br)c(F)cc1NC(=O)c1ccc(SC(F)(F)F)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of human TREK2 by thallium flux mobilization assay				Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Homo sapiens (Human))	BDBM50546005 (CHEMBL4758530) Show SMILES COc1ccc(C(O)=O)c(NC(=O)c2ccc(SC(F)(F)F)cc2)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.85E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of human TREK2 by thallium flux mobilization assay				Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Homo sapiens (Human))	BDBM50546006 (CHEMBL4747514) Show SMILES COc1ccc(NC(=O)c2ccc(SC(F)(F)F)cc2)c(c1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of human TREK2 by thallium flux mobilization assay				Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Homo sapiens (Human))	BDBM50546007 (CHEMBL4795261) Show SMILES OC(=O)c1cc(OC(F)(F)F)ccc1NC(=O)c1ccc(SC(F)(F)F)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of human TREK2 by thallium flux mobilization assay				Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Homo sapiens (Human))	BDBM50546008 (CHEMBL4784090) Show SMILES OC(=O)c1cc(ccc1NC(=O)c1ccc(SC(F)(F)F)cc1)[N+]([O-])=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.65E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of human TREK2 by thallium flux mobilization assay				Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Homo sapiens (Human))	BDBM50546009 (CHEMBL4750436) Show SMILES OC(=O)c1ccsc1NC(=O)c1ccc(SC(F)(F)F)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of human TREK2 by thallium flux mobilization assay				Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Homo sapiens (Human))	BDBM50546010 (CHEMBL4750599) Show SMILES Cc1sc(NC(=O)c2ccc(SC(F)(F)F)cc2)c(C(O)=O)c1C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	<3.60E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of human TREK2 by thallium flux mobilization assay				Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Homo sapiens (Human))	BDBM50545999 (CHEMBL4778307) Show SMILES OC(=O)c1cc(F)ccc1NC(=O)c1ccc(SC(F)(F)F)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of human TREK2 by thallium flux mobilization assay				Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Homo sapiens (Human))	BDBM50545998 (CHEMBL4745050) Show SMILES OC(=O)c1ccccc1NC(=O)c1ccc(SC(F)(F)F)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of human TREK2 by thallium flux mobilization assay				Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Homo sapiens (Human))	BDBM50197060 (CHEMBL1417584) Show SMILES C1CCc2c(C1)cccc2Nc1ccccc1-c1nnn[nH]1 Show InChI InChI=1S/C17H17N5/c1-2-8-13-12(6-1)7-5-11-15(13)18-16-10-4-3-9-14(16)17-19-21-22-20-17/h3-5,7,9-11,18H,1-2,6,8H2,(H,19,20,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of human TREK2 by thallium flux mobilization assay				Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Rattus norvegicus)	BDBM50482295 (CHEMBL401762) Show SMILES Cc1ccc(cc1)S(=O)(=O)Oc1ccc(cc1)C(=O)\C=C\c1ccc(O)cc1 Show InChI InChI=1S/C22H18O5S/c1-16-2-13-21(14-3-16)28(25,26)27-20-11-7-18(8-12-20)22(24)15-6-17-4-9-19(23)10-5-17/h2-15,23H,1H3/b15-6+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.67E+5	n/a	n/a	n/a	n/a
Gyeongsang National University Curated by ChEMBL					Assay Description Activation of rat TREK2 channel -mediated current expressed in HEK293 at 60 mV holding potential by patch clamp method				Bioorg Med Chem Lett 20: 4237-9 (2010) Article DOI: 10.1016/j.bmcl.2010.05.033 BindingDB Entry DOI: 10.7270/Q25Q4ZXM
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Homo sapiens (Human))	BDBM50180656 (CHEMBL3818503) Show SMILES CC1(C)c2cc(Cl)ccc2N(CCc2nnn[nH]2)c2ccc(Cl)cc12 Show InChI InChI=1S/C18H17Cl2N5/c1-18(2)13-9-11(19)3-5-15(13)25(8-7-17-21-23-24-22-17)16-6-4-12(20)10-14(16)18/h3-6,9-10H,7-8H2,1-2H3,(H,21,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
Universit£ Clermont Auvergne Curated by ChEMBL					Assay Description Activation of TREK2 (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currents				J Med Chem 59: 5149-57 (2016) Article DOI: 10.1021/acs.jmedchem.5b00671 BindingDB Entry DOI: 10.7270/Q2319XSS
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 10 (Homo sapiens (Human))	BDBM50546000 (CHEMBL4780579) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)c1ccc(SC(F)(F)F)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Activation of human TREK2 by thallium flux mobilization assay				Citation and Details Article DOI: 10.1016/j.bmcl.2019.04.048 BindingDB Entry DOI: 10.7270/Q2XS6006
					More data for this Ligand-Target Pair