Found 1065 hits Enz. Inhib. hit(s) with Target = 'Solute carrier family 22 member 12' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50538736
(CHEMBL4640580)Show InChI InChI=1S/C14H10Br2N2O3/c15-9-5-8(6-10(16)13(9)19)14(20)18-3-4-21-12-1-2-17-7-11(12)18/h1-2,5-7,19H,3-4H2 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid UniChem
| Article PubMed
| 57 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
West China Hospital of Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of human URAT1 |
Eur J Med Chem 166: 186-196 (2019)
Article DOI: 10.1016/j.ejmech.2019.01.043 BindingDB Entry DOI: 10.7270/Q20C50BS |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM26658
(2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopy...)Show InChI InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 5.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Chinese University of Hong Kong
Curated by ChEMBL
| Assay Description Inhibition of human URAT1-mediated urate uptake in HEK293 cells by competitive inhibition assay |
Drug Metab Dispos 35: 981-6 (2007)
Article DOI: 10.1124/dmd.106.012187 BindingDB Entry DOI: 10.7270/Q2KK9CPP |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM165905
(US9067922, 247)Show SMILES OCc1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc1Cl Show InChI InChI=1S/C19H13ClFN3O4S/c20-17-8-15(3-1-12(17)11-25)28-18-5-4-16(7-13(18)9-22)29(26,27)24-19-6-2-14(21)10-23-19/h1-8,10,25H,11H2,(H,23,24) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| MCE PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited
US Patent
| Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... |
US Patent US9067922 (2015)
BindingDB Entry DOI: 10.7270/Q2VQ31F0 |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50239134
(CHEMBL4087516)Show InChI InChI=1S/C13H8F3N3O2S/c14-13(15,16)22(20,21)19-12-5-6-18-8-11(12)10-3-1-9(7-17)2-4-10/h1-6,8H,(H,18,19) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou... |
Bioorg Med Chem Lett 27: 1919-1922 (2017)
Article DOI: 10.1016/j.bmcl.2017.03.041 BindingDB Entry DOI: 10.7270/Q2NK3H6D |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM165898
(US9067922, 239)Show SMILES OCc1ncc(Oc2ccc(c(F)c2)S(=O)(=O)Nc2ccc(F)cn2)cc1Cl Show InChI InChI=1S/C17H12ClF2N3O4S/c18-13-5-12(8-21-15(13)9-24)27-11-2-3-16(14(20)6-11)28(25,26)23-17-4-1-10(19)7-22-17/h1-8,24H,9H2,(H,22,23) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited
US Patent
| Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... |
US Patent US9067922 (2015)
BindingDB Entry DOI: 10.7270/Q2VQ31F0 |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM165900
(US9067922, 241)Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cc(Cl)c(C#N)c(Cl)c3)c(c2)C#N)nc1 Show InChI InChI=1S/C19H9Cl2FN4O3S/c20-16-6-13(7-17(21)15(16)9-24)29-18-3-2-14(5-11(18)8-23)30(27,28)26-19-4-1-12(22)10-25-19/h1-7,10H,(H,25,26) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited
US Patent
| Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... |
US Patent US9067922 (2015)
BindingDB Entry DOI: 10.7270/Q2VQ31F0 |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612481
(CHEMBL5271398) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50546900
(CHEMBL4756866)Show SMILES Brc1nnc(SCC(=O)NS(=O)(=O)c2ccc(Br)cc2)n1-c1ccc(C2CC2)c2ccccc12 |(37.92,-23.83,;39.38,-23.35,;39.87,-21.89,;41.4,-21.88,;41.88,-23.35,;43.41,-23.34,;44.18,-22,;45.72,-22,;46.49,-23.33,;46.48,-20.66,;48.02,-20.65,;49.34,-21.42,;48.02,-22.18,;48.78,-19.33,;50.32,-19.33,;51.08,-18,;50.31,-16.67,;51.06,-15.34,;48.77,-16.68,;48.02,-18.01,;40.63,-24.25,;40.64,-25.79,;39.31,-26.56,;39.31,-28.1,;40.64,-28.88,;40.65,-30.42,;39.9,-31.75,;41.44,-31.74,;41.99,-28.1,;43.32,-28.86,;44.66,-28.09,;44.65,-26.54,;43.31,-25.78,;41.98,-26.55,)| | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM165745
(US9067922, 235 | US9067922, 79)Show SMILES Cc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc(C)c1C#N Show InChI InChI=1S/C21H15FN4O3S/c1-13-7-17(8-14(2)19(13)11-24)29-20-5-4-18(9-15(20)10-23)30(27,28)26-21-6-3-16(22)12-25-21/h3-9,12H,1-2H3,(H,25,26) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited
US Patent
| Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... |
US Patent US9067922 (2015)
BindingDB Entry DOI: 10.7270/Q2VQ31F0 |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612476
(CHEMBL5277301) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612472
(CHEMBL5284974) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612468
(CHEMBL5287151) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612477
(CHEMBL5289202) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM165896
(US9067922, 237)Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3cc(F)c(C#N)c(Cl)c3)c(c2)C#N)nc1 Show InChI InChI=1S/C19H9ClF2N4O3S/c20-16-6-13(7-17(22)15(16)9-24)29-18-3-2-14(5-11(18)8-23)30(27,28)26-19-4-1-12(21)10-25-19/h1-7,10H,(H,25,26) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited
US Patent
| Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... |
US Patent US9067922 (2015)
BindingDB Entry DOI: 10.7270/Q2VQ31F0 |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM290450
(2{[4-(4-Cyanonaphthalen)isoquinolin-6-yl]thio}-2-m...)Show SMILES CC(C)(Sc1ccc2cncc(-c3ccc(C#N)c4ccccc34)c2c1)C(O)=O Show InChI InChI=1S/C24H18N2O2S/c1-24(2,23(27)28)29-17-9-7-16-13-26-14-22(21(16)11-17)20-10-8-15(12-25)18-5-3-4-6-19(18)20/h3-11,13-14H,1-2H3,(H,27,28) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf... |
US Patent US10100016 (2018)
BindingDB Entry DOI: 10.7270/Q2TH8PQZ |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612478
(CHEMBL5269373) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM37953
(US10093631, Compound Lesinurad | US10336710, Lesin...)Show SMILES OC(=O)CSc1nnc(Br)n1-c1ccc(C2CC2)c2ccccc12 |(-2.97,1.02,;-1.83,-.01,;-2.15,-1.52,;-.36,.46,;-.04,1.97,;1.42,2.45,;1.9,3.91,;3.44,3.91,;3.91,2.45,;5.38,1.97,;2.67,1.54,;2.67,,;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;2.67,-4.62,;3.44,-5.95,;1.9,-5.95,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;6.67,-.77,;5.33,,;4,-.77,)| Show InChI InChI=1S/C25H32N4O3/c1-18-13-14-19(2)21(16-18)29(17-24(31)27-20-8-3-4-9-20)25(32)12-7-11-23(30)28-22-10-5-6-15-26-22/h5-6,10,13-16,20H,3-4,7-9,11-12,17H2,1-2H3,(H,27,31)(H,26,28,30) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| | n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612475
(CHEMBL5278085) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612464
(CHEMBL5279672) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612485
(CHEMBL5289441) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 9.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612465
(CHEMBL5273217) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 9.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612469
(CHEMBL5277066) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 9.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM152041
(US8987473, 122)Show InChI InChI=1S/C18H16Cl2N2O2/c1-11-13-7-5-12(6-8-18(23)24)9-17(13)22(21-11)10-14-15(19)3-2-4-16(14)20/h2-5,7,9H,6,8,10H2,1H3,(H,23,24) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Sato Pharmaceutical Co., Ltd.
US Patent
| Assay Description It was introduced human URAT1 full-length cDNA into an expression vector
pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The
result... |
US Patent US8987473 (2015)
BindingDB Entry DOI: 10.7270/Q23F4NCB |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM152051
(US8987473, 137)Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(Cc3n[nH]c(=S)o3)ccc12 Show InChI InChI=1S/C18H14Cl2N4OS/c1-10-12-6-5-11(8-17-21-22-18(26)25-17)7-16(12)24(23-10)9-13-14(19)3-2-4-15(13)20/h2-7H,8-9H2,1H3,(H,22,26) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Sato Pharmaceutical Co., Ltd.
US Patent
| Assay Description It was introduced human URAT1 full-length cDNA into an expression vector
pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The
result... |
US Patent US8987473 (2015)
BindingDB Entry DOI: 10.7270/Q23F4NCB |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50239146
(CHEMBL4088988)Show SMILES FC(F)(F)S(=O)(=O)Nc1ccncc1-c1ccc(C#N)c2ccccc12 Show InChI InChI=1S/C17H10F3N3O2S/c18-17(19,20)26(24,25)23-16-7-8-22-10-15(16)14-6-5-11(9-21)12-3-1-2-4-13(12)14/h1-8,10H,(H,22,23) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human URAT1 expressed in HEK293T cells assessed as reduction in [14C]uric acid uptake measured after 5 mins by liquid scintillation cou... |
Bioorg Med Chem Lett 27: 1919-1922 (2017)
Article DOI: 10.1016/j.bmcl.2017.03.041 BindingDB Entry DOI: 10.7270/Q2NK3H6D |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612488
(CHEMBL5290258) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612490
(CHEMBL5268478) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM290480
(US10100016, Compound 45B)Show SMILES C[C@@H](CC(O)=O)c1cc2cncc(-c3ccc(C#N)c4ccccc34)c2s1 |r| Show InChI InChI=1S/C22H16N2O2S/c1-13(8-21(25)26)20-9-15-11-24-12-19(22(15)27-20)18-7-6-14(10-23)16-4-2-3-5-17(16)18/h2-7,9,11-13H,8H2,1H3,(H,25,26)/t13-/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf... |
US Patent US10100016 (2018)
BindingDB Entry DOI: 10.7270/Q2TH8PQZ |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM290470
(US10100016, Compound 43A)Show SMILES C[C@H](CC(O)=O)c1cc2c(cncc2s1)-c1ccc(C#N)c2ccccc12 |r| Show InChI InChI=1S/C22H16N2O2S/c1-13(8-22(25)26)20-9-18-19(11-24-12-21(18)27-20)17-7-6-14(10-23)15-4-2-3-5-16(15)17/h2-7,9,11-13H,8H2,1H3,(H,25,26)/t13-/m1/s1 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf... |
US Patent US10100016 (2018)
BindingDB Entry DOI: 10.7270/Q2TH8PQZ |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612470
(CHEMBL5291373) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612463
(CHEMBL5267010) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612482
(CHEMBL5282615) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612491
(CHEMBL5267727) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612479
(CHEMBL5285786) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM290481
(3-[4-(4-Cyanonaphthalen-1-yl)isoquinolin-6-yl]-2,2...)Show SMILES CC(C)(Cc1ccc2cncc(-c3ccc(C#N)c4ccccc34)c2c1)C(O)=O Show InChI InChI=1S/C25H20N2O2/c1-25(2,24(28)29)12-16-7-8-18-14-27-15-23(22(18)11-16)21-10-9-17(13-26)19-5-3-4-6-20(19)21/h3-11,14-15H,12H2,1-2H3,(H,28,29) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf... |
US Patent US10100016 (2018)
BindingDB Entry DOI: 10.7270/Q2TH8PQZ |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM290489
(3-[4-(4-Cyanophenyl)thieno[2,3-c]pyridin-2-yl]-2,2...)Show SMILES CC(C)(Cc1cc2c(cncc2s1)-c1ccc(cc1)C#N)C(O)=O Show InChI InChI=1S/C19H16N2O2S/c1-19(2,18(22)23)8-14-7-15-16(10-21-11-17(15)24-14)13-5-3-12(9-20)4-6-13/h3-7,10-11H,8H2,1-2H3,(H,22,23) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| US Patent
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
SHANGHAI YINGLI PHARMACEUTICAL CO., LTD.
US Patent
| Assay Description Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf... |
US Patent US10100016 (2018)
BindingDB Entry DOI: 10.7270/Q2TH8PQZ |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM318948
(2-Methyl-2-[[7-(4-nitrophenyl)benzo[d]isothiazol-6...)Show SMILES CC(C)(Sc1ccc2cnsc2c1-c1ccc(cc1)[N+]([O-])=O)C(O)=O Show InChI InChI=1S/C17H14N2O4S2/c1-17(2,16(20)21)24-13-8-5-11-9-18-25-15(11)14(13)10-3-6-12(7-4-10)19(22)23/h3-9H,1-2H3,(H,20,21) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Chemiphar Co., Ltd.; J-Pharma Co., Ltd.; DeThree Res. Lab. Inc.
US Patent
| Assay Description URAT1 stably expressed HEK293 cells (HEK-URAT1) or HEK293 cells transfected with empty vector (HEK-mock) were cultured in DMEM culture medium supplem... |
US Patent US10173990 (2019)
BindingDB Entry DOI: 10.7270/Q2RR21BP |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM165893
(US9067922, 232)Show SMILES Clc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(Cl)c3)c(c2)C#N)nc1 Show InChI InChI=1S/C19H10Cl2N4O3S/c20-14-2-6-19(24-11-14)25-29(26,27)16-4-5-18(13(7-16)10-23)28-15-3-1-12(9-22)17(21)8-15/h1-8,11H,(H,24,25) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited
US Patent
| Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... |
US Patent US9067922 (2015)
BindingDB Entry DOI: 10.7270/Q2VQ31F0 |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612493
(CHEMBL5266247) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612471
(CHEMBL5282586) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612480
(CHEMBL5268476) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612487
(CHEMBL5290341) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612466
(CHEMBL5285533) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM165745
(US9067922, 235 | US9067922, 79)Show SMILES Cc1cc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ccc(F)cn2)cc(C)c1C#N Show InChI InChI=1S/C21H15FN4O3S/c1-13-7-17(8-14(2)19(13)11-24)29-20-5-4-18(9-15(20)10-23)30(27,28)26-21-6-3-16(22)12-25-21/h3-9,12H,1-2H3,(H,25,26) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited
US Patent
| Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... |
US Patent US9067922 (2015)
BindingDB Entry DOI: 10.7270/Q2VQ31F0 |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612474
(CHEMBL5272958) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM165667
(US9067922, 1)Show SMILES Fc1ccc(NS(=O)(=O)c2ccc(Oc3ccc(C#N)c(Cl)c3)c(c2)C#N)nc1 Show InChI InChI=1S/C19H10ClFN4O3S/c20-17-8-15(3-1-12(17)9-22)28-18-5-4-16(7-13(18)10-23)29(26,27)25-19-6-2-14(21)11-24-19/h1-8,11H,(H,24,25) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| MCE PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Limited
US Patent
| Assay Description Assay compound plates were prepared by diluting the compounds of formula (I) with chloride-free buffer (125 mM Na-gluconate, 4.8 mM K-gluconate, 1.3 ... |
US Patent US9067922 (2015)
BindingDB Entry DOI: 10.7270/Q2VQ31F0 |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM152048
(US8987473, 134)Show SMILES Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(Cc3nnn[nH]3)ccc12 Show InChI InChI=1S/C17H14Cl2N6/c1-10-12-6-5-11(8-17-20-23-24-21-17)7-16(12)25(22-10)9-13-14(18)3-2-4-15(13)19/h2-7H,8-9H2,1H3,(H,20,21,23,24) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Sato Pharmaceutical Co., Ltd.
US Patent
| Assay Description It was introduced human URAT1 full-length cDNA into an expression vector
pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The
result... |
US Patent US8987473 (2015)
BindingDB Entry DOI: 10.7270/Q23F4NCB |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM377700
(US10266496, Example 27)Show InChI InChI=1S/C16H8ClNO4/c17-15-6-12-11(3-8(7-18)4-14(12)22-15)9-1-2-10(16(20)21)13(19)5-9/h1-6,19H,(H,20,21) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Curacyte Chemistry GmbH
| Assay Description a. Construction of a Cell Line Stably Expressing hURAT1hURAT1 plasmid was transfected into HEK293T cell, and a cell line stably expressing hURAT1 was... |
J Med Chem 49: 4116-26 (2006)
BindingDB Entry DOI: 10.7270/Q2ST7S5F |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM50612486
(CHEMBL5278304) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| UniChem
| | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 12
(Homo sapiens (Human)) | BDBM152017
(US8987473, 82)Show InChI InChI=1S/C18H15Cl2NO2/c1-11-9-21(10-14-15(19)3-2-4-16(14)20)17-7-12(8-18(22)23)5-6-13(11)17/h2-7,9H,8,10H2,1H3,(H,22,23) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Sato Pharmaceutical Co., Ltd.
US Patent
| Assay Description It was introduced human URAT1 full-length cDNA into an expression vector
pcDNA5 / FRT / V5-His TOPO (registered trademark) (Invitrogen). The
result... |
US Patent US8987473 (2015)
BindingDB Entry DOI: 10.7270/Q23F4NCB |
More data for this Ligand-Target Pair | |