Ki Summary

Reaction Details

Report a problem with these data

Target

Solute carrier family 22 member 12

Ligand

BDBM50612466

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2288277

IC50

12±n/a nM

Citation

Zhang, J; Dong, Y; Gao, S; Zhang, X; Liao, H; Shi, X; Zhang, Z; Zhao, T; Liang, R; Qi, D; Wu, T; Pang, J; Liu, X; Zhan, P Design, synthesis and activity evaluation of novel lesinurad analogues containing thienopyrimidinone or pyridine substructure as human urate transporter 1 inhibitors. Eur J Med Chem244:0 (2022) [PubMed]

More Info.:

Get all data from this article, Assay Method

Solute carrier family 22 member 12

Name:

Solute carrier family 22 member 12

Synonyms:

Type:

Enzyme

Mol. Mass.:

59638.65

Organism:

Homo sapiens (Human)

Description:

Q96S37

Residue:

553

Sequence:

MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
GTLGNSVLKSTQF

BDBM50612466

n/a

Name

BDBM50612466

Synonyms:

CHEMBL5285533

Type

Small organic molecule

Emp. Form.

C27H20N4O6S3

Mol. Mass.

592.666

SMILES

[O-][N+](=O)c1cccc(c1)S(=O)(=O)NC(=O)CSc1nc2sccc2c(=O)n1-c1ccc(C2CC2)c2ccccc12 |(2.26,5.74,;3.8,5.74,;4.57,7.07,;4.57,4.41,;6.11,4.4,;6.88,3.08,;6.11,1.74,;4.57,1.74,;3.8,3.08,;3.79,.41,;5.13,-.36,;3.02,-.92,;2.46,1.18,;1.13,.41,;1.12,-1.13,;-.21,1.18,;-1.54,.42,;-2.87,1.19,;-2.87,2.73,;-4.2,3.5,;-4.52,5.01,;-6.05,5.17,;-6.68,3.76,;-5.54,2.73,;-5.54,1.19,;-6.88,.42,;-4.21,.42,;-4.21,-1.12,;-5.55,-1.89,;-5.55,-3.43,;-4.21,-4.2,;-4.22,-5.74,;-3.45,-7.07,;-4.99,-7.07,;-2.88,-3.43,;-1.55,-4.2,;-.21,-3.43,;-.21,-1.89,;-1.54,-1.12,;-2.88,-1.89,)|

Structure