Compile Data Set for Download or QSAR

Found 255 hits Enz. Inhib. hit(s) with Target = '1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1' AND taxid = 9606   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM50037076 (CHEMBL3355737) Show SMILES O[C@H]1CC[C@@H](CC1)Nc1cc(cc(Nc2cc([nH]n2)C2CCCC2)n1)S(=O)(=O)c1ccccc1 |r,wU:4.7,wD:1.0,(11.82,-31.11,;11.83,-29.57,;13.16,-28.8,;13.17,-27.26,;11.84,-26.5,;10.5,-27.26,;10.5,-28.8,;11.83,-24.96,;10.5,-24.19,;9.16,-24.96,;7.83,-24.19,;7.83,-22.65,;9.16,-21.88,;9.15,-20.34,;10.49,-19.56,;11.9,-20.19,;12.93,-19.05,;12.15,-17.72,;10.65,-18.04,;14.46,-19.19,;15.24,-20.52,;16.74,-20.2,;16.9,-18.67,;15.49,-18.04,;10.49,-22.64,;6.49,-24.96,;7.25,-26.29,;5.72,-26.28,;5.16,-24.19,;5.17,-22.65,;3.84,-21.88,;2.5,-22.65,;2.51,-24.2,;3.84,-24.96,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Evotec UK Ltd Curated by ChEMBL					Assay Description Inhibition of PLC gamma-1 phosphorylation in human Jurkat T cells after 30 mins				Bioorg Med Chem Lett 24: 5818-23 (2014) Article DOI: 10.1016/j.bmcl.2014.10.020 BindingDB Entry DOI: 10.7270/Q2NK3GNT
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM50037063 (CHEMBL3355726) Show SMILES Cc1cc(Nc2cc(cc(N[C@H]3CC[C@H](O)CC3)n2)S(=O)(=O)c2ccccc2)n[nH]1 |r,wU:11.10,wD:14.14,(15.1,-16.36,;13.56,-16.21,;12.54,-17.35,;11.12,-16.72,;9.79,-17.5,;9.8,-19.04,;8.47,-19.81,;8.46,-21.35,;9.8,-22.12,;11.14,-21.35,;12.47,-22.12,;12.47,-23.66,;13.81,-24.42,;13.8,-25.96,;12.47,-26.73,;12.46,-28.27,;11.13,-25.96,;11.14,-24.42,;11.13,-19.8,;7.12,-22.12,;7.89,-23.45,;6.35,-23.44,;5.8,-21.35,;5.81,-19.81,;4.48,-19.04,;3.14,-19.81,;3.14,-21.36,;4.48,-22.12,;11.28,-15.2,;12.79,-14.88,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
Evotec UK Ltd Curated by ChEMBL					Assay Description Inhibition of PLC gamma-1 phosphorylation in human Jurkat T cells after 30 mins				Bioorg Med Chem Lett 24: 5818-23 (2014) Article DOI: 10.1016/j.bmcl.2014.10.020 BindingDB Entry DOI: 10.7270/Q2NK3GNT
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM108039 (US9695200, 80) Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)cc(c1)-c1cnn(C)c1 Show InChI InChI=1S/C26H22N6O2/c1-4-24(33)31-21-8-17(7-18(9-21)20-13-30-32(2)15-20)19-10-22-23(14-29-26(22)28-12-19)16-5-6-27-25(11-16)34-3/h4-15H,1H2,2-3H3,(H,28,29)(H,31,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM87738 (US9695200, 11) Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)cc(c1)C(F)(F)F Show InChI InChI=1S/C23H17F3N4O2/c1-3-20(31)30-17-7-14(6-16(10-17)23(24,25)26)15-8-18-19(12-29-22(18)28-11-15)13-4-5-27-21(9-13)32-2/h3-12H,1H2,2H3,(H,28,29)(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM107352 (US9695200, 74) Show SMILES CC(C)c1ccc(NC(=O)c2ccc(cc2)-c2c[nH]c3ncc(cc23)-c2cccc(NC(=O)C=C)c2)cc1 Show InChI InChI=1S/C32H28N4O2/c1-4-30(37)35-27-7-5-6-24(16-27)25-17-28-29(19-34-31(28)33-18-25)22-8-10-23(11-9-22)32(38)36-26-14-12-21(13-15-26)20(2)3/h4-20H,1H2,2-3H3,(H,33,34)(H,35,37)(H,36,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM103397 (US9695200, 72) Show SMILES Cn1cc(-c2c[nH]c3ncc(cc23)-c2cccc(NC(=O)C=C)c2)c2ccccc2c1=O Show InChI InChI=1S/C26H20N4O2/c1-3-24(31)29-18-8-6-7-16(11-18)17-12-21-22(14-28-25(21)27-13-17)23-15-30(2)26(32)20-10-5-4-9-19(20)23/h3-15H,1H2,2H3,(H,27,28)(H,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM100881 (US9695200, 67) Show SMILES Cc1ccc(NC(=O)c2ccc(cc2)-c2c[nH]c3ncc(cc23)-c2cccc(NC(=O)C=C)c2)c(C)c1 Show InChI InChI=1S/C31H26N4O2/c1-4-29(36)34-25-7-5-6-23(15-25)24-16-26-27(18-33-30(26)32-17-24)21-9-11-22(12-10-21)31(37)35-28-13-8-19(2)14-20(28)3/h4-18H,1H2,2-3H3,(H,32,33)(H,34,36)(H,35,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM100784 (US9695200, 62) Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccnc4[nH]ccc34)c2c1 Show InChI InChI=1S/C23H17N5O/c1-2-21(29)28-16-5-3-4-14(10-16)15-11-19-20(13-27-23(19)26-12-15)17-6-8-24-22-18(17)7-9-25-22/h2-13H,1H2,(H,24,25)(H,26,27)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM99857 (US9695200, 59) Show SMILES FC(F)(F)c1cc(NC(=O)C=C)cc(c1)-c1cnc2[nH]cc(-c3cccnc3)c2c1 Show InChI InChI=1S/C22H15F3N4O/c1-2-20(30)29-17-7-14(6-16(9-17)22(23,24)25)15-8-18-19(12-28-21(18)27-11-15)13-4-3-5-26-10-13/h2-12H,1H2,(H,27,28)(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM99847 (US9695200, 57) Show SMILES Fc1ccc(cn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)cc(c1)C(F)(F)F Show InChI InChI=1S/C22H14F4N4O/c1-2-20(31)30-16-6-13(5-15(8-16)22(24,25)26)14-7-17-18(11-29-21(17)28-10-14)12-3-4-19(23)27-9-12/h2-11H,1H2,(H,28,29)(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM99790 (US9695200, 50) Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccc(=O)n(CC4CC4)c3)c2c1 Show InChI InChI=1S/C25H22N4O2/c1-2-23(30)28-20-5-3-4-17(10-20)19-11-21-22(13-27-25(21)26-12-19)18-8-9-24(31)29(15-18)14-16-6-7-16/h2-5,8-13,15-16H,1,6-7,14H2,(H,26,27)(H,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM99786 (US9695200, 49) Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccncn3)c2c1 Show InChI InChI=1S/C20H15N5O/c1-2-19(26)25-15-5-3-4-13(8-15)14-9-16-17(11-23-20(16)22-10-14)18-6-7-21-12-24-18/h2-12H,1H2,(H,22,23)(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM99737 (US9695200, 46) Show SMILES Fc1ccc(cn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1 Show InChI InChI=1S/C21H15FN4O/c1-2-20(27)26-16-5-3-4-13(8-16)15-9-17-18(12-25-21(17)24-11-15)14-6-7-19(22)23-10-14/h2-12H,1H2,(H,24,25)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM98821 (US9695200, 41) Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)nc(c1)N1CCOCC1 Show InChI InChI=1S/C25H24N6O3/c1-3-23(32)30-21-11-17(12-22(29-21)31-6-8-34-9-7-31)18-10-19-20(15-28-25(19)27-14-18)16-4-5-26-24(13-16)33-2/h3-5,10-15H,1,6-9H2,2H3,(H,27,28)(H,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM98786 (US9695200, 32) Show SMILES CNc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1 |$;HN;;;;;;;;;;;;;;;;;;;;;;;;;;$| Show InChI InChI=1S/C22H19N5O/c1-3-21(28)27-17-6-4-5-14(9-17)16-10-18-19(13-26-22(18)25-12-16)15-7-8-24-20(11-15)23-2/h3-13H,1H2,2H3,(H,23,24)(H,25,26)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM98760 (US9695200, 28) Show SMILES Cc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cncc(NC(=O)C=C)c1 Show InChI InChI=1S/C21H17N5O/c1-3-20(27)26-17-7-15(9-22-11-17)16-8-18-19(12-25-21(18)24-10-16)14-4-5-23-13(2)6-14/h3-12H,1H2,2H3,(H,24,25)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM88670 (US9695200, 26) Show SMILES Cc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1 Show InChI InChI=1S/C22H18N4O/c1-3-21(27)26-18-6-4-5-15(10-18)17-11-19-20(13-25-22(19)24-12-17)16-7-8-23-14(2)9-16/h3-13H,1H2,2H3,(H,24,25)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM88653 (US9695200, 25) Show SMILES Fc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1 Show InChI InChI=1S/C21H15FN4O/c1-2-20(27)26-16-5-3-4-13(8-16)15-9-17-18(12-25-21(17)24-11-15)14-6-7-23-19(22)10-14/h2-12H,1H2,(H,24,25)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM88535 (US9695200, 20) Show SMILES FC(F)(F)c1cc(NC(=O)C=C)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1 Show InChI InChI=1S/C22H15F3N4O/c1-2-20(30)29-17-8-14(7-16(10-17)22(23,24)25)15-9-18-19(12-28-21(18)27-11-15)13-3-5-26-6-4-13/h2-12H,1H2,(H,27,28)(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM107952 (US9695200, 76) Show SMILES COc1cc(NC(=O)\C=C\CN(C)C)cc(c1)-c1cnc2[nH]cc(-c3ccnc(OC)c3)c2c1 Show InChI InChI=1S/C26H27N5O3/c1-31(2)9-5-6-24(32)30-20-10-18(11-21(14-20)33-3)19-12-22-23(16-29-26(22)28-15-19)17-7-8-27-25(13-17)34-4/h5-8,10-16H,9H2,1-4H3,(H,28,29)(H,30,32)/b6-5+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM81141 (US9695200, 6) Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1 Show InChI InChI=1S/C22H18N4O2/c1-3-20(27)26-17-6-4-5-14(9-17)16-10-18-19(13-25-22(18)24-12-16)15-7-8-23-21(11-15)28-2/h3-13H,1H2,2H3,(H,24,25)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM108763 (US9695200, 91) Show SMILES CNc1nccc(n1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1 Show InChI InChI=1S/C21H18N6O/c1-3-19(28)26-15-6-4-5-13(9-15)14-10-16-17(12-25-20(16)24-11-14)18-7-8-23-21(22-2)27-18/h3-12H,1H2,2H3,(H,24,25)(H,26,28)(H,22,23,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM108388 (US9695200, 89) Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccnc4[nH]ccc34)c2c1 Show InChI InChI=1S/C26H24N6O/c1-32(2)12-4-7-24(33)31-19-6-3-5-17(13-19)18-14-22-23(16-30-26(22)29-15-18)20-8-10-27-25-21(20)9-11-28-25/h3-11,13-16H,12H2,1-2H3,(H,27,28)(H,29,30)(H,31,33)/b7-4+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM100765 (US9695200, 61) Show SMILES Fc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)cc(c1)C(F)(F)F Show InChI InChI=1S/C22H14F4N4O/c1-2-20(31)30-16-6-13(5-15(9-16)22(24,25)26)14-7-17-18(11-29-21(17)28-10-14)12-3-4-27-19(23)8-12/h2-11H,1H2,(H,28,29)(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM88562 (US9695200, 24) Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1 Show InChI InChI=1S/C24H23N5O/c1-29(2)12-4-7-23(30)28-20-6-3-5-18(13-20)19-14-21-22(16-27-24(21)26-15-19)17-8-10-25-11-9-17/h3-11,13-16H,12H2,1-2H3,(H,26,27)(H,28,30)/b7-4+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM88551 (US9695200, 22) Show SMILES COc1cc(NC(=O)C=C)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1 Show InChI InChI=1S/C22H18N4O2/c1-3-21(27)26-17-8-15(9-18(11-17)28-2)16-10-19-20(13-25-22(19)24-12-16)14-4-6-23-7-5-14/h3-13H,1H2,2H3,(H,24,25)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [1-999,I813T] (Homo sapiens (Human))	BDBM84007 (CEFIXIME | Cefiximum [Latin] | MLS002222332 | SMR0...) Show SMILES Nc1nc(cs1)C(=N\OCC(O)=O)\C(=O)N[C@H]1[C@H]2SCC(C=C)=C(N2C1=O)C(O)=O |c:23| Show InChI InChI=1S/C16H15N5O7S2/c1-2-6-4-29-14-10(13(25)21(14)11(6)15(26)27)19-12(24)9(20-28-3-8(22)23)7-5-30-16(17)18-7/h2,5,10,14H,1,3-4H2,(H2,17,18)(H,19,24)(H,22,23)(H,26,27)/b20-9-/t10-,14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars	PCBioAssay	n/a	n/a	1.21E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...				PubChem Bioassay (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZV0
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [1-999,I813T] (Homo sapiens (Human))	BDBM52817 (2-[(5Z)-5-[(E)-3-(2-furanyl)prop-2-enylidene]-4-ox...) Show SMILES OC(=O)CC(N1C(=S)S\C(=C/C=C/c2ccco2)C1=O)C(O)=O Show InChI InChI=1S/C14H11NO6S2/c16-11(17)7-9(13(19)20)15-12(18)10(23-14(15)22)5-1-3-8-4-2-6-21-8/h1-6,9H,7H2,(H,16,17)(H,19,20)/b3-1+,10-5-	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	1.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...				PubChem Bioassay (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZV0
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [1-999,I813T] (Homo sapiens (Human))	BDBM34905 (1,6-dimethyl-3-propyl-pyrimido[5,4-e][1,2,4]triazi...) Show SMILES CCCc1nn(C)c2nc(=O)n(C)c(=O)c2n1 Show InChI InChI=1S/C10H13N5O2/c1-4-5-6-11-7-8(15(3)13-6)12-10(17)14(2)9(7)16/h4-5H2,1-3H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	1.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...				PubChem Bioassay (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZV0
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [1-999,I813T] (Homo sapiens (Human))	BDBM114297 (2-[(3R,6S)-1-acetyl-6-(tosylcarbamoyl)-3,6-dihydro...) Show SMILES COC(=O)C([C@@H]1CN([C@@H](C=C1)C(=O)NS(=O)(=O)c1ccc(C)cc1)C(C)=O)C(=O)OC |c:9| Show InChI InChI=1S/C20H24N2O8S/c1-12-5-8-15(9-6-12)31(27,28)21-18(24)16-10-7-14(11-22(16)13(2)23)17(19(25)29-3)20(26)30-4/h5-10,14,16-17H,11H2,1-4H3,(H,21,24)/t14-,16-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	2.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...				PubChem Bioassay (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZV0
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [1-999,I813T] (Homo sapiens (Human))	BDBM18136 (ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...) Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C11H17N5O9P2/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(25-11)1-24-27(22,23)4-26(19,20)21/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H2,12,13,14)(H2,19,20,21)/t5-,7-,8-,11-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...				PubChem Bioassay (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZV0
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM50037060 (CHEMBL3355311) Show SMILES Cc1cc(Nc2cc(Cc3ccccc3)nc(N[C@H]3CC[C@H](O)CC3)n2)n[nH]1 |r,wU:18.18,wD:21.22,(15.15,-15.42,;13.62,-15.27,;12.59,-16.41,;11.18,-15.78,;9.85,-16.56,;9.85,-18.1,;8.52,-18.87,;8.52,-20.41,;7.19,-21.18,;5.85,-20.41,;5.86,-18.87,;4.53,-18.1,;3.19,-18.87,;3.2,-20.42,;4.53,-21.18,;9.85,-21.18,;11.19,-20.41,;12.53,-21.18,;12.53,-22.72,;13.86,-23.48,;13.86,-25.02,;12.52,-25.79,;12.52,-27.33,;11.19,-25.02,;11.19,-23.48,;11.19,-18.86,;11.34,-14.26,;12.84,-13.93,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Evotec UK Ltd Curated by ChEMBL					Assay Description Inhibition of PLC gamma-1 phosphorylation in human Jurkat T cells after 30 mins				Bioorg Med Chem Lett 24: 5818-23 (2014) Article DOI: 10.1016/j.bmcl.2014.10.020 BindingDB Entry DOI: 10.7270/Q2NK3GNT
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [1-999,I813T] (Homo sapiens (Human))	BDBM114292 (2-(2-cyano-3-pyridinyl)-2-methylpropanoic acid met...) Show SMILES COC(=O)C(C)(C)c1cccnc1C#N Show InChI InChI=1S/C11H12N2O2/c1-11(2,10(14)15-3)8-5-4-6-13-9(8)7-12/h4-6H,1-3H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	PCBioAssay	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Ass...				PubChem Bioassay (2014) BindingDB Entry DOI: 10.7270/Q2NC5ZV0
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM88558 (US9695200, 23) Show SMILES O=C(Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1)\C=C\CN1CCOCC1 Show InChI InChI=1S/C26H25N5O2/c32-25(5-2-10-31-11-13-33-14-12-31)30-22-4-1-3-20(15-22)21-16-23-24(18-29-26(23)28-17-21)19-6-8-27-9-7-19/h1-9,15-18H,10-14H2,(H,28,29)(H,30,32)/b5-2+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM98918 (US9695200, 44) Show SMILES Cc1cc(ncn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1 Show InChI InChI=1S/C21H17N5O/c1-3-20(27)26-16-6-4-5-14(8-16)15-9-17-18(11-23-21(17)22-10-15)19-7-13(2)24-12-25-19/h3-12H,1H2,2H3,(H,22,23)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM99728 (US9695200, 45) Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)nc(OC(C)C)c1 Show InChI InChI=1S/C24H23N5O3/c1-5-21(30)28-20-9-16(11-23(29-20)32-14(2)3)17-8-18-19(13-27-24(18)26-12-17)15-6-7-25-22(10-15)31-4/h5-14H,1H2,2-4H3,(H,26,27)(H,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM100840 (US9695200, 64) Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccnc4ccccc34)c2c1 Show InChI InChI=1S/C25H18N4O/c1-2-24(30)29-18-7-5-6-16(12-18)17-13-21-22(15-28-25(21)27-14-17)19-10-11-26-23-9-4-3-8-20(19)23/h2-15H,1H2,(H,27,28)(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM98772 (US9695200, 29) Show SMILES COc1cc(cc(C)n1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1 Show InChI InChI=1S/C23H20N4O2/c1-4-21(28)27-18-7-5-6-15(9-18)17-10-19-20(13-25-23(19)24-12-17)16-8-14(2)26-22(11-16)29-3/h4-13H,1H2,2-3H3,(H,24,25)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM98813 (US9695200, 39) Show SMILES COc1cc(ncn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1 Show InChI InChI=1S/C21H17N5O2/c1-3-19(27)26-15-6-4-5-13(7-15)14-8-16-17(11-23-21(16)22-10-14)18-9-20(28-2)25-12-24-18/h3-12H,1H2,2H3,(H,22,23)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM98807 (US9695200, 37) Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)\C=C\CN(C)C)c1 Show InChI InChI=1S/C25H25N5O2/c1-30(2)11-5-8-23(31)29-20-7-4-6-17(12-20)19-13-21-22(16-28-25(21)27-15-19)18-9-10-26-24(14-18)32-3/h4-10,12-16H,11H2,1-3H3,(H,27,28)(H,29,31)/b8-5+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM102354 (US9695200, 71) Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccc4[nH]ccc34)c2c1 Show InChI InChI=1S/C24H18N4O/c1-2-23(29)28-17-6-3-5-15(11-17)16-12-20-21(14-27-24(20)26-13-16)18-7-4-8-22-19(18)9-10-25-22/h2-14,25H,1H2,(H,26,27)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM100870 (US9695200, 66) Show SMILES CC(C)(O)Cn1cc(ccc1=O)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1 Show InChI InChI=1S/C25H24N4O3/c1-4-22(30)28-19-7-5-6-16(10-19)18-11-20-21(13-27-24(20)26-12-18)17-8-9-23(31)29(14-17)15-25(2,3)32/h4-14,32H,1,15H2,2-3H3,(H,26,27)(H,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM98793 (US9695200, 33) Show SMILES Cc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(\C=C(/C#N)C(N)=O)c1 Show InChI InChI=1S/C23H17N5O/c1-14-7-17(5-6-26-14)21-13-28-23-20(21)10-19(12-27-23)16-4-2-3-15(8-16)9-18(11-24)22(25)29/h2-10,12-13H,1H3,(H2,25,29)(H,27,28)/b18-9+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM99852 (US9695200, 58) Show SMILES COc1ccc(cn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)cc(c1)C(F)(F)F Show InChI InChI=1S/C23H17F3N4O2/c1-3-20(31)30-17-7-14(6-16(9-17)23(24,25)26)15-8-18-19(12-29-22(18)28-11-15)13-4-5-21(32-2)27-10-13/h3-12H,1H2,2H3,(H,28,29)(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM99802 (US9695200, 56) Show SMILES CNc1cc(ncn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1 |$;HN;;;;;;;;;;;;;;;;;;;;;;;;;;$| Show InChI InChI=1S/C21H18N6O/c1-3-20(28)27-15-6-4-5-13(7-15)14-8-16-17(11-24-21(16)23-10-14)18-9-19(22-2)26-12-25-18/h3-12H,1H2,2H3,(H,23,24)(H,27,28)(H,22,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM99793 (US9695200, 51) Show SMILES COc1cccc(c1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1 Show InChI InChI=1S/C23H19N3O2/c1-3-22(27)26-18-8-4-6-15(10-18)17-12-20-21(14-25-23(20)24-13-17)16-7-5-9-19(11-16)28-2/h3-14H,1H2,2H3,(H,24,25)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM99779 (US9695200, 48) Show SMILES CNc1ccc(cn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1 Show InChI InChI=1S/C22H19N5O/c1-3-21(28)27-17-6-4-5-14(9-17)16-10-18-19(13-26-22(18)25-12-16)15-7-8-20(23-2)24-11-15/h3-13H,1H2,2H3,(H,23,24)(H,25,26)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM98779 (US9695200, 30) Show SMILES COc1ccc(cn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1 Show InChI InChI=1S/C22H18N4O2/c1-3-20(27)26-17-6-4-5-14(9-17)16-10-18-19(13-25-22(18)24-12-16)15-7-8-21(28-2)23-11-15/h3-13H,1H2,2H3,(H,24,25)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM88537 (US9695200, 21) Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(c1)N(C)C(=O)C=C Show InChI InChI=1S/C23H20N4O2/c1-4-22(28)27(2)18-7-5-6-15(10-18)17-11-19-20(14-26-23(19)25-13-17)16-8-9-24-21(12-16)29-3/h4-14H,1H2,2-3H3,(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Homo sapiens (Human))	BDBM98850 (US9695200, 43) Show SMILES Clc1cncc(c1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1 Show InChI InChI=1S/C21H15ClN4O/c1-2-20(27)26-17-5-3-4-13(7-17)14-8-18-19(12-25-21(18)24-10-14)15-6-16(22)11-23-9-15/h2-12H,1H2,(H,24,25)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	37
Confluence Life Sciences, Inc. US Patent					Assay Description Compounds were serially diluted into DMSO, and then into media to concentrations 10× that of the final assay concentration. Compounds were then added...				US Patent US9695200 (2017) BindingDB Entry DOI: 10.7270/Q20G3H9T
					More data for this Ligand-Target Pair

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