Found 176 hits of ic50 for UniProtKB: P09217 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50468260
(CHEMBL4282837)Show SMILES [H][C@]12C[C@@H](NC)[C@@H](OC)[C@](C)(O1)n1c3ccc(O)cc3c3c4CNC(=O)c4c4c5cc(O)ccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O5/c1-28-26(36-3)17(29-2)10-20(37-28)31-18-6-4-12(33)8-14(18)22-23-16(11-30-27(23)35)21-15-9-13(34)5-7-19(15)32(28)25(21)24(22)31/h4-9,17,20,26,29,33-34H,10-11H2,1-3H3,(H,30,35)/t17-,20-,26-,28+/m1/s1 | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
PAK Research Center
Curated by ChEMBL
| Assay Description
Inhibition of rat brain PKC using RGFR derived peptide substrate |
Eur J Med Chem 142: 229-243 (2017)
Article DOI: 10.1016/j.ejmech.2017.07.043
BindingDB Entry DOI: 10.7270/Q21J9DG3 |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50469649
(CHEMBL283259)Show SMILES O=C1NC(=O)c2c1c1c3ccccc3n3CS(=O)(=O)Cn4c5ccccc5c2c4c13 Show InChI InChI=1S/C22H13N3O4S/c26-21-17-15-11-5-1-3-7-13(11)24-9-30(28,29)10-25-14-8-4-2-6-12(14)16(20(25)19(15)24)18(17)22(27)23-21/h1-8H,9-10H2,(H,23,26,27) | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50469642
(CHEMBL282805)Show SMILES CC1n2c3ccccc3c3c4C(=O)NC(=O)c4c4c5ccccc5n(C(C)S1(=O)=O)c4c23 Show InChI InChI=1S/C24H17N3O4S/c1-11-26-15-9-5-3-7-13(15)17-19-20(24(29)25-23(19)28)18-14-8-4-6-10-16(14)27(22(18)21(17)26)12(2)32(11,30)31/h3-12H,1-2H3,(H,25,28,29) | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50469642
(CHEMBL282805)Show SMILES CC1n2c3ccccc3c3c4C(=O)NC(=O)c4c4c5ccccc5n(C(C)S1(=O)=O)c4c23 Show InChI InChI=1S/C24H17N3O4S/c1-11-26-15-9-5-3-7-13(15)17-19-20(24(29)25-23(19)28)18-14-8-4-6-10-16(14)27(22(18)21(17)26)12(2)32(11,30)31/h3-12H,1-2H3,(H,25,28,29) | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB
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| Article
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cephalon, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of protein kinase C |
J Med Chem 40: 2994-6 (1997)
Article DOI: 10.1021/jm9702037
BindingDB Entry DOI: 10.7270/Q2377CF0 |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM50108296
(CHEMBL289772 | Indolocarbazole analogue)Show SMILES COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccc(CO)cc3c3c4CNC(=O)c4c4c5cc(CO)ccc5n2c4c13 Show InChI InChI=1S/C29H25N3O7/c1-28-29(37,27(36)38-2)9-20(39-28)31-18-5-3-13(11-33)7-15(18)22-23-17(10-30-26(23)35)21-16-8-14(12-34)4-6-19(16)32(28)25(21)24(22)31/h3-8,20,33-34,37H,9-12H2,1-2H3,(H,30,35)/t20?,28-,29-/m0/s1 | PDB
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa-Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor |
Bioorg Med Chem Lett 12: 147-50 (2001)
BindingDB Entry DOI: 10.7270/Q2571B94 |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50469644
(CHEMBL281448)Show SMILES O=C1NCc2c1c1c3ccccc3n3CS(=O)(=O)Cn4c5ccccc5c2c4c13 Show InChI InChI=1S/C22H15N3O3S/c26-22-19-14(9-23-22)17-12-5-1-3-7-15(12)24-10-29(27,28)11-25-16-8-4-2-6-13(16)18(19)21(25)20(17)24/h1-8H,9-11H2,(H,23,26) | PDB
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| PC cid
PC sid
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| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB
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TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50469655
(CHEMBL26872)Show InChI InChI=1S/C22H15N3OS/c26-22-19-14(9-23-22)17-12-5-1-3-7-15(12)24-10-27-11-25-16-8-4-2-6-13(16)18(19)21(25)20(17)24/h1-8H,9-11H2,(H,23,26) | PDB
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| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB
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| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain |
Bioorg Med Chem Lett 3: 1959-1964 (1993)
Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50469652
(CHEMBL285613)Show SMILES OCC(CO)N1Cn2c3ccccc3c3c4C(=O)NC(=O)c4c4c5ccccc5n(C1)c4c23 Show InChI InChI=1S/C25H20N4O4/c30-9-13(10-31)27-11-28-16-7-3-1-5-14(16)18-20-21(25(33)26-24(20)32)19-15-6-2-4-8-17(15)29(12-27)23(19)22(18)28/h1-8,13,30-31H,9-12H2,(H,26,32,33) | PDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of protein kinase C |
Bioorg Med Chem Lett 9: 2279-82 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2K90 |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50469643
(CHEMBL284632)Show SMILES O=C1NC(=O)c2c1c1c3ccccc3n3COCn4c5ccccc5c2c4c13 Show InChI InChI=1S/C22H13N3O3/c26-21-17-15-11-5-1-3-7-13(11)24-9-28-10-25-14-8-4-2-6-12(14)16(20(25)19(15)24)18(17)22(27)23-21/h1-8H,9-10H2,(H,23,26,27) | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50469641
(CHEMBL283903)Show SMILES O=C1NC(=O)c2c1c1c3ccccc3n3CSCn4c5ccccc5c2c4c13 Show InChI InChI=1S/C22H13N3O2S/c26-21-17-15-11-5-1-3-7-13(11)24-9-28-10-25-14-8-4-2-6-12(14)16(20(25)19(15)24)18(17)22(27)23-21/h1-8H,9-10H2,(H,23,26,27) | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
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| Article
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50469640
(CHEMBL26817)Show SMILES OCCN1Cn2c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n(C1)c4c23 Show InChI InChI=1S/C24H20N4O2/c29-10-9-26-12-27-17-7-3-1-5-14(17)19-16-11-25-24(30)21(16)20-15-6-2-4-8-18(15)28(13-26)23(20)22(19)27/h1-8,29H,9-13H2,(H,25,30) | PDB
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| PC cid
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50478518
(CHEMBL514017)Show SMILES [H][C@]12[C@]3([H])C=C(CO)C[C@]4(O)C(=O)C(C)=C[C@@]4([H])[C@@]3(O)[C@@H](C)C[C@@]1(OC(=O)C\C=C\C=C\CCCC)C2(C)C |r,c:14,t:4| Show InChI InChI=1S/C30H42O6/c1-6-7-8-9-10-11-12-13-24(32)36-29-16-20(3)30(35)22(25(29)27(29,4)5)15-21(18-31)17-28(34)23(30)14-19(2)26(28)33/h9-12,14-15,20,22-23,25,31,34-35H,6-8,13,16-18H2,1-5H3/b10-9+,12-11+/t20-,22-,23+,25+,28+,29-,30+/m0/s1 | PDB
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| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute
Curated by ChEMBL
| Assay Description
Displacement of [3H]PDBu from rat brain membrane PKC |
J Nat Prod 58: 769-72 (1995)
Article DOI: 10.1021/np50119a020
BindingDB Entry DOI: 10.7270/Q2NZ8BF5 |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50469645
(CHEMBL26074)Show SMILES OCCN1Cn2c3ccccc3c3c4C(=O)NC(=O)c4c4c5ccccc5n(C1)c4c23 Show InChI InChI=1S/C24H18N4O3/c29-10-9-26-11-27-15-7-3-1-5-13(15)17-19-20(24(31)25-23(19)30)18-14-6-2-4-8-16(14)28(12-26)22(18)21(17)27/h1-8,29H,9-12H2,(H,25,30,31) | PDB
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| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50469646
(CHEMBL27387)Show SMILES [O-][S+]1Cn2c3ccccc3c3c4C(=O)NC(=O)c4c4c5ccccc5n(C1)c4c23 Show InChI InChI=1S/C22H13N3O3S/c26-21-17-15-11-5-1-3-7-13(11)24-9-29(28)10-25-14-8-4-2-6-12(14)16(20(25)19(15)24)18(17)22(27)23-21/h1-8H,9-10H2,(H,23,26,27) | PDB
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| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50469639
(CHEMBL282298)Show SMILES CCOC(=O)C1n2c3ccccc3c3c4C(=O)NC(=O)c4c4c5ccccc5n(CS1(=O)=O)c4c23 Show InChI InChI=1S/C25H17N3O6S/c1-2-34-25(31)24-28-15-10-6-4-8-13(15)17-19-18(22(29)26-23(19)30)16-12-7-3-5-9-14(12)27(11-35(24,32)33)20(16)21(17)28/h3-10,24H,2,11H2,1H3,(H,26,29,30) | PDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50469650
(CHEMBL283399)Show SMILES O=C1NC(=O)c2c1c1c3ccccc3n3C4COCC(n5c6ccccc6c2c5c13)S4(=O)=O Show InChI InChI=1S/C24H15N3O5S/c28-23-19-17-11-5-1-3-7-13(11)26-15-9-32-10-16(33(15,30)31)27-14-8-4-2-6-12(14)18(22(27)21(17)26)20(19)24(29)25-23/h1-8,15-16H,9-10H2,(H,25,28,29) | PDB
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TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM3033
(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)Show SMILES Cn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CCC#N)c3c12 Show InChI InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29) | PDB
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TBA
Curated by ChEMBL
| Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain |
Bioorg Med Chem Lett 3: 1959-1964 (1993)
Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50469647
(CHEMBL283930)Show SMILES NC1=NC(=O)c2c1c1c3ccccc3n3COCn4c5ccccc5c2c4c13 |t:1| Show InChI InChI=1S/C22H14N4O2/c23-21-17-15-11-5-1-3-7-13(11)25-9-28-10-26-14-8-4-2-6-12(14)16(20(26)19(15)25)18(17)22(27)24-21/h1-8H,9-10H2,(H2,23,24,27) | PDB
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TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50469653
(CHEMBL282612)Show SMILES NC1=NC(=O)c2c1c1c3ccccc3n3CSCn4c5ccccc5c2c4c13 |t:1| Show InChI InChI=1S/C22H14N4OS/c23-21-17-15-11-5-1-3-7-13(11)25-9-28-10-26-14-8-4-2-6-12(14)16(20(26)19(15)25)18(17)22(27)24-21/h1-8H,9-10H2,(H2,23,24,27) | PDB
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TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM50280871
(12-(3-azidopropyl)-13-methyl-6,7,12,13-tetrahydro-...)Show SMILES Cn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CCCN=[N+]=[N-])c3c12 Show InChI InChI=1S/C24H20N6O/c1-29-17-9-4-2-7-14(17)20-21-16(13-26-24(21)31)19-15-8-3-5-10-18(15)30(23(19)22(20)29)12-6-11-27-28-25/h2-5,7-10H,6,11-13H2,1H3,(H,26,31) | PDB
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TBA
Curated by ChEMBL
| Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain |
Bioorg Med Chem Lett 3: 1959-1964 (1993)
Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM50280873
(2-(13-ethyl-5-oxo-6,7,12,13-tetrahydro-5H-indolo[2...)Show SMILES CCn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CCC#N)c3c12 Show InChI InChI=1S/C25H20N4O/c1-2-28-18-10-5-4-9-16(18)21-22-17(14-27-25(22)30)20-15-8-3-6-11-19(15)29(13-7-12-26)23(20)24(21)28/h3-6,8-11H,2,7,13-14H2,1H3,(H,27,30) | PDB
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TBA
Curated by ChEMBL
| Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain |
Bioorg Med Chem Lett 3: 1959-1964 (1993)
Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM50280870
(12-(2,2-difluoroethyl)-13-methyl-6,7,12,13-tetrahy...)Show SMILES Cn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CC(F)F)c3c12 Show InChI InChI=1S/C23H17F2N3O/c1-27-15-8-4-2-6-12(15)19-20-14(10-26-23(20)29)18-13-7-3-5-9-16(13)28(11-17(24)25)22(18)21(19)27/h2-9,17H,10-11H2,1H3,(H,26,29) | PDB
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TBA
Curated by ChEMBL
| Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain |
Bioorg Med Chem Lett 3: 1959-1964 (1993)
Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50478561
(CHEBI:69599 | Methylpendolmycin)Show SMILES [H][C@@]1([C@@H](C)CC)N(C)c2ccc(c3[nH]cc(C[C@@H](CO)NC1=O)c23)C(C)(C)C=C |r| Show InChI InChI=1S/C23H33N3O2/c1-7-14(3)21-22(28)25-16(13-27)11-15-12-24-20-17(23(4,5)8-2)9-10-18(19(15)20)26(21)6/h8-10,12,14,16,21,24,27H,2,7,11,13H2,1,3-6H3,(H,25,28)/t14-,16-,21-/m0/s1 | PDB
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Sterling Research Group
Curated by ChEMBL
| Assay Description
Displacement of radiolabeled PDBU from PKC in rat forebrain |
J Nat Prod 54: 1440-3
Article DOI: 10.1021/np50077a040
BindingDB Entry DOI: 10.7270/Q2377CGF |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM6760
((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)Show SMILES COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18?,26-,27-/m0/s1 | PDB
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TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50241867
(((2R,3R,4R,5R,6R)-6-(3,4-dihydroxyphenethoxy)-5-hy...)Show SMILES C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](OCCc3ccc(O)c(O)c3)O[C@H](CO)[C@H]2OC(=O)\C=C\c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O |r| Show InChI InChI=1S/C29H36O15/c1-13-22(36)23(37)24(38)29(41-13)44-27-25(39)28(40-9-8-15-3-6-17(32)19(34)11-15)42-20(12-30)26(27)43-21(35)7-4-14-2-5-16(31)18(33)10-14/h2-7,10-11,13,20,22-34,36-39H,8-9,12H2,1H3/b7-4+/t13-,20+,22-,23+,24+,25+,26+,27+,28+,29-/m0/s1 | PDB
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Sanofi Recherche
Curated by ChEMBL
| Assay Description
Displacement of [3H]PDBu from rat brain PKC by scintillation counting |
J Nat Prod 54: 1595-600
Article DOI: 10.1021/np50078a016
BindingDB Entry DOI: 10.7270/Q23T9KWX |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM50280877
(2-(5-oxo-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrr...)Show SMILES O=C1NCc2c1c1c3ccccc3[nH]c1c1n(CCC#N)c3ccccc3c21 Show InChI InChI=1S/C23H16N4O/c24-10-5-11-27-17-9-4-2-7-14(17)18-15-12-25-23(28)20(15)19-13-6-1-3-8-16(13)26-21(19)22(18)27/h1-4,6-9,26H,5,11-12H2,(H,25,28) | PDB
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TBA
Curated by ChEMBL
| Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain |
Bioorg Med Chem Lett 3: 1959-1964 (1993)
Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50469654
(CHEMBL28202)Show SMILES CN1Cn2c3ccccc3c3c4C(=O)NC(=O)c4c4c5ccccc5n(C1)c4c23 Show InChI InChI=1S/C23H16N4O2/c1-25-10-26-14-8-4-2-6-12(14)16-18-19(23(29)24-22(18)28)17-13-7-3-5-9-15(13)27(11-25)21(17)20(16)26/h2-9H,10-11H2,1H3,(H,24,28,29) | PDB
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TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50469651
(CHEMBL26996)Show SMILES ON1Cn2c3ccccc3c3c4C(=O)NC(=O)c4c4c5ccccc5n(C1)c4c23 Show InChI InChI=1S/C22H14N4O3/c27-21-17-15-11-5-1-3-7-13(11)25-9-24(29)10-26-14-8-4-2-6-12(14)16(20(26)19(15)25)18(17)22(28)23-21/h1-8,29H,9-10H2,(H,23,27,28) | PDB
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TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM50280868
(12-(2,3-dihydroxypropyl)-6,7,12,13-tetrahydro-5H-i...)Show SMILES OCC(O)Cn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4[nH]c3c12 Show InChI InChI=1S/C23H19N3O3/c27-11-12(28)10-26-17-8-4-2-6-14(17)18-15-9-24-23(29)20(15)19-13-5-1-3-7-16(13)25-21(19)22(18)26/h1-8,12,25,27-28H,9-11H2,(H,24,29) | PDB
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TBA
Curated by ChEMBL
| Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain |
Bioorg Med Chem Lett 3: 1959-1964 (1993)
Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM50280869
(13-methyl-12-propyl-6,7,12,13-tetrahydro-5H-indolo...)Show SMILES CCCn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4n(C)c3c12 Show InChI InChI=1S/C24H21N3O/c1-3-12-27-18-11-7-5-9-15(18)19-16-13-25-24(28)21(16)20-14-8-4-6-10-17(14)26(2)22(20)23(19)27/h4-11H,3,12-13H2,1-2H3,(H,25,28) | PDB
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TBA
Curated by ChEMBL
| Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain |
Bioorg Med Chem Lett 3: 1959-1964 (1993)
Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM50280875
(3-(5-oxo-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrr...)Show SMILES NC(=O)CCn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4[nH]c3c12 Show InChI InChI=1S/C23H18N4O2/c24-17(28)9-10-27-16-8-4-2-6-13(16)18-14-11-25-23(29)20(14)19-12-5-1-3-7-15(12)26-21(19)22(18)27/h1-8,26H,9-11H2,(H2,24,28)(H,25,29) | PDB
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TBA
Curated by ChEMBL
| Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain |
Bioorg Med Chem Lett 3: 1959-1964 (1993)
Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50469648
(CHEMBL26936)Show SMILES O=C1NC(=O)c2c1c1c3ccccc3n3CNCn4c5ccccc5c2c4c13 Show InChI InChI=1S/C22H14N4O2/c27-21-17-15-11-5-1-3-7-13(11)25-9-23-10-26-14-8-4-2-6-12(14)16(20(26)19(15)25)18(17)22(28)24-21/h1-8,23H,9-10H2,(H,24,27,28) | PDB
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TBA
| Assay Description
In vitro inhibition of protein kinase C from rat brain. |
Citation and Details
Article DOI: 10.1016/S0960-894X(01)80356-5
BindingDB Entry DOI: 10.7270/Q25M68DB |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB
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| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Protein kinase C beta 1 |
Bioorg Med Chem Lett 13: 1857-9 (2003)
BindingDB Entry DOI: 10.7270/Q2319V87 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM50280879
(12,13-diethyl-6,7,12,13-tetrahydro-5H-indolo[2,3-a...)Show SMILES CCn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4n(CC)c3c12 Show InChI InChI=1S/C24H21N3O/c1-3-26-17-11-7-5-9-14(17)19-16-13-25-24(28)21(16)20-15-10-6-8-12-18(15)27(4-2)23(20)22(19)26/h5-12H,3-4,13H2,1-2H3,(H,25,28) | PDB
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TBA
Curated by ChEMBL
| Assay Description
In vitro for inhibitory activity against protein kinase C from rat brain |
Bioorg Med Chem Lett 3: 1959-1964 (1993)
Article DOI: 10.1016/S0960-894X(01)80995-1
BindingDB Entry DOI: 10.7270/Q2QC03DJ |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM50128287
(3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-methyl-piperidi...)Show SMILES CN1CCC(CC1)n1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12 |t:11| Show InChI InChI=1S/C27H26N4O2/c1-29-13-11-17(12-14-29)31-16-21(19-8-4-6-10-23(19)31)25-24(26(32)28-27(25)33)20-15-30(2)22-9-5-3-7-18(20)22/h3-10,15-17H,11-14H2,1-2H3,(H,28,32,33) | PDB
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Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of purified rat brain protein kinase C (RB-PKC) |
Bioorg Med Chem Lett 13: 1857-9 (2003)
BindingDB Entry DOI: 10.7270/Q2319V87 |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM50128280
(3-[1-(1-Ethyl-piperidin-4-yl)-1H-indol-3-yl]-4-(1-...)Show SMILES CCN1CCC(CC1)n1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12 |t:12| Show InChI InChI=1S/C28H28N4O2/c1-3-31-14-12-18(13-15-31)32-17-22(20-9-5-7-11-24(20)32)26-25(27(33)29-28(26)34)21-16-30(2)23-10-6-4-8-19(21)23/h4-11,16-18H,3,12-15H2,1-2H3,(H,29,33,34) | PDB
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Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Protein kinase C beta 1 |
Bioorg Med Chem Lett 13: 1857-9 (2003)
BindingDB Entry DOI: 10.7270/Q2319V87 |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM50128282
(3-(1H-Indol-3-yl)-4-[1-(1-methyl-piperidin-4-yl)-1...)Show SMILES CN1CCC(CC1)n1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12 |t:11| Show InChI InChI=1S/C26H24N4O2/c1-29-12-10-16(11-13-29)30-15-20(18-7-3-5-9-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-4-2-6-17(19)21/h2-9,14-16,27H,10-13H2,1H3,(H,28,31,32) | PDB
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Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Protein kinase C beta 1 |
Bioorg Med Chem Lett 13: 1857-9 (2003)
BindingDB Entry DOI: 10.7270/Q2319V87 |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM50108291
(CHEMBL36891 | Indolocarbazole analogue)Show SMILES CCSCc1ccc2n3[C@H]4C[C@](O)(C(=O)OC)[C@](C)(O4)n4c5ccccc5c5c6CNC(=O)c6c(c2c1)c3c45 Show InChI InChI=1S/C30H27N3O5S/c1-4-39-14-15-9-10-19-17(11-15)23-24-18(13-31-27(24)34)22-16-7-5-6-8-20(16)33-26(22)25(23)32(19)21-12-30(36,28(35)37-3)29(33,2)38-21/h5-11,21,36H,4,12-14H2,1-3H3,(H,31,34)/t21?,29-,30-/m0/s1 | PDB
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Kyowa-Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor |
Bioorg Med Chem Lett 12: 147-50 (2001)
BindingDB Entry DOI: 10.7270/Q2571B94 |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM6760
((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)Show SMILES COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18?,26-,27-/m0/s1 | PDB
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Cephalon, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of protein kinase C |
J Med Chem 40: 2994-6 (1997)
Article DOI: 10.1021/jm9702037
BindingDB Entry DOI: 10.7270/Q2377CF0 |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM50128286
(3-[1-(1-Isopropyl-piperidin-4-yl)-1H-indol-3-yl]-4...)Show SMILES CC(C)N1CCC(CC1)n1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12 |t:13| Show InChI InChI=1S/C29H30N4O2/c1-18(2)32-14-12-19(13-15-32)33-17-23(21-9-5-7-11-25(21)33)27-26(28(34)30-29(27)35)22-16-31(3)24-10-6-4-8-20(22)24/h4-11,16-19H,12-15H2,1-3H3,(H,30,34,35) | PDB
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Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Protein kinase C beta 1 |
Bioorg Med Chem Lett 13: 1857-9 (2003)
BindingDB Entry DOI: 10.7270/Q2319V87 |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM50128290
(3-[1-(1-Cyclopropylmethyl-piperidin-4-yl)-1H-indol...)Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C3CCN(CC4CC4)CC3)c3ccccc23)c2ccccc12 |t:4| Show InChI InChI=1S/C30H30N4O2/c1-32-17-23(21-6-2-4-8-25(21)32)27-28(30(36)31-29(27)35)24-18-34(26-9-5-3-7-22(24)26)20-12-14-33(15-13-20)16-19-10-11-19/h2-9,17-20H,10-16H2,1H3,(H,31,35,36) | PDB
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Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of purified rat brain protein kinase C (RB-PKC) |
Bioorg Med Chem Lett 13: 1857-9 (2003)
BindingDB Entry DOI: 10.7270/Q2319V87 |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM50217039
(CHEMBL420938)Show InChI InChI=1S/C14H10O2S3/c15-6-9-5-14(17-8-9)13-4-3-12(19-13)11-2-1-10(7-16)18-11/h1-5,7-8,15H,6H2 | PDB
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Purdue University
Curated by ChEMBL
| Assay Description
Inhibition of protein kinase C |
Bioorg Med Chem Lett 9: 2279-82 (1999)
BindingDB Entry DOI: 10.7270/Q2MW2K90 |
More data for this
Ligand-Target Pair | |
Protein kinase C zeta type
(Rattus norvegicus) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB
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Tokyo University of Agriculture
Curated by ChEMBL
| Assay Description
Inhibition of PKC in rat RBL2H3 cells assessed as inhibition of mouse anti-DNP IgE-stimulated beta-hexosaminidase release preincubated for 15 mins fo... |
Bioorg Med Chem Lett 30: (2020)
Article DOI: 10.1016/j.bmcl.2019.126886
BindingDB Entry DOI: 10.7270/Q26Q21RR |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM50128281
(18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...)Show SMILES CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 |t:10| Show InChI InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 | PDB
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Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of purified rat brain protein kinase C (RB-PKC) |
Bioorg Med Chem Lett 13: 1857-9 (2003)
BindingDB Entry DOI: 10.7270/Q2319V87 |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM50108299
(CHEMBL288229 | Indolocarbazole analogue)Show SMILES CCSCc1ccc2n3c4c(c5CNC(=O)c5c5c6ccccc6n([C@H]6C[C@](O)(C(=O)OC)[C@]3(C)O6)c45)c2c1 Show InChI InChI=1S/C30H27N3O5S/c1-4-39-14-15-9-10-20-17(11-15)22-18-13-31-27(34)24(18)23-16-7-5-6-8-19(16)32-21-12-30(36,28(35)37-3)29(2,38-21)33(20)26(22)25(23)32/h5-11,21,36H,4,12-14H2,1-3H3,(H,31,34)/t21?,29-,30-/m0/s1 | PDB
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Kyowa-Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor |
Bioorg Med Chem Lett 12: 147-50 (2001)
BindingDB Entry DOI: 10.7270/Q2571B94 |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
(Rattus norvegicus-Rattus norvegicus (Rat)-Rattus n...) | BDBM50128288
(3-(1-Methyl-1H-indol-3-yl)-4-(1-piperidin-4-yl-1H-...)Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C3CCNCC3)c3ccccc23)c2ccccc12 |t:4| Show InChI InChI=1S/C26H24N4O2/c1-29-14-19(17-6-2-4-8-21(17)29)23-24(26(32)28-25(23)31)20-15-30(16-10-12-27-13-11-16)22-9-5-3-7-18(20)22/h2-9,14-16,27H,10-13H2,1H3,(H,28,31,32) | PDB
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Lilly Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of purified rat brain protein kinase C (RB-PKC) |
Bioorg Med Chem Lett 13: 1857-9 (2003)
BindingDB Entry DOI: 10.7270/Q2319V87 |
More data for this
Ligand-Target Pair | |
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