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Compile Data Set for Download or QSAR

Found 327 hits of ic50 for UniProtKB: P0C1R8   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phospho-N-acetylmuramoyl-pentapeptide-transferase


(Staphylococcus aureus (strain MRSA252))		BDBM50465326
PNG
(CHEMBL4283345)
Show SMILES [H][C@](O[C@@H]1O[C@H](CN)[C@@H](O)[C@H]1OC)([C@H](NCCCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)N[C@@H](C(C)C)C(O)=O)[C@]1([H])CCNC(=N)N1)[C@@H](OC(=O)CCCCCCCCCCCCC(C)C)C(C)C)C(O)=O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C54H93N11O18/c1-28(2)19-16-14-12-10-8-9-11-13-15-17-20-34(67)81-42(30(5)6)37(62-47(72)36(31-21-25-59-52(56)60-31)64-53(77)63-35(29(3)4)49(73)74)46(71)58-24-18-23-57-38(50(75)76)43(83-51-45(79-7)39(68)32(27-55)80-51)44-40(69)41(70)48(82-44)65-26-22-33(66)61-54(65)78/h22,26,28-32,35-45,48,51,57,68-70H,8-21,23-25,27,55H2,1-7H3,(H,58,71)(H,62,72)(H,73,74)(H,75,76)(H3,56,59,60)(H,61,66,78)(H2,63,64,77)/t31-,32+,35-,36-,37-,38-,39+,40-,41+,42-,43-,44-,45+,48+,51-/m0/s1
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n/an/a 0.00400n/an/an/an/an/an/a



Nanjing University of Chinese Medicine

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus MraY expressed in Escherichia coli membrane using Park's nucleotide as substrate pretreated for 30 mins followed ...

J Nat Prod 81: 942-948 (2018)


Article DOI: 10.1021/acs.jnatprod.7b01054
BindingDB Entry DOI: 10.7270/Q2XS5Z1V
More data for this
Ligand-Target Pair
Phospho-N-acetylmuramoyl-pentapeptide-transferase


(Staphylococcus aureus (strain MRSA252))		BDBM50465324
PNG
(CHEMBL4286766)
Show SMILES [H][C@](O[C@@H]1O[C@H](CN)[C@@H](O)[C@H]1OC)([C@H](NCCCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)N[C@@H](C(C)C)C(O)=O)[C@]1([H])CCNC(=N)N1)[C@@H](O)C(C)C)C(O)=O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C38H63N11O17/c1-14(2)19(33(57)58)47-37(61)48-20(16-7-11-43-36(40)44-16)31(56)46-21(23(51)15(3)4)30(55)42-10-6-9-41-22(34(59)60)27(66-35-29(63-5)24(52)17(13-39)64-35)28-25(53)26(54)32(65-28)49-12-8-18(50)45-38(49)62/h8,12,14-17,19-29,32,35,41,51-54H,6-7,9-11,13,39H2,1-5H3,(H,42,55)(H,46,56)(H,57,58)(H,59,60)(H3,40,43,44)(H,45,50,62)(H2,47,48,61)/t16-,17+,19-,20-,21-,22-,23-,24+,25-,26+,27-,28-,29+,32+,35-/m0/s1
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n/an/a 0.0160n/an/an/an/an/an/a



Nanjing University of Chinese Medicine

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus MraY expressed in Escherichia coli membrane using Park's nucleotide as substrate pretreated for 30 mins followed ...

J Nat Prod 81: 942-948 (2018)


Article DOI: 10.1021/acs.jnatprod.7b01054
BindingDB Entry DOI: 10.7270/Q2XS5Z1V
More data for this
Ligand-Target Pair
Phospho-N-acetylmuramoyl-pentapeptide-transferase


(Staphylococcus aureus (strain MRSA252))		BDBM50465327
PNG
(CHEMBL4279378)
Show SMILES [H][C@](O[C@@H]1O[C@H](CN)[C@@H](O)[C@H]1OC)([C@H](NCCCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)N[C@@H](C(C)C)C(O)=O)[C@]1([H])CCNC(=N)N1)[C@@H](OC(=O)CCCCCCCCCCC(C)C)C(C)C)C(O)=O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C52H89N11O18/c1-26(2)17-14-12-10-8-9-11-13-15-18-32(65)79-40(28(5)6)35(60-45(70)34(29-19-23-57-50(54)58-29)62-51(75)61-33(27(3)4)47(71)72)44(69)56-22-16-21-55-36(48(73)74)41(81-49-43(77-7)37(66)30(25-53)78-49)42-38(67)39(68)46(80-42)63-24-20-31(64)59-52(63)76/h20,24,26-30,33-43,46,49,55,66-68H,8-19,21-23,25,53H2,1-7H3,(H,56,69)(H,60,70)(H,71,72)(H,73,74)(H3,54,57,58)(H,59,64,76)(H2,61,62,75)/t29-,30+,33-,34-,35-,36-,37+,38-,39+,40-,41-,42-,43+,46+,49-/m0/s1
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n/an/a 0.0220n/an/an/an/an/an/a



Nanjing University of Chinese Medicine

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus MraY expressed in Escherichia coli membrane using Park's nucleotide as substrate pretreated for 30 mins followed ...

J Nat Prod 81: 942-948 (2018)


Article DOI: 10.1021/acs.jnatprod.7b01054
BindingDB Entry DOI: 10.7270/Q2XS5Z1V
More data for this
Ligand-Target Pair
Phospho-N-acetylmuramoyl-pentapeptide-transferase


(Staphylococcus aureus (strain MRSA252))		BDBM50465325
PNG
(CHEMBL4284923)
Show SMILES [H][C@](O[C@@H]1O[C@H](CNC(C)=O)[C@@H](O)[C@H]1OC)([C@H](NCCCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)N[C@@H](C(C)C)C(O)=O)[C@]1([H])CCNC(=N)N1)[C@@H](O)C(C)C)C(O)=O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Show InChI InChI=1S/C40H65N11O18/c1-15(2)21(35(60)61)49-39(64)50-22(18-8-12-44-38(41)46-18)33(59)48-23(25(54)16(3)4)32(58)43-11-7-10-42-24(36(62)63)29(69-37-31(66-6)26(55)19(67-37)14-45-17(5)52)30-27(56)28(57)34(68-30)51-13-9-20(53)47-40(51)65/h9,13,15-16,18-19,21-31,34,37,42,54-57H,7-8,10-12,14H2,1-6H3,(H,43,58)(H,45,52)(H,48,59)(H,60,61)(H,62,63)(H3,41,44,46)(H,47,53,65)(H2,49,50,64)/t18-,19+,21-,22-,23-,24-,25-,26+,27-,28+,29-,30-,31+,34+,37-/m0/s1
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n/an/a 0.0930n/an/an/an/an/an/a



Nanjing University of Chinese Medicine

Curated by ChEMBL


Assay Description
Inhibition of Staphylococcus aureus MraY expressed in Escherichia coli membrane using Park's nucleotide as substrate pretreated for 30 mins followed ...

J Nat Prod 81: 942-948 (2018)


Article DOI: 10.1021/acs.jnatprod.7b01054
BindingDB Entry DOI: 10.7270/Q2XS5Z1V
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475025
PNG
(CHEMBL181339)
Show SMILES O=C(C1CCOCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:15|
Show InChI InChI=1S/C28H25N5O4/c34-26-23(24(27(35)30-26)21-14-29-22-6-1-2-9-33(21)22)20-16-31-10-11-32(28(36)17-7-12-37-13-8-17)15-18-4-3-5-19(20)25(18)31/h1-6,9,14,16-17H,7-8,10-13,15H2,(H,30,34,35)
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n/an/a 0.800n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475007
PNG
(Bisarylmaleimide 2)
Show SMILES O=C(N1CCOCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cncc4ccoc34)c3cccc(C1)c23 |t:15|
Show InChI InChI=1S/C27H23N5O5/c33-25-21(19-13-28-12-16-4-9-37-24(16)19)22(26(34)29-25)20-15-31-5-6-32(27(35)30-7-10-36-11-8-30)14-17-2-1-3-18(20)23(17)31/h1-4,9,12-13,15H,5-8,10-11,14H2,(H,29,33,34)
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n/an/a 0.800n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475024
PNG
(CHEMBL181371)
Show SMILES CC(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cncc4ccoc34)c3cccc(C1)c23 |t:9|
Show InChI InChI=1S/C24H18N4O4/c1-13(29)27-6-7-28-12-18(16-4-2-3-15(11-27)21(16)28)20-19(23(30)26-24(20)31)17-10-25-9-14-5-8-32-22(14)17/h2-5,8-10,12H,6-7,11H2,1H3,(H,26,30,31)
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n/an/a 0.900n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475018
PNG
(CHEMBL181518)
Show SMILES CCC(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cncc4ccoc34)c3cccc(C1)c23 |t:10|
Show InChI InChI=1S/C25H20N4O4/c1-2-19(30)28-7-8-29-13-18(16-5-3-4-15(12-28)22(16)29)21-20(24(31)27-25(21)32)17-11-26-10-14-6-9-33-23(14)17/h3-6,9-11,13H,2,7-8,12H2,1H3,(H,27,31,32)
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n/an/a 1n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475031
PNG
(CHEMBL359871)
Show SMILES CC(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cccc4CCOc34)c3cccc(C1)c23 |t:9|
Show InChI InChI=1S/C25H21N3O4/c1-14(29)27-9-10-28-13-19(17-6-3-5-16(12-27)22(17)28)21-20(24(30)26-25(21)31)18-7-2-4-15-8-11-32-23(15)18/h2-7,13H,8-12H2,1H3,(H,26,30,31)
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n/an/a 1.10n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475029
PNG
(CHEMBL180779)
Show SMILES CN(C)C(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cncc4ccoc34)c3cccc(C1)c23 |t:11|
Show InChI InChI=1S/C25H21N5O4/c1-28(2)25(33)30-8-7-29-13-18(16-5-3-4-15(12-30)21(16)29)20-19(23(31)27-24(20)32)17-11-26-10-14-6-9-34-22(14)17/h3-6,9-11,13H,7-8,12H2,1-2H3,(H,27,31,32)
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n/an/a 1.20n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50150698
PNG
(3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...)
Show SMILES O=C(N1CCOCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:15|
Show InChI InChI=1S/C27H24N6O4/c34-25-22(23(26(35)29-25)20-14-28-21-6-1-2-7-33(20)21)19-16-31-8-9-32(27(36)30-10-12-37-13-11-30)15-17-4-3-5-18(19)24(17)31/h1-7,14,16H,8-13,15H2,(H,29,34,35)
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n/an/a 1.30n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475008
PNG
(CHEMBL369090)
Show SMILES O=C(N1CCOCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3ccn4ncccc34)c3cccc(C1)c23 |t:15|
Show InChI InChI=1S/C27H24N6O4/c34-25-22(19-6-8-33-21(19)5-2-7-28-33)23(26(35)29-25)20-16-31-9-10-32(27(36)30-11-13-37-14-12-30)15-17-3-1-4-18(20)24(17)31/h1-8,16H,9-15H2,(H,29,34,35)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50252729
PNG
((2''Z-3''E)-6-Bromoindirubin-3''-(O-{2-[4-(2-hydro...)
Show SMILES Cl.Cl.Brc1ccc2\C(C(=O)Nc2c1)=C1\Nc2ccccc2\C\1=N/OCCN1CCNCC1
Show InChI InChI=1S/C24H26BrN5O3/c25-16-5-6-17-20(15-16)27-24(32)21(17)23-22(18-3-1-2-4-19(18)26-23)28-33-14-12-30-9-7-29(8-10-30)11-13-31/h1-6,15,26,31H,7-14H2,(H,27,32)/b23-21-,28-22+
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TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113652
BindingDB Entry DOI: 10.7270/Q27H1PN4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475022
PNG
(CHEMBL361765)
Show SMILES CC(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cccc4ccoc34)c3cccc(C1)c23 |t:9|
Show InChI InChI=1S/C25H19N3O4/c1-14(29)27-9-10-28-13-19(17-6-3-5-16(12-27)22(17)28)21-20(24(30)26-25(21)31)18-7-2-4-15-8-11-32-23(15)18/h2-8,11,13H,9-10,12H2,1H3,(H,26,30,31)
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n/an/a 1.5n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50150701
PNG
(7-(4-(H-imidazo[1,2-a]pyridin-3-yl)-2,5-dioxo-2,5-...)
Show SMILES CN(C)C(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:11|
Show InChI InChI=1S/C25H22N6O3/c1-28(2)25(34)30-11-10-29-14-17(16-7-5-6-15(13-30)22(16)29)20-21(24(33)27-23(20)32)18-12-26-19-8-3-4-9-31(18)19/h3-9,12,14H,10-11,13H2,1-2H3,(H,27,32,33)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50474994
PNG
(Bisarylmaleimide 1)
Show SMILES O=C(N1CCCCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4cccnn34)c3cccc(C1)c23 |t:15|
Show InChI InChI=1S/C27H25N7O3/c35-25-22(23(26(36)30-25)20-14-28-21-8-5-9-29-34(20)21)19-16-32-12-13-33(27(37)31-10-2-1-3-11-31)15-17-6-4-7-18(19)24(17)32/h4-9,14,16H,1-3,10-13,15H2,(H,30,35,36)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50219326
PNG
(PYRAZOLOPYRIMIDINE 1)
Show SMILES CN(C)CCNC(=O)c1ccc(\C=N\Nc2ncnc3n(ncc23)-c2cccc3[nH]cnc23)cc1
Show InChI InChI=1S/C24H24N10O/c1-33(2)11-10-25-24(35)17-8-6-16(7-9-17)12-30-32-22-18-13-31-34(23(18)29-15-28-22)20-5-3-4-19-21(20)27-14-26-19/h3-9,12-15H,10-11H2,1-2H3,(H,25,35)(H,26,27)(H,28,29,32)/b30-12+
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n/an/a 1.60n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of glycogen synthase kinase-3 (GSK3-beta)

Bioorg Med Chem Lett 14: 2127-30 (2004)


BindingDB Entry DOI: 10.7270/Q2Q242DJ
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475010
PNG
(CHEMBL369316)
Show SMILES O=C(N1CCOCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ncccn34)c3cccc(C1)c23 |t:15|
Show InChI InChI=1S/C26H23N7O4/c34-23-20(21(24(35)29-23)19-13-28-25-27-5-2-6-33(19)25)18-15-31-7-8-32(26(36)30-9-11-37-12-10-30)14-16-3-1-4-17(18)22(16)31/h1-6,13,15H,7-12,14H2,(H,29,34,35)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50601873
PNG
(CHEMBL5190086)
Show SMILES CCn1cc(C2=C(C(=O)NC2=O)c2cccc(OCC[18F])c2)c2cc(F)ccc12 |t:5|
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TBA



Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c01571
BindingDB Entry DOI: 10.7270/Q25H7MBX
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475001
PNG
(CHEMBL368246)
Show SMILES CC(C)C(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:11|
Show InChI InChI=1S/C26H23N5O3/c1-15(2)26(34)30-11-10-29-14-18(17-7-5-6-16(13-30)23(17)29)21-22(25(33)28-24(21)32)19-12-27-20-8-3-4-9-31(19)20/h3-9,12,14-15H,10-11,13H2,1-2H3,(H,28,32,33)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475014
PNG
(CHEMBL361948)
Show SMILES CC(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:9|
Show InChI InChI=1S/C24H19N5O3/c1-14(30)27-9-10-28-13-17(16-6-4-5-15(12-27)22(16)28)20-21(24(32)26-23(20)31)18-11-25-19-7-2-3-8-29(18)19/h2-8,11,13H,9-10,12H2,1H3,(H,26,31,32)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475004
PNG
(CHEMBL369572)
Show SMILES O=C(N1CCCCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ncccn34)c3cccc(C1)c23 |t:15|
Show InChI InChI=1S/C27H25N7O3/c35-24-21(22(25(36)30-24)20-14-29-26-28-8-5-11-34(20)26)19-16-32-12-13-33(27(37)31-9-2-1-3-10-31)15-17-6-4-7-18(19)23(17)32/h4-8,11,14,16H,1-3,9-10,12-13,15H2,(H,30,35,36)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50150702
PNG
(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Show SMILES O=C(N1CCCCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4ccccn34)c3cccc(C1)c23 |t:15|
Show InChI InChI=1S/C28H26N6O3/c35-26-23(24(27(36)30-26)21-15-29-22-9-2-5-12-34(21)22)20-17-32-13-14-33(28(37)31-10-3-1-4-11-31)16-18-7-6-8-19(20)25(18)32/h2,5-9,12,15,17H,1,3-4,10-11,13-14,16H2,(H,30,35,36)
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n/an/a 2n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50386935
PNG
(CHEMBL2048680)
Show SMILES COc1ccc(cc1)-c1nc2nccc(C(=O)Nc3cnccc3C)c2[nH]1
Show InChI InChI=1S/C20H17N5O2/c1-12-7-9-21-11-16(12)23-20(26)15-8-10-22-19-17(15)24-18(25-19)13-3-5-14(27-2)6-4-13/h3-11H,1-2H3,(H,23,26)(H,22,24,25)
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Palack£ University

Curated by ChEMBL


Assay Description
Inhibition of GSK3 (unknown origin)

Eur J Med Chem 181: (2019)


Article DOI: 10.1016/j.ejmech.2019.111569
BindingDB Entry DOI: 10.7270/Q2H41VXG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50386935
PNG
(CHEMBL2048680)
Show SMILES COc1ccc(cc1)-c1nc2nccc(C(=O)Nc3cnccc3C)c2[nH]1
Show InChI InChI=1S/C20H17N5O2/c1-12-7-9-21-11-16(12)23-20(26)15-8-10-22-19-17(15)24-18(25-19)13-3-5-14(27-2)6-4-13/h3-11H,1-2H3,(H,23,26)(H,22,24,25)
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Palack£ University

Curated by ChEMBL


Assay Description
Inhibition of GSK3 (unknown origin)

Eur J Med Chem 181: (2019)


Article DOI: 10.1016/j.ejmech.2019.111569
BindingDB Entry DOI: 10.7270/Q2H41VXG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50474996
PNG
(CHEMBL178646)
Show SMILES O=C(N1CCCCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cncc4ccoc34)c3cccc(C1)c23 |t:15|
Show InChI InChI=1S/C28H25N5O4/c34-26-22(20-14-29-13-17-7-12-37-25(17)20)23(27(35)30-26)21-16-32-10-11-33(28(36)31-8-2-1-3-9-31)15-18-5-4-6-19(21)24(18)32/h4-7,12-14,16H,1-3,8-11,15H2,(H,30,34,35)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475006
PNG
(CHEMBL178851)
Show SMILES O=C(N1CCCCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4cnccn34)c3cccc(C1)c23 |t:15|
Show InChI InChI=1S/C27H25N7O3/c35-25-22(23(26(36)30-25)20-13-29-21-14-28-7-10-34(20)21)19-16-32-11-12-33(27(37)31-8-2-1-3-9-31)15-17-5-4-6-18(19)24(17)32/h4-7,10,13-14,16H,1-3,8-9,11-12,15H2,(H,30,35,36)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475000
PNG
(CHEMBL181296)
Show SMILES CC(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cccc4OCOc34)c3cccc(C1)c23 |t:9|
Show InChI InChI=1S/C24H19N3O5/c1-13(28)26-8-9-27-11-17(15-5-2-4-14(10-26)21(15)27)20-19(23(29)25-24(20)30)16-6-3-7-18-22(16)32-12-31-18/h2-7,11H,8-10,12H2,1H3,(H,25,29,30)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50219327
PNG
(GW811168X | PYRAZOLOPYRIMIDINE 2)
Show SMILES COc1cccc(c1)-n1ncc2c(N\N=C\c3ccc(cc3)S(C)(=O)=O)ncnc12
Show InChI InChI=1S/C20H18N6O3S/c1-29-16-5-3-4-15(10-16)26-20-18(12-24-26)19(21-13-22-20)25-23-11-14-6-8-17(9-7-14)30(2,27)28/h3-13H,1-2H3,(H,21,22,25)/b23-11+
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GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of glycogen synthase kinase-3 (GSK3-beta)

Bioorg Med Chem Lett 14: 2127-30 (2004)


BindingDB Entry DOI: 10.7270/Q2Q242DJ
More data for this
Ligand-Target Pair
Phospho-N-acetylmuramoyl-pentapeptide-transferase


(Staphylococcus aureus (strain MRSA252))		BDBM50526643
PNG
(CHEMBL4475677)
Show SMILES [H][C@@]1(O[C@H]([C@@]2([H])O[C@H]([C@H](O)[C@@H]2O)n2ccc(=O)[nH]c2=O)[C@]2([H])NC[C@@H](CCCCCCCCCCCCCCCCC)[C@H](N(C)C2=O)C(O)=O)O[C@H](CN)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C38H65N5O12/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23-22-40-26(34(49)42(2)27(23)36(50)51)32(55-37-31(48)28(45)24(21-39)53-37)33-29(46)30(47)35(54-33)43-20-19-25(44)41-38(43)52/h19-20,23-24,26-33,35,37,40,45-48H,3-18,21-22,39H2,1-2H3,(H,50,51)(H,41,44,52)/t23-,24-,26+,27+,28-,29+,30-,31-,32+,33+,35-,37+/m1/s1
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Griffith University

Curated by ChEMBL


Assay Description
Inhibition of MraY in Staphylococcus aureus

Eur J Med Chem 171: 462-474 (2019)


Article DOI: 10.1016/j.ejmech.2019.01.071
BindingDB Entry DOI: 10.7270/Q2K35Z3R
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475011
PNG
(CHEMBL178850)
Show SMILES CN(C)C(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cccc4ccoc34)c3cccc(C1)c23 |t:11|
Show InChI InChI=1S/C26H22N4O4/c1-28(2)26(33)30-11-10-29-14-19(17-7-4-6-16(13-30)22(17)29)21-20(24(31)27-25(21)32)18-8-3-5-15-9-12-34-23(15)18/h3-9,12,14H,10-11,13H2,1-2H3,(H,27,31,32)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50530427
PNG
(CHEMBL4562585)
Show SMILES CCSc1ccncc1NC(=O)c1ccnc2[nH]c(nc12)-c1ccc(cc1)N1CCCC1
Show InChI InChI=1S/C24H24N6OS/c1-2-32-20-10-11-25-15-19(20)27-24(31)18-9-12-26-23-21(18)28-22(29-23)16-5-7-17(8-6-16)30-13-3-4-14-30/h5-12,15H,2-4,13-14H2,1H3,(H,27,31)(H,26,28,29)
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Palack£ University

Curated by ChEMBL


Assay Description
Inhibition of GSK3 (unknown origin)

Eur J Med Chem 181: (2019)


Article DOI: 10.1016/j.ejmech.2019.111569
BindingDB Entry DOI: 10.7270/Q2H41VXG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50386917
PNG
(CHEMBL2048662)
Show SMILES CCS(=O)(=O)Nc1ccc(CCNC(=O)c2ccnc3nc([nH]c23)-c2ccsc2)cc1
Show InChI InChI=1S/C21H21N5O3S2/c1-2-31(28,29)26-16-5-3-14(4-6-16)7-10-23-21(27)17-8-11-22-20-18(17)24-19(25-20)15-9-12-30-13-15/h3-6,8-9,11-13,26H,2,7,10H2,1H3,(H,23,27)(H,22,24,25)
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Palack£ University

Curated by ChEMBL


Assay Description
Inhibition of GSK3 (unknown origin)

Eur J Med Chem 181: (2019)


Article DOI: 10.1016/j.ejmech.2019.111569
BindingDB Entry DOI: 10.7270/Q2H41VXG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50530427
PNG
(CHEMBL4562585)
Show SMILES CCSc1ccncc1NC(=O)c1ccnc2[nH]c(nc12)-c1ccc(cc1)N1CCCC1
Show InChI InChI=1S/C24H24N6OS/c1-2-32-20-10-11-25-15-19(20)27-24(31)18-9-12-26-23-21(18)28-22(29-23)16-5-7-17(8-6-16)30-13-3-4-14-30/h5-12,15H,2-4,13-14H2,1H3,(H,27,31)(H,26,28,29)
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Palack£ University

Curated by ChEMBL


Assay Description
Inhibition of GSK3 (unknown origin)

Eur J Med Chem 181: (2019)


Article DOI: 10.1016/j.ejmech.2019.111569
BindingDB Entry DOI: 10.7270/Q2H41VXG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50386917
PNG
(CHEMBL2048662)
Show SMILES CCS(=O)(=O)Nc1ccc(CCNC(=O)c2ccnc3nc([nH]c23)-c2ccsc2)cc1
Show InChI InChI=1S/C21H21N5O3S2/c1-2-31(28,29)26-16-5-3-14(4-6-16)7-10-23-21(27)17-8-11-22-20-18(17)24-19(25-20)15-9-12-30-13-15/h3-6,8-9,11-13,26H,2,7,10H2,1H3,(H,23,27)(H,22,24,25)
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Palack£ University

Curated by ChEMBL


Assay Description
Inhibition of GSK3 (unknown origin)

Eur J Med Chem 181: (2019)


Article DOI: 10.1016/j.ejmech.2019.111569
BindingDB Entry DOI: 10.7270/Q2H41VXG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475021
PNG
(CHEMBL445649)
Show SMILES CN(C)C(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3cccc4OCOc34)c3cccc(C1)c23 |t:11|
Show InChI InChI=1S/C25H22N4O5/c1-27(2)25(32)29-10-9-28-12-17(15-6-3-5-14(11-29)21(15)28)20-19(23(30)26-24(20)31)16-7-4-8-18-22(16)34-13-33-18/h3-8,12H,9-11,13H2,1-2H3,(H,26,30,31)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475016
PNG
(CHEMBL361007)
Show SMILES O=C(N1CCOCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3cnc4cnccn34)c3cccc(C1)c23 |t:15|
Show InChI InChI=1S/C26H23N7O4/c34-24-21(22(25(35)29-24)19-12-28-20-13-27-4-5-33(19)20)18-15-31-6-7-32(26(36)30-8-10-37-11-9-30)14-16-2-1-3-17(18)23(16)31/h1-5,12-13,15H,6-11,14H2,(H,29,34,35)
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n/an/a 3.20n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475009
PNG
(CHEMBL361635)
Show SMILES O=C1NC(=O)C(=C1c1cn2CCNCc3cccc1c23)c1cncc2ccoc12 |c:5|
Show InChI InChI=1S/C22H16N4O3/c27-21-17(15-10-24-9-13-4-7-29-20(13)15)18(22(28)25-21)16-11-26-6-5-23-8-12-2-1-3-14(16)19(12)26/h1-4,7,9-11,23H,5-6,8H2,(H,25,27,28)
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n/an/a 3.20n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475005
PNG
(CHEMBL178820)
Show SMILES O=C1NC(=O)C(=C1c1cn2CCNCc3cccc1c23)c1cccc2CCOc12 |c:5|
Show InChI InChI=1S/C23H19N3O3/c27-22-18(16-6-1-3-13-7-10-29-21(13)16)19(23(28)25-22)17-12-26-9-8-24-11-14-4-2-5-15(17)20(14)26/h1-6,12,24H,7-11H2,(H,25,27,28)
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n/an/a 3.30n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50474993
PNG
(CHEMBL361996)
Show SMILES O=C1NC(=O)C(=C1c1cn2CCNCc3cccc1c23)c1cccc2ccoc12 |c:5|
Show InChI InChI=1S/C23H17N3O3/c27-22-18(16-6-1-3-13-7-10-29-21(13)16)19(23(28)25-22)17-12-26-9-8-24-11-14-4-2-5-15(17)20(14)26/h1-7,10,12,24H,8-9,11H2,(H,25,27,28)
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n/an/a 3.40n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475028
PNG
(CHEMBL179725)
Show SMILES CC(C)C(=O)N1CCn2cc(C3=C(C(=O)NC3=O)C3=CN=[N+]4C=CC=CC34)c3cccc(C1)c23 |c:23,25,t:11,19,21|
Show InChI InChI=1S/C26H23N5O3/c1-15(2)26(34)30-11-10-29-14-19(17-7-5-6-16(13-30)23(17)29)22-21(24(32)28-25(22)33)18-12-27-31-9-4-3-8-20(18)31/h3-9,12,14-15,20H,10-11,13H2,1-2H3/p+1
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n/an/a 3.5n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50259157
PNG
(CHEMBL4061357)
Show SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2cc(Cl)c(Cl)cc12
Show InChI InChI=1S/C16H9Cl2N3O2/c17-9-5-8-12(6-10(9)18)20-16(22)13(8)15-14(21-23)7-3-1-2-4-11(7)19-15/h1-6,19,23H,(H,20,22)/b15-13-,21-14+
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n/an/a 4n/an/an/an/an/an/a



Jamia Hamdard (Hamdard University)

Curated by ChEMBL


Assay Description
Inhibition of GSK3alpha/beta (unknown origin) using GS-1 as substrate

Eur J Med Chem 125: 464-477 (2017)


Article DOI: 10.1016/j.ejmech.2016.09.058
BindingDB Entry DOI: 10.7270/Q2CN76CN
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50219340
PNG
(CHEMBL65944)
Show SMILES N(\N=C\c1ccncc1)c1ncnc2n(ncc12)-c1cccc2[nH]cnc12
Show InChI InChI=1S/C18H13N9/c1-2-14-16(21-10-20-14)15(3-1)27-18-13(9-25-27)17(22-11-23-18)26-24-8-12-4-6-19-7-5-12/h1-11H,(H,20,21)(H,22,23,26)/b24-8+
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n/an/a 4n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of glycogen synthase kinase-3 (GSK3-beta)

Bioorg Med Chem Lett 14: 2127-30 (2004)


BindingDB Entry DOI: 10.7270/Q2Q242DJ
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475020
PNG
(CHEMBL181464)
Show SMILES CN(C)C(=O)N1CCn2cc(C3=C(C(=O)NC3=O)c3ccn4ncccc34)c3cccc(C1)c23 |t:11|
Show InChI InChI=1S/C25H22N6O3/c1-28(2)25(34)30-12-11-29-14-18(16-6-3-5-15(13-30)22(16)29)21-20(23(32)27-24(21)33)17-8-10-31-19(17)7-4-9-26-31/h3-10,14H,11-13H2,1-2H3,(H,27,32,33)
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n/an/a 4.70n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50475027
PNG
(CHEMBL359537)
Show SMILES O=C1NC(=O)C(=C1c1cn2CCNCc3cccc1c23)c1cnc2cccnn12 |c:5|
Show InChI InChI=1S/C21H16N6O2/c28-20-17(14-11-26-8-7-22-9-12-3-1-4-13(14)19(12)26)18(21(29)25-20)15-10-23-16-5-2-6-24-27(15)16/h1-6,10-11,22H,7-9H2,(H,25,28,29)
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n/an/a 4.80n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against the Glycogen synthase kinase-3

Bioorg Med Chem Lett 15: 899-903 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.063
BindingDB Entry DOI: 10.7270/Q2H70JJG
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50025628
PNG
(CHEMBL3335124)
Show SMILES CO[C@H]1CC[C@@H](CC1)NC(=O)c1n[nH]cc1NC(=O)c1ccccc1 |r,wU:5.8,wD:2.1,(25.2,-17.72,;23.66,-17.71,;22.88,-19.04,;21.34,-19.03,;20.56,-20.36,;21.32,-21.69,;22.87,-21.71,;23.64,-20.38,;20.55,-23.02,;19.01,-23.02,;18.24,-21.68,;18.24,-24.35,;18.75,-25.81,;17.53,-26.74,;16.26,-25.87,;16.7,-24.4,;15.91,-23.07,;14.37,-23.09,;13.62,-24.43,;13.59,-21.76,;14.35,-20.43,;13.57,-19.1,;12.02,-19.12,;11.27,-20.47,;12.06,-21.79,)|
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University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human GSK3 using biotinylated GSP2 substrate by flashplate assay

J Med Chem 57: 7536-49 (2014)


Article DOI: 10.1021/jm500239b
BindingDB Entry DOI: 10.7270/Q2M04712
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM7262
PNG
(14-nitro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Show SMILES [O-][N+](=O)c1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
Show InChI InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
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n/an/a 5n/an/an/an/an/an/a



Central University

Curated by ChEMBL


Assay Description
Inhibition of glycogen synthase kinase-3 (unknown origin)

Eur J Med Chem 107: 63-81 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.018
BindingDB Entry DOI: 10.7270/Q2TH8PH8
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50025640
PNG
(CHEMBL3335141)
Show SMILES CO[C@H]1CC[C@@H](CC1)NC(=O)c1n[nH]cc1NC(=O)c1c(OC)cccc1OC |r,wU:5.8,wD:2.1,(25.2,-17.72,;23.66,-17.71,;22.88,-19.04,;21.34,-19.03,;20.56,-20.36,;21.32,-21.69,;22.87,-21.71,;23.64,-20.38,;20.55,-23.02,;19.01,-23.02,;18.24,-21.68,;18.24,-24.35,;18.75,-25.81,;17.53,-26.74,;16.26,-25.87,;16.7,-24.4,;15.91,-23.07,;14.37,-23.09,;13.62,-24.43,;13.59,-21.76,;12.06,-21.79,;11.3,-23.15,;12.1,-24.48,;11.27,-20.47,;12.02,-19.12,;13.57,-19.1,;14.35,-20.43,;15.9,-20.41,;16.67,-19.06,)|
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University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human GSK3 using biotinylated GSP2 substrate by flashplate assay

J Med Chem 57: 7536-49 (2014)


Article DOI: 10.1021/jm500239b
BindingDB Entry DOI: 10.7270/Q2M04712
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50025642
PNG
(CHEMBL3335143)
Show SMILES CO[C@H]1CC[C@@H](CC1)NC(=O)c1n[nH]cc1NC(=O)c1ccc(F)cc1F |r,wU:5.8,wD:2.1,(25.2,-17.72,;23.66,-17.71,;22.88,-19.04,;21.34,-19.03,;20.56,-20.36,;21.32,-21.69,;22.87,-21.71,;23.64,-20.38,;20.55,-23.02,;19.01,-23.02,;18.24,-21.68,;18.24,-24.35,;18.75,-25.81,;17.53,-26.74,;16.26,-25.87,;16.7,-24.4,;15.91,-23.07,;14.37,-23.09,;13.62,-24.43,;13.59,-21.76,;14.35,-20.43,;13.57,-19.1,;12.02,-19.12,;11.24,-17.79,;11.27,-20.47,;12.06,-21.79,;11.31,-23.13,)|
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University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human GSK3 using biotinylated GSP2 substrate by flashplate assay

J Med Chem 57: 7536-49 (2014)


Article DOI: 10.1021/jm500239b
BindingDB Entry DOI: 10.7270/Q2M04712
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))		BDBM50025643
PNG
(CHEMBL3335144)
Show SMILES CO[C@H]1CC[C@@H](CC1)NC(=O)c1n[nH]cc1NC(=O)c1cc(F)cc(F)c1 |r,wU:5.8,wD:2.1,(25.2,-17.72,;23.66,-17.71,;22.88,-19.04,;21.34,-19.03,;20.56,-20.36,;21.32,-21.69,;22.87,-21.71,;23.64,-20.38,;20.55,-23.02,;19.01,-23.02,;18.24,-21.68,;18.24,-24.35,;18.75,-25.81,;17.53,-26.74,;16.26,-25.87,;16.7,-24.4,;15.91,-23.07,;14.37,-23.09,;13.62,-24.43,;13.59,-21.76,;12.06,-21.79,;11.27,-20.47,;9.71,-20.49,;12.02,-19.12,;13.57,-19.1,;14.33,-17.75,;14.35,-20.43,)|
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University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human GSK3 using biotinylated GSP2 substrate by flashplate assay

J Med Chem 57: 7536-49 (2014)


Article DOI: 10.1021/jm500239b
BindingDB Entry DOI: 10.7270/Q2M04712
More data for this
Ligand-Target Pair
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