| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 |
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| Ligand | BDBM50475008 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305938 (CHEMBL833485) |
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| IC50 | 1.3±n/a nM |
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| Citation |  Engler, TA; Malhotra, S; Burkholder, TP; Henry, JR; Mendel, D; Porter, WJ; Furness, K; Diefenbacher, C; Marquart, A; Reel, JK; Li, Y; Clayton, J; Cunningham, B; McLean, J; O'toole, JC; Brozinick, J; Hawkins, E; Misener, E; Briere, D; Brier, RA; Wagner, JR; Campbell, RM; Anderson, BD; Vaughn, R; Bennett, DB; Meier, TI; Cook, JA The development of potent and selective bisarylmaleimide GSK3 inhibitors. Bioorg Med Chem Lett15:899-903 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 |
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| Name: | Glycogen synthase kinase-3 |
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| Synonyms: | Glycogen synthase kinase-3 alpha/beta |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 2193535 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Glycogen synthase kinase-3 alpha |
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| Synonyms: | GSK-3 alpha | GSK3A | GSK3A_HUMAN | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 50991.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49840 |
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| Residue: | 483 |
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| Sequence: | MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV
GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP
PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT
NSS
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| Component 2 |
| Name: | Glycogen synthase kinase-3 beta |
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| Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
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| Type: | Enzyme |
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| Mol. Mass.: | 46756.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49841 |
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| Residue: | 420 |
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| Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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| BDBM50475008 |
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| n/a |
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| Name | BDBM50475008 |
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| Synonyms: | CHEMBL369090 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H24N6O4 |
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| Mol. Mass. | 496.5173 |
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| SMILES | O=C(N1CCOCC1)N1CCn2cc(C3=C(C(=O)NC3=O)c3ccn4ncccc34)c3cccc(C1)c23 |t:15| |
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| Structure | 
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