Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ribosomal protein S6 kinase beta-2 (Homo sapiens (Human)) | BDBM2579![]() ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 0.726 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human p70S6Kb using KKRNRTLTK as substrate by [gamma-33P]-ATP assay | Citation and Details Article DOI: 10.1016/j.bmc.2018.02.022 BindingDB Entry DOI: 10.7270/Q2DJ5KB8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-2 (Homo sapiens (Human)) | BDBM2579![]() ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida Curated by ChEMBL | Assay Description Inhibition of human p70S6Kb using KKRNRTLTK as substrate by [gamma-33P]-ATP assay | Eur J Med Chem 161: 456-467 (2019) Article DOI: 10.1016/j.ejmech.2018.10.052 BindingDB Entry DOI: 10.7270/Q2W380MT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-2 (Homo sapiens (Human)) | BDBM50168247![]() (2,3-Di-thiophen-2-yl-benzo[g]quinoxaline-7-carboxy...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description In vitro inhibition of SR protein kinase 1 by compound dissolved in 100% DMSO using 5'-[gamma-33P]-triphosphate | Bioorg Med Chem Lett 15: 3241-6 (2005) Article DOI: 10.1016/j.bmcl.2005.04.064 BindingDB Entry DOI: 10.7270/Q2W37VVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-2 (Homo sapiens (Human)) | BDBM50168248![]() (CHEMBL192909 | {5-[3-(4-Carboxymethyl-thiophen-2-y...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description In vitro inhibition of SR protein kinase 1 by compound dissolved in 100% DMSO using 5'-[gamma-33P]-triphosphate | Bioorg Med Chem Lett 15: 3241-6 (2005) Article DOI: 10.1016/j.bmcl.2005.04.064 BindingDB Entry DOI: 10.7270/Q2W37VVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-2 (Homo sapiens (Human)) | BDBM50168244![]() (4-(5-{3-[5-(3-Carboxy-propyl)-thiophen-2-yl]-benzo...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 820 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description In vitro inhibition of SR protein kinase 1 by compound dissolved in 100% DMSO using 5'-[gamma-33P]-triphosphate | Bioorg Med Chem Lett 15: 3241-6 (2005) Article DOI: 10.1016/j.bmcl.2005.04.064 BindingDB Entry DOI: 10.7270/Q2W37VVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-2 (Homo sapiens (Human)) | BDBM50168242![]() (3-(5-{3-[5-(2-Carboxy-ethyl)-thiophen-2-yl]-benzo[...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 870 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description In vitro inhibition of SR protein kinase 1 by compound dissolved in 100% DMSO using 5'-[gamma-33P]-triphosphate | Bioorg Med Chem Lett 15: 3241-6 (2005) Article DOI: 10.1016/j.bmcl.2005.04.064 BindingDB Entry DOI: 10.7270/Q2W37VVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-2 (Homo sapiens (Human)) | BDBM50168241![]() (6,7-Di-thiophen-2-yl-2,3-dihydro-1,4-dioxa-5,8-dia...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 950 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description In vitro inhibition of SR protein kinase 1 by compound dissolved in 100% DMSO using 5'-[gamma-33P]-triphosphate | Bioorg Med Chem Lett 15: 3241-6 (2005) Article DOI: 10.1016/j.bmcl.2005.04.064 BindingDB Entry DOI: 10.7270/Q2W37VVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-1/beta-2 (Homo sapiens (Human)) | BDBM50196392![]() (3-hydroxy-N-(2-hydroxy-1-methyl-ethyl)-5-(4-phenyl...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Valeant Pharmaceuticals Research & Development Curated by ChEMBL | Assay Description Inhibition of p70 S6 kinase | Bioorg Med Chem Lett 16: 5561-6 (2006) Article DOI: 10.1016/j.bmcl.2006.08.048 BindingDB Entry DOI: 10.7270/Q2J38S5D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-1/beta-2 (Homo sapiens (Human)) | BDBM50192071![]() ((13R,15S)-13-methyl-16-oxa-8,9,12,22,24-pentaazahe...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of p706SK | Bioorg Med Chem Lett 16: 5122-6 (2006) Article DOI: 10.1016/j.bmcl.2006.07.026 BindingDB Entry DOI: 10.7270/Q2K35VF0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase alpha-1/alpha-2/alpha-3/alpha-4/alpha-5/alpha-6/beta-1/beta-2 (Homo sapiens (Human)) | BDBM50532181![]() (CHEMBL4474690) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE KEGG PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. Curated by ChEMBL | Assay Description Inhibition of human full-length N-terminal His-tagged p70S6K expressed in baculovirus infected Sf21 insect cells using CKRRRLASLR as substrate | Bioorg Med Chem Lett 29: 873-877 (2019) Article DOI: 10.1016/j.bmcl.2019.02.006 BindingDB Entry DOI: 10.7270/Q22F7RXK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase alpha-1/alpha-2/alpha-3/alpha-4/alpha-5/alpha-6/beta-1/beta-2 (Homo sapiens (Human)) | BDBM50460772![]() (CHEMBL4225923) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Inhibition of S6K (unknown origin) | Bioorg Med Chem Lett 28: 1397-1403 (2018) Article DOI: 10.1016/j.bmcl.2018.02.037 BindingDB Entry DOI: 10.7270/Q2K35X91 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-1/beta-2 (Homo sapiens (Human)) | BDBM50126732![]() (2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of Ribosomal protein S6 kinase (P70S6K kinase) | J Med Chem 46: 1337-49 (2003) Article DOI: 10.1021/jm020446l BindingDB Entry DOI: 10.7270/Q2DN44FW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-2 (Homo sapiens (Human)) | BDBM50168239![]() (7,8-Dimethoxy-2,3-di-thiophen-2-yl-pyrazino[2,3-b]...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description In vitro inhibition of SR protein kinase 1 by compound dissolved in 100% DMSO using 5'-[gamma-33P]-triphosphate | Bioorg Med Chem Lett 15: 3241-6 (2005) Article DOI: 10.1016/j.bmcl.2005.04.064 BindingDB Entry DOI: 10.7270/Q2W37VVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-2 (Homo sapiens (Human)) | BDBM50168236![]() (CHEMBL193162 | {5-[3-(5-Carboxymethyl-thiophen-2-y...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description In vitro inhibition of SR protein kinase 1 by compound dissolved in 100% DMSO using 5'-[gamma-33P]-triphosphate | Bioorg Med Chem Lett 15: 3241-6 (2005) Article DOI: 10.1016/j.bmcl.2005.04.064 BindingDB Entry DOI: 10.7270/Q2W37VVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-2 (Homo sapiens (Human)) | BDBM50168235![]() (2,3-Di-thiophen-2-yl-benzo[g]quinoxaline | CHEMBL3...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description In vitro inhibition of SR protein kinase 1 by compound dissolved in 100% DMSO using 5'-[gamma-33P]-triphosphate | Bioorg Med Chem Lett 15: 3241-6 (2005) Article DOI: 10.1016/j.bmcl.2005.04.064 BindingDB Entry DOI: 10.7270/Q2W37VVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-2 (Homo sapiens (Human)) | BDBM50583520![]() (CHEMBL5094006) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human recombinant P70S6Kbeta expressed in Sf9 insect cells using [KKRNRTLTK] as substrate in presence of [33P]-ATP by radiometric hotsp... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01165 BindingDB Entry DOI: 10.7270/Q2T157JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-1/beta-2 (Homo sapiens (Human)) | BDBM50194024![]() (3-hydroxy-N-1-hydroxypropan-2-yl)-5-4-phenoxypheny...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.62E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Valeant Pharmaceuticals Research & Development Curated by ChEMBL | Assay Description Inhibition of p70 S6 kinase | Bioorg Med Chem Lett 16: 5561-6 (2006) Article DOI: 10.1016/j.bmcl.2006.08.048 BindingDB Entry DOI: 10.7270/Q2J38S5D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-2 (Homo sapiens (Human)) | BDBM50168243![]() (3-(5-{3-[5-(2-Methoxycarbonyl-ethyl)-thiophen-2-yl...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description In vitro inhibition of SR protein kinase 1 by compound dissolved in 100% DMSO using 5'-[gamma-33P]-triphosphate | Bioorg Med Chem Lett 15: 3241-6 (2005) Article DOI: 10.1016/j.bmcl.2005.04.064 BindingDB Entry DOI: 10.7270/Q2W37VVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-2 (Homo sapiens (Human)) | BDBM50168246![]() (2,3-Di-thiophen-2-yl-quinoxaline-6,7-diol | CHEMBL...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description In vitro inhibition of SR protein kinase 1 by compound dissolved in 100% DMSO using 5'-[gamma-33P]-triphosphate | Bioorg Med Chem Lett 15: 3241-6 (2005) Article DOI: 10.1016/j.bmcl.2005.04.064 BindingDB Entry DOI: 10.7270/Q2W37VVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-2 (Homo sapiens (Human)) | BDBM50135286![]() (CHEMBL3745885) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Icahn School of Medicine at Mount Sinai Curated by ChEMBL | Assay Description Inhibition of human RPS6KB2 using [KKRNRTLTK] as substrate | Bioorg Med Chem 24: 521-44 (2016) Article DOI: 10.1016/j.bmc.2015.11.045 BindingDB Entry DOI: 10.7270/Q24Q7WT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-2 (Homo sapiens (Human)) | BDBM50168249![]() (5-[3-(5-carboxythien-2-yl)benzo[g]quinoxalin-2-yl]...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description In vitro inhibition of SR protein kinase 1 by compound dissolved in 100% DMSO using 5'-[gamma-33P]-triphosphate | Bioorg Med Chem Lett 15: 3241-6 (2005) Article DOI: 10.1016/j.bmcl.2005.04.064 BindingDB Entry DOI: 10.7270/Q2W37VVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-1/beta-2 (Homo sapiens (Human)) | BDBM50169959![]() (2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Serono Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of p70S6K | J Med Chem 48: 4596-607 (2005) Article DOI: 10.1021/jm0310986 BindingDB Entry DOI: 10.7270/Q2K9389G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-2 (Homo sapiens (Human)) | BDBM50168250![]() (CHEMBL192974 | {5-[3-(4-Methoxycarbonylmethyl-thio...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.18E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description In vitro inhibition of SR protein kinase 1 by compound dissolved in 100% DMSO using 5'-[gamma-33P]-triphosphate | Bioorg Med Chem Lett 15: 3241-6 (2005) Article DOI: 10.1016/j.bmcl.2005.04.064 BindingDB Entry DOI: 10.7270/Q2W37VVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-2 (Homo sapiens (Human)) | BDBM50168238![]() (6,7-Dimethoxy-2,3-di-thiophen-2-yl-quinoxaline | C...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.63E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description In vitro inhibition of SR protein kinase 1 by compound dissolved in 100% DMSO using 5'-[gamma-33P]-triphosphate | Bioorg Med Chem Lett 15: 3241-6 (2005) Article DOI: 10.1016/j.bmcl.2005.04.064 BindingDB Entry DOI: 10.7270/Q2W37VVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-2 (Homo sapiens (Human)) | BDBM50168237![]() (6,7-Di-thiophen-2-yl-2,3-dihydro-1,4-dioxa-5,8-dia...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.34E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description In vitro inhibition of SR protein kinase 1 by compound dissolved in 100% DMSO using 5'-[gamma-33P]-triphosphate | Bioorg Med Chem Lett 15: 3241-6 (2005) Article DOI: 10.1016/j.bmcl.2005.04.064 BindingDB Entry DOI: 10.7270/Q2W37VVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase beta-2 (Homo sapiens (Human)) | BDBM50168240![]() (6,7-Di-thiophen-2-yl-[1,3]dioxolo[4,5-g]quinoxalin...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.85E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Semmelweis University Curated by ChEMBL | Assay Description In vitro inhibition of SR protein kinase 1 by compound dissolved in 100% DMSO using 5'-[gamma-33P]-triphosphate | Bioorg Med Chem Lett 15: 3241-6 (2005) Article DOI: 10.1016/j.bmcl.2005.04.064 BindingDB Entry DOI: 10.7270/Q2W37VVX | |||||||||||
More data for this Ligand-Target Pair |