BindingDB PrimarySearch

Found 162 hits of ec50 for UniProtKB: P23204
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50171900 ((S)-3-Phenyl-2-(4-thiophen-2-yl-phenoxy)-propionic...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.150	n/a	n/a	n/a	n/a
Università degli Studi di Milano Curated by ChEMBL					Assay Description Effective concentration against murine PPARalpha in transactivation assay				J Med Chem 48: 5509-19 (2005) Article DOI: 10.1021/jm0502844 BindingDB Entry DOI: 10.7270/Q2PV6JXF
Università degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM28759 ((2S)-3-phenyl-2-(4-phenylphenoxy)propanoic acid \| ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a
Università degli Studi di Milano Curated by ChEMBL					Assay Description Effective concentration against murine PPARalpha in transactivation assay				J Med Chem 48: 5509-19 (2005) Article DOI: 10.1021/jm0502844 BindingDB Entry DOI: 10.7270/Q2PV6JXF
Università degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50171898 ((S)-3-Phenyl-2-(4-trifluoromethyl-phenoxy)-propion...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.270	n/a	n/a	n/a	n/a
Università degli Studi di Milano Curated by ChEMBL					Assay Description Effective concentration against murine PPARalpha in transactivation assay				J Med Chem 48: 5509-19 (2005) Article DOI: 10.1021/jm0502844 BindingDB Entry DOI: 10.7270/Q2PV6JXF
Università degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50171895 ((2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid \| (...) Show SMILES CCc1ccc(O[C@@H](Cc2ccccc2)C(O)=O)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.350	n/a	n/a	n/a	n/a
Università degli Studi di Milano Curated by ChEMBL					Assay Description Effective concentration against murine PPARalpha in transactivation assay				J Med Chem 48: 5509-19 (2005) Article DOI: 10.1021/jm0502844 BindingDB Entry DOI: 10.7270/Q2PV6JXF
Università degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50099491 (2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Activation of murine PPAR alpha ligand binding domain				Bioorg Med Chem Lett 11: 1225-7 (2001) BindingDB Entry DOI: 10.7270/Q2Z31XX0
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50171897 ((2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid \| ...) Show SMILES OC(=O)[C@H](Cc1ccccc1)Oc1ccc(Cl)cc1 \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
Università degli Studi di Milano Curated by ChEMBL					Assay Description Effective concentration against murine PPARalpha in transactivation assay				J Med Chem 48: 5509-19 (2005) Article DOI: 10.1021/jm0502844 BindingDB Entry DOI: 10.7270/Q2PV6JXF
Università degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50229206 (CHEMBL253310 \| N-(4-(trifluoromethylsulfonamido)be...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50568096 (CHEMBL4866115) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at Gal4-fused mouse PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated f...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116193 BindingDB Entry DOI: 10.7270/Q2N01B8M
TBA					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50568100 (CHEMBL4861761) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at Gal4-fused mouse PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated f...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116193 BindingDB Entry DOI: 10.7270/Q2N01B8M
TBA					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM28799 (2-{[4-(2-{[(2,4-difluorophenyl)carbamoyl](heptyl)a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
Glaxo Wellcome Research & Development Curated by ChEMBL					Assay Description Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor transfected CV-1 ...				J Med Chem 42: 3785-8 (1999) BindingDB Entry DOI: 10.7270/Q29C6WM9
Glaxo Wellcome Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM28799 (2-{[4-(2-{[(2,4-difluorophenyl)carbamoyl](heptyl)a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
Glaxo Wellcome Research & Development Curated by ChEMBL					Assay Description Agonist activity for murine PPAR alpha receptor in transcriptional activation assay				J Med Chem 43: 527-50 (2000) BindingDB Entry DOI: 10.7270/Q2H994DT
Glaxo Wellcome Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50568097 (CHEMBL4879102) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at Gal4-fused mouse PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated f...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116193 BindingDB Entry DOI: 10.7270/Q2N01B8M
TBA					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50081223 (2-(4-{2-[3-(2,4-Difluoro-phenyl)-1-heptyl-ureido]-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Glaxo Wellcome Research & Development Curated by ChEMBL					Assay Description Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor transfected CV-1 ...				J Med Chem 42: 3785-8 (1999) BindingDB Entry DOI: 10.7270/Q29C6WM9
Glaxo Wellcome Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM28799 (2-{[4-(2-{[(2,4-difluorophenyl)carbamoyl](heptyl)a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Bayer-Schering Pharma Curated by ChEMBL					Assay Description Agonist activity at Gal4-fused mouse PPARalpha				Bioorg Med Chem Lett 20: 3376-9 (2010) Article DOI: 10.1016/j.bmcl.2010.04.019 BindingDB Entry DOI: 10.7270/Q27944V8
Bayer-Schering Pharma Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50568102 (CHEMBL4847453) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at Gal4-fused mouse PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated f...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116193 BindingDB Entry DOI: 10.7270/Q2N01B8M
TBA					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50584465 (CHEMBL5084377) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at mouse PPARalpha transfected in Cos7 cells co-expressing with pBIND and pGL4.35 Gal4 UAS Luc reporter plasmid by measuring lucifer...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02002 BindingDB Entry DOI: 10.7270/Q2VQ36KV
TBA					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM28706 (2-methyl-2-phenoxypropanoic acid, 25a \| 2-methyl-2...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50568103 (CHEMBL4847989) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at Gal4-fused mouse PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated f...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116193 BindingDB Entry DOI: 10.7270/Q2N01B8M
TBA					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50229219 (4'-chloro-biphenyl-4-carboxylic acid 4-trifluorome...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50568099 (CHEMBL4855604) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at Gal4-fused mouse PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated f...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116193 BindingDB Entry DOI: 10.7270/Q2N01B8M
TBA					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50568098 (CHEMBL4877444) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at Gal4-fused mouse PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated f...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116193 BindingDB Entry DOI: 10.7270/Q2N01B8M
TBA					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50319262 (2-(4-(((2-(2,4-dimethylphenylamino)-2-oxoethyl)(fu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Bayer-Schering Pharma Curated by ChEMBL					Assay Description Agonist activity at Gal4-fused mouse PPARalpha				Bioorg Med Chem Lett 20: 3376-9 (2010) Article DOI: 10.1016/j.bmcl.2010.04.019 BindingDB Entry DOI: 10.7270/Q27944V8
Bayer-Schering Pharma Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50244809 ((2R)-2-[3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(triflu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	28	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha receptor expressed in african green monkey COS1 cells co-transfected with fused yeast Gal4-DBD by transactivation...				J Med Chem 52: 4443-53 (2009) Article DOI: 10.1021/jm900367w BindingDB Entry DOI: 10.7270/Q2028RK2
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50568101 (CHEMBL4870407) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at Gal4-fused mouse PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated f...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116193 BindingDB Entry DOI: 10.7270/Q2N01B8M
TBA					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50225835 ((2s,5s)-2-methyl-5-(4-(5-methyl-2-p-tolyloxazol-4-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
Nippon Shinyaku Co., Ltd Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha expressed in CV1 cells by transactivation assay				Bioorg Med Chem 16: 981-94 (2008) Article DOI: 10.1016/j.bmc.2007.10.007 BindingDB Entry DOI: 10.7270/Q2862H95
Nippon Shinyaku Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50373907 (CHEMBL271394) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
Nippon Shinyaku Co., Ltd Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha expressed in CV1 cells by transactivation assay				Bioorg Med Chem 16: 981-94 (2008) Article DOI: 10.1016/j.bmc.2007.10.007 BindingDB Entry DOI: 10.7270/Q2862H95
Nippon Shinyaku Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50081225 (2-(4-{2-[3-(4-Fluoro-phenyl)-1-heptyl-ureido]-ethy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	33	n/a	n/a	n/a	n/a
Glaxo Wellcome Research & Development Curated by ChEMBL					Assay Description Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor transfected CV-1 ...				J Med Chem 42: 3785-8 (1999) BindingDB Entry DOI: 10.7270/Q29C6WM9
Glaxo Wellcome Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM24566 (2-({4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidi...) Show SMILES Cc1cccc(Nc2cc(Cl)nc(SCC(O)=O)n2)c1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Università degli Studi di Milano Curated by ChEMBL					Assay Description Effective concentration against murine PPARalpha in transactivation assay				J Med Chem 48: 5509-19 (2005) Article DOI: 10.1021/jm0502844 BindingDB Entry DOI: 10.7270/Q2PV6JXF
Università degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM24566 (2-({4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidi...) Show SMILES Cc1cccc(Nc2cc(Cl)nc(SCC(O)=O)n2)c1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Consiglio Nazionale delle Ricerche					Assay Description The HepG2 cells were co-transfected with DNA construct containing PPAR-Gal4 chimeric receptor and Gal4-luciferase reporter. The luciferase activity w...				J Med Chem 51: 7768-76 (2008) Article DOI: 10.1021/jm800733h BindingDB Entry DOI: 10.7270/Q2CC0Z0D
Consiglio Nazionale delle Ricerche					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50293847 ((2R)-2-{3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(triflu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha receptor expressed in african green monkey COS1 cells co-transfected with fused yeast Gal4-DBD by transactivation...				J Med Chem 52: 4443-53 (2009) Article DOI: 10.1021/jm900367w BindingDB Entry DOI: 10.7270/Q2028RK2
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM28699 (2-(4-chlorophenoxy)-2-methylpropanoic acid \| CHEMB...) Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	42	n/a	n/a	n/a	n/a
Università degli Studi di Milano Curated by ChEMBL					Assay Description Effective concentration against murine PPARalpha in transactivation assay				J Med Chem 48: 5509-19 (2005) Article DOI: 10.1021/jm0502844 BindingDB Entry DOI: 10.7270/Q2PV6JXF
Università degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50081224 (2-(4-{2-[1-(5-Cyclohexyl-pentyl)-3-(4-fluoro-pheny...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	53	n/a	n/a	n/a	n/a
Glaxo Wellcome Research & Development Curated by ChEMBL					Assay Description Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor transfected CV-1 ...				J Med Chem 42: 3785-8 (1999) BindingDB Entry DOI: 10.7270/Q29C6WM9
Glaxo Wellcome Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50229208 (CHEMBL427890 \| N-(4-(2,2,2-trifluoroethylsulfonami...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50229207 (CHEMBL403637 \| N-(4-(trifluoromethylsulfonamido)be...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50156523 (3-{4-[2-(2-Biphenyl-3-yl-5-methyl-oxazol-4-yl)-eth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	91	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Transactivation activity for mouse Peroxisome proliferator activated receptor alpha				Bioorg Med Chem Lett 14: 6113-6 (2004) Article DOI: 10.1016/j.bmcl.2004.09.031 BindingDB Entry DOI: 10.7270/Q2QN67J1
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50373910 (CHEMBL410704) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Nippon Shinyaku Co., Ltd Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha expressed in CV1 cells by transactivation assay				Bioorg Med Chem 16: 981-94 (2008) Article DOI: 10.1016/j.bmc.2007.10.007 BindingDB Entry DOI: 10.7270/Q2862H95
Nippon Shinyaku Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50373024 (CHEMBL447533) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Nippon Shinyaku Co., Ltd Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha by transactivation assay				Bioorg Med Chem Lett 18: 2128-32 (2008) Article DOI: 10.1016/j.bmcl.2008.01.086 BindingDB Entry DOI: 10.7270/Q2K0755V
Nippon Shinyaku Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50293849 ((2R)-2-{3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(triflu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha receptor expressed in african green monkey COS1 cells co-transfected with fused yeast Gal4-DBD by transactivation...				J Med Chem 52: 4443-53 (2009) Article DOI: 10.1021/jm900367w BindingDB Entry DOI: 10.7270/Q2028RK2
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50293851 ((2R)-2-{3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(triflu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha receptor expressed in african green monkey COS1 cells co-transfected with fused yeast Gal4-DBD by transactivation...				J Med Chem 52: 4443-53 (2009) Article DOI: 10.1021/jm900367w BindingDB Entry DOI: 10.7270/Q2028RK2
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50081222 (2-(4-{2-[1-Cycloheptyl-3-(2,4-difluoro-phenyl)-ure...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
Glaxo Wellcome Research & Development Curated by ChEMBL					Assay Description Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor transfected CV-1 ...				J Med Chem 42: 3785-8 (1999) BindingDB Entry DOI: 10.7270/Q29C6WM9
Glaxo Wellcome Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50229210 (CHEMBL438346 \| N-(4-(trifluoromethylsulfonamido)be...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	130	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM28802 (2-{[(5-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	144	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Agonist activity at mouse PPAR-alpha				ACS Med Chem Lett 7: 590-4 (2016) Article DOI: 10.1021/acsmedchemlett.6b00033 BindingDB Entry DOI: 10.7270/Q2CR5W99
Bristol-Myers Squibb Company Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM28802 (2-{[(5-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	145	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description EC50 is the concentration of test compounds needed to induce 50% of the maximum luciferase activity in HEK cells transfected with PPAR and Gal4-lucif...				J Pharmacol Exp Ther 327: 716-26 (2008) Article DOI: 10.1124/jpet.108.143271 BindingDB Entry DOI: 10.7270/Q2VD6WT9
Bristol-Myers Squibb Company					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50293844 (1-{3-[[3-(4-Chlorobenzoyl)-2-methyl-6-(trifluorome...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha receptor expressed in african green monkey COS1 cells co-transfected with fused yeast Gal4-DBD by transactivation...				J Med Chem 52: 4443-53 (2009) Article DOI: 10.1021/jm900367w BindingDB Entry DOI: 10.7270/Q2028RK2
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50156524 (3-{4-[2-(2-Biphenyl-3-yl-5-methyl-oxazol-4-yl)-eth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	151	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Transactivation activity for mouse Peroxisome proliferator activated receptor alpha				Bioorg Med Chem Lett 14: 6113-6 (2004) Article DOI: 10.1016/j.bmcl.2004.09.031 BindingDB Entry DOI: 10.7270/Q2QN67J1
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50448033 (CHEMBL3115237) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a
GlaxoSmithKline R&D Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha expressed in CV-1 cells by reporter gene assay				Bioorg Med Chem Lett 24: 1098-103 (2014) Article DOI: 10.1016/j.bmcl.2014.01.004 BindingDB Entry DOI: 10.7270/Q2SQ91V1
GlaxoSmithKline R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50145723 (3-{4-[2-(2-Biphenyl-3-yl-5-methyl-oxazol-4-yl)-eth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	173	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Transactivation activity for mouse Peroxisome proliferator activated receptor alpha				Bioorg Med Chem Lett 14: 6113-6 (2004) Article DOI: 10.1016/j.bmcl.2004.09.031 BindingDB Entry DOI: 10.7270/Q2QN67J1
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50164210 (2-(5,7-Dipropyl-3-trifluoromethyl-benzo[d]isoxazol...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	180	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Agonist activity against mouse Peroxisome proliferator activated receptor alpha				J Med Chem 48: 2262-5 (2005) Article DOI: 10.1021/jm048993p BindingDB Entry DOI: 10.7270/Q2VT1RM6
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50229223 (4'-cyano-biphenyl-4-carboxylic acid 4-trifluoromet...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Agonist activity at mouse PPARalpha assessed as receptor activation by cell based assay				Bioorg Med Chem Lett 18: 710-5 (2008) Article DOI: 10.1016/j.bmcl.2007.11.053 BindingDB Entry DOI: 10.7270/Q2542NBN
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Mus musculus)	BDBM50156527 (2-(4-tert-Butyl-phenoxy)-2-methyl-3-{4-[2-(5-methy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	211	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Transactivation activity for mouse Peroxisome proliferator activated receptor alpha				Bioorg Med Chem Lett 14: 6113-6 (2004) Article DOI: 10.1016/j.bmcl.2004.09.031 BindingDB Entry DOI: 10.7270/Q2QN67J1
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair

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