Found 42 hits of ic50 for UniProtKB: P16233 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM24567
((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| DrugBank
Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PL expressed in HEK293F cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by s... |
ACS Med Chem Lett 9: 1263-1268 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00424
BindingDB Entry DOI: 10.7270/Q2TF01QC |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM24567
((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| DrugBank
Article
PubMed
| n/a | n/a | 80.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Toho University
Curated by ChEMBL
| Assay Description
Inhibition of pancreatic lipase assessed as umoles of oleic acic released per millimiter of triolein per hour |
J Nat Prod 69: 1577-81 (2006)
Article DOI: 10.1021/np060195+
BindingDB Entry DOI: 10.7270/Q2SX6FQ4 |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM24567
((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| DrugBank
Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST)
Curated by ChEMBL
| Assay Description
Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me... |
ACS Med Chem Lett 9: 662-666 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00109
BindingDB Entry DOI: 10.7270/Q2F47RPR |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM24567
((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| DrugBank
Article
PubMed
| n/a | n/a | 780 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PTL (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113358
BindingDB Entry DOI: 10.7270/Q2V69PBM |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM24567
((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r| Show InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| DrugBank
PubMed
| n/a | n/a | 806 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut
Curated by ChEMBL
| Assay Description
Compound was tested for inhibition of porcine pancreatic lipase |
Bioorg Med Chem Lett 8: 977-8 (1998)
BindingDB Entry DOI: 10.7270/Q2J38VRV |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50367145
(CHEMBL4173252)Show SMILES [H][C@@]12CCC(=C)C(C\C=C(/CC(=O)OCc3cn(Cc4ccc(F)cc4)nn3)C=O)[C@@]1(C)CCCC2(C)C |r| Show InChI InChI=1S/C30H38FN3O3/c1-21-6-13-27-29(2,3)14-5-15-30(27,4)26(21)12-9-23(19-35)16-28(36)37-20-25-18-34(33-32-25)17-22-7-10-24(31)11-8-22/h7-11,18-19,26-27H,1,5-6,12-17,20H2,2-4H3/b23-9+/t26?,27-,30+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST)
Curated by ChEMBL
| Assay Description
Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me... |
ACS Med Chem Lett 9: 662-666 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00109
BindingDB Entry DOI: 10.7270/Q2F47RPR |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50367138
(CHEMBL4160519)Show SMILES [H][C@@]12CCC(=C)C(C\C=C(/CC(=O)OCc3cn(Cc4ccc(Cl)cc4)nn3)C=O)[C@@]1(C)CCCC2(C)C |r| Show InChI InChI=1S/C30H38ClN3O3/c1-21-6-13-27-29(2,3)14-5-15-30(27,4)26(21)12-9-23(19-35)16-28(36)37-20-25-18-34(33-32-25)17-22-7-10-24(31)11-8-22/h7-11,18-19,26-27H,1,5-6,12-17,20H2,2-4H3/b23-9+/t26?,27-,30+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST)
Curated by ChEMBL
| Assay Description
Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me... |
ACS Med Chem Lett 9: 662-666 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00109
BindingDB Entry DOI: 10.7270/Q2F47RPR |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50367133
(CHEMBL4164998)Show SMILES [H][C@@]12CCC(=C)C(C\C=C(/CC(=O)OCc3cn(Cc4ccc(SC)cc4)nn3)C=O)[C@@]1(C)CCCC2(C)C |r| Show InChI InChI=1S/C31H41N3O3S/c1-22-7-14-28-30(2,3)15-6-16-31(28,4)27(22)13-10-24(20-35)17-29(36)37-21-25-19-34(33-32-25)18-23-8-11-26(38-5)12-9-23/h8-12,19-20,27-28H,1,6-7,13-18,21H2,2-5H3/b24-10+/t27?,28-,31+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST)
Curated by ChEMBL
| Assay Description
Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me... |
ACS Med Chem Lett 9: 662-666 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00109
BindingDB Entry DOI: 10.7270/Q2F47RPR |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50367134
(CHEMBL4167341)Show SMILES [H][C@@]12CCC(=C)C(C\C=C(/CC(=O)OCc3cn(Cc4ccc(OC)cc4)nn3)C=O)[C@@]1(C)CCCC2(C)C |r| Show InChI InChI=1S/C31H41N3O4/c1-22-7-14-28-30(2,3)15-6-16-31(28,4)27(22)13-10-24(20-35)17-29(36)38-21-25-19-34(33-32-25)18-23-8-11-26(37-5)12-9-23/h8-12,19-20,27-28H,1,6-7,13-18,21H2,2-5H3/b24-10+/t27?,28-,31+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST)
Curated by ChEMBL
| Assay Description
Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me... |
ACS Med Chem Lett 9: 662-666 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00109
BindingDB Entry DOI: 10.7270/Q2F47RPR |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50367211
(CHEMBL4165339)Show SMILES [H][C@@]12CCC(=C)C(C\C=C(/CC(=O)OCc3cn(Cc4ccc(cc4)[N+]([O-])=O)nn3)C=O)[C@@]1(C)CCCC2(C)C |r| Show InChI InChI=1S/C30H38N4O5/c1-21-6-13-27-29(2,3)14-5-15-30(27,4)26(21)12-9-23(19-35)16-28(36)39-20-24-18-33(32-31-24)17-22-7-10-25(11-8-22)34(37)38/h7-11,18-19,26-27H,1,5-6,12-17,20H2,2-4H3/b23-9+/t26?,27-,30+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST)
Curated by ChEMBL
| Assay Description
Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me... |
ACS Med Chem Lett 9: 662-666 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00109
BindingDB Entry DOI: 10.7270/Q2F47RPR |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50569167
(CHEMBL4847734)Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)c1ccc(O)cc1 |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PTL (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113358
BindingDB Entry DOI: 10.7270/Q2V69PBM |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50367212
(CHEMBL4168413)Show SMILES [H][C@@]12CCC(=C)C(C\C=C(/CC(=O)OCc3cn(Cc4ccc(cc4)C(C)(C)C)nn3)C=O)[C@@]1(C)CCCC2(C)C |r| Show InChI InChI=1S/C34H47N3O3/c1-24-9-16-30-33(5,6)17-8-18-34(30,7)29(24)15-12-26(22-38)19-31(39)40-23-28-21-37(36-35-28)20-25-10-13-27(14-11-25)32(2,3)4/h10-14,21-22,29-30H,1,8-9,15-20,23H2,2-7H3/b26-12+/t29?,30-,34+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST)
Curated by ChEMBL
| Assay Description
Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me... |
ACS Med Chem Lett 9: 662-666 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00109
BindingDB Entry DOI: 10.7270/Q2F47RPR |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50367214
(CHEMBL4163899)Show SMILES [H][C@@]12CCC(=C)C(C\C=C(/CC(=O)OCc3cn(Cc4ccc(F)cc4Br)nn3)C=O)[C@@]1(C)CCCC2(C)C |r| Show InChI InChI=1S/C30H37BrFN3O3/c1-20-6-11-27-29(2,3)12-5-13-30(27,4)25(20)10-7-21(18-36)14-28(37)38-19-24-17-35(34-33-24)16-22-8-9-23(32)15-26(22)31/h7-9,15,17-18,25,27H,1,5-6,10-14,16,19H2,2-4H3/b21-7+/t25?,27-,30+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST)
Curated by ChEMBL
| Assay Description
Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me... |
ACS Med Chem Lett 9: 662-666 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00109
BindingDB Entry DOI: 10.7270/Q2F47RPR |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50614084
(CHEMBL4128298)Show SMILES Brc1ccc(Cc2nc3ccccc3c(=O)n2CC(=O)NNC(=O)c2cc3ccccc3oc2=O)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50232349
(CHEMBL4102155)Show SMILES [H][C@]12[#6]-[#6](=[#6][C@@]1([#6]\[#6]=[#6](\[#6])-[#6])[#6](=O)-[#8]2)-[#6](-[#8]-[#6])-[#8]-[#6] |r,c:3| Show InChI InChI=1S/C14H20O4/c1-9(2)5-6-14-8-10(12(16-3)17-4)7-11(14)18-13(14)15/h5,8,11-12H,6-7H2,1-4H3/t11-,14+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Konkuk University
Curated by ChEMBL
| Assay Description
Inhibition of human pancreatic lipase using 4-methylumbelliferyl oleate as substrate after 30 mins by fluorometric method |
J Nat Prod 79: 3148-3151 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00647
BindingDB Entry DOI: 10.7270/Q24B33JV |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50215413
(CHEMBL360443)Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=C)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O Show InChI InChI=1S/C30H55NO4/c1-6-8-10-12-13-14-15-16-17-19-26(35-30(33)28(31-23-32)21-24(3)4)22-29-27(25(5)34-29)20-18-11-9-7-2/h23-24,26-29H,5-22H2,1-4H3,(H,31,32)/t26-,27+,28-,29-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut
Curated by ChEMBL
| Assay Description
Compound was tested for inhibition of porcine pancreatic lipase |
Bioorg Med Chem Lett 8: 977-8 (1998)
BindingDB Entry DOI: 10.7270/Q2J38VRV |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50569165
(CHEMBL4856331)Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)c1ccc(OCC#C)cc1 |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PTL (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113358
BindingDB Entry DOI: 10.7270/Q2V69PBM |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50569166
(CHEMBL4860907)Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)c1cccc(OC)c1 |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PTL (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113358
BindingDB Entry DOI: 10.7270/Q2V69PBM |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50569168
(CHEMBL4847071)Show SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)c1ccc(OC)cc1 |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of PTL (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113358
BindingDB Entry DOI: 10.7270/Q2V69PBM |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50367213
(CHEMBL4175223)Show SMILES [H][C@@]12CCC(=C)C(C\C=C(/CC(=O)OCc3cn(Cc4cc(OC)ccc4Br)nn3)C=O)[C@@]1(C)CCCC2(C)C |r| Show InChI InChI=1S/C31H40BrN3O4/c1-21-7-12-28-30(2,3)13-6-14-31(28,4)26(21)10-8-22(19-36)15-29(37)39-20-24-18-35(34-33-24)17-23-16-25(38-5)9-11-27(23)32/h8-9,11,16,18-19,26,28H,1,6-7,10,12-15,17,20H2,2-5H3/b22-8+/t26?,28-,31+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST)
Curated by ChEMBL
| Assay Description
Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me... |
ACS Med Chem Lett 9: 662-666 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00109
BindingDB Entry DOI: 10.7270/Q2F47RPR |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50367216
(CHEMBL4176621)Show SMILES [H][C@@]12CCC(=C)C(C\C=C(/CC(=O)OCC#C)C=O)[C@@]1(C)CCCC2(C)C |r| Show InChI InChI=1S/C23H32O3/c1-6-14-26-21(25)15-18(16-24)9-10-19-17(2)8-11-20-22(3,4)12-7-13-23(19,20)5/h1,9,16,19-20H,2,7-8,10-15H2,3-5H3/b18-9+/t19?,20-,23+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST)
Curated by ChEMBL
| Assay Description
Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me... |
ACS Med Chem Lett 9: 662-666 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00109
BindingDB Entry DOI: 10.7270/Q2F47RPR |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50367135
(CHEMBL4160094)Show SMILES [H][C@@]12CCC(=C)C(C\C=C(/CC(=O)OCc3cn(CC(=O)c4ccccc4)nn3)C=O)[C@@]1(C)CCCC2(C)C |r| Show InChI InChI=1S/C31H39N3O4/c1-22-11-14-28-30(2,3)15-8-16-31(28,4)26(22)13-12-23(20-35)17-29(37)38-21-25-18-34(33-32-25)19-27(36)24-9-6-5-7-10-24/h5-7,9-10,12,18,20,26,28H,1,8,11,13-17,19,21H2,2-4H3/b23-12+/t26?,28-,31+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST)
Curated by ChEMBL
| Assay Description
Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me... |
ACS Med Chem Lett 9: 662-666 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00109
BindingDB Entry DOI: 10.7270/Q2F47RPR |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50232348
(CHEMBL4077903)Show SMILES [H][C@]12CC(CO)=C[C@@]1(C\C=C(/C)CO)C(=O)O2 |r,c:5| Show InChI InChI=1S/C12H16O4/c1-8(6-13)2-3-12-5-9(7-14)4-10(12)16-11(12)15/h2,5,10,13-14H,3-4,6-7H2,1H3/b8-2+/t10-,12+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Konkuk University
Curated by ChEMBL
| Assay Description
Inhibition of human pancreatic lipase using 4-methylumbelliferyl oleate as substrate after 30 mins by fluorometric method |
J Nat Prod 79: 3148-3151 (2016)
Article DOI: 10.1021/acs.jnatprod.6b00647
BindingDB Entry DOI: 10.7270/Q24B33JV |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50367143
(CHEMBL4168757)Show SMILES [H][C@@]12CCC(=C)C(C\C=C(/CC(=O)OCc3cn(Cc4ccccc4)nn3)C=O)[C@@]1(C)CCCC2(C)C |r| Show InChI InChI=1S/C30H39N3O3/c1-22-11-14-27-29(2,3)15-8-16-30(27,4)26(22)13-12-24(20-34)17-28(35)36-21-25-19-33(32-31-25)18-23-9-6-5-7-10-23/h5-7,9-10,12,19-20,26-27H,1,8,11,13-18,21H2,2-4H3/b24-12+/t26?,27-,30+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST)
Curated by ChEMBL
| Assay Description
Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me... |
ACS Med Chem Lett 9: 662-666 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00109
BindingDB Entry DOI: 10.7270/Q2F47RPR |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50138739
(4-tert-Butyl-N-[4-(5-methoxy-2-oxo-[1,3,4]oxadiazo...)Show SMILES COc1nn(-c2ccc(NC(=O)c3ccc(cc3)C(C)(C)C)cc2)c(=O)o1 Show InChI InChI=1S/C20H21N3O4/c1-20(2,3)14-7-5-13(6-8-14)17(24)21-15-9-11-16(12-10-15)23-19(25)27-18(22-23)26-4/h5-12H,1-4H3,(H,21,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Compound was tested to inhibit pancreatic lipase (PL) |
J Med Chem 47: 400-10 (2004)
Article DOI: 10.1021/jm031004s
BindingDB Entry DOI: 10.7270/Q2ZG6RN1 |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50138734
(3-(3-(benzyloxy)phenyl)-5-ethoxy-1,3,4-oxadiazol-2...)Show InChI InChI=1S/C17H16N2O4/c1-2-21-16-18-19(17(20)23-16)14-9-6-10-15(11-14)22-12-13-7-4-3-5-8-13/h3-11H,2,12H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Compound was tested to inhibit pancreatic lipase (PL) |
J Med Chem 47: 400-10 (2004)
Article DOI: 10.1021/jm031004s
BindingDB Entry DOI: 10.7270/Q2ZG6RN1 |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50367136
(CHEMBL4172103)Show SMILES [H][C@@]12CCC(=C)C(C\C=C(/CC(O)=O)C=O)[C@@]1(C)CCCC2(C)C |r| Show InChI InChI=1S/C20H30O3/c1-14-6-9-17-19(2,3)10-5-11-20(17,4)16(14)8-7-15(13-21)12-18(22)23/h7,13,16-17H,1,5-6,8-12H2,2-4H3,(H,22,23)/b15-7+/t16?,17-,20+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.18E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST)
Curated by ChEMBL
| Assay Description
Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me... |
ACS Med Chem Lett 9: 662-666 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00109
BindingDB Entry DOI: 10.7270/Q2F47RPR |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50213683
(CHEMBL218693 | carnosol)Show SMILES CC(C)c1cc2[C@@H]3C[C@H]4C(C)(C)CCC[C@]4(C(=O)O3)c2c(O)c1O |r| Show InChI InChI=1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sinhgad College of Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of pancreatic lipase |
Bioorg Med Chem 15: 4674-99 (2007)
Article DOI: 10.1016/j.bmc.2007.04.031
BindingDB Entry DOI: 10.7270/Q24J0FZ9 |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50367215
(CHEMBL4170734)Show SMILES [H][C@@]12CCC(=C)C(C\C=C(/CC(=O)OCc3cn(Cc4ccccc4-c4ccccc4)nn3)C=O)[C@@]1(C)CCCC2(C)C |r| Show InChI InChI=1S/C36H43N3O3/c1-26-15-18-33-35(2,3)19-10-20-36(33,4)32(26)17-16-27(24-40)21-34(41)42-25-30-23-39(38-37-30)22-29-13-8-9-14-31(29)28-11-6-5-7-12-28/h5-9,11-14,16,23-24,32-33H,1,10,15,17-22,25H2,2-4H3/b27-16+/t32?,33-,36+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.35E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST)
Curated by ChEMBL
| Assay Description
Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me... |
ACS Med Chem Lett 9: 662-666 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00109
BindingDB Entry DOI: 10.7270/Q2F47RPR |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50367142
(CHEMBL4161505)Show SMILES [H][C@@]12CCC(=C)C(C\C=C(/CC=O)C=O)[C@@]1(C)CCCC2(C)C |r| Show InChI InChI=1S/C20H30O2/c1-15-6-9-18-19(2,3)11-5-12-20(18,4)17(15)8-7-16(14-22)10-13-21/h7,13-14,17-18H,1,5-6,8-12H2,2-4H3/b16-7+/t17?,18-,20+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.45E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
CSIR - National Institute for Interdisciplinary Science and Technology (CSIR-NIIST)
Curated by ChEMBL
| Assay Description
Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me... |
ACS Med Chem Lett 9: 662-666 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00109
BindingDB Entry DOI: 10.7270/Q2F47RPR |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50326047
((6S,9R,12R)-1-((R)-1-((R)-2-((S)-1-((S)-5-amino-2-...)Show SMILES C[C@@H](O)[C@@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)CNC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CS)C(=O)N[C@H](CS)C(O)=O |r| Show InChI InChI=1S/C38H59N13O13S2/c1-18(52)30(35(60)48-24(16-66)38(63)64)49-32(57)21(6-8-27(40)53)45-29(55)14-43-33(58)25-4-2-10-50(25)37(62)23(12-19-13-42-17-44-19)47-34(59)26-5-3-11-51(26)36(61)22(7-9-28(41)54)46-31(56)20(39)15-65/h13,17-18,20-26,30,52,65-66H,2-12,14-16,39H2,1H3,(H2,40,53)(H2,41,54)(H,42,44)(H,43,58)(H,45,55)(H,46,56)(H,47,59)(H,48,60)(H,49,57)(H,63,64)/t18-,20+,21-,22+,23+,24-,25-,26+,30-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratory of Molecular Biology, Medical Research Council
Curated by ChEMBL
| Assay Description
Binding affinity to pancreatic lipase |
Nat Chem Biol 5: 502-7 (2009)
Article DOI: 10.1038/nchembio.184
BindingDB Entry DOI: 10.7270/Q2Z60P9P |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50207385
(CHEBI:6646 | Mahanimbine | Rel-(+)-Mahanimbine)Show SMILES CC(C)=CCCC1(C)Oc2c(C)cc3c([nH]c4ccccc34)c2C=C1 |c:26,(11.36,-24.12,;9.81,-24.12,;9.04,-25.45,;9.04,-22.78,;7.5,-22.77,;6.74,-21.43,;5.19,-21.43,;5.96,-20.08,;3.86,-20.66,;2.52,-21.44,;1.19,-20.67,;1.19,-19.13,;-.14,-21.44,;-.14,-22.98,;1.2,-23.74,;.88,-25.25,;-.65,-25.41,;-1.57,-26.66,;-3.11,-26.49,;-3.73,-25.09,;-2.81,-23.84,;-1.28,-24,;2.52,-22.97,;3.86,-23.73,;5.18,-22.96,)| Show InChI InChI=1S/C23H25NO/c1-15(2)8-7-12-23(4)13-11-18-21-19(14-16(3)22(18)25-23)17-9-5-6-10-20(17)24-21/h5-6,8-11,13-14,24H,7,12H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.79E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Birla Institute of Technology and Science Pilani (Pilani Campus)
Curated by ChEMBL
| Assay Description
Inhibition of pancreatic lipase (unknown origin) |
Bioorg Med Chem 25: 609-620 (2017)
Article DOI: 10.1016/j.bmc.2016.11.031
BindingDB Entry DOI: 10.7270/Q2J968C6 |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50213689
((S)-2-((2E,8E)-deca-2,8-dienoylamino)-3-((S)-5-hyd...)Show SMILES COC(=O)[C@H](C[C@]1(O)C2OC2C2OC2C1=O)NC(=O)\C=C\CCCC\C=C\C |w:10.9,8.8,13.13,11.12| Show InChI InChI=1S/C20H27NO7/c1-3-4-5-6-7-8-9-10-13(22)21-12(19(24)26-2)11-20(25)17(23)15-14(27-15)16-18(20)28-16/h3-4,9-10,12,14-16,18,25H,5-8,11H2,1-2H3,(H,21,22)/b4-3+,10-9+/t12-,14?,15?,16?,18?,20+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sinhgad College of Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of pancreatic lipase |
Bioorg Med Chem 15: 4674-99 (2007)
Article DOI: 10.1016/j.bmc.2007.04.031
BindingDB Entry DOI: 10.7270/Q24J0FZ9 |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50371232
(CARNOSIC ACID)Show SMILES CC(C)c1cc2CC[C@H]3C(C)(C)CCC[C@]3(C(O)=O)c2c(O)c1O |r| Show InChI InChI=1S/C20H28O4/c1-11(2)13-10-12-6-7-14-19(3,4)8-5-9-20(14,18(23)24)15(12)17(22)16(13)21/h10-11,14,21-22H,5-9H2,1-4H3,(H,23,24)/t14-,20+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sinhgad College of Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of pancreatic lipase |
Bioorg Med Chem 15: 4674-99 (2007)
Article DOI: 10.1016/j.bmc.2007.04.031
BindingDB Entry DOI: 10.7270/Q24J0FZ9 |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50521226
(CHEMBL4471545)Show SMILES CS(=O)(=O)C(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccccc1 Show InChI InChI=1S/C18H17N5O5S3/c1-30(24,25)16(17-23-22-15(28-17)10-20-31(19,26)27)18-21-13-8-7-12(9-14(13)29-18)11-5-3-2-4-6-11/h2-9,16,20H,10H2,1H3,(H2,19,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PL expressed in HEK293F cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by s... |
ACS Med Chem Lett 9: 1263-1268 (2018)
Article DOI: 10.1021/acsmedchemlett.8b00424
BindingDB Entry DOI: 10.7270/Q2TF01QC |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50138735
((S)-4-isopropyl-3-methyl-2-(3-methylpiperidine-1-c...)Show SMILES CC(C)c1c(C)n(oc1=O)C(=O)N1CCC[C@H](C)C1 |r| Show InChI InChI=1S/C14H22N2O3/c1-9(2)12-11(4)16(19-13(12)17)14(18)15-7-5-6-10(3)8-15/h9-10H,5-8H2,1-4H3/t10-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Compound was tested to inhibit pancreatic lipase (PL) |
J Med Chem 47: 400-10 (2004)
Article DOI: 10.1021/jm031004s
BindingDB Entry DOI: 10.7270/Q2ZG6RN1 |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50138751
(5-Methylsulfanyl-3-(4-trifluoromethoxy-phenyl)-[1,...)Show SMILES CSc1nc(nn1C(=O)N(C)c1ccccc1)-c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C18H15F3N4O2S/c1-24(13-6-4-3-5-7-13)17(26)25-16(28-2)22-15(23-25)12-8-10-14(11-9-12)27-18(19,20)21/h3-11H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Compound was tested to inhibit pancreatic lipase (PL) |
J Med Chem 47: 400-10 (2004)
Article DOI: 10.1021/jm031004s
BindingDB Entry DOI: 10.7270/Q2ZG6RN1 |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50138737
(3-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethylsulfan...)Show SMILES CN(C(=O)n1nc(nc1SCC(F)(F)F)-c1ccc(Cl)cc1)c1ccccc1 Show InChI InChI=1S/C18H14ClF3N4OS/c1-25(14-5-3-2-4-6-14)17(27)26-16(28-11-18(20,21)22)23-15(24-26)12-7-9-13(19)10-8-12/h2-10H,11H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Compound was tested to inhibit pancreatic lipase (PL) |
J Med Chem 47: 400-10 (2004)
Article DOI: 10.1021/jm031004s
BindingDB Entry DOI: 10.7270/Q2ZG6RN1 |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50213686
(2-((2E,8E)-deca-2,8-dienoylamino)-3-(5-hydroxy-6-o...)Show SMILES COC(=O)C(CC1(O)C2OC2C2OC2C1=O)NC(=O)\C=C\CCCC\C=C\C |w:4.18,10.9,8.8,6.6,13.13,11.12| Show InChI InChI=1S/C20H27NO7/c1-3-4-5-6-7-8-9-10-13(22)21-12(19(24)26-2)11-20(25)17(23)15-14(27-15)16-18(20)28-16/h3-4,9-10,12,14-16,18,25H,5-8,11H2,1-2H3,(H,21,22)/b4-3+,10-9+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sinhgad College of Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of pancreatic lipase |
Bioorg Med Chem 15: 4674-99 (2007)
Article DOI: 10.1016/j.bmc.2007.04.031
BindingDB Entry DOI: 10.7270/Q24J0FZ9 |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50207384
(Koenimbine)Show SMILES COc1ccc2[nH]c3c4C=CC(C)(C)Oc4c(C)cc3c2c1 |c:9| Show InChI InChI=1S/C19H19NO2/c1-11-9-15-14-10-12(21-4)5-6-16(14)20-17(15)13-7-8-19(2,3)22-18(11)13/h5-10,20H,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.69E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Birla Institute of Technology and Science Pilani (Pilani Campus)
Curated by ChEMBL
| Assay Description
Inhibition of pancreatic lipase (unknown origin) |
Bioorg Med Chem 25: 609-620 (2017)
Article DOI: 10.1016/j.bmc.2016.11.031
BindingDB Entry DOI: 10.7270/Q2J968C6 |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50213694
((R)-2-((2E,8E)-deca-2,8-dienoylamino)-3-((R)-5-hyd...)Show SMILES COC(=O)[C@@H](C[C@@]1(O)C2OC2C2OC2C1=O)NC(=O)\C=C\CCCC\C=C\C |w:10.9,8.8,13.13,11.12| Show InChI InChI=1S/C20H27NO7/c1-3-4-5-6-7-8-9-10-13(22)21-12(19(24)26-2)11-20(25)17(23)15-14(27-15)16-18(20)28-16/h3-4,9-10,12,14-16,18,25H,5-8,11H2,1-2H3,(H,21,22)/b4-3+,10-9+/t12-,14?,15?,16?,18?,20+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sinhgad College of Pharmacy
Curated by ChEMBL
| Assay Description
Inhibition of pancreatic lipase |
Bioorg Med Chem 15: 4674-99 (2007)
Article DOI: 10.1016/j.bmc.2007.04.031
BindingDB Entry DOI: 10.7270/Q24J0FZ9 |
More data for this
Ligand-Target Pair | |
Pancreatic triacylglycerol lipase
(Homo sapiens (Human)) | BDBM50207383
(CHEMBL3893262)Show SMILES COc1cc2[nH]c3c4C=CC(C)(C)Oc4c(C)cc3c2cc1OC |c:8| Show InChI InChI=1S/C20H21NO3/c1-11-8-14-13-9-16(22-4)17(23-5)10-15(13)21-18(14)12-6-7-20(2,3)24-19(11)12/h6-10,21H,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.29E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Birla Institute of Technology and Science Pilani (Pilani Campus)
Curated by ChEMBL
| Assay Description
Inhibition of pancreatic lipase (unknown origin) |
Bioorg Med Chem 25: 609-620 (2017)
Article DOI: 10.1016/j.bmc.2016.11.031
BindingDB Entry DOI: 10.7270/Q2J968C6 |
More data for this
Ligand-Target Pair | |
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