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Compile Data Set for Download or QSAR

Found 35 hits of ic50 for UniProtKB: P19440   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50615643
PNG
(CHEMBL5286162)
Show SMILES CO[C@@H](C)CN1CC[C@@]2(C)c3cccc(O)c3C[C@@H]1C2(C)C |r,THB:4:5:16.10.17:19|
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n/an/a 39n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50615644
PNG
(CROBENETINE | Crobenetine)
Show SMILES [H][C@]12Cc3c(O)cccc3[C@](C)(CCN1C[C@H](C)OCc1ccccc1)C2(C)C
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n/an/a 322n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50208436
PNG
(CHEMBL3885040)
Show SMILES CSCCc1c(OCCCC(=O)N[C@@H](Cc2ccc(F)cc2)C(N)=O)n(nc1-c1cccnc1)-c1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C30H30Cl2FN5O3S/c1-42-15-12-23-28(20-4-2-13-35-18-20)37-38(22-10-11-24(31)25(32)17-22)30(23)41-14-3-5-27(39)36-26(29(34)40)16-19-6-8-21(33)9-7-19/h2,4,6-11,13,17-18,26H,3,5,12,14-16H2,1H3,(H2,34,40)(H,36,39)/t26-/m0/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



King Fahd University of Petroleum and Minerals

Curated by ChEMBL


Assay Description
Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...

Eur J Med Chem 124: 666-676 (2016)


Article DOI: 10.1016/j.ejmech.2016.09.002
BindingDB Entry DOI: 10.7270/Q2XG9T3H
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50208427
PNG
(CHEMBL3884872)
Show SMILES COc1ccc(C[C@H](NC(=O)CCCOc2c(CCSC)c(nn2-c2ccc(Cl)c(Cl)c2)-c2cccnc2)C(N)=O)cc1 |r|
Show InChI InChI=1S/C31H33Cl2N5O4S/c1-41-23-10-7-20(8-11-23)17-27(30(34)40)36-28(39)6-4-15-42-31-24(13-16-43-2)29(21-5-3-14-35-19-21)37-38(31)22-9-12-25(32)26(33)18-22/h3,5,7-12,14,18-19,27H,4,6,13,15-17H2,1-2H3,(H2,34,40)(H,36,39)/t27-/m0/s1
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n/an/a 3.10E+3n/an/an/an/an/an/a



King Fahd University of Petroleum and Minerals

Curated by ChEMBL


Assay Description
Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...

Eur J Med Chem 124: 666-676 (2016)


Article DOI: 10.1016/j.ejmech.2016.09.002
BindingDB Entry DOI: 10.7270/Q2XG9T3H
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM14713
PNG
(GGTI-DU40 | N-[(1S)-1-carbamoyl-2-phenylethyl]-4-{...)
Show SMILES CSCCc1c(OCCCC(=O)N[C@@H](Cc2ccccc2)C(N)=O)n(nc1-c1cccnc1)-c1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C30H31Cl2N5O3S/c1-41-16-13-23-28(21-9-5-14-34-19-21)36-37(22-11-12-24(31)25(32)18-22)30(23)40-15-6-10-27(38)35-26(29(33)39)17-20-7-3-2-4-8-20/h2-5,7-9,11-12,14,18-19,26H,6,10,13,15-17H2,1H3,(H2,33,39)(H,35,38)/t26-/m0/s1
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n/an/a 3.30E+3n/an/an/an/an/an/a



King Fahd University of Petroleum and Minerals

Curated by ChEMBL


Assay Description
Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...

Eur J Med Chem 124: 666-676 (2016)


Article DOI: 10.1016/j.ejmech.2016.09.002
BindingDB Entry DOI: 10.7270/Q2XG9T3H
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50208433
PNG
(CHEMBL3885443)
Show SMILES CSCCc1c(OCCCC(=O)N[C@@H](Cc2ccncc2)C(N)=O)n(nc1-c1cccnc1)-c1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C29H30Cl2N6O3S/c1-41-15-10-22-27(20-4-2-11-34-18-20)36-37(21-6-7-23(30)24(31)17-21)29(22)40-14-3-5-26(38)35-25(28(32)39)16-19-8-12-33-13-9-19/h2,4,6-9,11-13,17-18,25H,3,5,10,14-16H2,1H3,(H2,32,39)(H,35,38)/t25-/m0/s1
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n/an/a 7.80E+3n/an/an/an/an/an/a



King Fahd University of Petroleum and Minerals

Curated by ChEMBL


Assay Description
Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...

Eur J Med Chem 124: 666-676 (2016)


Article DOI: 10.1016/j.ejmech.2016.09.002
BindingDB Entry DOI: 10.7270/Q2XG9T3H
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50208426
PNG
(CHEMBL3883795)
Show SMILES COc1ccc(C[C@H](NS(C)(=O)=O)C(=O)NCCCOc2c(CCSC)c(nn2-c2ccc(Cl)c(Cl)c2)-c2cccnc2)cc1 |r|
Show InChI InChI=1S/C31H35Cl2N5O5S2/c1-42-24-10-7-21(8-11-24)18-28(37-45(3,40)41)30(39)35-15-5-16-43-31-25(13-17-44-2)29(22-6-4-14-34-20-22)36-38(31)23-9-12-26(32)27(33)19-23/h4,6-12,14,19-20,28,37H,5,13,15-18H2,1-3H3,(H,35,39)/t28-/m0/s1
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n/an/a 9.90E+3n/an/an/an/an/an/a



King Fahd University of Petroleum and Minerals

Curated by ChEMBL


Assay Description
Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...

Eur J Med Chem 124: 666-676 (2016)


Article DOI: 10.1016/j.ejmech.2016.09.002
BindingDB Entry DOI: 10.7270/Q2XG9T3H
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50208438
PNG
(CHEMBL3885188)
Show SMILES CSCCc1c(OCCCC(=O)N[C@@H](Cc2cccnc2)C(N)=O)n(nc1-c1cccnc1)-c1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C29H30Cl2N6O3S/c1-41-14-10-22-27(20-6-3-12-34-18-20)36-37(21-8-9-23(30)24(31)16-21)29(22)40-13-4-7-26(38)35-25(28(32)39)15-19-5-2-11-33-17-19/h2-3,5-6,8-9,11-12,16-18,25H,4,7,10,13-15H2,1H3,(H2,32,39)(H,35,38)/t25-/m0/s1
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n/an/a 1.16E+4n/an/an/an/an/an/a



King Fahd University of Petroleum and Minerals

Curated by ChEMBL


Assay Description
Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...

Eur J Med Chem 124: 666-676 (2016)


Article DOI: 10.1016/j.ejmech.2016.09.002
BindingDB Entry DOI: 10.7270/Q2XG9T3H
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50248738
PNG
(2-(2-Chlorophenyl)-N,N',4-trimethyl-10Hphenothiazi...)
Show SMILES CNC(=O)c1c(C)c2Sc3ccccc3Nc2c(C(=O)NC)c1-c1ccccc1Cl |(29.29,-26.84,;27.96,-27.61,;27.97,-29.15,;29.31,-29.91,;26.64,-29.93,;25.3,-29.17,;25.28,-27.63,;23.96,-29.95,;22.61,-29.17,;21.28,-29.96,;19.94,-29.2,;18.61,-29.97,;18.61,-31.51,;19.95,-32.28,;21.28,-31.51,;22.62,-32.28,;23.97,-31.5,;25.31,-32.27,;25.32,-33.81,;26.66,-34.57,;23.99,-34.58,;24,-36.12,;26.66,-31.49,;27.99,-32.25,;28,-33.78,;29.33,-34.55,;30.66,-33.77,;30.65,-32.22,;29.31,-31.47,;30.63,-30.69,)|
Show InChI InChI=1S/C23H20ClN3O2S/c1-12-17(22(28)25-2)18(13-8-4-5-9-14(13)24)19(23(29)26-3)20-21(12)30-16-11-7-6-10-15(16)27-20/h4-11,27H,1-3H3,(H,25,28)(H,26,29)
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n/an/a 1.80E+4n/an/an/an/an/an/a



Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of gamma-glutamyltranspeptidase (unknown origin) by colorimetric assay

Eur J Med Chem 44: 197-202 (2008)


Article DOI: 10.1016/j.ejmech.2008.02.028
BindingDB Entry DOI: 10.7270/Q20K28B1
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50248772
PNG
(2-(1,3-benzodioxol-5-yl)-N,N',4-trimethyl-10Hpheno...)
Show SMILES CNC(=O)c1c2Nc3ccccc3Sc2c(C)c(C(C)=O)c1-c1ccc2OCOc2c1
Show InChI InChI=1S/C24H20N2O4S/c1-12-19(13(2)27)20(14-8-9-16-17(10-14)30-11-29-16)21(24(28)25-3)22-23(12)31-18-7-5-4-6-15(18)26-22/h4-10,26H,11H2,1-3H3,(H,25,28)
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n/an/a 1.80E+4n/an/an/an/an/an/a



Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of gamma-glutamyltranspeptidase (unknown origin) by colorimetric assay

Eur J Med Chem 44: 197-202 (2008)


Article DOI: 10.1016/j.ejmech.2008.02.028
BindingDB Entry DOI: 10.7270/Q20K28B1
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50248626
PNG
(2-(2-Chlorophenyl)-N,N',4-trimethyl-2,10-dihydro-1...)
Show SMILES CNC(=O)C1C(C(C(=O)NC)=C(C)C2Sc3ccccc3N=C12)c1ccccc1Cl |t:10,22|
Show InChI InChI=1S/C23H22ClN3O2S/c1-12-17(22(28)25-2)18(13-8-4-5-9-14(13)24)19(23(29)26-3)20-21(12)30-16-11-7-6-10-15(16)27-20/h4-11,18-19,21H,1-3H3,(H,25,28)(H,26,29)
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n/an/a 1.90E+4n/an/an/an/an/an/a



Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of gamma-glutamyltranspeptidase (unknown origin) by colorimetric assay

Eur J Med Chem 44: 197-202 (2008)


Article DOI: 10.1016/j.ejmech.2008.02.028
BindingDB Entry DOI: 10.7270/Q20K28B1
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50208434
PNG
(CHEMBL3884826)
Show SMILES CSCCc1c(OCCCNC(=O)[C@H](Cc2ccncc2)NS(C)(=O)=O)n(nc1-c1cccnc1)-c1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C29H32Cl2N6O4S2/c1-42-16-10-23-27(21-5-3-11-33-19-21)35-37(22-6-7-24(30)25(31)18-22)29(23)41-15-4-12-34-28(38)26(36-43(2,39)40)17-20-8-13-32-14-9-20/h3,5-9,11,13-14,18-19,26,36H,4,10,12,15-17H2,1-2H3,(H,34,38)/t26-/m0/s1
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n/an/a 1.90E+4n/an/an/an/an/an/a



King Fahd University of Petroleum and Minerals

Curated by ChEMBL


Assay Description
Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...

Eur J Med Chem 124: 666-676 (2016)


Article DOI: 10.1016/j.ejmech.2016.09.002
BindingDB Entry DOI: 10.7270/Q2XG9T3H
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50208431
PNG
(CHEMBL3883522)
Show SMILES CSCCc1c(OCCCNC(=O)[C@H](Cc2ccc(F)cc2)NS(C)(=O)=O)n(nc1-c1cccnc1)-c1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C30H32Cl2FN5O4S2/c1-43-16-12-24-28(21-5-3-13-34-19-21)36-38(23-10-11-25(31)26(32)18-23)30(24)42-15-4-14-35-29(39)27(37-44(2,40)41)17-20-6-8-22(33)9-7-20/h3,5-11,13,18-19,27,37H,4,12,14-17H2,1-2H3,(H,35,39)/t27-/m0/s1
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n/an/a 1.97E+4n/an/an/an/an/an/a



King Fahd University of Petroleum and Minerals

Curated by ChEMBL


Assay Description
Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...

Eur J Med Chem 124: 666-676 (2016)


Article DOI: 10.1016/j.ejmech.2016.09.002
BindingDB Entry DOI: 10.7270/Q2XG9T3H
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50248739
PNG
(2-(4-Chlorophenyl)-N,N',4-trimethyl-10Hphenothiazi...)
Show SMILES CNC(=O)c1c(C)c2Sc3ccccc3Nc2c(C(=O)NC)c1-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H20ClN3O2S/c1-12-17(22(28)25-2)18(13-8-10-14(24)11-9-13)19(23(29)26-3)20-21(12)30-16-7-5-4-6-15(16)27-20/h4-11,27H,1-3H3,(H,25,28)(H,26,29)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of gamma-glutamyltranspeptidase (unknown origin) by colorimetric assay

Eur J Med Chem 44: 197-202 (2008)


Article DOI: 10.1016/j.ejmech.2008.02.028
BindingDB Entry DOI: 10.7270/Q20K28B1
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50248736
PNG
(2-Phenyl-N,N',4-trimethyl-10H-phenothiazine-1,3-di...)
Show SMILES CNC(=O)c1c(C)c2Sc3ccccc3Nc2c(C(=O)NC)c1-c1ccccc1
Show InChI InChI=1S/C23H21N3O2S/c1-13-17(22(27)24-2)18(14-9-5-4-6-10-14)19(23(28)25-3)20-21(13)29-16-12-8-7-11-15(16)26-20/h4-12,26H,1-3H3,(H,24,27)(H,25,28)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of gamma-glutamyltranspeptidase (unknown origin) by colorimetric assay

Eur J Med Chem 44: 197-202 (2008)


Article DOI: 10.1016/j.ejmech.2008.02.028
BindingDB Entry DOI: 10.7270/Q20K28B1
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50248624
PNG
(2-Phenyl-N,N',4-trimethyl-2,10-dihydro-1Hphenothia...)
Show SMILES CNC(=O)C1C(C(C(=O)NC)C2=Nc3ccccc3SC2=C1C)c1ccccc1 |c:22,t:11|
Show InChI InChI=1S/C23H23N3O2S/c1-13-17(22(27)24-2)18(14-9-5-4-6-10-14)19(23(28)25-3)20-21(13)29-16-12-8-7-11-15(16)26-20/h4-12,17-19H,1-3H3,(H,24,27)(H,25,28)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of gamma-glutamyltranspeptidase (unknown origin) by colorimetric assay

Eur J Med Chem 44: 197-202 (2008)


Article DOI: 10.1016/j.ejmech.2008.02.028
BindingDB Entry DOI: 10.7270/Q20K28B1
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50248771
PNG
(2-(4-Methoxyphenyl)-N,N',4-trimethyl-10Hphenothiaz...)
Show SMILES CNC(=O)c1c(C)c2Sc3ccccc3Nc2c(C(=O)NC)c1-c1ccc(OC)cc1
Show InChI InChI=1S/C24H23N3O3S/c1-13-18(23(28)25-2)19(14-9-11-15(30-4)12-10-14)20(24(29)26-3)21-22(13)31-17-8-6-5-7-16(17)27-21/h5-12,27H,1-4H3,(H,25,28)(H,26,29)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of gamma-glutamyltranspeptidase (unknown origin) by colorimetric assay

Eur J Med Chem 44: 197-202 (2008)


Article DOI: 10.1016/j.ejmech.2008.02.028
BindingDB Entry DOI: 10.7270/Q20K28B1
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50248773
PNG
(2-(4-Nitrophenyl)-N,N',4-trimethyl-10Hphenothiazin...)
Show SMILES CNC(=O)c1c2Nc3ccccc3Sc2c(C)c(C(C)=O)c1-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C23H19N3O4S/c1-12-18(13(2)27)19(14-8-10-15(11-9-14)26(29)30)20(23(28)24-3)21-22(12)31-17-7-5-4-6-16(17)25-21/h4-11,25H,1-3H3,(H,24,28)
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n/an/a 2.20E+4n/an/an/an/an/an/a



Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of gamma-glutamyltranspeptidase (unknown origin) by colorimetric assay

Eur J Med Chem 44: 197-202 (2008)


Article DOI: 10.1016/j.ejmech.2008.02.028
BindingDB Entry DOI: 10.7270/Q20K28B1
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50248625
PNG
(2-(2-Methylphenyl)-N,N',4-trimethyl-2,10-dihydro-1...)
Show SMILES CNC(=O)C1C(C(C(=O)NC)C2=Nc3ccccc3SC2=C1C)c1ccccc1C |c:22,t:11|
Show InChI InChI=1S/C24H25N3O2S/c1-13-9-5-6-10-15(13)19-18(23(28)25-3)14(2)22-21(20(19)24(29)26-4)27-16-11-7-8-12-17(16)30-22/h5-12,18-20H,1-4H3,(H,25,28)(H,26,29)
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n/an/a 2.20E+4n/an/an/an/an/an/a



Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of gamma-glutamyltranspeptidase (unknown origin) by colorimetric assay

Eur J Med Chem 44: 197-202 (2008)


Article DOI: 10.1016/j.ejmech.2008.02.028
BindingDB Entry DOI: 10.7270/Q20K28B1
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50208423
PNG
(CHEMBL3884658)
Show SMILES CSCCc1c(OCCCNC(=O)[C@H](Cc2ccccc2)NC(C)=O)n(nc1-c1cccnc1)-c1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C31H33Cl2N5O3S/c1-21(39)36-28(18-22-8-4-3-5-9-22)30(40)35-15-7-16-41-31-25(13-17-42-2)29(23-10-6-14-34-20-23)37-38(31)24-11-12-26(32)27(33)19-24/h3-6,8-12,14,19-20,28H,7,13,15-18H2,1-2H3,(H,35,40)(H,36,39)/t28-/m0/s1
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n/an/a 2.29E+4n/an/an/an/an/an/a



King Fahd University of Petroleum and Minerals

Curated by ChEMBL


Assay Description
Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...

Eur J Med Chem 124: 666-676 (2016)


Article DOI: 10.1016/j.ejmech.2016.09.002
BindingDB Entry DOI: 10.7270/Q2XG9T3H
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50248701
PNG
(2-(4-Methoxyphenyl)-N,N',4-trimethyl-2,10-dihydro-...)
Show SMILES CNC(=O)C1C(C(C(=O)NC)=C(C)C2Sc3ccccc3N=C12)c1ccc(OC)cc1 |t:10,22|
Show InChI InChI=1S/C24H25N3O3S/c1-13-18(23(28)25-2)19(14-9-11-15(30-4)12-10-14)20(24(29)26-3)21-22(13)31-17-8-6-5-7-16(17)27-21/h5-12,19-20,22H,1-4H3,(H,25,28)(H,26,29)
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n/an/a 2.50E+4n/an/an/an/an/an/a



Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of gamma-glutamyltranspeptidase (unknown origin) by colorimetric assay

Eur J Med Chem 44: 197-202 (2008)


Article DOI: 10.1016/j.ejmech.2008.02.028
BindingDB Entry DOI: 10.7270/Q20K28B1
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50248737
PNG
(2-(2-Methylphenyl)-N,N',4-trimethyl-10Hphenothiazi...)
Show SMILES CNC(=O)c1c(C)c2Sc3ccccc3Nc2c(C(=O)NC)c1-c1ccccc1C |(14.18,-27.19,;12.85,-27.96,;12.86,-29.49,;14.2,-30.25,;11.53,-30.28,;10.19,-29.51,;10.17,-27.97,;8.85,-30.3,;7.5,-29.52,;6.17,-30.31,;4.83,-29.54,;3.5,-30.31,;3.5,-31.86,;4.84,-32.63,;6.17,-31.86,;7.52,-32.63,;8.86,-31.85,;10.2,-32.62,;10.21,-34.16,;11.55,-34.92,;8.88,-34.93,;8.89,-36.47,;11.55,-31.84,;12.88,-32.6,;12.89,-34.13,;14.22,-34.89,;15.55,-34.12,;15.54,-32.57,;14.2,-31.81,;15.53,-31.04,)|
Show InChI InChI=1S/C24H23N3O2S/c1-13-9-5-6-10-15(13)19-18(23(28)25-3)14(2)22-21(20(19)24(29)26-4)27-16-11-7-8-12-17(16)30-22/h5-12,27H,1-4H3,(H,25,28)(H,26,29)
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n/an/a 2.50E+4n/an/an/an/an/an/a



Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of gamma-glutamyltranspeptidase (unknown origin) by colorimetric assay

Eur J Med Chem 44: 197-202 (2008)


Article DOI: 10.1016/j.ejmech.2008.02.028
BindingDB Entry DOI: 10.7270/Q20K28B1
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50208437
PNG
(CHEMBL3884852)
Show SMILES CSCCc1c(OCCCNC(=O)[C@H](Cc2ccc(F)cc2)NC(C)=O)n(nc1-c1cccnc1)-c1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C31H32Cl2FN5O3S/c1-20(40)37-28(17-21-6-8-23(34)9-7-21)30(41)36-14-4-15-42-31-25(12-16-43-2)29(22-5-3-13-35-19-22)38-39(31)24-10-11-26(32)27(33)18-24/h3,5-11,13,18-19,28H,4,12,14-17H2,1-2H3,(H,36,41)(H,37,40)/t28-/m0/s1
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n/an/a 2.63E+4n/an/an/an/an/an/a



King Fahd University of Petroleum and Minerals

Curated by ChEMBL


Assay Description
Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...

Eur J Med Chem 124: 666-676 (2016)


Article DOI: 10.1016/j.ejmech.2016.09.002
BindingDB Entry DOI: 10.7270/Q2XG9T3H
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50208430
PNG
(CHEMBL3884083)
Show SMILES CSCCc1c(OCCCNC(=O)[C@H](Cc2ccncc2)NC(C)=O)n(nc1-c1cccnc1)-c1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C30H32Cl2N6O3S/c1-20(39)36-27(17-21-8-13-33-14-9-21)29(40)35-12-4-15-41-30-24(10-16-42-2)28(22-5-3-11-34-19-22)37-38(30)23-6-7-25(31)26(32)18-23/h3,5-9,11,13-14,18-19,27H,4,10,12,15-17H2,1-2H3,(H,35,40)(H,36,39)/t27-/m0/s1
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n/an/a 2.69E+4n/an/an/an/an/an/a



King Fahd University of Petroleum and Minerals

Curated by ChEMBL


Assay Description
Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...

Eur J Med Chem 124: 666-676 (2016)


Article DOI: 10.1016/j.ejmech.2016.09.002
BindingDB Entry DOI: 10.7270/Q2XG9T3H
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50248770
PNG
(2-(2-Methoxyphenyl)-N,N',4-trimethyl-10Hphenothiaz...)
Show SMILES CNC(=O)c1c(C)c2Sc3ccccc3Nc2c(C(=O)NC)c1-c1ccccc1OC |(14.81,-40.77,;13.29,-41.54,;13.28,-43.08,;14.61,-43.85,;11.94,-43.85,;10.6,-43.08,;10.6,-41.54,;9.27,-43.85,;7.94,-43.08,;6.6,-43.85,;5.27,-43.08,;3.93,-43.85,;3.93,-45.39,;5.27,-46.16,;6.6,-45.39,;7.94,-46.16,;9.27,-45.39,;10.6,-46.16,;10.6,-47.7,;11.93,-48.47,;9.26,-48.47,;9.26,-50.02,;11.93,-45.39,;13.4,-45.86,;14.21,-44.5,;15.75,-44.54,;16.49,-45.89,;15.68,-47.21,;14.14,-47.16,;13.46,-48.47,;14.45,-49.92,)|
Show InChI InChI=1S/C24H23N3O3S/c1-13-18(23(28)25-2)19(14-9-5-7-11-16(14)30-4)20(24(29)26-3)21-22(13)31-17-12-8-6-10-15(17)27-21/h5-12,27H,1-4H3,(H,25,28)(H,26,29)
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n/an/a 2.80E+4n/an/an/an/an/an/a



Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of gamma-glutamyltranspeptidase (unknown origin) by colorimetric assay

Eur J Med Chem 44: 197-202 (2008)


Article DOI: 10.1016/j.ejmech.2008.02.028
BindingDB Entry DOI: 10.7270/Q20K28B1
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50248700
PNG
(2-(2-Methoxyphenyl)-N,N',4-trimethyl-2,10-dihydro-...)
Show SMILES CNC(=O)C1C(C(C(=O)NC)=C(C)C2Sc3ccccc3N=C12)c1ccccc1OC |t:10,22|
Show InChI InChI=1S/C24H25N3O3S/c1-13-18(23(28)25-2)19(14-9-5-7-11-16(14)30-4)20(24(29)26-3)21-22(13)31-17-12-8-6-10-15(17)27-21/h5-12,19-20,22H,1-4H3,(H,25,28)(H,26,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of gamma-glutamyltranspeptidase (unknown origin) by colorimetric assay

Eur J Med Chem 44: 197-202 (2008)


Article DOI: 10.1016/j.ejmech.2008.02.028
BindingDB Entry DOI: 10.7270/Q20K28B1
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50248702
PNG
(2-(1,3-Benzodioxol-5-yl)-N,N',4-trimethyl-2,10-dih...)
Show SMILES CNC(=O)C1C(C(C(=O)NC)=C(C)C2Sc3ccccc3N=C12)c1ccc2OCOc2c1 |t:10,22|
Show InChI InChI=1S/C24H23N3O4S/c1-12-18(23(28)25-2)19(13-8-9-15-16(10-13)31-11-30-15)20(24(29)26-3)21-22(12)32-17-7-5-4-6-14(17)27-21/h4-10,19-20,22H,11H2,1-3H3,(H,25,28)(H,26,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of gamma-glutamyltranspeptidase (unknown origin) by colorimetric assay

Eur J Med Chem 44: 197-202 (2008)


Article DOI: 10.1016/j.ejmech.2008.02.028
BindingDB Entry DOI: 10.7270/Q20K28B1
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50208429
PNG
(CHEMBL3883400)
Show SMILES CSCCc1c(OCCCNC(=O)[C@H](Cc2ccccc2)NS(C)(=O)=O)n(nc1-c1cccnc1)-c1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C30H33Cl2N5O4S2/c1-42-17-13-24-28(22-10-6-14-33-20-22)35-37(23-11-12-25(31)26(32)19-23)30(24)41-16-7-15-34-29(38)27(36-43(2,39)40)18-21-8-4-3-5-9-21/h3-6,8-12,14,19-20,27,36H,7,13,15-18H2,1-2H3,(H,34,38)/t27-/m0/s1
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n/an/a 3.19E+4n/an/an/an/an/an/a



King Fahd University of Petroleum and Minerals

Curated by ChEMBL


Assay Description
Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...

Eur J Med Chem 124: 666-676 (2016)


Article DOI: 10.1016/j.ejmech.2016.09.002
BindingDB Entry DOI: 10.7270/Q2XG9T3H
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50208435
PNG
(CHEMBL3885260)
Show SMILES COc1ccc(C[C@H](NC(C)=O)C(=O)NCCCOc2c(CCSC)c(nn2-c2ccc(Cl)c(Cl)c2)-c2cccnc2)cc1 |r|
Show InChI InChI=1S/C32H35Cl2N5O4S/c1-21(40)37-29(18-22-7-10-25(42-2)11-8-22)31(41)36-15-5-16-43-32-26(13-17-44-3)30(23-6-4-14-35-20-23)38-39(32)24-9-12-27(33)28(34)19-24/h4,6-12,14,19-20,29H,5,13,15-18H2,1-3H3,(H,36,41)(H,37,40)/t29-/m0/s1
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n/an/a 3.48E+4n/an/an/an/an/an/a



King Fahd University of Petroleum and Minerals

Curated by ChEMBL


Assay Description
Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...

Eur J Med Chem 124: 666-676 (2016)


Article DOI: 10.1016/j.ejmech.2016.09.002
BindingDB Entry DOI: 10.7270/Q2XG9T3H
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50248655
PNG
(2-(4-Chlorophenyl)-N,N',4-trimethyl-2,10-dihydro-1...)
Show SMILES CNC(=O)C1C(C(C(=O)NC)=C(C)C2Sc3ccccc3N=C12)c1ccc(Cl)cc1 |t:10,22|
Show InChI InChI=1S/C23H22ClN3O2S/c1-12-17(22(28)25-2)18(13-8-10-14(24)11-9-13)19(23(29)26-3)20-21(12)30-16-7-5-4-6-15(16)27-20/h4-11,18-19,21H,1-3H3,(H,25,28)(H,26,29)
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n/an/a>3.50E+4n/an/an/an/an/an/a



Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of gamma-glutamyltranspeptidase (unknown origin) by colorimetric assay

Eur J Med Chem 44: 197-202 (2008)


Article DOI: 10.1016/j.ejmech.2008.02.028
BindingDB Entry DOI: 10.7270/Q20K28B1
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM22360
PNG
(2-(acetyloxy)benzoate | 2-(acetyloxy)benzoic acid ...)
Show SMILES CC(=O)Oc1ccccc1C(O)=O
Show InChI InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
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n/an/a 3.60E+4n/an/an/an/an/an/a



Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of gamma-glutamyltranspeptidase (unknown origin) by colorimetric assay

Eur J Med Chem 44: 197-202 (2008)


Article DOI: 10.1016/j.ejmech.2008.02.028
BindingDB Entry DOI: 10.7270/Q20K28B1
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50248703
PNG
(2-(4-Nitrophenyl)-N,N',4-trimethyl-2,10-dihydro-1H...)
Show SMILES CNC(=O)C1C(C(C(=O)NC)=C(C)C2Sc3ccccc3N=C12)c1ccc(cc1)[N+]([O-])=O |t:10,22|
Show InChI InChI=1S/C23H22N4O4S/c1-12-17(22(28)24-2)18(13-8-10-14(11-9-13)27(30)31)19(23(29)25-3)20-21(12)32-16-7-5-4-6-15(16)26-20/h4-11,18-19,21H,1-3H3,(H,24,28)(H,25,29)
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n/an/a 3.60E+4n/an/an/an/an/an/a



Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of gamma-glutamyltranspeptidase (unknown origin) by colorimetric assay

Eur J Med Chem 44: 197-202 (2008)


Article DOI: 10.1016/j.ejmech.2008.02.028
BindingDB Entry DOI: 10.7270/Q20K28B1
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50208425
PNG
(CHEMBL3884603)
Show SMILES COc1ccc(C[C@H](NC(=O)OC(C)(C)C)C(=O)NCCCOc2c(CCSC)c(nn2-c2ccc(Cl)c(Cl)c2)-c2cccnc2)cc1 |r|
Show InChI InChI=1S/C35H41Cl2N5O5S/c1-35(2,3)47-34(44)40-30(20-23-9-12-26(45-4)13-10-23)32(43)39-17-7-18-46-33-27(15-19-48-5)31(24-8-6-16-38-22-24)41-42(33)25-11-14-28(36)29(37)21-25/h6,8-14,16,21-22,30H,7,15,17-20H2,1-5H3,(H,39,43)(H,40,44)/t30-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



King Fahd University of Petroleum and Minerals

Curated by ChEMBL


Assay Description
Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...

Eur J Med Chem 124: 666-676 (2016)


Article DOI: 10.1016/j.ejmech.2016.09.002
BindingDB Entry DOI: 10.7270/Q2XG9T3H
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50208428
PNG
(CHEMBL3883981)
Show SMILES CSCCc1c(OCCCNC(=O)[C@H](Cc2cccnc2)NC(C)=O)n(nc1-c1cccnc1)-c1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C30H32Cl2N6O3S/c1-20(39)36-27(16-21-6-3-11-33-18-21)29(40)35-13-5-14-41-30-24(10-15-42-2)28(22-7-4-12-34-19-22)37-38(30)23-8-9-25(31)26(32)17-23/h3-4,6-9,11-12,17-19,27H,5,10,13-16H2,1-2H3,(H,35,40)(H,36,39)/t27-/m0/s1
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PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



King Fahd University of Petroleum and Minerals

Curated by ChEMBL


Assay Description
Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...

Eur J Med Chem 124: 666-676 (2016)


Article DOI: 10.1016/j.ejmech.2016.09.002
BindingDB Entry DOI: 10.7270/Q2XG9T3H
More data for this
Ligand-Target Pair
Glutathione hydrolase 1 proenzyme


(Homo sapiens (Human))		BDBM50208432
PNG
(CHEMBL3884346)
Show SMILES CSCCc1c(OCCCNC(=O)[C@H](Cc2cccnc2)NS(C)(=O)=O)n(nc1-c1cccnc1)-c1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C29H32Cl2N6O4S2/c1-42-15-10-23-27(21-7-4-12-33-19-21)35-37(22-8-9-24(30)25(31)17-22)29(23)41-14-5-13-34-28(38)26(36-43(2,39)40)16-20-6-3-11-32-18-20/h3-4,6-9,11-12,17-19,26,36H,5,10,13-16H2,1-2H3,(H,34,38)/t26-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



King Fahd University of Petroleum and Minerals

Curated by ChEMBL


Assay Description
Inhibition of recombinant GGT1 (unknown origin) using GGPP as substrate preincubated for 5 mins followed by protein addition measured over 20 mins by...

Eur J Med Chem 124: 666-676 (2016)


Article DOI: 10.1016/j.ejmech.2016.09.002
BindingDB Entry DOI: 10.7270/Q2XG9T3H
More data for this
Ligand-Target Pair