Compile Data Set for Download or QSAR

Found 50 hits of ic50 for UniProtKB: Q9UKL0   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
REST corepressor 1 (Homo sapiens (Human))	BDBM50568523 (CHEMBL4875015) Show SMILES Cl.Cn1cc(cn1)C(=O)Nc1ccc(cc1)[C@@H]1C[C@H]1NCC1CC1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of N-terminal His-SUMO tagged human LSD1 (172 to 852 residues)/His-tagged CoREST (286 to 482 residues) expressed in Escherichia coli BL21 ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00919 BindingDB Entry DOI: 10.7270/Q28K7DTB
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50410785 (CHEMBL5291155) Show SMILES C\C(CCCN1CCN([C@H](Cc2c[nH]c3ccccc23)C1)C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)=N\OCCN1CCOCC1 Show InChI InChI=1S/C33H39F6N5O3/c1-23(41-47-16-13-42-11-14-46-15-12-42)5-4-8-43-9-10-44(28(22-43)19-25-21-40-30-7-3-2-6-29(25)30)31(45)24-17-26(32(34,35)36)20-27(18-24)33(37,38)39/h2-3,6-7,17-18,20-21,28,40H,4-5,8-16,19,22H2,1H3/b41-23-/t28-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against FAAH in Wistar rat brain homogenate				Citation and Details
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50410784 (CHEMBL5280566) Show SMILES CN(C)CCO\N=C(\C)CN1CCN([C@H](Cc2c[nH]c3ccccc23)C1)C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C29H33F6N5O2/c1-19(37-42-11-10-38(2)3)17-39-8-9-40(24(18-39)14-21-16-36-26-7-5-4-6-25(21)26)27(41)20-12-22(28(30,31)32)15-23(13-20)29(33,34)35/h4-7,12-13,15-16,24,36H,8-11,14,17-18H2,1-3H3/b37-19-/t24-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against FAAH in Wistar rat brain homogenate				Citation and Details
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50410789 (CHEMBL5277056) Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCN(CC2=NOC(CN3CCOCC3)C2)C[C@H]1Cc1c[nH]c2ccccc12 |t:22| Show InChI InChI=1S/C31H33F6N5O3/c32-30(33,34)22-11-20(12-23(14-22)31(35,36)37)29(43)42-6-5-41(17-24-15-26(45-39-24)19-40-7-9-44-10-8-40)18-25(42)13-21-16-38-28-4-2-1-3-27(21)28/h1-4,11-12,14,16,25-26,38H,5-10,13,15,17-19H2/t25-,26?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against FAAH in Wistar rat brain homogenate				Citation and Details
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50410788 (CHEMBL5281376) Show SMILES C\C(CCN1CCN([C@H](Cc2c[nH]c3ccccc23)C1)C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)=N\OCCN1CCOCC1 Show InChI InChI=1S/C32H37F6N5O3/c1-22(40-46-15-12-41-10-13-45-14-11-41)6-7-42-8-9-43(27(21-42)18-24-20-39-29-5-3-2-4-28(24)29)30(44)23-16-25(31(33,34)35)19-26(17-23)32(36,37)38/h2-5,16-17,19-20,27,39H,6-15,18,21H2,1H3/b40-22-/t27-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against FAAH in Wistar rat brain homogenate				Citation and Details
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50410786 (CHEMBL5270114) Show SMILES C\C(CN1CCN([C@H](Cc2c[nH]c3ccccc23)C1)C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)=N\OCCN1CCOCC1 Show InChI InChI=1S/C31H35F6N5O3/c1-21(39-45-13-10-40-8-11-44-12-9-40)19-41-6-7-42(26(20-41)16-23-18-38-28-5-3-2-4-27(23)28)29(43)22-14-24(30(32,33)34)17-25(15-22)31(35,36)37/h2-5,14-15,17-18,26,38H,6-13,16,19-20H2,1H3/b39-21-/t26-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against FAAH in Wistar rat brain homogenate				Citation and Details
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498143 (CHEMBL3407602) Show SMILES Cl.CC[C@]1(N)C[C@@H]1c1cccc(Br)c1 |r| Show InChI InChI=1S/C11H14BrN.ClH/c1-2-11(13)7-10(11)8-4-3-5-9(12)6-8;/h3-6,10H,2,7,13H2,1H3;1H/t10-,11+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498128 (CHEMBL3410944) Show SMILES Cl.CC[C@]1(N)C[C@@H]1c1ccc(Br)c(F)c1 |r| Show InChI InChI=1S/C11H13BrFN.ClH/c1-2-11(14)6-8(11)7-3-4-9(12)10(13)5-7;/h3-5,8H,2,6,14H2,1H3;1H/t8-,11+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498142 (CHEMBL3407601) Show SMILES Cl.CC[C@]1(N)C[C@@H]1c1cccc(Cl)c1 |r| Show InChI InChI=1S/C11H14ClN.ClH/c1-2-11(13)7-10(11)8-4-3-5-9(12)6-8;/h3-6,10H,2,7,13H2,1H3;1H/t10-,11+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498137 (CHEMBL3410941) Show SMILES Cl.N[C@]1(C[C@@H]1c1ccc(Br)cc1)c1ccccc1 |r| Show InChI InChI=1S/C15H14BrN.ClH/c16-13-8-6-11(7-9-13)14-10-15(14,17)12-4-2-1-3-5-12;/h1-9,14H,10,17H2;1H/t14-,15-;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50410787 (CHEMBL5270703) Show SMILES CO\N=C(\C)CN1CCN([C@H](Cc2c[nH]c3ccccc23)C1)C(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C26H26F6N4O2/c1-16(34-38-2)14-35-7-8-36(21(15-35)11-18-13-33-23-6-4-3-5-22(18)23)24(37)17-9-19(25(27,28)29)12-20(10-17)26(30,31)32/h3-6,9-10,12-13,21,33H,7-8,11,14-15H2,1-2H3/b34-16-/t21-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory activity against FAAH in Wistar rat brain homogenate				Citation and Details
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498150 (CHEMBL3407599) Show SMILES Cl.CC[C@]1(N)C[C@@H]1c1cccc(F)c1 |r| Show InChI InChI=1S/C11H14FN.ClH/c1-2-11(13)7-10(11)8-4-3-5-9(12)6-8;/h3-6,10H,2,7,13H2,1H3;1H/t10-,11+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50568517 (CHEMBL4848459) Show SMILES NC1CC1c1ccc(NC(=O)c2ccc(NC(=O)OCc3ccccc3)cc2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human LSD1/CoREST expressed in Escherichia coli using monomethylated H3-K4 peptide as substrate preincubated for 15 mins followed by su...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00919 BindingDB Entry DOI: 10.7270/Q28K7DTB
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498135 (CHEMBL3407603) Show SMILES Cl.N[C@@]1(CCc2ccccc2)C[C@@H]1c1cccc(Br)c1 |r| Show InChI InChI=1S/C17H18BrN.ClH/c18-15-8-4-7-14(11-15)16-12-17(16,19)10-9-13-5-2-1-3-6-13;/h1-8,11,16H,9-10,12,19H2;1H/t16-,17+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498134 (CHEMBL3407605) Show SMILES Cl.N[C@@]1(CCc2ccccc2)C[C@@H]1c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C17H18ClN.ClH/c18-15-8-6-14(7-9-15)16-12-17(16,19)11-10-13-4-2-1-3-5-13;/h1-9,16H,10-12,19H2;1H/t16-,17+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	96	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498147 (CHEMBL3407604) Show SMILES Cl.N[C@@]1(CCc2ccccc2)C[C@@H]1c1ccc(Br)cc1 |r| Show InChI InChI=1S/C17H18BrN.ClH/c18-15-8-6-14(7-9-15)16-12-17(16,19)11-10-13-4-2-1-3-5-13;/h1-9,16H,10-12,19H2;1H/t16-,17+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	101	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50458056 (CHEMBL4208031) Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O |r| Show InChI InChI=1S/C95H172N36O25S/c1-48(2)45-66(88(152)114-50(4)74(101)138)128-84(148)63(31-33-68(100)134)124-80(144)57(24-12-16-37-97)122-83(147)61(28-20-41-110-94(104)105)126-89(153)67-30-22-43-131(67)92(156)53(7)117-78(142)56(23-11-15-36-96)118-71(137)47-112-70(136)46-113-76(140)51(5)115-79(143)64-32-34-69(135)108-39-18-14-26-59(123-85(149)65(35-44-157-10)127-91(155)73(55(9)133)130-87(151)62(119-75(139)49(3)99)29-21-42-111-95(106)107)86(150)129-72(54(8)132)90(154)116-52(6)77(141)120-60(27-19-40-109-93(102)103)82(146)121-58(81(145)125-64)25-13-17-38-98/h48-67,72-73,132-133H,11-47,96-99H2,1-10H3,(H2,100,134)(H2,101,138)(H,108,135)(H,112,136)(H,113,140)(H,114,152)(H,115,143)(H,116,154)(H,117,142)(H,118,137)(H,119,139)(H,120,141)(H,121,146)(H,122,147)(H,123,149)(H,124,144)(H,125,145)(H,126,153)(H,127,155)(H,128,148)(H,129,150)(H,130,151)(H4,102,103,109)(H4,104,105,110)(H4,106,107,111)/t49-,50-,51-,52-,53-,54+,55+,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,72-,73-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	107	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina Curated by ChEMBL					Assay Description Inhibition of recombinant human LSD1/CoREST preincubated for 5 mins followed by ART-(N,N-dimethyl-K)-QTARKSTGGKAPRKQLA substrate addition measured af...				Eur J Med Chem 148: 210-220 (2018) Article DOI: 10.1016/j.ejmech.2018.01.098 BindingDB Entry DOI: 10.7270/Q2N0195V
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50458056 (CHEMBL4208031) Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O |r| Show InChI InChI=1S/C95H172N36O25S/c1-48(2)45-66(88(152)114-50(4)74(101)138)128-84(148)63(31-33-68(100)134)124-80(144)57(24-12-16-37-97)122-83(147)61(28-20-41-110-94(104)105)126-89(153)67-30-22-43-131(67)92(156)53(7)117-78(142)56(23-11-15-36-96)118-71(137)47-112-70(136)46-113-76(140)51(5)115-79(143)64-32-34-69(135)108-39-18-14-26-59(123-85(149)65(35-44-157-10)127-91(155)73(55(9)133)130-87(151)62(119-75(139)49(3)99)29-21-42-111-95(106)107)86(150)129-72(54(8)132)90(154)116-52(6)77(141)120-60(27-19-40-109-93(102)103)82(146)121-58(81(145)125-64)25-13-17-38-98/h48-67,72-73,132-133H,11-47,96-99H2,1-10H3,(H2,100,134)(H2,101,138)(H,108,135)(H,112,136)(H,113,140)(H,114,152)(H,115,143)(H,116,154)(H,117,142)(H,118,137)(H,119,139)(H,120,141)(H,121,146)(H,122,147)(H,123,149)(H,124,144)(H,125,145)(H,126,153)(H,127,155)(H,128,148)(H,129,150)(H,130,151)(H4,102,103,109)(H4,104,105,110)(H4,106,107,111)/t49-,50-,51-,52-,53-,54+,55+,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,72-,73-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	107	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina Curated by ChEMBL					Assay Description Inhibition of recombinant human LSD1/CoREST preincubated for 5 mins followed by ART-(N,N-dimethyl-K)-QTARKSTGGKAPRKQLA substrate addition measured af...				Eur J Med Chem 148: 210-220 (2018) Article DOI: 10.1016/j.ejmech.2018.01.098 BindingDB Entry DOI: 10.7270/Q2N0195V
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498141 (CHEMBL3407597) Show SMILES Cl.CC[C@]1(N)C[C@@H]1c1cccc(c1)C(F)(F)F |r| Show InChI InChI=1S/C12H14F3N.ClH/c1-2-11(16)7-10(11)8-4-3-5-9(6-8)12(13,14)15;/h3-6,10H,2,7,16H2,1H3;1H/t10-,11+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	118	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498130 (CHEMBL3407600) Show SMILES Cl.CC[C@]1(N)C[C@@H]1c1ccc(Br)cc1 |r| Show InChI InChI=1S/C11H14BrN.ClH/c1-2-11(13)7-10(11)8-3-5-9(12)6-4-8;/h3-6,10H,2,7,13H2,1H3;1H/t10-,11+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	121	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498140 (CHEMBL3407596) Show SMILES Cl.CC[C@]1(N)C[C@@H]1c1cccc(OC)c1 |r| Show InChI InChI=1S/C12H17NO.ClH/c1-3-12(13)8-11(12)9-5-4-6-10(7-9)14-2;/h4-7,11H,3,8,13H2,1-2H3;1H/t11-,12+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	123	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50458055 (CHEMBL4214605) Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)N)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O |r| Show InChI InChI=1S/C95H172N36O25S/c1-48(2)45-66(88(152)114-50(4)74(101)138)128-84(148)63(31-33-68(100)134)125-80(144)57(24-12-16-37-97)123-83(147)62(29-21-42-111-95(106)107)127-89(153)67-30-22-43-131(67)92(156)53(7)117-78(142)56(23-11-15-36-96)118-71(137)47-112-70(136)46-113-90(154)72(54(8)132)129-87(151)64-32-34-69(135)108-39-18-14-26-59(124-85(149)65(35-44-157-10)121-76(140)51(5)115-79(143)60(119-75(139)49(3)99)27-19-40-109-93(102)103)86(150)130-73(55(9)133)91(155)116-52(6)77(141)120-61(28-20-41-110-94(104)105)82(146)122-58(81(145)126-64)25-13-17-38-98/h48-67,72-73,132-133H,11-47,96-99H2,1-10H3,(H2,100,134)(H2,101,138)(H,108,135)(H,112,136)(H,113,154)(H,114,152)(H,115,143)(H,116,155)(H,117,142)(H,118,137)(H,119,139)(H,120,141)(H,121,140)(H,122,146)(H,123,147)(H,124,149)(H,125,144)(H,126,145)(H,127,153)(H,128,148)(H,129,151)(H,130,150)(H4,102,103,109)(H4,104,105,110)(H4,106,107,111)/t49-,50-,51-,52-,53-,54+,55+,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,72-,73-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	136	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina Curated by ChEMBL					Assay Description Inhibition of recombinant human LSD1/CoREST preincubated for 5 mins followed by ART-(N,N-dimethyl-K)-QTARKSTGGKAPRKQLA substrate addition measured af...				Eur J Med Chem 148: 210-220 (2018) Article DOI: 10.1016/j.ejmech.2018.01.098 BindingDB Entry DOI: 10.7270/Q2N0195V
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50458055 (CHEMBL4214605) Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)N)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O |r| Show InChI InChI=1S/C95H172N36O25S/c1-48(2)45-66(88(152)114-50(4)74(101)138)128-84(148)63(31-33-68(100)134)125-80(144)57(24-12-16-37-97)123-83(147)62(29-21-42-111-95(106)107)127-89(153)67-30-22-43-131(67)92(156)53(7)117-78(142)56(23-11-15-36-96)118-71(137)47-112-70(136)46-113-90(154)72(54(8)132)129-87(151)64-32-34-69(135)108-39-18-14-26-59(124-85(149)65(35-44-157-10)121-76(140)51(5)115-79(143)60(119-75(139)49(3)99)27-19-40-109-93(102)103)86(150)130-73(55(9)133)91(155)116-52(6)77(141)120-61(28-20-41-110-94(104)105)82(146)122-58(81(145)126-64)25-13-17-38-98/h48-67,72-73,132-133H,11-47,96-99H2,1-10H3,(H2,100,134)(H2,101,138)(H,108,135)(H,112,136)(H,113,154)(H,114,152)(H,115,143)(H,116,155)(H,117,142)(H,118,137)(H,119,139)(H,120,141)(H,121,140)(H,122,146)(H,123,147)(H,124,149)(H,125,144)(H,126,145)(H,127,153)(H,128,148)(H,129,151)(H,130,150)(H4,102,103,109)(H4,104,105,110)(H4,106,107,111)/t49-,50-,51-,52-,53-,54+,55+,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,72-,73-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	136	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina Curated by ChEMBL					Assay Description Inhibition of recombinant human LSD1/CoREST preincubated for 5 mins followed by ART-(N,N-dimethyl-K)-QTARKSTGGKAPRKQLA substrate addition measured af...				Eur J Med Chem 148: 210-220 (2018) Article DOI: 10.1016/j.ejmech.2018.01.098 BindingDB Entry DOI: 10.7270/Q2N0195V
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498144 (CHEMBL3407608) Show SMILES Cl.N[C@]1(C[C@@H]1c1cccc(Cl)c1)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C19H16ClN.ClH/c20-17-7-3-6-15(11-17)18-12-19(18,21)16-9-8-13-4-1-2-5-14(13)10-16;/h1-11,18H,12,21H2;1H/t18-,19-;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498133 (CHEMBL3407606) Show SMILES Cl.N[C@@]1(CCc2ccccc2)C[C@@H]1c1ccc(F)cc1 |r| Show InChI InChI=1S/C17H18FN.ClH/c18-15-8-6-14(7-9-15)16-12-17(16,19)11-10-13-4-2-1-3-5-13;/h1-9,16H,10-12,19H2;1H/t16-,17+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	173	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498151 (CHEMBL3407598) Show SMILES Cl.CC[C@]1(N)C[C@@H]1c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C11H14ClN.ClH/c1-2-11(13)7-10(11)8-3-5-9(12)6-4-8;/h3-6,10H,2,7,13H2,1H3;1H/t10-,11+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	178	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498132 (CHEMBL3407612) Show SMILES Cl.N[C@@]1(Cc2ccccc2)C[C@@H]1c1ccc(Br)cc1 |r| Show InChI InChI=1S/C16H16BrN.ClH/c17-14-8-6-13(7-9-14)15-11-16(15,18)10-12-4-2-1-3-5-12;/h1-9,15H,10-11,18H2;1H/t15-,16+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	187	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498131 (CHEMBL3407613) Show SMILES Cl.N[C@@]1(Cc2ccccc2)C[C@@H]1c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C16H16ClN.ClH/c17-14-8-6-13(7-9-14)15-11-16(15,18)10-12-4-2-1-3-5-12;/h1-9,15H,10-11,18H2;1H/t15-,16+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498149 (CHEMBL3407594) Show SMILES Cl.CC[C@]1(N)C[C@@H]1c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C12H14F3N.ClH/c1-2-11(16)7-10(11)8-3-5-9(6-4-8)12(13,14)15;/h3-6,10H,2,7,16H2,1H3;1H/t10-,11+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	248	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498127 (CHEMBL3407607) Show SMILES Cl.N[C@]1(C[C@@H]1c1cccc(Br)c1)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C19H16BrN.ClH/c20-17-7-3-6-15(11-17)18-12-19(18,21)16-9-8-13-4-1-2-5-14(13)10-16;/h1-11,18H,12,21H2;1H/t18-,19-;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498145 (CHEMBL3407593) Show SMILES Cl.CC[C@]1(N)C[C@@H]1c1ccccc1Cl |r| Show InChI InChI=1S/C11H14ClN.ClH/c1-2-11(13)7-9(11)8-5-3-4-6-10(8)12;/h3-6,9H,2,7,13H2,1H3;1H/t9-,11+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	258	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498152 (CHEMBL3407611) Show SMILES Cl.N[C@]1(C[C@@H]1c1ccc(Cl)cc1)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C19H16ClN.ClH/c20-17-9-6-14(7-10-17)18-12-19(18,21)16-8-5-13-3-1-2-4-15(13)11-16;/h1-11,18H,12,21H2;1H/t18-,19-;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	263	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498129 (CHEMBL3407609) Show SMILES Cl.N[C@]1(C[C@@H]1c1ccc(Br)cc1)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C19H16BrN.ClH/c20-17-9-6-14(7-10-17)18-12-19(18,21)16-8-5-13-3-1-2-4-15(13)11-16;/h1-11,18H,12,21H2;1H/t18-,19-;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	279	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50568518 (CHEMBL4877195) Show SMILES N[C@@H]1C[C@H]1c1ccc(cc1)C(=O)NCc1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114143 BindingDB Entry DOI: 10.7270/Q28W3J9V
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50548040 (CHEMBL4791172) Show SMILES NC1CC1c1ccc(NC(=O)CCCc2ccc(cc2)C(=O)Nc2ccccc2N)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of LSD1/FLAG-tagged CoREST (unknown origin) expressed in HEK293F cells using diMeK4H3(1 to 21 residues) as substrate preincubated for 5 mi...				Citation and Details Article DOI: 10.1039/d0md00141d BindingDB Entry DOI: 10.7270/Q23R0XGK
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50610592 (CHEMBL5272967) Show SMILES N[C@@H]1C[C@H]1c1ccc(NC(=O)CCCc2ccc(cc2)C(=O)Nc2ccccc2N)cc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498139 (CHEMBL3407592) Show SMILES Cl.CC[C@]1(N)C[C@@H]1c1ccccc1Br |r| Show InChI InChI=1S/C11H14BrN.ClH/c1-2-11(13)7-9(11)8-5-3-4-6-10(8)12;/h3-6,9H,2,7,13H2,1H3;1H/t9-,11+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498138 (CHEMBL3410945) Show SMILES Cl.CC[C@]1(N)C[C@@H]1c1ccccc1F |r| Show InChI InChI=1S/C11H14FN.ClH/c1-2-11(13)7-9(11)8-5-3-4-6-10(8)12;/h3-6,9H,2,7,13H2,1H3;1H/t9-,11+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	352	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498136 (CHEMBL3410942) Show SMILES Cl.N[C@]1(C[C@@H]1c1ccc(Cl)cc1)c1ccccc1 |r| Show InChI InChI=1S/C15H14ClN.ClH/c16-13-8-6-11(7-9-13)14-10-15(14,17)12-4-2-1-3-5-12;/h1-9,14H,10,17H2;1H/t14-,15-;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	554	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498146 (CHEMBL3407610) Show SMILES Cl.N[C@]1(C[C@@H]1c1ccc(F)cc1)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C19H16FN.ClH/c20-17-9-6-14(7-10-17)18-12-19(18,21)16-8-5-13-3-1-2-4-15(13)11-16;/h1-11,18H,12,21H2;1H/t18-,19-;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	642	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498153 (CHEMBL3407595) Show SMILES Cl.CC[C@]1(N)C[C@@H]1c1ccc(F)cc1 |r| Show InChI InChI=1S/C11H14FN.ClH/c1-2-11(13)7-10(11)8-3-5-9(12)6-4-8;/h3-6,10H,2,7,13H2,1H3;1H/t10-,11+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498154 (CHEMBL3407614) Show SMILES Cl.N[C@@]1(Cc2ccccc2)C[C@@H]1c1ccc(F)cc1 |r| Show InChI InChI=1S/C16H16FN.ClH/c17-14-8-6-13(7-9-14)15-11-16(15,18)10-12-4-2-1-3-5-12;/h1-9,15H,10-11,18H2;1H/t15-,16+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.05E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50464671 (CHEMBL3621615) Show SMILES Nc1nnc(NCc2c(Cl)cccc2Oc2ccccc2)[nH]1 Show InChI InChI=1S/C15H14ClN5O/c16-12-7-4-8-13(22-10-5-2-1-3-6-10)11(12)9-18-15-19-14(17)20-21-15/h1-8H,9H2,(H4,17,18,19,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human LSD1/CoREST using 10-acetyl-3,7-dihydroxyphenoxazine as substrate incubated for 30 mins by fluorescence based assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.5b00383 BindingDB Entry DOI: 10.7270/Q2JM2FBD
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498148 (CHEMBL3410943) Show SMILES Cl.CC[C@]1(N)C[C@@H]1c1ccc(OC(F)(F)F)cc1 |r| Show InChI InChI=1S/C12H14F3NO.ClH/c1-2-11(16)7-10(11)8-3-5-9(6-4-8)17-12(13,14)15;/h3-6,10H,2,7,16H2,1H3;1H/t10-,11+;/m1./s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Parma Curated by ChEMBL					Assay Description Inhibition of human recombinant KDM1A/CoREST complex expressed in Escherichia coli using mono-methylated H3-K4 peptide containing 21 amino acids as s...				Eur J Med Chem 92: 377-86 (2015) Article DOI: 10.1016/j.ejmech.2014.12.032 BindingDB Entry DOI: 10.7270/Q2X351F5
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50464671 (CHEMBL3621615) Show SMILES Nc1nnc(NCc2c(Cl)cccc2Oc2ccccc2)[nH]1 Show InChI InChI=1S/C15H14ClN5O/c16-12-7-4-8-13(22-10-5-2-1-3-6-10)11(12)9-18-15-19-14(17)20-21-15/h1-8H,9H2,(H4,17,18,19,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.19E+3	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina Curated by ChEMBL					Assay Description Inhibition of recombinant LSD1/CoREST (unknown origin) assessed as residual activity for 30 mins to 4 hrs by fluorescence based assay relative to con...				Medchemcomm 5: 1863-1870 (2014) Article DOI: 10.1039/c4md00283k BindingDB Entry DOI: 10.7270/Q2Q81H3T
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50548040 (CHEMBL4791172) Show SMILES NC1CC1c1ccc(NC(=O)CCCc2ccc(cc2)C(=O)Nc2ccccc2N)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of LSD1/FLAG-tagged CoREST (unknown origin) expressed in HEK293F cells using diMeK4H3(1 to 21) as substrate preincubated for 5 mins follow...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00919 BindingDB Entry DOI: 10.7270/Q28K7DTB
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50446143 (CHEMBL3108897) Show SMILES [#6]-[#16]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7])-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@H]-1-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6]-1=O)-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](-[#7])=O |r| Show InChI InChI=1S/C96H174N36O26S/c1-48(2)45-66(88(153)115-50(4)75(102)140)128-83(148)63(31-33-68(101)136)124-79(144)57(24-12-16-37-98)122-82(147)61(28-20-41-111-95(105)106)126-89(154)67-30-22-43-132(67)93(158)52(6)117-78(143)56(23-11-15-36-97)118-71(139)47-113-70(138)46-114-90(155)72(53(7)133)129-87(152)64-32-34-69(137)109-39-18-14-26-59(123-84(149)65(35-44-159-10)127-92(157)74(55(9)135)131-86(151)62(119-76(141)49(3)100)29-21-42-112-96(107)108)85(150)130-73(54(8)134)91(156)116-51(5)77(142)120-60(27-19-40-110-94(103)104)81(146)121-58(80(145)125-64)25-13-17-38-99/h48-67,72-74,133-135H,11-47,97-100H2,1-10H3,(H2,101,136)(H2,102,140)(H,109,137)(H,113,138)(H,114,155)(H,115,153)(H,116,156)(H,117,143)(H,118,139)(H,119,141)(H,120,142)(H,121,146)(H,122,147)(H,123,149)(H,124,144)(H,125,145)(H,126,154)(H,127,157)(H,128,148)(H,129,152)(H,130,150)(H,131,151)(H4,103,104,110)(H4,105,106,111)(H4,107,108,112)/t49-,50-,51-,52-,53+,54+,55+,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,72-,73-,74-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina Curated by ChEMBL					Assay Description Inhibition of recombinant human LSD1/CoREST preincubated for 5 mins followed by ART-(N,N-dimethyl-K)-QTARKSTGGKAPRKQLA substrate addition measured af...				Eur J Med Chem 148: 210-220 (2018) Article DOI: 10.1016/j.ejmech.2018.01.098 BindingDB Entry DOI: 10.7270/Q2N0195V
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498660 (CHEMBL1605826) Show SMILES COc1ccccc1CNc1n[nH]c(NCc2ccccc2OC)n1 Show InChI InChI=1S/C18H21N5O2/c1-24-15-9-5-3-7-13(15)11-19-17-21-18(23-22-17)20-12-14-8-4-6-10-16(14)25-2/h3-10H,11-12H2,1-2H3,(H3,19,20,21,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human LSD1/CoREST using 10-acetyl-3,7-dihydroxyphenoxazine as substrate incubated for 30 mins by fluorescence based assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.5b00383 BindingDB Entry DOI: 10.7270/Q2JM2FBD
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50498660 (CHEMBL1605826) Show SMILES COc1ccccc1CNc1n[nH]c(NCc2ccccc2OC)n1 Show InChI InChI=1S/C18H21N5O2/c1-24-15-9-5-3-7-13(15)11-19-17-21-18(23-22-17)20-12-14-8-4-6-10-16(14)25-2/h3-10H,11-12H2,1-2H3,(H3,19,20,21,22,23)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina Curated by ChEMBL					Assay Description Inhibition of recombinant LSD1/CoREST (unknown origin) assessed as residual activity for 30 mins to 4 hrs by fluorescence based assay relative to con...				Medchemcomm 5: 1863-1870 (2014) Article DOI: 10.1039/c4md00283k BindingDB Entry DOI: 10.7270/Q2Q81H3T
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50236898 ((1S,2R)-(+)-2-phenylcyclopropylamine | CHEMBL25799...) Show SMILES N[C@H]1C[C@@H]1c1ccccc1 |r| Show InChI InChI=1S/C9H11N/c10-9-6-8(9)7-4-2-1-3-5-7/h1-5,8-9H,6,10H2/t8-,9+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.07E+4	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina Curated by ChEMBL					Assay Description Inhibition of recombinant LSD1/CoREST (unknown origin) assessed as residual activity for 30 mins to 4 hrs by fluorescence based assay relative to con...				Medchemcomm 5: 1863-1870 (2014) Article DOI: 10.1039/c4md00283k BindingDB Entry DOI: 10.7270/Q2Q81H3T
					More data for this Ligand-Target Pair