Found 36 hits Enz. Inhib. hit(s) with all data for entry = 50006426 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048982
((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propi...)Show SMILES CSCC[C@@H](NC(=O)[C@H]1Cc2ccccc2CN1C[C@H](NC(=O)[C@H](N)CS)C(C)C)C(O)=O Show InChI InChI=1S/C23H36N4O4S2/c1-14(2)19(26-21(28)17(24)13-32)12-27-11-16-7-5-4-6-15(16)10-20(27)22(29)25-18(23(30)31)8-9-33-3/h4-7,14,17-20,32H,8-13,24H2,1-3H3,(H,25,29)(H,26,28)(H,30,31)/t17-,18-,19+,20-/m1/s1 | PDB
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| n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048970
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES CC(C)(C)[C@H](NC[C@@H](N)CS)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](CCS(C)(=O)=O)C(O)=O Show InChI InChI=1S/C24H38N4O6S2/c1-24(2,3)20(26-12-17(25)14-35)22(30)28-13-16-8-6-5-7-15(16)11-19(28)21(29)27-18(23(31)32)9-10-36(4,33)34/h5-8,17-20,26,35H,9-14,25H2,1-4H3,(H,27,29)(H,31,32)/t17-,18-,19+,20-/m1/s1 | PDB
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| n/a | n/a | 0.460 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048963
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES CSCC[C@@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC[C@@H](N)CS)C(C)(C)C)C(O)=O Show InChI InChI=1S/C24H38N4O4S2/c1-24(2,3)20(26-12-17(25)14-33)22(30)28-13-16-8-6-5-7-15(16)11-19(28)21(29)27-18(23(31)32)9-10-34-4/h5-8,17-20,26,33H,9-14,25H2,1-4H3,(H,27,29)(H,31,32)/t17-,18-,19+,20-/m1/s1 | PDB
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| n/a | n/a | 0.570 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048972
((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propy...)Show SMILES CSCC[C@@H](NC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](NC[C@H](N)CS)C(C)C)C(O)=O Show InChI InChI=1S/C23H36N4O4S2/c1-14(2)20(25-11-17(24)13-32)22(29)27-12-16-7-5-4-6-15(16)10-19(27)21(28)26-18(23(30)31)8-9-33-3/h4-7,14,17-20,25,32H,8-13,24H2,1-3H3,(H,26,28)(H,30,31)/t17-,18+,19+,20+/m0/s1 | PDB
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| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048967
((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propy...)Show SMILES CSCC[C@@H](NC(=O)[C@H]1Cc2ccccc2CN1C[C@H](NC[C@H](N)CS)C(C)C)C(O)=O Show InChI InChI=1S/C23H38N4O3S2/c1-15(2)20(25-11-18(24)14-31)13-27-12-17-7-5-4-6-16(17)10-21(27)22(28)26-19(23(29)30)8-9-32-3/h4-7,15,18-21,25,31H,8-14,24H2,1-3H3,(H,26,28)(H,29,30)/t18-,19+,20-,21+/m0/s1 | PDB
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| n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048964
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES CC(C)[C@H](NC[C@@H](N)CS)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](CCS(C)(=O)=O)C(O)=O Show InChI InChI=1S/C23H36N4O6S2/c1-14(2)20(25-11-17(24)13-34)22(29)27-12-16-7-5-4-6-15(16)10-19(27)21(28)26-18(23(30)31)8-9-35(3,32)33/h4-7,14,17-20,25,34H,8-13,24H2,1-3H3,(H,26,28)(H,30,31)/t17-,18-,19+,20+/m1/s1 | PDB
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| n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048981
((S)-2-({(R)-2-[(S)-2-((R)-3-Mercapto-2-methyl-prop...)Show SMILES CSCC[C@H](NC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@@H](C)CS)C(C)C)C(O)=O Show InChI InChI=1S/C24H35N3O5S2/c1-14(2)20(26-21(28)15(3)13-33)23(30)27-12-17-8-6-5-7-16(17)11-19(27)22(29)25-18(24(31)32)9-10-34-4/h5-8,14-15,18-20,33H,9-13H2,1-4H3,(H,25,29)(H,26,28)(H,31,32)/t15-,18-,19+,20-/m0/s1 | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50048966
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES CCCC[C@@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC[C@@H](N)CS)C(C)C)C(O)=O Show InChI InChI=1S/C24H38N4O4S/c1-4-5-10-19(24(31)32)27-22(29)20-11-16-8-6-7-9-17(16)13-28(20)23(30)21(15(2)3)26-12-18(25)14-33/h6-9,15,18-21,26,33H,4-5,10-14,25H2,1-3H3,(H,27,29)(H,31,32)/t18-,19-,20+,21+/m1/s1 | PDB
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| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibition of Geranylgeranyl transferase type I |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048968
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES COCC[C@@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC[C@@H](N)CS)C(C)(C)C)C(O)=O Show InChI InChI=1S/C24H38N4O5S/c1-24(2,3)20(26-12-17(25)14-34)22(30)28-13-16-8-6-5-7-15(16)11-19(28)21(29)27-18(23(31)32)9-10-33-4/h5-8,17-20,26,34H,9-14,25H2,1-4H3,(H,27,29)(H,31,32)/t17-,18-,19+,20-/m1/s1 | PDB
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| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048969
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES CN(C)C(=O)CC[C@@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC[C@@H](N)CS)C(C)(C)C)C(O)=O Show InChI InChI=1S/C26H41N5O5S/c1-26(2,3)22(28-13-18(27)15-37)24(34)31-14-17-9-7-6-8-16(17)12-20(31)23(33)29-19(25(35)36)10-11-21(32)30(4)5/h6-9,18-20,22,28,37H,10-15,27H2,1-5H3,(H,29,33)(H,35,36)/t18-,19-,20+,22-/m1/s1 | PDB
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| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048974
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES CC(C)(C)[C@H](NC[C@@H](N)CS)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](CCC(N)=O)C(O)=O Show InChI InChI=1S/C24H37N5O5S/c1-24(2,3)20(27-11-16(25)13-35)22(32)29-12-15-7-5-4-6-14(15)10-18(29)21(31)28-17(23(33)34)8-9-19(26)30/h4-7,16-18,20,27,35H,8-13,25H2,1-3H3,(H2,26,30)(H,28,31)(H,33,34)/t16-,17-,18+,20-/m1/s1 | PDB
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| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048975
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES CC(C)[C@H](NC[C@@H](N)CS)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](CCC(N)=O)C(O)=O Show InChI InChI=1S/C23H35N5O5S/c1-13(2)20(26-10-16(24)12-34)22(31)28-11-15-6-4-3-5-14(15)9-18(28)21(30)27-17(23(32)33)7-8-19(25)29/h3-6,13,16-18,20,26,34H,7-12,24H2,1-2H3,(H2,25,29)(H,27,30)(H,32,33)/t16-,17-,18+,20+/m1/s1 | PDB
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| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50048963
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES CSCC[C@@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC[C@@H](N)CS)C(C)(C)C)C(O)=O Show InChI InChI=1S/C24H38N4O4S2/c1-24(2,3)20(26-12-17(25)14-33)22(30)28-13-16-8-6-5-7-15(16)11-19(28)21(29)27-18(23(31)32)9-10-34-4/h5-8,17-20,26,33H,9-14,25H2,1-4H3,(H,27,29)(H,31,32)/t17-,18-,19+,20-/m1/s1 | PDB
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| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibition of Geranylgeranyl transferase type I |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50048970
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES CC(C)(C)[C@H](NC[C@@H](N)CS)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](CCS(C)(=O)=O)C(O)=O Show InChI InChI=1S/C24H38N4O6S2/c1-24(2,3)20(26-12-17(25)14-35)22(30)28-13-16-8-6-5-7-15(16)11-19(28)21(29)27-18(23(31)32)9-10-36(4,33)34/h5-8,17-20,26,35H,9-14,25H2,1-4H3,(H,27,29)(H,31,32)/t17-,18-,19+,20-/m1/s1 | PDB
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibition of Geranylgeranyl transferase type I |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048983
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES CC[C@H](NC[C@@H](N)CS)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](CCSC)C(O)=O Show InChI InChI=1S/C22H34N4O4S2/c1-3-17(24-11-16(23)13-31)21(28)26-12-15-7-5-4-6-14(15)10-19(26)20(27)25-18(22(29)30)8-9-32-2/h4-7,16-19,24,31H,3,8-13,23H2,1-2H3,(H,25,27)(H,29,30)/t16-,17+,18-,19+/m1/s1 | PDB
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50048968
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES COCC[C@@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC[C@@H](N)CS)C(C)(C)C)C(O)=O Show InChI InChI=1S/C24H38N4O5S/c1-24(2,3)20(26-12-17(25)14-34)22(30)28-13-16-8-6-5-7-15(16)11-19(28)21(29)27-18(23(31)32)9-10-33-4/h5-8,17-20,26,34H,9-14,25H2,1-4H3,(H,27,29)(H,31,32)/t17-,18-,19+,20-/m1/s1 | PDB
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| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibition of Geranylgeranyl transferase type I |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048965
((S)-2-{(R)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)Show SMILES CSCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O Show InChI InChI=1S/C22H34N4O5S2/c1-13(2)18(26-19(27)15(23)12-32)21(29)25-17(11-14-7-5-4-6-8-14)20(28)24-16(22(30)31)9-10-33-3/h4-8,13,15-18,32H,9-12,23H2,1-3H3,(H,24,28)(H,25,29)(H,26,27)(H,30,31)/t15-,16-,17+,18-/m0/s1 | PDB
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| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048973
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES CSCC[C@@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](C)NC[C@@H](N)CS)C(O)=O Show InChI InChI=1S/C21H32N4O4S2/c1-13(23-10-16(22)12-30)20(27)25-11-15-6-4-3-5-14(15)9-18(25)19(26)24-17(21(28)29)7-8-31-2/h3-6,13,16-18,23,30H,7-12,22H2,1-2H3,(H,24,26)(H,28,29)/t13-,16+,17+,18-/m0/s1 | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048962
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES COC(=O)[C@@H](CCSC)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC[C@@H](N)CS)C(C)(C)C Show InChI InChI=1S/C25H40N4O4S2/c1-25(2,3)21(27-13-18(26)15-34)23(31)29-14-17-9-7-6-8-16(17)12-20(29)22(30)28-19(10-11-35-5)24(32)33-4/h6-9,18-21,27,34H,10-15,26H2,1-5H3,(H,28,30)/t18-,19-,20+,21-/m1/s1 | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048978
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES CC(C)[C@H](NC[C@@H](N)CS)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](CCS(N)(=O)=O)C(O)=O Show InChI InChI=1S/C22H35N5O6S2/c1-13(2)19(25-10-16(23)12-34)21(29)27-11-15-6-4-3-5-14(15)9-18(27)20(28)26-17(22(30)31)7-8-35(24,32)33/h3-6,13,16-19,25,34H,7-12,23H2,1-2H3,(H,26,28)(H,30,31)(H2,24,32,33)/t16-,17-,18+,19+/m1/s1 | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50048972
((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propy...)Show SMILES CSCC[C@@H](NC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](NC[C@H](N)CS)C(C)C)C(O)=O Show InChI InChI=1S/C23H36N4O4S2/c1-14(2)20(25-11-17(24)13-32)22(29)27-12-16-7-5-4-6-15(16)10-19(27)21(28)26-18(23(30)31)8-9-33-3/h4-7,14,17-20,25,32H,8-13,24H2,1-3H3,(H,26,28)(H,30,31)/t17-,18+,19+,20+/m0/s1 | PDB
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| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibition of Geranylgeranyl transferase type I |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048977
((R)-2-({(R)-1-[(R)-2-((S)-2-Amino-3-mercapto-propi...)Show SMILES CSCC[C@@H](NC(=O)[C@H]1Cc2ccccc2N1C(=O)[C@H](NC(=O)[C@H](N)CS)C(C)C)C(O)=O Show InChI InChI=1S/C22H32N4O5S2/c1-12(2)18(25-19(27)14(23)11-32)21(29)26-16-7-5-4-6-13(16)10-17(26)20(28)24-15(22(30)31)8-9-33-3/h4-7,12,14-15,17-18,32H,8-11,23H2,1-3H3,(H,24,28)(H,25,27)(H,30,31)/t14-,15-,17-,18-/m1/s1 | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048980
((S)-2-{(E)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)Show SMILES CSCC[C@H](NC(=O)C(\NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)=C/c1ccccc1)C(O)=O Show InChI InChI=1S/C22H32N4O5S2/c1-13(2)18(26-19(27)15(23)12-32)21(29)25-17(11-14-7-5-4-6-8-14)20(28)24-16(22(30)31)9-10-33-3/h4-8,11,13,15-16,18,32H,9-10,12,23H2,1-3H3,(H,24,28)(H,25,29)(H,26,27)(H,30,31)/b17-11+/t15-,16-,18-/m0/s1 | PDB
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| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50048962
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES COC(=O)[C@@H](CCSC)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC[C@@H](N)CS)C(C)(C)C Show InChI InChI=1S/C25H40N4O4S2/c1-25(2,3)21(27-13-18(26)15-34)23(31)29-14-17-9-7-6-8-16(17)12-20(29)22(30)28-19(10-11-35-5)24(32)33-4/h6-9,18-21,27,34H,10-15,26H2,1-5H3,(H,28,30)/t18-,19-,20+,21-/m1/s1 | PDB
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| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibition of Geranylgeranyl transferase type I |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048979
((R)-2-({(R)-1-[(R)-2-((S)-2-Amino-3-mercapto-propy...)Show SMILES CSCC[C@@H](NC(=O)[C@H]1CC=CCN1C(=O)[C@H](NC[C@H](N)CS)C(C)C)C(O)=O |c:10| Show InChI InChI=1S/C19H34N4O4S2/c1-12(2)16(21-10-13(20)11-28)18(25)23-8-5-4-6-15(23)17(24)22-14(19(26)27)7-9-29-3/h4-5,12-16,21,28H,6-11,20H2,1-3H3,(H,22,24)(H,26,27)/t13-,14+,15+,16+/m0/s1 | PDB
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| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50048964
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES CC(C)[C@H](NC[C@@H](N)CS)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](CCS(C)(=O)=O)C(O)=O Show InChI InChI=1S/C23H36N4O6S2/c1-14(2)20(25-11-17(24)13-34)22(29)27-12-16-7-5-4-6-15(16)10-19(27)21(28)26-18(23(30)31)8-9-35(3,32)33/h4-7,14,17-20,25,34H,8-13,24H2,1-3H3,(H,26,28)(H,30,31)/t17-,18-,19+,20+/m1/s1 | PDB
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| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibition of Geranylgeranyl transferase type I |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048966
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES CCCC[C@@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC[C@@H](N)CS)C(C)C)C(O)=O Show InChI InChI=1S/C24H38N4O4S/c1-4-5-10-19(24(31)32)27-22(29)20-11-16-8-6-7-9-17(16)13-28(20)23(30)21(15(2)3)26-12-18(25)14-33/h6-9,15,18-21,26,33H,4-5,10-14,25H2,1-3H3,(H,27,29)(H,31,32)/t18-,19-,20+,21+/m1/s1 | PDB
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Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50048975
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES CC(C)[C@H](NC[C@@H](N)CS)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](CCC(N)=O)C(O)=O Show InChI InChI=1S/C23H35N5O5S/c1-13(2)20(26-10-16(24)12-34)22(31)28-11-15-6-4-3-5-14(15)9-18(28)21(30)27-17(23(32)33)7-8-19(25)29/h3-6,13,16-18,20,26,34H,7-12,24H2,1-2H3,(H2,25,29)(H,27,30)(H,32,33)/t16-,17-,18+,20+/m1/s1 | PDB
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibition of Geranylgeranyl transferase type I |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048984
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES CC(C)[C@H](NC[C@@H](N)CS)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](CC(N)=O)C(O)=O Show InChI InChI=1S/C22H33N5O5S/c1-12(2)19(25-9-15(23)11-33)21(30)27-10-14-6-4-3-5-13(14)7-17(27)20(29)26-16(22(31)32)8-18(24)28/h3-6,12,15-17,19,25,33H,7-11,23H2,1-2H3,(H2,24,28)(H,26,29)(H,31,32)/t15-,16-,17+,19+/m1/s1 | PDB
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| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50048974
((R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propy...)Show SMILES CC(C)(C)[C@H](NC[C@@H](N)CS)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](CCC(N)=O)C(O)=O Show InChI InChI=1S/C24H37N5O5S/c1-24(2,3)20(27-11-16(25)13-35)22(32)29-12-15-7-5-4-6-14(15)10-18(29)21(31)28-17(23(33)34)8-9-19(26)30/h4-7,16-18,20,27,35H,8-13,25H2,1-3H3,(H2,26,30)(H,28,31)(H,33,34)/t16-,17-,18+,20-/m1/s1 | PDB
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| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibition of Geranylgeranyl transferase type I |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048976
((S)-2-({2-[(S)-2-((R)-2-Amino-3-mercapto-propionyl...)Show SMILES CSCC[C@H](NC(=O)C1(Cc2ccccc2C1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O Show InChI InChI=1S/C23H34N4O5S2/c1-13(2)18(26-19(28)16(24)12-33)20(29)27-23(10-14-6-4-5-7-15(14)11-23)22(32)25-17(21(30)31)8-9-34-3/h4-7,13,16-18,33H,8-12,24H2,1-3H3,(H,25,32)(H,26,28)(H,27,29)(H,30,31)/t16-,17-,18-/m0/s1 | PDB
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| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048971
((R)-2-({(S)-1-[(R)-2-((S)-2-Amino-3-mercapto-propy...)Show SMILES CSCC[C@@H](NC(=O)[C@@H]1CC=CCN1C(=O)[C@H](NC[C@H](N)CS)C(C)C)C(O)=O |c:10| Show InChI InChI=1S/C19H34N4O4S2/c1-12(2)16(21-10-13(20)11-28)18(25)23-8-5-4-6-15(23)17(24)22-14(19(26)27)7-9-29-3/h4-5,12-16,21,28H,6-11,20H2,1-3H3,(H,22,24)(H,26,27)/t13-,14+,15-,16+/m0/s1 | PDB
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| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50048967
((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propy...)Show SMILES CSCC[C@@H](NC(=O)[C@H]1Cc2ccccc2CN1C[C@H](NC[C@H](N)CS)C(C)C)C(O)=O Show InChI InChI=1S/C23H38N4O3S2/c1-15(2)20(25-11-18(24)14-31)13-27-12-17-7-5-4-6-16(17)10-21(27)22(28)26-19(23(29)30)8-9-32-3/h4-7,15,18-21,25,31H,8-14,24H2,1-3H3,(H,26,28)(H,29,30)/t18-,19+,20-,21+/m0/s1 | PDB
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UniProtKB/SwissProt
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antibodypedia
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UniChem
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| Article
PubMed
| n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibition of Geranylgeranyl transferase type I |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048985
((R)-2-({(R)-2-[(R)-2-((S)-2-Amino-3-mercapto-propi...)Show SMILES CSCC[C@@H](NC[C@H]1Cc2ccccc2CN1C(=O)[C@H](NC(=O)[C@H](N)CS)C(C)C)C(O)=O Show InChI InChI=1S/C23H36N4O4S2/c1-14(2)20(26-21(28)18(24)13-32)22(29)27-12-16-7-5-4-6-15(16)10-17(27)11-25-19(23(30)31)8-9-33-3/h4-7,14,17-20,25,32H,8-13,24H2,1-3H3,(H,26,28)(H,30,31)/t17-,18-,19-,20-/m1/s1 | PDB
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UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50048965
((S)-2-{(R)-2-[(S)-2-((R)-2-Amino-3-mercapto-propio...)Show SMILES CSCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O Show InChI InChI=1S/C22H34N4O5S2/c1-13(2)18(26-19(27)15(23)12-32)21(29)25-17(11-14-7-5-4-6-8-14)20(28)24-16(22(30)31)9-10-33-3/h4-8,13,15-18,32H,9-12,23H2,1-3H3,(H,24,28)(H,25,29)(H,26,27)(H,30,31)/t15-,16-,17+,18-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibition of Geranylgeranyl transferase type I |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50048986
((R)-2-({3-[(S)-2-((R)-2-Amino-3-mercapto-propylami...)Show SMILES CSCC[C@@H](NC(=O)c1cc2ccccc2cc1NC(=O)[C@@H](NC[C@@H](N)CS)C(C)C)C(O)=O Show InChI InChI=1S/C24H34N4O4S2/c1-14(2)21(26-12-17(25)13-33)23(30)28-20-11-16-7-5-4-6-15(16)10-18(20)22(29)27-19(24(31)32)8-9-34-3/h4-7,10-11,14,17,19,21,26,33H,8-9,12-13,25H2,1-3H3,(H,27,29)(H,28,30)(H,31,32)/t17-,19-,21+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against Farnesyltransferase |
J Med Chem 39: 224-36 (1996)
Article DOI: 10.1021/jm950642a
BindingDB Entry DOI: 10.7270/Q2610ZDS |
More data for this
Ligand-Target Pair | |
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