Found 15 hits Enz. Inhib. hit(s) with all data for entry = 50018034 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Metabotropic glutamate receptor 1
(RAT) | BDBM50177080
(3-azepan-1-yl-9-dimethylamino-3H-pyrido[3',2':4,5]...)Show InChI InChI=1S/C17H21N5OS/c1-20(2)12-7-8-18-16-13(12)14-15(24-16)17(23)22(11-19-14)21-9-5-3-4-6-10-21/h7-8,11H,3-6,9-10H2,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat mGluR1 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053
BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human mGluR1 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053
BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat mGluR1 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053
BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50190236
(9-dimethylamino-3-(3-fluoro-4-methyl-phenyl)-3H-py...)Show SMILES CN(C)c1cncc2sc3c(ncn(-c4ccc(C)c(F)c4)c3=O)c12 Show InChI InChI=1S/C18H15FN4OS/c1-10-4-5-11(6-12(10)19)23-9-21-16-15-13(22(2)3)7-20-8-14(15)25-17(16)18(23)24/h4-9H,1-3H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat mGluR1 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053
BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50177051
(3-azepan-1-yl-9-(dimethylnitroryl)pyrido[3',2':4,5...)Show SMILES C[N+](C)([O-])c1ccnc2sc3c(ncn(N4CCCCCC4)c3=O)c12 Show InChI InChI=1S/C17H21N5O2S/c1-22(2,24)12-7-8-18-16-13(12)14-15(25-16)17(23)21(11-19-14)20-9-5-3-4-6-10-20/h7-8,11H,3-6,9-10H2,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat mGluR1 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053
BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(RAT) | BDBM50190237
(3-(4-Ethyl-phenyl)-9-[methyl-(2-pyridin-2-yl-ethyl...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)CCc4ccccn4)c23)c1=O Show InChI InChI=1S/C25H23N5OS/c1-3-17-7-9-19(10-8-17)30-16-28-22-21-20(11-14-27-24(21)32-23(22)25(30)31)29(2)15-12-18-6-4-5-13-26-18/h4-11,13-14,16H,3,12,15H2,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat mGluR1 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053
BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 442 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human mGluR5 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053
BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat mGluR5 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053
BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50177080
(3-azepan-1-yl-9-dimethylamino-3H-pyrido[3',2':4,5]...)Show InChI InChI=1S/C17H21N5OS/c1-20(2)12-7-8-18-16-13(12)14-15(24-16)17(23)22(11-19-14)21-9-5-3-4-6-10-21/h7-8,11H,3-6,9-10H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat mGluR5 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053
BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50190237
(3-(4-Ethyl-phenyl)-9-[methyl-(2-pyridin-2-yl-ethyl...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)CCc4ccccn4)c23)c1=O Show InChI InChI=1S/C25H23N5OS/c1-3-17-7-9-19(10-8-17)30-16-28-22-21-20(11-14-27-24(21)32-23(22)25(30)31)29(2)15-12-18-6-4-5-13-26-18/h4-11,13-14,16H,3,12,15H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat mGluR5 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053
BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human mGluR2 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053
BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50177051
(3-azepan-1-yl-9-(dimethylnitroryl)pyrido[3',2':4,5...)Show SMILES C[N+](C)([O-])c1ccnc2sc3c(ncn(N4CCCCCC4)c3=O)c12 Show InChI InChI=1S/C17H21N5O2S/c1-22(2,24)12-7-8-18-16-13(12)14-15(25-16)17(23)21(11-19-14)20-9-5-3-4-6-10-20/h7-8,11H,3-6,9-10H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat mGluR5 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053
BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 7
(Homo sapiens (Human)) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human mGluR7 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053
BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 4
(Homo sapiens (Human)) | BDBM50177053
(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)Show SMILES CCc1ccc(cc1)-n1cnc2c(sc3nccc(N(C)C)c23)c1=O Show InChI InChI=1S/C19H18N4OS/c1-4-12-5-7-13(8-6-12)23-11-21-16-15-14(22(2)3)9-10-20-18(15)25-17(16)19(23)24/h5-11H,4H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human mGluR4 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053
BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50190236
(9-dimethylamino-3-(3-fluoro-4-methyl-phenyl)-3H-py...)Show SMILES CN(C)c1cncc2sc3c(ncn(-c4ccc(C)c(F)c4)c3=O)c12 Show InChI InChI=1S/C18H15FN4OS/c1-10-4-5-11(6-12(10)19)23-9-21-16-15-13(22(2)3)7-20-8-14(15)25-17(16)18(23)24/h4-9H,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at rat mGluR5 expressed in 1321N1 cells |
Bioorg Med Chem Lett 16: 4936-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.053
BindingDB Entry DOI: 10.7270/Q2C24W2W |
More data for this
Ligand-Target Pair | |
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