Found 49 hits Enz. Inhib. hit(s) with all data for entry = 50018164 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192169
((R)-3,5-dimethoxy-N-(1-(naphthalen-2-ylmethyl)pyrr...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@@H]1CCN(Cc2ccc3ccccc3c2)C1 Show InChI InChI=1S/C24H26N2O3/c1-28-22-12-20(13-23(14-22)29-2)24(27)25-21-9-10-26(16-21)15-17-7-8-18-5-3-4-6-19(18)11-17/h3-8,11-14,21H,9-10,15-16H2,1-2H3,(H,25,27)/t21-/m1/s1 | PDB
Reactome pathway
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| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192189
(3,4,5-trifluoro-N-(1-(naphthalen-2-ylmethyl)piperi...)Show SMILES Fc1cc(cc(F)c1F)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C23H21F3N2O/c24-20-12-18(13-21(25)22(20)26)23(29)27-19-7-9-28(10-8-19)14-15-5-6-16-3-1-2-4-17(16)11-15/h1-6,11-13,19H,7-10,14H2,(H,27,29) | PDB
Reactome pathway
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| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50168507
((E)-N-(1-cinnamylpiperidin-4-yl)-3,5-dimethoxybenz...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(C\C=C\c2ccccc2)CC1 Show InChI InChI=1S/C23H28N2O3/c1-27-21-15-19(16-22(17-21)28-2)23(26)24-20-10-13-25(14-11-20)12-6-9-18-7-4-3-5-8-18/h3-9,15-17,20H,10-14H2,1-2H3,(H,24,26)/b9-6+ | PDB
Reactome pathway
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192178
(3,5-dimethoxy-N-((3R)-1-(1-(naphthalen-2-yl)ethyl)...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@@H]1CCN(C1)C(C)c1ccc2ccccc2c1 Show InChI InChI=1S/C25H28N2O3/c1-17(19-9-8-18-6-4-5-7-20(18)12-19)27-11-10-22(16-27)26-25(28)21-13-23(29-2)15-24(14-21)30-3/h4-9,12-15,17,22H,10-11,16H2,1-3H3,(H,26,28)/t17?,22-/m1/s1 | PDB
Reactome pathway
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| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192174
(4-fluoro-3-methoxy-N-(1-(naphthalen-2-ylmethyl)pip...)Show SMILES COc1cc(ccc1F)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C24H25FN2O2/c1-29-23-15-20(8-9-22(23)25)24(28)26-21-10-12-27(13-11-21)16-17-6-7-18-4-2-3-5-19(18)14-17/h2-9,14-15,21H,10-13,16H2,1H3,(H,26,28) | PDB
Reactome pathway
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| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192163
((R,E)-N-(1-cinnamylpyrrolidin-3-yl)-3,5-dimethoxyb...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@@H]1CCN(C\C=C\c2ccccc2)C1 Show InChI InChI=1S/C22H26N2O3/c1-26-20-13-18(14-21(15-20)27-2)22(25)23-19-10-12-24(16-19)11-6-9-17-7-4-3-5-8-17/h3-9,13-15,19H,10-12,16H2,1-2H3,(H,23,25)/b9-6+/t19-/m1/s1 | PDB
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| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192161
(3,4-difluoro-N-(1-(naphthalen-2-ylmethyl)piperidin...)Show SMILES Fc1ccc(cc1F)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C23H22F2N2O/c24-21-8-7-19(14-22(21)25)23(28)26-20-9-11-27(12-10-20)15-16-5-6-17-3-1-2-4-18(17)13-16/h1-8,13-14,20H,9-12,15H2,(H,26,28) | PDB
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| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192162
(3,5-dimethoxy-N-((3R)-1-((E)-4-phenylbut-3-en-2-yl...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@@H]1CCN(C1)C(C)\C=C\c1ccccc1 Show InChI InChI=1S/C23H28N2O3/c1-17(9-10-18-7-5-4-6-8-18)25-12-11-20(16-25)24-23(26)19-13-21(27-2)15-22(14-19)28-3/h4-10,13-15,17,20H,11-12,16H2,1-3H3,(H,24,26)/b10-9+/t17?,20-/m1/s1 | PDB
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| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192160
(3,5-dimethoxy-N-(1-(1-(naphthalen-2-yl)ethyl)piper...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(CC1)C(C)c1ccc2ccccc2c1 Show InChI InChI=1S/C26H30N2O3/c1-18(20-9-8-19-6-4-5-7-21(19)14-20)28-12-10-23(11-13-28)27-26(29)22-15-24(30-2)17-25(16-22)31-3/h4-9,14-18,23H,10-13H2,1-3H3,(H,27,29) | PDB
Reactome pathway
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| 25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192177
(3,5-dimethoxy-N-(1-(naphthalen-2-ylmethyl)piperidi...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C25H28N2O3/c1-29-23-14-21(15-24(16-23)30-2)25(28)26-22-9-11-27(12-10-22)17-18-7-8-19-5-3-4-6-20(19)13-18/h3-8,13-16,22H,9-12,17H2,1-2H3,(H,26,28) | PDB
Reactome pathway
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| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192165
(3-methoxy-N-(1-(naphthalen-2-ylmethyl)piperidin-4-...)Show SMILES COc1cccc(c1)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C24H26N2O2/c1-28-23-8-4-7-21(16-23)24(27)25-22-11-13-26(14-12-22)17-18-9-10-19-5-2-3-6-20(19)15-18/h2-10,15-16,22H,11-14,17H2,1H3,(H,25,27) | PDB
Reactome pathway
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| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192182
(CHEMBL214778 | N-(1-((6-fluoronaphthalen-2-yl)meth...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 Show InChI InChI=1S/C25H27FN2O3/c1-30-23-13-20(14-24(15-23)31-2)25(29)27-22-7-9-28(10-8-22)16-17-3-4-19-12-21(26)6-5-18(19)11-17/h3-6,11-15,22H,7-10,16H2,1-2H3,(H,27,29) | PDB
Reactome pathway
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| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192157
(4-fluoro-N-(1-(naphthalen-2-ylmethyl)piperidin-4-y...)Show InChI InChI=1S/C23H23FN2O/c24-21-9-7-19(8-10-21)23(27)25-22-11-13-26(14-12-22)16-17-5-6-18-3-1-2-4-20(18)15-17/h1-10,15,22H,11-14,16H2,(H,25,27) | PDB
Reactome pathway
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| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192173
((1R,5S,6r)-N-(3,4-difluorobenzyl)-3-(naphthalen-2-...)Show SMILES Fc1ccc(CNC(=O)[C@@H]2[C@H]3CN(Cc4ccc5ccccc5c4)C[C@@H]23)cc1F Show InChI InChI=1S/C24H22F2N2O/c25-21-8-6-15(10-22(21)26)11-27-24(29)23-19-13-28(14-20(19)23)12-16-5-7-17-3-1-2-4-18(17)9-16/h1-10,19-20,23H,11-14H2,(H,27,29)/t19-,20+,23+ | PDB
Reactome pathway
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| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192183
(3,5-diethoxy-N-(1-(naphthalen-2-ylmethyl)piperidin...)Show SMILES CCOc1cc(OCC)cc(c1)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C27H32N2O3/c1-3-31-25-16-23(17-26(18-25)32-4-2)27(30)28-24-11-13-29(14-12-24)19-20-9-10-21-7-5-6-8-22(21)15-20/h5-10,15-18,24H,3-4,11-14,19H2,1-2H3,(H,28,30) | PDB
Reactome pathway
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| 56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192168
((R)-4-fluoro-3-methoxy-N-(1-(naphthalen-2-ylmethyl...)Show SMILES COc1cc(ccc1F)C(=O)N[C@@H]1CCN(Cc2ccc3ccccc3c2)C1 Show InChI InChI=1S/C23H23FN2O2/c1-28-22-13-19(8-9-21(22)24)23(27)25-20-10-11-26(15-20)14-16-6-7-17-4-2-3-5-18(17)12-16/h2-9,12-13,20H,10-11,14-15H2,1H3,(H,25,27)/t20-/m1/s1 | PDB
Reactome pathway
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| 62 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192195
(3,5-difluoro-N-(1-(naphthalen-2-ylmethyl)piperidin...)Show SMILES Fc1cc(F)cc(c1)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C23H22F2N2O/c24-20-12-19(13-21(25)14-20)23(28)26-22-7-9-27(10-8-22)15-16-5-6-17-3-1-2-4-18(17)11-16/h1-6,11-14,22H,7-10,15H2,(H,26,28) | PDB
Reactome pathway
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| 65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192192
((R)-3-methoxy-N-(1-(naphthalen-2-ylmethyl)pyrrolid...)Show SMILES COc1cccc(c1)C(=O)N[C@@H]1CCN(Cc2ccc3ccccc3c2)C1 Show InChI InChI=1S/C23H24N2O2/c1-27-22-8-4-7-20(14-22)23(26)24-21-11-12-25(16-21)15-17-9-10-18-5-2-3-6-19(18)13-17/h2-10,13-14,21H,11-12,15-16H2,1H3,(H,24,26)/t21-/m1/s1 | PDB
Reactome pathway
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Similars
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PubMed
| 67 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192164
(3,5-dimethoxy-N-(4-methyl-1-(naphthalen-2-ylmethyl...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1(C)CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C26H30N2O3/c1-26(27-25(29)22-15-23(30-2)17-24(16-22)31-3)10-12-28(13-11-26)18-19-8-9-20-6-4-5-7-21(20)14-19/h4-9,14-17H,10-13,18H2,1-3H3,(H,27,29) | PDB
Reactome pathway
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PC cid
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UniChem
Similars
| Article
PubMed
| 86 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50241090
(3,5-dimethoxy-N-(1-((6-methoxynaphthalen-2-yl)meth...)Show SMILES COc1ccc2cc(CN3CCC(CC3)NC(=O)c3cc(OC)cc(OC)c3)ccc2c1 Show InChI InChI=1S/C26H30N2O4/c1-30-23-7-6-19-12-18(4-5-20(19)13-23)17-28-10-8-22(9-11-28)27-26(29)21-14-24(31-2)16-25(15-21)32-3/h4-7,12-16,22H,8-11,17H2,1-3H3,(H,27,29) | PDB
Reactome pathway
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UniChem
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PubMed
| 99 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192167
(CHEMBL214726 | N-(1-((6-fluoronaphthalen-2-yl)meth...)Show InChI InChI=1S/C23H23FN2O/c24-21-9-8-19-14-17(6-7-20(19)15-21)16-26-12-10-22(11-13-26)25-23(27)18-4-2-1-3-5-18/h1-9,14-15,22H,10-13,16H2,(H,25,27) | PDB
Reactome pathway
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UniChem
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PubMed
| 125 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192184
(3-(dimethylamino)-N-(1-(naphthalen-2-ylmethyl)pipe...)Show SMILES CN(C)c1cccc(c1)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C25H29N3O/c1-27(2)24-9-5-8-22(17-24)25(29)26-23-12-14-28(15-13-23)18-19-10-11-20-6-3-4-7-21(20)16-19/h3-11,16-17,23H,12-15,18H2,1-2H3,(H,26,29) | PDB
Reactome pathway
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UniChem
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| 125 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192187
(3,5-dimethoxy-N-((3R,4R)-3-methyl-1-(naphthalen-2-...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@@H]1CCN(Cc2ccc3ccccc3c2)C[C@H]1C Show InChI InChI=1S/C26H30N2O3/c1-18-16-28(17-19-8-9-20-6-4-5-7-21(20)12-19)11-10-25(18)27-26(29)22-13-23(30-2)15-24(14-22)31-3/h4-9,12-15,18,25H,10-11,16-17H2,1-3H3,(H,27,29)/t18-,25-/m1/s1 | PDB
Reactome pathway
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UniChem
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PubMed
| 133 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192191
(3,5-dimethoxy-N-(1-((1,2,3,4-tetrahydronaphthalen-...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(CC2CCc3ccccc3C2)CC1 Show InChI InChI=1S/C25H32N2O3/c1-29-23-14-21(15-24(16-23)30-2)25(28)26-22-9-11-27(12-10-22)17-18-7-8-19-5-3-4-6-20(19)13-18/h3-6,14-16,18,22H,7-13,17H2,1-2H3,(H,26,28) | PDB
Reactome pathway
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| 136 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192170
(3,5-dimethoxy-N-(1-((1-methyl-1H-indol-2-yl)methyl...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(Cc2cc3ccccc3n2C)CC1 Show InChI InChI=1S/C24H29N3O3/c1-26-20(12-17-6-4-5-7-23(17)26)16-27-10-8-19(9-11-27)25-24(28)18-13-21(29-2)15-22(14-18)30-3/h4-7,12-15,19H,8-11,16H2,1-3H3,(H,25,28) | PDB
Reactome pathway
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UniChem
Similars
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PubMed
| 142 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192193
(3,5-dimethoxy-N-methyl-N-(1-(naphthalen-2-ylmethyl...)Show SMILES COc1cc(OC)cc(c1)C(=O)N(C)C1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C26H30N2O3/c1-27(26(29)22-15-24(30-2)17-25(16-22)31-3)23-10-12-28(13-11-23)18-19-8-9-20-6-4-5-7-21(20)14-19/h4-9,14-17,23H,10-13,18H2,1-3H3 | PDB
Reactome pathway
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PubMed
| 169 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192186
(3,5-dimethoxy-N-((3S,4R)-3-methyl-1-(naphthalen-2-...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@@H]1CCN(Cc2ccc3ccccc3c2)C[C@@H]1C Show InChI InChI=1S/C26H30N2O3/c1-18-16-28(17-19-8-9-20-6-4-5-7-21(20)12-19)11-10-25(18)27-26(29)22-13-23(30-2)15-24(14-22)31-3/h4-9,12-15,18,25H,10-11,16-17H2,1-3H3,(H,27,29)/t18-,25+/m0/s1 | PDB
Reactome pathway
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PubMed
| 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192159
(CHEMBL385535 | N-(1-(3,4-dichlorobenzyl)piperidin-...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 Show InChI InChI=1S/C21H24Cl2N2O3/c1-27-17-10-15(11-18(12-17)28-2)21(26)24-16-5-7-25(8-6-16)13-14-3-4-19(22)20(23)9-14/h3-4,9-12,16H,5-8,13H2,1-2H3,(H,24,26) | PDB
Reactome pathway
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UniChem
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PubMed
| 205 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192188
(4-chloro-N-(1-(naphthalen-2-ylmethyl)piperidin-4-y...)Show SMILES Clc1ccc(cc1)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C23H23ClN2O/c24-21-9-7-19(8-10-21)23(27)25-22-11-13-26(14-12-22)16-17-5-6-18-3-1-2-4-20(18)15-17/h1-10,15,22H,11-14,16H2,(H,25,27) | PDB
Reactome pathway
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UniChem
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PubMed
| 232 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192166
(3,4,5-trimethoxy-N-(1-(naphthalen-2-ylmethyl)piper...)Show SMILES COc1cc(cc(OC)c1OC)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C26H30N2O4/c1-30-23-15-21(16-24(31-2)25(23)32-3)26(29)27-22-10-12-28(13-11-22)17-18-8-9-19-6-4-5-7-20(19)14-18/h4-9,14-16,22H,10-13,17H2,1-3H3,(H,27,29) | PDB
Reactome pathway
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PubMed
| 286 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192158
(CHEMBL214684 | N-(1-benzylpiperidin-4-yl)-3,5-dime...)Show InChI InChI=1S/C21H26N2O3/c1-25-19-12-17(13-20(14-19)26-2)21(24)22-18-8-10-23(11-9-18)15-16-6-4-3-5-7-16/h3-7,12-14,18H,8-11,15H2,1-2H3,(H,22,24) | PDB
Reactome pathway
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| 302 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192179
(CHEMBL215388 | N-(1-(naphthalen-2-ylmethyl)piperid...)Show InChI InChI=1S/C23H24N2O/c26-23(20-7-2-1-3-8-20)24-22-12-14-25(15-13-22)17-18-10-11-19-6-4-5-9-21(19)16-18/h1-11,16,22H,12-15,17H2,(H,24,26) | PDB
Reactome pathway
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| 347 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192194
((S)-3,5-dimethoxy-N-(1-(naphthalen-2-ylmethyl)pyrr...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@H]1CCN(Cc2ccc3ccccc3c2)C1 Show InChI InChI=1S/C24H26N2O3/c1-28-22-12-20(13-23(14-22)29-2)24(27)25-21-9-10-26(16-21)15-17-7-8-18-5-3-4-6-19(18)11-17/h3-8,11-14,21H,9-10,15-16H2,1-2H3,(H,25,27)/t21-/m0/s1 | PDB
Reactome pathway
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PubMed
| 484 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192190
((S)-N-(1-(3-hydroxy-3-phenylpropyl)piperidin-4-yl)...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(CC[C@H](O)c2ccccc2)CC1 Show InChI InChI=1S/C23H30N2O4/c1-28-20-14-18(15-21(16-20)29-2)23(27)24-19-8-11-25(12-9-19)13-10-22(26)17-6-4-3-5-7-17/h3-7,14-16,19,22,26H,8-13H2,1-2H3,(H,24,27)/t22-/m0/s1 | PDB
Reactome pathway
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PubMed
| 505 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192181
(3-hydroxy-N-(1-(naphthalen-2-ylmethyl)piperidin-4-...)Show InChI InChI=1S/C23H24N2O2/c26-22-7-3-6-20(15-22)23(27)24-21-10-12-25(13-11-21)16-17-8-9-18-4-1-2-5-19(18)14-17/h1-9,14-15,21,26H,10-13,16H2,(H,24,27) | PDB
Reactome pathway
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PubMed
| 570 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192172
(3,5-dimethoxy-N-(1-(quinolin-2-ylmethyl)piperidin-...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(Cc2ccc3ccccc3n2)CC1 Show InChI InChI=1S/C24H27N3O3/c1-29-21-13-18(14-22(15-21)30-2)24(28)26-19-9-11-27(12-10-19)16-20-8-7-17-5-3-4-6-23(17)25-20/h3-8,13-15,19H,9-12,16H2,1-2H3,(H,26,28) | PDB
Reactome pathway
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| 625 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192171
(3,4-dimethoxy-N-(1-(naphthalen-2-ylmethyl)piperidi...)Show SMILES COc1ccc(cc1OC)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C25H28N2O3/c1-29-23-10-9-21(16-24(23)30-2)25(28)26-22-11-13-27(14-12-22)17-18-7-8-19-5-3-4-6-20(19)15-18/h3-10,15-16,22H,11-14,17H2,1-2H3,(H,26,28) | PDB
Reactome pathway
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PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192175
((R)-N-(1-benzylpyrrolidin-3-yl)-3,5-dimethoxybenza...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@@H]1CCN(Cc2ccccc2)C1 Show InChI InChI=1S/C20H24N2O3/c1-24-18-10-16(11-19(12-18)25-2)20(23)21-17-8-9-22(14-17)13-15-6-4-3-5-7-15/h3-7,10-12,17H,8-9,13-14H2,1-2H3,(H,21,23)/t17-/m1/s1 | PDB
Reactome pathway
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PubMed
| 8.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192180
(3,5-dimethoxy-N-(2,2,6,6-tetramethyl-1-(naphthalen...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CC(C)(C)N(Cc2ccc3ccccc3c2)C(C)(C)C1 Show InChI InChI=1S/C29H36N2O3/c1-28(2)17-24(30-27(32)23-14-25(33-5)16-26(15-23)34-6)18-29(3,4)31(28)19-20-11-12-21-9-7-8-10-22(21)13-20/h7-16,24H,17-19H2,1-6H3,(H,30,32) | PDB
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| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192176
(3,5-dimethoxy-N-(3-(naphthalen-2-ylmethylamino)pro...)Show InChI InChI=1S/C23H26N2O3/c1-27-21-13-20(14-22(15-21)28-2)23(26)25-11-5-10-24-16-17-8-9-18-6-3-4-7-19(18)12-17/h3-4,6-9,12-15,24H,5,10-11,16H2,1-2H3,(H,25,26) | PDB
Reactome pathway
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| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192185
((1R,5S,6s)-N-(3,4-difluorobenzyl)-3-(naphthalen-2-...)Show SMILES Fc1ccc(CNC(=O)[C@H]2[C@H]3CN(Cc4ccc5ccccc5c4)C[C@@H]23)cc1F Show InChI InChI=1S/C24H22F2N2O/c25-21-8-6-15(10-22(21)26)11-27-24(29)23-19-13-28(14-20(19)23)12-16-5-7-17-3-1-2-4-18(17)9-16/h1-10,19-20,23H,11-14H2,(H,27,29)/t19-,20+,23- | PDB
Reactome pathway
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| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192156
(3,5-dimethoxy-N-(1-(3-phenylpropyl)piperidin-4-yl)...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(CCCc2ccccc2)CC1 Show InChI InChI=1S/C23H30N2O3/c1-27-21-15-19(16-22(17-21)28-2)23(26)24-20-10-13-25(14-11-20)12-6-9-18-7-4-3-5-8-18/h3-5,7-8,15-17,20H,6,9-14H2,1-2H3,(H,24,26) | PDB
Reactome pathway
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| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50173041
(3,5-dimethoxy-N-(1-(naphthalen-2-ylmethyl)piperidi...)Show SMILES NC(=O)c1ccc(cc1)-c1nnc(Nc2cccc(Br)c2)c2ccccc12 Show InChI InChI=1S/C21H15BrN4O/c22-15-4-3-5-16(12-15)24-21-18-7-2-1-6-17(18)19(25-26-21)13-8-10-14(11-9-13)20(23)27/h1-12H,(H2,23,27)(H,24,26) | PDB
Reactome pathway
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| >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Binding activity against human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192169
((R)-3,5-dimethoxy-N-(1-(naphthalen-2-ylmethyl)pyrr...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@@H]1CCN(Cc2ccc3ccccc3c2)C1 Show InChI InChI=1S/C24H26N2O3/c1-28-22-12-20(13-23(14-22)29-2)24(27)25-21-9-10-26(16-21)15-17-7-8-18-5-3-4-6-19(18)11-17/h3-8,11-14,21H,9-10,15-16H2,1-2H3,(H,25,27)/t21-/m1/s1 | PDB
Reactome pathway
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| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of MCH-mediated calcium release by CHO cells expressing human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192163
((R,E)-N-(1-cinnamylpyrrolidin-3-yl)-3,5-dimethoxyb...)Show SMILES COc1cc(OC)cc(c1)C(=O)N[C@@H]1CCN(C\C=C\c2ccccc2)C1 Show InChI InChI=1S/C22H26N2O3/c1-26-20-13-18(14-21(15-20)27-2)22(25)23-19-10-12-24(16-19)11-6-9-17-7-4-3-5-8-17/h3-9,13-15,19H,10-12,16H2,1-2H3,(H,23,25)/b9-6+/t19-/m1/s1 | PDB
Reactome pathway
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| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of MCH-mediated calcium release by CHO cells expressing human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192161
(3,4-difluoro-N-(1-(naphthalen-2-ylmethyl)piperidin...)Show SMILES Fc1ccc(cc1F)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C23H22F2N2O/c24-21-8-7-19(14-22(21)25)23(28)26-20-9-11-27(12-10-20)15-16-5-6-17-3-1-2-4-18(17)13-16/h1-8,13-14,20H,9-12,15H2,(H,26,28) | PDB
Reactome pathway
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| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of MCH-mediated calcium release by CHO cells expressing human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192177
(3,5-dimethoxy-N-(1-(naphthalen-2-ylmethyl)piperidi...)Show SMILES COc1cc(OC)cc(c1)C(=O)NC1CCN(Cc2ccc3ccccc3c2)CC1 Show InChI InChI=1S/C25H28N2O3/c1-29-23-14-21(15-24(16-23)30-2)25(28)26-22-9-11-27(12-10-22)17-18-7-8-19-5-3-4-6-20(19)13-18/h3-8,13-16,22H,9-12,17H2,1-2H3,(H,26,28) | PDB
Reactome pathway
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| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of MCH-mediated calcium release by CHO cells expressing human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192167
(CHEMBL214726 | N-(1-((6-fluoronaphthalen-2-yl)meth...)Show InChI InChI=1S/C23H23FN2O/c24-21-9-8-19-14-17(6-7-20(19)15-21)16-26-12-10-22(11-13-26)25-23(27)18-4-2-1-3-5-18/h1-9,14-15,22H,10-13,16H2,(H,25,27) | PDB
Reactome pathway
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| n/a | n/a | 109 | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of MCH-mediated calcium release by CHO cells expressing human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192179
(CHEMBL215388 | N-(1-(naphthalen-2-ylmethyl)piperid...)Show InChI InChI=1S/C23H24N2O/c26-23(20-7-2-1-3-8-20)24-22-12-14-25(15-13-22)17-18-10-11-19-6-4-5-9-21(19)16-18/h1-11,16,22H,12-15,17H2,(H,24,26) | PDB
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| n/a | n/a | 948 | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of MCH-mediated calcium release by CHO cells expressing human MCH-R1 |
Bioorg Med Chem Lett 16: 5445-50 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.053
BindingDB Entry DOI: 10.7270/Q2CR5T0F |
More data for this
Ligand-Target Pair | |
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