Found 40 hits Enz. Inhib. hit(s) with all data for entry = 50040288 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391953
(CHEMBL2152288)Show SMILES Nc1cc(NS(=O)(=O)c2cccc(c2)C(F)(F)F)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1 Show InChI InChI=1S/C25H18F3N5O2S/c26-25(27,28)18-2-1-3-21(11-18)36(34,35)33-20-9-16(8-19(29)12-20)17-10-22-23(14-32-24(22)31-13-17)15-4-6-30-7-5-15/h1-14,33H,29H2,(H,31,32) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.67 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391978
(CHEMBL2152287)Show SMILES Nc1cc(NS(=O)(=O)c2ccc(F)cc2F)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1 Show InChI InChI=1S/C24H17F2N5O2S/c25-17-1-2-23(22(26)10-17)34(32,33)31-19-8-15(7-18(27)11-19)16-9-20-21(13-30-24(20)29-12-16)14-3-5-28-6-4-14/h1-13,31H,27H2,(H,29,30) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.97 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391977
(CHEMBL2152286)Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1cc(N)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1 Show InChI InChI=1S/C25H21N5O2S/c1-16-2-4-22(5-3-16)33(31,32)30-21-11-18(10-20(26)13-21)19-12-23-24(15-29-25(23)28-14-19)17-6-8-27-9-7-17/h2-15,30H,26H2,1H3,(H,28,29) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.62 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391950
(CHEMBL2152289)Show SMILES CC(=O)Nc1cc(N)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1 Show InChI InChI=1S/C20H17N5O/c1-12(26)25-17-7-14(6-16(21)9-17)15-8-18-19(11-24-20(18)23-10-15)13-2-4-22-5-3-13/h2-11H,21H2,1H3,(H,23,24)(H,25,26) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.41 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391974
(CHEMBL2152283)Show SMILES Nc1cc(OCCN2CCOCC2)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1 Show InChI InChI=1S/C24H25N5O2/c25-20-11-18(12-21(14-20)31-10-7-29-5-8-30-9-6-29)19-13-22-23(16-28-24(22)27-15-19)17-1-3-26-4-2-17/h1-4,11-16H,5-10,25H2,(H,27,28) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.36 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391976
(CHEMBL2152285)Show SMILES Nc1cc(NS(=O)(=O)c2ccccc2)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1 Show InChI InChI=1S/C24H19N5O2S/c25-19-10-17(11-20(13-19)29-32(30,31)21-4-2-1-3-5-21)18-12-22-23(15-28-24(22)27-14-18)16-6-8-26-9-7-16/h1-15,29H,25H2,(H,27,28) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391973
(CHEMBL2152282)Show SMILES CN(C)CCOc1cc(N)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1 Show InChI InChI=1S/C22H23N5O/c1-27(2)7-8-28-19-10-16(9-18(23)12-19)17-11-20-21(14-26-22(20)25-13-17)15-3-5-24-6-4-15/h3-6,9-14H,7-8,23H2,1-2H3,(H,25,26) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391971
(CHEMBL2152280)Show SMILES COc1cc(N)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1 Show InChI InChI=1S/C19H16N4O/c1-24-16-7-13(6-15(20)9-16)14-8-17-18(11-23-19(17)22-10-14)12-2-4-21-5-3-12/h2-11H,20H2,1H3,(H,22,23) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 18.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391968
(CHEMBL2152277)Show InChI InChI=1S/C19H16N4/c1-12-2-3-14(9-18(12)20)15-8-16-17(11-23-19(16)22-10-15)13-4-6-21-7-5-13/h2-11H,20H2,1H3,(H,22,23) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391963
(CHEMBL2152272)Show InChI InChI=1S/C19H15N3O/c1-23-16-4-2-3-14(9-16)15-10-17-18(12-22-19(17)21-11-15)13-5-7-20-8-6-13/h2-12H,1H3,(H,21,22) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391965
(CHEMBL2152274)Show InChI InChI=1S/C18H14N4/c19-15-3-1-12(2-4-15)14-9-16-17(11-22-18(16)21-10-14)13-5-7-20-8-6-13/h1-11H,19H2,(H,21,22) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25.0 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391962
(CHEMBL2152271)Show SMILES CN(C)c1cccc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1 Show InChI InChI=1S/C20H18N4/c1-24(2)17-5-3-4-15(10-17)16-11-18-19(13-23-20(18)22-12-16)14-6-8-21-9-7-14/h3-13H,1-2H3,(H,22,23) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 26.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391961
(CHEMBL2152270)Show InChI InChI=1S/C19H16N4/c1-20-16-4-2-3-14(9-16)15-10-17-18(12-23-19(17)22-11-15)13-5-7-21-8-6-13/h2-12,20H,1H3,(H,22,23) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 31.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391966
(CHEMBL2152275)Show InChI InChI=1S/C19H16N4O/c1-24-18-3-2-13(9-17(18)20)14-8-15-16(11-23-19(15)22-10-14)12-4-6-21-7-5-12/h2-11H,20H2,1H3,(H,22,23) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 33.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391975
(CHEMBL2152284)Show SMILES CS(=O)(=O)Nc1cc(N)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1 Show InChI InChI=1S/C19H17N5O2S/c1-27(25,26)24-16-7-13(6-15(20)9-16)14-8-17-18(11-23-19(17)22-10-14)12-2-4-21-5-3-12/h2-11,24H,20H2,1H3,(H,22,23) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 33.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391964
(CHEMBL2152273)Show SMILES CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1 Show InChI InChI=1S/C20H16N4O/c1-13(25)24-17-4-2-3-15(9-17)16-10-18-19(12-23-20(18)22-11-16)14-5-7-21-8-6-14/h2-12H,1H3,(H,22,23)(H,24,25) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 34.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391955
(CHEMBL2152264)Show InChI InChI=1S/C18H14N4/c19-15-3-1-2-13(8-15)14-9-16-17(11-22-18(16)21-10-14)12-4-6-20-7-5-12/h1-11H,19H2,(H,21,22) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 42.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391970
(CHEMBL2152279)Show SMILES CN(C)CCOc1ccc(cc1N)-c1cnc2[nH]cc(-c3ccncc3)c2c1 Show InChI InChI=1S/C22H23N5O/c1-27(2)9-10-28-21-4-3-16(12-20(21)23)17-11-18-19(14-26-22(18)25-13-17)15-5-7-24-8-6-15/h3-8,11-14H,9-10,23H2,1-2H3,(H,25,26) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391967
(CHEMBL2152276)Show InChI InChI=1S/C18H13ClN4/c19-16-2-1-12(8-17(16)20)13-7-14-15(10-23-18(14)22-9-13)11-3-5-21-6-4-11/h1-10H,20H2,(H,22,23) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 53.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391972
(CHEMBL2152281)Show SMILES Nc1cc(cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1)C(=O)N1CCOCC1 Show InChI InChI=1S/C23H21N5O2/c24-19-10-16(9-17(11-19)23(29)28-5-7-30-8-6-28)18-12-20-21(14-27-22(20)26-13-18)15-1-3-25-4-2-15/h1-4,9-14H,5-8,24H2,(H,26,27) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 64.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391960
(CHEMBL2152269)Show InChI InChI=1S/C17H13N5/c18-14-5-12(7-20-9-14)13-6-15-16(10-22-17(15)21-8-13)11-1-3-19-4-2-11/h1-10H,18H2,(H,21,22) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 69.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391969
(CHEMBL2152278)Show SMILES Nc1cc(ccc1C(=O)N1CCOCC1)-c1cnc2[nH]cc(-c3ccncc3)c2c1 Show InChI InChI=1S/C23H21N5O2/c24-21-12-16(1-2-18(21)23(29)28-7-9-30-10-8-28)17-11-19-20(14-27-22(19)26-13-17)15-3-5-25-6-4-15/h1-6,11-14H,7-10,24H2,(H,26,27) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 88.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391951
(CHEMBL2152290)Show InChI InChI=1S/C19H16N4O/c1-24-18-3-2-14(20)9-15(18)13-8-16-17(11-23-19(16)22-10-13)12-4-6-21-7-5-12/h2-11H,20H2,1H3,(H,22,23) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50391953
(CHEMBL2152288)Show SMILES Nc1cc(NS(=O)(=O)c2cccc(c2)C(F)(F)F)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1 Show InChI InChI=1S/C25H18F3N5O2S/c26-25(27,28)18-2-1-3-21(11-18)36(34,35)33-20-9-16(8-19(29)12-20)17-10-22-23(14-32-24(22)31-13-17)15-4-6-30-7-5-15/h1-14,33H,29H2,(H,31,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 145 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of KIT by high throughput binding assay |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391952
(CHEMBL2152291)Show SMILES Nc1ccc(NS(=O)(=O)c2ccccc2)c(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1 Show InChI InChI=1S/C24H19N5O2S/c25-18-6-7-23(29-32(30,31)19-4-2-1-3-5-19)20(13-18)17-12-21-22(15-28-24(21)27-14-17)16-8-10-26-11-9-16/h1-15,29H,25H2,(H,27,28) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Inhibition of TRKA assessed as [gamma33P]ATP incorporation into substrate |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50332019
(5-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridi...)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cncc(N)c1 Show InChI InChI=1S/C20H18N4O2/c1-25-18-4-3-12(7-19(18)26-2)17-11-24-20-16(17)6-14(9-23-20)13-5-15(21)10-22-8-13/h3-11H,21H2,1-2H3,(H,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 960 | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Binding affinity to PI3Kalpha by high throughput assay |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50332020
(CHEMBL1289468 | N-(3-(3-(3,4-dimethoxyphenyl)-1H-p...)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(NS(=O)(=O)c2ccccc2)c1 Show InChI InChI=1S/C27H23N3O4S/c1-33-25-12-11-19(15-26(25)34-2)24-17-29-27-23(24)14-20(16-28-27)18-7-6-8-21(13-18)30-35(31,32)22-9-4-3-5-10-22/h3-17,30H,1-2H3,(H,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Binding affinity to PI3Kalpha by high throughput assay |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50332012
(CHEMBL1290790 | N-(5-(3-(3,4-dimethoxyphenyl)-1H-p...)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cncc(NS(=O)(=O)c2ccccc2)c1 Show InChI InChI=1S/C26H22N4O4S/c1-33-24-9-8-17(12-25(24)34-2)23-16-29-26-22(23)11-19(14-28-26)18-10-20(15-27-13-18)30-35(31,32)21-6-4-3-5-7-21/h3-16,30H,1-2H3,(H,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Binding affinity to PI3Kalpha by high throughput assay |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391957
(CHEMBL2152266)Show InChI InChI=1S/C19H15N3/c20-16-8-4-7-14(9-16)15-10-17-18(12-22-19(17)21-11-15)13-5-2-1-3-6-13/h1-12H,20H2,(H,21,22) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Binding affinity to TRKA by high throughput assay |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391956
(CHEMBL2152265)Show InChI InChI=1S/C18H14N4/c19-15-5-1-3-12(7-15)14-8-16-17(11-22-18(16)21-10-14)13-4-2-6-20-9-13/h1-11H,19H2,(H,21,22) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Binding affinity to TRKA by high throughput assay |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391955
(CHEMBL2152264)Show InChI InChI=1S/C18H14N4/c19-15-3-1-2-13(8-15)14-9-16-17(11-22-18(16)21-10-14)12-4-6-20-7-5-12/h1-11H,19H2,(H,21,22) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Binding affinity to TRKA by high throughput assay |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391954
(CHEMBL2152262)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(N)c1 Show InChI InChI=1S/C21H19N3O2/c1-25-19-7-6-14(10-20(19)26-2)18-12-24-21-17(18)9-15(11-23-21)13-4-3-5-16(22)8-13/h3-12H,22H2,1-2H3,(H,23,24) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 125 | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Binding affinity to TRKA by high throughput assay |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50332019
(5-(3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridi...)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cncc(N)c1 Show InChI InChI=1S/C20H18N4O2/c1-25-18-4-3-12(7-19(18)26-2)17-11-24-20-16(17)6-14(9-23-20)13-5-15(21)10-22-8-13/h3-11H,21H2,1-2H3,(H,23,24) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Binding affinity to TRKA by high throughput assay |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50332020
(CHEMBL1289468 | N-(3-(3-(3,4-dimethoxyphenyl)-1H-p...)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cccc(NS(=O)(=O)c2ccccc2)c1 Show InChI InChI=1S/C27H23N3O4S/c1-33-25-12-11-19(15-26(25)34-2)24-17-29-27-23(24)14-20(16-28-27)18-7-6-8-21(13-18)30-35(31,32)22-9-4-3-5-10-22/h3-17,30H,1-2H3,(H,28,29) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Binding affinity to TRKA by high throughput assay |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50332012
(CHEMBL1290790 | N-(5-(3-(3,4-dimethoxyphenyl)-1H-p...)Show SMILES COc1ccc(cc1OC)-c1c[nH]c2ncc(cc12)-c1cncc(NS(=O)(=O)c2ccccc2)c1 Show InChI InChI=1S/C26H22N4O4S/c1-33-24-9-8-17(12-25(24)34-2)23-16-29-26-22(23)11-19(14-28-26)18-10-20(15-27-13-18)30-35(31,32)21-6-4-3-5-7-21/h3-16,30H,1-2H3,(H,28,29) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 145 | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Binding affinity to TRKA by high throughput assay |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391959
(CHEMBL2152268)Show SMILES Nc1cccc(c1)-c1c[nH]c2ncc(cc12)-c1cccc(c1)C#N Show InChI InChI=1S/C20H14N4/c21-10-13-3-1-4-14(7-13)16-9-18-19(12-24-20(18)23-11-16)15-5-2-6-17(22)8-15/h1-9,11-12H,22H2,(H,23,24) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Binding affinity to TRKA by high throughput assay |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50391958
(CHEMBL2152267)Show SMILES Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccc(c3)C#N)c2c1 Show InChI InChI=1S/C20H14N4/c21-10-13-3-1-5-15(7-13)19-12-24-20-18(19)9-16(11-23-20)14-4-2-6-17(22)8-14/h1-9,11-12H,22H2,(H,23,24) | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Binding affinity to TRKA by high throughput assay |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50391959
(CHEMBL2152268)Show SMILES Nc1cccc(c1)-c1c[nH]c2ncc(cc12)-c1cccc(c1)C#N Show InChI InChI=1S/C20H14N4/c21-10-13-3-1-4-14(7-13)16-9-18-19(12-24-20(18)23-11-16)15-5-2-6-17(22)8-15/h1-9,11-12H,22H2,(H,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Binding affinity to PI3Kalpha by high throughput assay |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50391956
(CHEMBL2152265)Show InChI InChI=1S/C18H14N4/c19-15-5-1-3-12(7-15)14-8-16-17(11-22-18(16)21-10-14)13-4-2-6-20-9-13/h1-11H,19H2,(H,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Binding affinity to PI3Kalpha by high throughput assay |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50391955
(CHEMBL2152264)Show InChI InChI=1S/C18H14N4/c19-15-3-1-2-13(8-15)14-9-16-17(11-22-18(16)21-10-14)12-4-6-20-7-5-12/h1-11H,19H2,(H,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a |
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
| Assay Description Binding affinity to PI3Kalpha by high throughput assay |
J Med Chem 55: 5337-49 (2012)
Article DOI: 10.1021/jm3002982 BindingDB Entry DOI: 10.7270/Q2JM2BQ3 |
More data for this Ligand-Target Pair | |