Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113298 (US10336717, Compound 76 | US8633212, 76 | US921215...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113223 (US8633212, 1) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113224 (US8633212, 2) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113392 (US10336717, Compound 578 | US8633212, 578 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113226 (US8633212, 4) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113227 (US8633212, 5) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113225 (US10336717, Compound 3 | US8633212, 3) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113364 (US10336717, Compound 543 | US8633212, 543 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113228 (US8633212, 6) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113352 (US10336717, Compound 524 | US8633212, 524 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113251 (US10336717, Compound 29 | US8633212, 29 | US921215...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113230 (US8633212, 8) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113229 (US8633212, 7) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113403 (US10336717, Compound 593 | US8633212, 593 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113412 (US10336717, Compound 602 | US8633212, 602 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113402 (US8633212, 592 | US9212153, 592) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113231 (US8633212, 9) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113232 (US10336717, Compound 10 | US8633212, 10 | US921215...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113233 (US10336717, Compound 11 | US8633212, 11) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113234 (US8633212, 12) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113346 (US10336717, Compound 514 | US8633212, 514 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113235 (US8633212, 13) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.80 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113345 (US10336717, Compound 513 | US8633212, 513 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113343 (US10336717, Compound 511 | US8633212, 511 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113366 (US10336717, Compound 545 | US8633212, 545 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113333 (US10336717, Compound 515 | US8633212, 501 | US8633...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113363 (US10336717, Compound 542 | US8633212, 542 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113236 (US10336717, Compound 14 | US8633212, 14) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 11.1 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113237 (US10336717, Compound 15 | US8633212, 15 | US921215...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 11.2 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113238 (US10336717, Compound 16 | US8633212, 16) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 11.5 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113377 (US10336717, Compound 561 | US8633212, 561 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 11.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113409 (US10336717, Compound 599 | US8633212, 599 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113239 (US10336717, Compound 17 | US8633212, 17 | US921215...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 12.1 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113241 (US8633212, 19) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 14.6 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113408 (US10336717, Compound 598 | US8633212, 598 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113333 (US10336717, Compound 515 | US8633212, 501 | US8633...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 15.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113393 (US10336717, Compound 579 | US8633212, 579 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 15.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113240 (US10336717, Compound 18 | US8633212, 18 | US921215...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 16.8 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113242 (US8633212, 20) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 18.7 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113243 (US10336717, Compound 21 | US8633212, 21 | US921215...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 18.9 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113244 (US10336717, Compound 22 | US8633212, 22 | US921215...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 19.3 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113245 (US10336717, Compound 23 | US8633212, 23 | US921215...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 20.7 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113246 (US10336717, Compound 24 | US8633212, 24 | US921215...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 21 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113365 (US10336717, Compound 544 | US8633212, 544 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113369 (US8633212, 548) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113372 (US10336717, Compound 552 | US8633212, 552 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113247 (US8633212, 25) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 26.2 | n/a | n/a | n/a | n/a | 4.5 | 25 |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description Inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE activity. The assay was performed at room temperature in 96-well... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113330 (US10336717, Compound 498 | US8633212, 498 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 27.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113325 (US10336717, Compound 493 | US8633212, 493 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 29.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform C of Beta-secretase 1 (BACE-I-457) (Homo sapiens (Human)) | BDBM113414 (US10336717, Compound 604 | US8633212, 604 | US9212...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent | Assay Description For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse... | US Patent US8633212 (2014) BindingDB Entry DOI: 10.7270/Q2V123D3 | |||||||||||
More data for this Ligand-Target Pair |
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