| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform C of Beta-secretase 1 (BACE-I-457) |
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| Ligand | BDBM113223 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| pH | 4.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 2.6±n/a nM |
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| Comments | extracted |
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| Citation |  Cacatian, S; Claremon, DA; Dillard, LW; Fuchs, K; Heine, N; Jia, L; Leftheris, K; McKeever, B; Morales-Ramos, A; Singh, SB; Venkatraman, S; Wu, G; Wu, Z; Xu, Z; Yuan, J; Zheng, Y Inhibitors of beta-secretase US Patent US8633212 Publication Date 1/21/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform C of Beta-secretase 1 (BACE-I-457) |
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| Name: | Isoform C of Beta-secretase 1 (BACE-I-457) |
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| Synonyms: | BACE | BACE1 | BACE1_HUMAN | Beta-secretase 1 (BACE) | Beta-secretase 1 (BACE-I-457) | KIAA1149 |
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| Type: | Enzyme |
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| Mol. Mass.: | 51006.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P56817-3 |
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| Residue: | 457 |
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| Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQ
SEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYD
KSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVI
SLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYV
VFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAA
ICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK
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| BDBM113223 |
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| n/a |
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| Name | BDBM113223 |
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| Synonyms: | US8633212, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25ClFN3O2 |
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| Mol. Mass. | 429.915 |
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| SMILES | n/a |
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| Structure | 
|
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