Compile Data Set for Download or QSAR

Found 732 hits Enz. Inhib. hit(s) with all data for entry = 8903   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293454 (US10106527, Compound 57 | US10544128, Compound 57 ...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CC(N)C3)cc2c1 Show InChI InChI=1S/C22H21N7O/c1-28-11-18(10-26-28)14-2-3-16-9-25-20(7-17(16)6-14)27-22(30)15-4-5-24-21(8-15)29-12-19(23)13-29/h2-11,19H,12-13,23H2,1H3,(H,25,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.60	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293455 (US10106527, Compound 59 | US10544128, Compound 59 ...) Show SMILES CN(C)C1CN(C1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C24H25N7O/c1-29(2)21-14-31(15-21)23-10-17(6-7-25-23)24(32)28-22-9-19-8-16(4-5-18(19)11-26-22)20-12-27-30(3)13-20/h4-13,21H,14-15H2,1-3H3,(H,26,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293456 (US10106527, Compound 60 | US10544128, Compound 60 ...) Show SMILES Cn1cc(nn1)-c1ccc2cnc(NC(=O)c3ccccc3F)cc2c1 Show InChI InChI=1S/C19H14FN5O/c1-25-11-17(23-24-25)12-6-7-13-10-21-18(9-14(13)8-12)22-19(26)15-4-2-3-5-16(15)20/h2-11H,1H3,(H,21,22,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.70	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293457 (US10106527, Compound 61 | US10544128, Compound 61 ...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CCOCC3)cc2c1 Show InChI InChI=1S/C23H22N6O2/c1-28-15-20(14-26-28)16-2-3-18-13-25-21(11-19(18)10-16)27-23(30)17-4-5-24-22(12-17)29-6-8-31-9-7-29/h2-5,10-15H,6-9H2,1H3,(H,25,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.60	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293458 (US10106527, Compound 62 | US10544128, Compound 62 ...) Show SMILES CN(C)CCNc1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C23H25N7O/c1-29(2)9-8-25-21-11-17(6-7-24-21)23(31)28-22-12-19-10-16(4-5-18(19)13-26-22)20-14-27-30(3)15-20/h4-7,10-15H,8-9H2,1-3H3,(H,24,25)(H,26,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.30	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293459 (US10106527, Compound 63 | US10544128, Compound 63 ...) Show SMILES CN(C)CCOc1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C23H24N6O2/c1-28(2)8-9-31-22-12-17(6-7-24-22)23(30)27-21-11-19-10-16(4-5-18(19)13-25-21)20-14-26-29(3)15-20/h4-7,10-15H,8-9H2,1-3H3,(H,25,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.70	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293460 (US10106527, Compound 64 | US10544128, Compound 64 ...) Show SMILES CC(C)CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C27H31N7O/c1-19(2)17-33-8-10-34(11-9-33)26-14-21(6-7-28-26)27(35)31-25-13-23-12-20(4-5-22(23)15-29-25)24-16-30-32(3)18-24/h4-7,12-16,18-19H,8-11,17H2,1-3H3,(H,29,31,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.30	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293461 (US10106527, Compound 65 | US10544128, Compound 65 ...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccnc(OC4CNC4)c3)cc2c1 Show InChI InChI=1S/C22H20N6O2/c1-28-13-18(10-26-28)14-2-3-16-9-25-20(7-17(16)6-14)27-22(29)15-4-5-24-21(8-15)30-19-11-23-12-19/h2-10,13,19,23H,11-12H2,1H3,(H,25,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM427094 (US10544128, Compound 66) Show SMILES CN1CC(C1)Oc1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cn(C)nn1 Show InChI InChI=1S/C22H21N7O2/c1-28-11-18(12-28)31-21-9-15(5-6-23-21)22(30)25-20-8-17-7-14(3-4-16(17)10-24-20)19-13-29(2)27-26-19/h3-10,13,18H,11-12H2,1-2H3,(H,24,25,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.5	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293463 (US10106527, Compound 67 | US10544128, Compound 67 ...) Show SMILES CCN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C25H27N7O/c1-3-31-8-10-32(11-9-31)24-14-19(6-7-26-24)25(33)29-23-13-21-12-18(4-5-20(21)15-27-23)22-16-28-30(2)17-22/h4-7,12-17H,3,8-11H2,1-2H3,(H,27,29,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.70	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293464 (BDBM427096 | US10106527, Compound 71 | US11548872,...) Show SMILES CN(C)Cc1ccc(cc1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C23H23N5O/c1-27(2)14-16-4-6-17(7-5-16)23(29)26-22-11-20-10-18(8-9-19(20)12-24-22)21-13-25-28(3)15-21/h4-13,15H,14H2,1-3H3,(H,24,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.90	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM427097 (US10544128, Compound 72) Show SMILES CN1CCC(CC1)c1cccc(c1)C(=O)Nc1cc2cc(ccc2cn1)-c1cn(C)nn1 Show InChI InChI=1S/C25H26N6O/c1-30-10-8-17(9-11-30)18-4-3-5-20(12-18)25(32)27-24-14-22-13-19(6-7-21(22)15-26-24)23-16-31(2)29-28-23/h3-7,12-17H,8-11H2,1-2H3,(H,26,27,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.90	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293466 (US10106527, Compound 74 | US10544128, Compound 74 ...) Show SMILES CN1CCN(Cc2cccc(c2)C(=O)Nc2cc3cc(ccc3cn2)-c2cnn(C)c2)CC1 Show InChI InChI=1S/C26H28N6O/c1-30-8-10-32(11-9-30)17-19-4-3-5-21(12-19)26(33)29-25-14-23-13-20(6-7-22(23)15-27-25)24-16-28-31(2)18-24/h3-7,12-16,18H,8-11,17H2,1-2H3,(H,27,29,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293467 (US10106527, Compound 76 | US10544128, Compound 76 ...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccncc3)cc2c1 Show InChI InChI=1S/C19H15N5O/c1-24-12-17(11-22-24)14-2-3-15-10-21-18(9-16(15)8-14)23-19(25)13-4-6-20-7-5-13/h2-12H,1H3,(H,21,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.80	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM427100 (US10544128, Compound 78) Show SMILES Cn1cc(nn1)-c1ccc2cnc(NC(=O)c3ccnc(O)c3)cc2c1 Show InChI InChI=1S/C18H14N6O2/c1-24-10-15(22-23-24)11-2-3-13-9-20-16(7-14(13)6-11)21-18(26)12-4-5-19-17(25)8-12/h2-10H,1H3,(H,19,25)(H,20,21,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.10	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293469 (US10106527, Compound 80 | US10544128, Compound 80 ...) Show SMILES CC(C)Oc1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C22H21N5O2/c1-14(2)29-21-10-16(6-7-23-21)22(28)26-20-9-18-8-15(4-5-17(18)11-24-20)19-12-25-27(3)13-19/h4-14H,1-3H3,(H,24,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	13.6	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293546 (US10106527, Compound 238 | US10544128, Compound 23...) Show SMILES CN1CCC(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cn(C)nn1 Show InChI InChI=1S/C24H25N7O/c1-30-9-6-16(7-10-30)21-12-18(5-8-25-21)24(32)27-23-13-20-11-17(3-4-19(20)14-26-23)22-15-31(2)29-28-22/h3-5,8,11-16H,6-7,9-10H2,1-2H3,(H,26,27,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.90	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293471 (US10106527, Compound 85 | US10544128, Compound 85 ...) Show SMILES CN1CCC(=CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 |c:4| Show InChI InChI=1S/C25H24N6O/c1-30-9-6-17(7-10-30)23-12-19(5-8-26-23)25(32)29-24-13-21-11-18(3-4-20(21)14-27-24)22-15-28-31(2)16-22/h3-6,8,11-16H,7,9-10H2,1-2H3,(H,27,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.60	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293472 (US10106527, Compound 86 | US10544128, Compound 86 ...) Show SMILES CN1CCN(CC1)c1ccc(cn1)C(=O)N1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C34H36N10O2/c1-40-9-11-42(12-10-40)31-6-5-27(21-37-31)34(46)44-15-13-43(14-16-44)32-19-25(7-8-35-32)33(45)39-30-18-28-17-24(3-4-26(28)20-36-30)29-22-38-41(2)23-29/h3-8,17-23H,9-16H2,1-2H3,(H,36,39,45)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.90	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293473 (US10106527, Compound 87 | US10544128, Compound 87 ...) Show SMILES [#6]-n1cc(cn1)-c1ccc2cnc(-[#7]-[#6](=O)-c3ccnc(c3)-[#7]-3-[#6]-[#6][N]([#6])([#8])[#6]-[#6]-3)cc2c1 Show InChI InChI=1S/C24H26N7O2/c1-29-16-21(15-27-29)17-3-4-19-14-26-22(12-20(19)11-17)28-24(32)18-5-6-25-23(13-18)30-7-9-31(2,33)10-8-30/h3-6,11-16,33H,7-10H2,1-2H3,(H,26,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.90	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293474 (US10106527, Compound 88 | US10544128, Compound 88 ...) Show SMILES CN1CCN(CC1)c1cc(cc(C)n1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C25H27N7O/c1-17-10-21(13-24(28-17)32-8-6-30(2)7-9-32)25(33)29-23-12-20-11-18(4-5-19(20)14-26-23)22-15-27-31(3)16-22/h4-5,10-16H,6-9H2,1-3H3,(H,26,29,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.80	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293475 (US10106527, Compound 89 | US10544128, Compound 89 ...) Show SMILES CN1CCN(CC1)c1nccc(C(=O)Nc2cc3cc(ccc3cn2)-c2cnn(C)c2)c1C Show InChI InChI=1S/C25H27N7O/c1-17-22(6-7-26-24(17)32-10-8-30(2)9-11-32)25(33)29-23-13-20-12-18(4-5-19(20)14-27-23)21-15-28-31(3)16-21/h4-7,12-16H,8-11H2,1-3H3,(H,27,29,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	22.3	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293476 (US10106527, Compound 90 | US10544128, Compound 90 ...) Show SMILES CN1CCCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C25H27N7O/c1-30-8-3-9-32(11-10-30)24-14-19(6-7-26-24)25(33)29-23-13-21-12-18(4-5-20(21)15-27-23)22-16-28-31(2)17-22/h4-7,12-17H,3,8-11H2,1-2H3,(H,27,29,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.30	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293477 (US10106527, Compound 91 | US10544128, Compound 91 ...) Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 |r| Show InChI InChI=1S/C25H26N6O2/c1-16-13-31(14-17(2)33-16)24-10-19(6-7-26-24)25(32)29-23-9-21-8-18(4-5-20(21)11-27-23)22-12-28-30(3)15-22/h4-12,15-17H,13-14H2,1-3H3,(H,27,29,32)/t16-,17+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.70	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293478 (US10106527, Compound 92 | US10544128, Compound 92 ...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CC4(C3)CCNCC4)cc2c1 Show InChI InChI=1S/C26H27N7O/c1-32-15-22(14-30-32)18-2-3-20-13-29-23(11-21(20)10-18)31-25(34)19-4-7-28-24(12-19)33-16-26(17-33)5-8-27-9-6-26/h2-4,7,10-15,27H,5-6,8-9,16-17H2,1H3,(H,29,31,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293479 (US10106527, Compound 93 | US10544128, Compound 93 ...) Show SMILES CN1CCC2(CN(C2)c2cc(ccn2)C(=O)Nc2cc3cc(ccc3cn2)-c2cnn(C)c2)CC1 Show InChI InChI=1S/C27H29N7O/c1-32-9-6-27(7-10-32)17-34(18-27)25-13-20(5-8-28-25)26(35)31-24-12-22-11-19(3-4-21(22)14-29-24)23-15-30-33(2)16-23/h3-5,8,11-16H,6-7,9-10,17-18H2,1-2H3,(H,29,31,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.700	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293480 (US10106527, Compound 94 | US10544128, Compound 94 ...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CCC4(CNC4)CC3)cc2c1 Show InChI InChI=1S/C26H27N7O/c1-32-15-22(14-30-32)18-2-3-20-13-29-23(11-21(20)10-18)31-25(34)19-4-7-28-24(12-19)33-8-5-26(6-9-33)16-27-17-26/h2-4,7,10-15,27H,5-6,8-9,16-17H2,1H3,(H,29,31,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293481 (US10106527, Compound 95 | US10544128, Compound 95 ...) Show SMILES CN1CC2(C1)CCN(CC2)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C27H29N7O/c1-32-17-27(18-32)6-9-34(10-7-27)25-13-20(5-8-28-25)26(35)31-24-12-22-11-19(3-4-21(22)14-29-24)23-15-30-33(2)16-23/h3-5,8,11-16H,6-7,9-10,17-18H2,1-2H3,(H,29,31,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.40	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293482 (US10106527, Compound 97 | US10544128, Compound 97 ...) Show SMILES CN(C1CCN(C)CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C26H29N7O/c1-31-10-7-23(8-11-31)33(3)25-14-19(6-9-27-25)26(34)30-24-13-21-12-18(4-5-20(21)15-28-24)22-16-29-32(2)17-22/h4-6,9,12-17,23H,7-8,10-11H2,1-3H3,(H,28,30,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293483 (US10106527, Compound 99 | US10544128, Compound 99 ...) Show SMILES CN1CCC(CC1)Sc1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C25H26N6OS/c1-30-9-6-22(7-10-30)33-24-13-18(5-8-26-24)25(32)29-23-12-20-11-17(3-4-19(20)14-27-23)21-15-28-31(2)16-21/h3-5,8,11-16,22H,6-7,9-10H2,1-2H3,(H,27,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.5	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293484 (US10106527, Compound 100 | US10544128, Compound 10...) Show SMILES CN1CCN(CC1)c1nccc(n1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C23H24N8O/c1-29-7-9-31(10-8-29)23-24-6-5-20(27-23)22(32)28-21-12-18-11-16(3-4-17(18)13-25-21)19-14-26-30(2)15-19/h3-6,11-15H,7-10H2,1-2H3,(H,25,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	44.4	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293485 (US10106527, Compound 101 | US10544128, Compound 10...) Show SMILES CN1CCN(CC1)c1cc(cnn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C23H24N8O/c1-29-5-7-31(8-6-29)22-11-19(13-25-28-22)23(32)27-21-10-18-9-16(3-4-17(18)12-24-21)20-14-26-30(2)15-20/h3-4,9-15H,5-8H2,1-2H3,(H,24,27,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	25.7	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293486 (US10106527, Compound 102 | US10544128, Compound 10...) Show SMILES CN1CCN(CC1)c1cc(ncn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C23H24N8O/c1-29-5-7-31(8-6-29)22-11-20(25-15-26-22)23(32)28-21-10-18-9-16(3-4-17(18)12-24-21)19-13-27-30(2)14-19/h3-4,9-15H,5-8H2,1-2H3,(H,24,28,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	9.30	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293487 (US10106527, Compound 103 | US10544128, Compound 10...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)Cc3ccccc3)cc2c1 Show InChI InChI=1S/C21H18N4O/c1-25-14-19(13-23-25)16-7-8-17-12-22-20(11-18(17)10-16)24-21(26)9-15-5-3-2-4-6-15/h2-8,10-14H,9H2,1H3,(H,22,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.5	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293488 (US10106527, Compound 104 | US10544128, Compound 10...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)CCc3ccccc3)cc2c1 Show InChI InChI=1S/C22H20N4O/c1-26-15-20(14-24-26)17-8-9-18-13-23-21(12-19(18)11-17)25-22(27)10-7-16-5-3-2-4-6-16/h2-6,8-9,11-15H,7,10H2,1H3,(H,23,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.70	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293489 (US10106527, Compound 105 | US10544128, Compound 10...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)Cc3cccnc3)cc2c1 Show InChI InChI=1S/C20H17N5O/c1-25-13-18(12-23-25)15-4-5-16-11-22-19(9-17(16)8-15)24-20(26)7-14-3-2-6-21-10-14/h2-6,8-13H,7H2,1H3,(H,22,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	43.5	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293490 (US10106527, Compound 106 | US10544128, Compound 10...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)CCc3cccnc3)cc2c1 Show InChI InChI=1S/C21H19N5O/c1-26-14-19(13-24-26)16-5-6-17-12-23-20(10-18(17)9-16)25-21(27)7-4-15-3-2-8-22-11-15/h2-3,5-6,8-14H,4,7H2,1H3,(H,23,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.40	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293491 (US10106527, Compound 107 | US10544128, Compound 10...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)Cc3ccncc3)cc2c1 Show InChI InChI=1S/C20H17N5O/c1-25-13-18(12-23-25)15-2-3-16-11-22-19(10-17(16)9-15)24-20(26)8-14-4-6-21-7-5-14/h2-7,9-13H,8H2,1H3,(H,22,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.10	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293492 (US10106527, Compound 108 | US10544128, Compound 10...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)CCc3ccncc3)cc2c1 Show InChI InChI=1S/C21H19N5O/c1-26-14-19(13-24-26)16-3-4-17-12-23-20(11-18(17)10-16)25-21(27)5-2-15-6-8-22-9-7-15/h3-4,6-14H,2,5H2,1H3,(H,23,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.40	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293493 (US10106527, Compound 109 | US10544128, Compound 10...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccc4CNCc4c3)cc2c1 Show InChI InChI=1S/C22H19N5O/c1-27-13-20(12-25-27)14-2-4-17-11-24-21(8-18(17)6-14)26-22(28)15-3-5-16-9-23-10-19(16)7-15/h2-8,11-13,23H,9-10H2,1H3,(H,24,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.20	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293494 (US10106527, Compound 110 | US10544128, Compound 11...) Show SMILES CN1Cc2ccc(cc2C1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C23H21N5O/c1-27-12-18-6-4-16(8-20(18)13-27)23(29)26-22-9-19-7-15(3-5-17(19)10-24-22)21-11-25-28(2)14-21/h3-11,14H,12-13H2,1-2H3,(H,24,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.40	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293495 (US10106527, Compound 111 | US10544128, Compound 11...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccc4CCNCc4c3)cc2c1 Show InChI InChI=1S/C23H21N5O/c1-28-14-21(13-26-28)16-3-5-18-12-25-22(10-19(18)8-16)27-23(29)17-4-2-15-6-7-24-11-20(15)9-17/h2-5,8-10,12-14,24H,6-7,11H2,1H3,(H,25,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.70	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293496 (US10106527, Compound 112 | US10544128, Compound 11...) Show SMILES CN1CCc2ccc(cc2C1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C24H23N5O/c1-28-8-7-16-3-5-18(10-21(16)14-28)24(30)27-23-11-20-9-17(4-6-19(20)12-25-23)22-13-26-29(2)15-22/h3-6,9-13,15H,7-8,14H2,1-2H3,(H,25,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.30	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM293497 (US10106527, Compound 113 | US10544128, Compound 11...) Show SMILES CN1CCc2cc(ccc2C1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C24H23N5O/c1-28-8-7-17-9-18(4-6-20(17)14-28)24(30)27-23-11-21-10-16(3-5-19(21)12-25-23)22-13-26-29(2)15-22/h3-6,9-13,15H,7-8,14H2,1-2H3,(H,25,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.90	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies—a Divis...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Proto-oncogene Wnt-1 (Homo sapiens (human))	BDBM293415 (US10106527, Compound 1 | US10106527, Compound 145 ...) Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cn[nH]c1 Show InChI InChI=1S/C23H23N7O/c1-29-6-8-30(9-7-29)22-12-17(4-5-24-22)23(31)28-21-11-19-10-16(20-14-26-27-15-20)2-3-18(19)13-25-21/h2-5,10-15H,6-9H2,1H3,(H,26,27)(H,25,28,31)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	67	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Proto-oncogene Wnt-1 (Homo sapiens (human))	BDBM293416 (US10106527, Compound 2 | US10544128, Compound 2 | ...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3cccc(c3)N3CCNCC3)cc2c1 Show InChI InChI=1S/C24H24N6O/c1-29-16-21(15-27-29)17-5-6-19-14-26-23(13-20(19)11-17)28-24(31)18-3-2-4-22(12-18)30-9-7-25-8-10-30/h2-6,11-16,25H,7-10H2,1H3,(H,26,28,31)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	91	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Proto-oncogene Wnt-1 (Homo sapiens (human))	BDBM293417 (US10106527, Compound 3 | US10544128, Compound 3 | ...) Show SMILES CN1CCN(CC1)c1cccc(c1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C25H26N6O/c1-29-8-10-31(11-9-29)23-5-3-4-19(13-23)25(32)28-24-14-21-12-18(6-7-20(21)15-26-24)22-16-27-30(2)17-22/h3-7,12-17H,8-11H2,1-2H3,(H,26,28,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	116	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Proto-oncogene Wnt-1 (Homo sapiens (human))	BDBM293418 (US10106527, Compound 4 | US10544128, Compound 4 | ...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3cccc(CN4CCCC4)c3)cc2c1 Show InChI InChI=1S/C25H25N5O/c1-29-17-23(15-27-29)19-7-8-21-14-26-24(13-22(21)12-19)28-25(31)20-6-4-5-18(11-20)16-30-9-2-3-10-30/h4-8,11-15,17H,2-3,9-10,16H2,1H3,(H,26,28,31)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	370	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Proto-oncogene Wnt-1 (Homo sapiens (human))	BDBM293419 (US10106527, Compound 5 | US10544128, Compound 5 | ...) Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3cccc(OC4CCNCC4)c3)cc2c1 Show InChI InChI=1S/C25H25N5O2/c1-30-16-21(15-28-30)17-5-6-19-14-27-24(13-20(19)11-17)29-25(31)18-3-2-4-23(12-18)32-22-7-9-26-10-8-22/h2-6,11-16,22,26H,7-10H2,1H3,(H,27,29,31)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	89	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair
Proto-oncogene Wnt-1 (Homo sapiens (human))	BDBM293420 (US10106527, Compound 6 | US10544128, Compound 6 | ...) Show SMILES CN1CCC(CC1)Oc1cccc(c1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1 Show InChI InChI=1S/C26H27N5O2/c1-30-10-8-23(9-11-30)33-24-5-3-4-19(13-24)26(32)29-25-14-21-12-18(6-7-20(21)15-27-25)22-16-28-31(2)17-22/h3-7,12-17,23H,8-11H2,1-2H3,(H,27,29,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
Samumed, LLC US Patent					Assay Description The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...				US Patent US10544128 (2020) BindingDB Entry DOI: 10.7270/Q2H134DS
					More data for this Ligand-Target Pair

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