Compile Data Set for Download or QSAR

Found 70 hits Enz. Inhib. hit(s) with all data for entry = 9200   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448544 (N-(2-(4-(furan-2-ylmethyl)piperazin-1-yl)-5- (trif...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccco3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C26H23F3N4O3/c27-26(28,29)19-3-4-22(33-13-11-32(12-14-33)17-20-2-1-15-35-20)21(16-19)31-25(34)24-6-5-23(36-24)18-7-9-30-10-8-18/h1-10,15-16H,11-14,17H2,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.370	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448727 (5-(tetrahydro-2H-pyran-4-yl)-N-(2-(4-(thiazol-5- y...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cncs3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1 Show InChI InChI=1S/C25H27F3N4O3S/c26-25(27,28)18-1-2-21(32-9-7-31(8-10-32)15-19-14-29-16-36-19)20(13-18)30-24(33)23-4-3-22(35-23)17-5-11-34-12-6-17/h1-4,13-14,16-17H,5-12,15H2,(H,30,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448683 (N-(2-(4-(thiazol-5-ylmethyl)piperazin-1-yl)-5- (tr...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cncs3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H20F3N5OS/c22-21(23,24)15-4-5-19(18(11-15)27-20(30)17-3-1-2-6-26-17)29-9-7-28(8-10-29)13-16-12-25-14-31-16/h1-6,11-12,14H,7-10,13H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448695 (N-(2-(4-(furan-3-ylmethyl)piperazin-1-yl)-5- (trif...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccoc3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1 Show InChI InChI=1S/C26H28F3N3O4/c27-26(28,29)20-1-2-22(32-10-8-31(9-11-32)16-18-5-12-35-17-18)21(15-20)30-25(33)24-4-3-23(36-24)19-6-13-34-14-7-19/h1-5,12,15,17,19H,6-11,13-14,16H2,(H,30,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448663 (N-(2-(4-(oxazol-5-ylmethyl)piperazin-1-yl)-5- (tri...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnco3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)18-1-2-21(33-11-9-32(10-12-33)15-19-14-30-16-35-19)20(13-18)31-24(34)23-4-3-22(36-23)17-5-7-29-8-6-17/h1-8,13-14,16H,9-12,15H2,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.760	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448673 (N-(5-chloro-2-(4-(furan-2-ylmethyl)piperazin-1-yl)...) Show SMILES Clc1ccc(N2CCN(Cc3ccco3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C25H23ClN4O3/c26-19-3-4-22(30-13-11-29(12-14-30)17-20-2-1-15-32-20)21(16-19)28-25(31)24-6-5-23(33-24)18-7-9-27-10-8-18/h1-10,15-16H,11-14,17H2,(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448662 (N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5- (tri...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)18-1-2-21(33-11-9-32(10-12-33)14-19-15-35-16-30-19)20(13-18)31-24(34)23-4-3-22(36-23)17-5-7-29-8-6-17/h1-8,13,15-16H,9-12,14H2,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448675 (N-(2-(4-(furan-2-ylmethyl)piperazin-1-yl)-5- (trif...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccco3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)16-6-7-20(19(14-16)27-21(30)18-5-1-2-8-26-18)29-11-9-28(10-12-29)15-17-4-3-13-31-17/h1-8,13-14H,9-12,15H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448664 (5-(tetrahydro-2H-pyran-4-yl)-N-(2-(4-(thiazol-4- y...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cscn3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1 Show InChI InChI=1S/C25H27F3N4O3S/c26-25(27,28)18-1-2-21(32-9-7-31(8-10-32)14-19-15-36-16-29-19)20(13-18)30-24(33)23-4-3-22(35-23)17-5-11-34-12-6-17/h1-4,13,15-17H,5-12,14H2,(H,30,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448697 (N-(2-(4-(furan-3-ylmethyl)piperazin-1-yl)-5- (trif...) Show SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccoc2)CC1)C(F)(F)F Show InChI InChI=1S/C22H22F3N3O3/c1-15-2-5-20(31-15)21(29)26-18-12-17(22(23,24)25)3-4-19(18)28-9-7-27(8-10-28)13-16-6-11-30-14-16/h2-6,11-12,14H,7-10,13H2,1H3,(H,26,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448726 (N-(2-(4-(isoxazol-5-ylmethyl)piperazin-1-yl)-5-(tr...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccno3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)18-1-2-21(33-13-11-32(12-14-33)16-19-7-10-30-36-19)20(15-18)31-24(34)23-4-3-22(35-23)17-5-8-29-9-6-17/h1-10,15H,11-14,16H2,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448715 (N-(2-(4-(isoxazol-5-ylmethyl)piperazin-1-yl)-5-(tr...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccno3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H20F3N5O2/c22-21(23,24)15-4-5-19(18(13-15)27-20(30)17-3-1-2-7-25-17)29-11-9-28(10-12-29)14-16-6-8-26-31-16/h1-8,13H,9-12,14H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448647 (N-(2-(4-((1H-pyrazol-3-yl)methyl)piperazin-1-yl)-5...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cc[nH]n3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1 Show InChI InChI=1S/C25H28F3N5O3/c26-25(27,28)18-1-2-21(33-11-9-32(10-12-33)16-19-5-8-29-31-19)20(15-18)30-24(34)23-4-3-22(36-23)17-6-13-35-14-7-17/h1-5,8,15,17H,6-7,9-14,16H2,(H,29,31)(H,30,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448696 (N-(2-(4-((5-methylfuran-2-yl)methyl)piperazin-1-yl...) Show SMILES Cc1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(o2)C2CCOCC2)C(F)(F)F)o1 Show InChI InChI=1S/C27H30F3N3O4/c1-18-2-4-21(36-18)17-32-10-12-33(13-11-32)23-5-3-20(27(28,29)30)16-22(23)31-26(34)25-7-6-24(37-25)19-8-14-35-15-9-19/h2-7,16,19H,8-15,17H2,1H3,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448661 (N-(2-(4-(oxazol-2-ylmethyl)piperazin-1-yl)-5- (tri...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ncco3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)18-1-2-20(33-12-10-32(11-13-33)16-23-30-9-14-35-23)19(15-18)31-24(34)22-4-3-21(36-22)17-5-7-29-8-6-17/h1-9,14-15H,10-13,16H2,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448729 (N-(2-(4-(furan-3-ylmethyl)piperazin-1-yl)-5- (trif...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccoc3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)17-4-5-20(19(13-17)27-21(30)18-3-1-2-7-26-18)29-10-8-28(9-11-29)14-16-6-12-31-15-16/h1-7,12-13,15H,8-11,14H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448717 (N-(2-(4-(isoxazol-5-ylmethyl)piperazin-1-yl)-5-(tr...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccno3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1 Show InChI InChI=1S/C25H27F3N4O4/c26-25(27,28)18-1-2-21(32-11-9-31(10-12-32)16-19-5-8-29-36-19)20(15-18)30-24(33)23-4-3-22(35-23)17-6-13-34-14-7-17/h1-5,8,15,17H,6-7,9-14,16H2,(H,30,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448682 (N-(2-(4-(thiazol-4-ylmethyl)piperazin-1-yl)-5- (tr...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cscn3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H20F3N5OS/c22-21(23,24)15-4-5-19(18(11-15)27-20(30)17-3-1-2-6-25-17)29-9-7-28(8-10-29)12-16-13-31-14-26-16/h1-6,11,13-14H,7-10,12H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448674 (N-(5-chloro-2-(4-(oxazol-4-ylmethyl)piperazin-1-yl...) Show SMILES Clc1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C24H22ClN5O3/c25-18-1-2-21(30-11-9-29(10-12-30)14-19-15-32-16-27-19)20(13-18)28-24(31)23-4-3-22(33-23)17-5-7-26-8-6-17/h1-8,13,15-16H,9-12,14H2,(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448723 (N-(2-(4-(isoxazol-4-ylmethyl)piperazin-1-yl)-5-(tr...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnoc3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H20F3N5O2/c22-21(23,24)16-4-5-19(18(11-16)27-20(30)17-3-1-2-6-25-17)29-9-7-28(8-10-29)13-15-12-26-31-14-15/h1-6,11-12,14H,7-10,13H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.80	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448718 (US10696661, Compound 65) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnoc3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1 Show InChI InChI=1S/C25H27F3N4O4/c26-25(27,28)19-1-2-21(32-9-7-31(8-10-32)15-17-14-29-35-16-17)20(13-19)30-24(33)23-4-3-22(36-23)18-5-11-34-12-6-18/h1-4,13-14,16,18H,5-12,15H2,(H,30,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448698 (5-methyl-N-(2-(4-((5-methylfuran-2-yl)methyl)piper...) Show SMILES Cc1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(C)o2)C(F)(F)F)o1 Show InChI InChI=1S/C23H24F3N3O3/c1-15-3-6-18(31-15)14-28-9-11-29(12-10-28)20-7-5-17(23(24,25)26)13-19(20)27-22(30)21-8-4-16(2)32-21/h3-8,13H,9-12,14H2,1-2H3,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.7	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448670 (N-(2-(4-((1H-pyrazol-3-yl)methyl)piperazin-1-yl)-5...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cc[nH]n3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C25H23F3N6O2/c26-25(27,28)18-1-2-21(34-13-11-33(12-14-34)16-19-7-10-30-32-19)20(15-18)31-24(35)23-4-3-22(36-23)17-5-8-29-9-6-17/h1-10,15H,11-14,16H2,(H,30,32)(H,31,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.9	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448672 (N-(2-(4-((1-methyl-1H-pyrazol-3-yl)methyl)piperazi...) Show SMILES Cn1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(o2)-c2ccncc2)C(F)(F)F)n1 Show InChI InChI=1S/C26H25F3N6O2/c1-33-11-8-20(32-33)17-34-12-14-35(15-13-34)22-3-2-19(26(27,28)29)16-21(22)31-25(36)24-5-4-23(37-24)18-6-9-30-10-7-18/h2-11,16H,12-15,17H2,1H3,(H,31,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.3	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448684 (N-(2-(4-((1H-pyrazol-3-yl)methyl)piperazin-1-yl)-5...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cc[nH]n3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H21F3N6O/c22-21(23,24)15-4-5-19(18(13-15)27-20(31)17-3-1-2-7-25-17)30-11-9-29(10-12-30)14-16-6-8-26-28-16/h1-8,13H,9-12,14H2,(H,26,28)(H,27,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.7	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448667 (5-(pyridin-4-yl)-N-(2-(4-(thiazol-4-ylmethyl)piper...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cscn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C25H22F3N5O2S/c26-25(27,28)18-1-2-21(33-11-9-32(10-12-33)14-19-15-36-16-30-19)20(13-18)31-24(34)23-4-3-22(35-23)17-5-7-29-8-6-17/h1-8,13,15-16H,9-12,14H2,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.7	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448681 (N-(2-(4-(thiazol-2-ylmethyl)piperazin-1-yl)-5- (tr...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3nccs3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H20F3N5OS/c22-21(23,24)15-4-5-18(17(13-15)27-20(30)16-3-1-2-6-25-16)29-10-8-28(9-11-29)14-19-26-7-12-31-19/h1-7,12-13H,8-11,14H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.1	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448548 (5-methyl-N-(2-(4-((furan-2-yl)methyl)piperazin-1-y...) Show SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccco2)CC1)C(F)(F)F Show InChI InChI=1S/C22H22F3N3O3/c1-15-4-7-20(31-15)21(29)26-18-13-16(22(23,24)25)5-6-19(18)28-10-8-27(9-11-28)14-17-3-2-12-30-17/h2-7,12-13H,8-11,14H2,1H3,(H,26,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17.6	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448704 (N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5-(trif...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2cc3ccccc3o2)c1 Show InChI InChI=1S/C24H21F3N4O3/c25-24(26,27)17-5-6-20(31-9-7-30(8-10-31)13-18-14-33-15-28-18)19(12-17)29-23(32)22-11-16-3-1-2-4-21(16)34-22/h1-6,11-12,14-15H,7-10,13H2,(H,29,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448657 (N-(2-(4-((5-methylfuran-2-yl)methyl)piperazin-1-yl...) Show SMILES Cc1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(o2)-c2ccncc2)C(F)(F)F)o1 Show InChI InChI=1S/C27H25F3N4O3/c1-18-2-4-21(36-18)17-33-12-14-34(15-13-33)23-5-3-20(27(28,29)30)16-22(23)32-26(35)25-7-6-24(37-25)19-8-10-31-11-9-19/h2-11,16H,12-15,17H2,1H3,(H,32,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.4	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448687 (N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5- (tri...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H20F3N5O2/c22-21(23,24)15-4-5-19(18(11-15)27-20(30)17-3-1-2-6-25-17)29-9-7-28(8-10-29)12-16-13-31-14-26-16/h1-6,11,13-14H,7-10,12H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.6	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448699 (N-(2-(4-(furan-3-ylmethyl)piperazin-1-yl)-5- (trif...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccoc3)CC2)c(NC(=O)c2ccco2)c1 Show InChI InChI=1S/C21H20F3N3O3/c22-21(23,24)16-3-4-18(17(12-16)25-20(28)19-2-1-10-30-19)27-8-6-26(7-9-27)13-15-5-11-29-14-15/h1-5,10-12,14H,6-9,13H2,(H,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.9	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448685 (N-(2-(4-((1-methyl-1H-pyrazol-3-yl)methyl)piperazi...) Show SMILES Cn1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccccn2)C(F)(F)F)n1 Show InChI InChI=1S/C22H23F3N6O/c1-29-9-7-17(28-29)15-30-10-12-31(13-11-30)20-6-5-16(22(23,24)25)14-19(20)27-21(32)18-4-2-3-8-26-18/h2-9,14H,10-13,15H2,1H3,(H,27,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448680 (N-(5-chloro-2-(4-(furan-2-ylmethyl)piperazin-1- yl...) Show SMILES Clc1ccc(N2CCN(Cc3ccco3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H21ClN4O2/c22-16-6-7-20(19(14-16)24-21(27)18-5-1-2-8-23-18)26-11-9-25(10-12-26)15-17-4-3-13-28-17/h1-8,13-14H,9-12,15H2,(H,24,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27.3	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448668 (5-(pyridin-4-yl)-N-(2-(5-(thiazol-2-ylmethyl)piper...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cncs3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C25H22F3N5O2S/c26-25(27,28)18-1-2-21(33-11-9-32(10-12-33)15-19-14-30-16-36-19)20(13-18)31-24(34)23-4-3-22(35-23)17-5-7-29-8-6-17/h1-8,13-14,16H,9-12,15H2,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27.5	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448693 (N-(2-(4-(1H-imidazol-4-ylmethyl)piperazin-1-yl)-5-...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3c[nH]cn3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H21F3N6O/c22-21(23,24)15-4-5-19(18(11-15)28-20(31)17-3-1-2-6-26-17)30-9-7-29(8-10-30)13-16-12-25-14-27-16/h1-6,11-12,14H,7-10,13H2,(H,25,27)(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28.7	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448693 (N-(2-(4-(1H-imidazol-4-ylmethyl)piperazin-1-yl)-5-...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3c[nH]cn3)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C21H21F3N6O/c22-21(23,24)15-4-5-19(18(11-15)28-20(31)17-3-1-2-6-26-17)30-9-7-29(8-10-30)13-16-12-25-14-27-16/h1-6,11-12,14H,7-10,13H2,(H,25,27)(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28.7	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448690 (N-(2-(4-((1H-indol-3-yl)methyl)piperazin-1-yl)-5- ...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)c(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C26H24F3N5O/c27-26(28,29)19-8-9-24(23(15-19)32-25(35)22-7-3-4-10-30-22)34-13-11-33(12-14-34)17-18-16-31-21-6-2-1-5-20(18)21/h1-10,15-16,31H,11-14,17H2,(H,32,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31.3	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448700 (N-(2-(4-((5-methylfuran-2-yl)methyl)piperazin-1-yl...) Show SMILES Cc1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccco2)C(F)(F)F)o1 Show InChI InChI=1S/C22H22F3N3O3/c1-15-4-6-17(31-15)14-27-8-10-28(11-9-27)19-7-5-16(22(23,24)25)13-18(19)26-21(29)20-3-2-12-30-20/h2-7,12-13H,8-11,14H2,1H3,(H,26,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32.6	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448722 (N-(2-(4-(isoxazol-4-ylmethyl)piperazin-1-yl)-5-(tr...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnoc3)CC2)c(NC(=O)c2ccco2)c1 Show InChI InChI=1S/C20H19F3N4O3/c21-20(22,23)15-3-4-17(16(10-15)25-19(28)18-2-1-9-29-18)27-7-5-26(6-8-27)12-14-11-24-30-13-14/h1-4,9-11,13H,5-8,12H2,(H,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33.5	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448725 (N-(2-(4-(isoxazol-4-ylmethyl)piperazin-1-yl)-5- (t...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnoc3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C25H22F3N5O3/c26-25(27,28)19-1-2-21(33-11-9-32(10-12-33)15-17-14-30-35-16-17)20(13-19)31-24(34)23-4-3-22(36-23)18-5-7-29-8-6-18/h1-8,13-14,16H,9-12,15H2,(H,31,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35.3	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448621 (N-(2-(4-(thiazol-5-ylmethyl)piperazin-1-yl)-5- (tr...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cncs3)CC2)c(NC(=O)c2ccco2)c1 Show InChI InChI=1S/C20H19F3N4O2S/c21-20(22,23)14-3-4-17(16(10-14)25-19(28)18-2-1-9-29-18)27-7-5-26(6-8-27)12-15-11-24-13-30-15/h1-4,9-11,13H,5-8,12H2,(H,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39.5	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448691 (US10696661, Compound 39) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2ccco2)c1 Show InChI InChI=1S/C20H19F3N4O3/c21-20(22,23)14-3-4-17(16(10-14)25-19(28)18-2-1-9-30-18)27-7-5-26(6-8-27)11-15-12-29-13-24-15/h1-4,9-10,12-13H,5-8,11H2,(H,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	60.7	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448574 (N-(2-(4-((1H-pyrazol-3-yl)methyl)piperazin-1-yl)-5...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cc[nH]n3)CC2)c(NC(=O)c2ccco2)c1 Show InChI InChI=1S/C20H20F3N5O2/c21-20(22,23)14-3-4-17(16(12-14)25-19(29)18-2-1-11-30-18)28-9-7-27(8-10-28)13-15-5-6-24-26-15/h1-6,11-12H,7-10,13H2,(H,24,26)(H,25,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	62.4	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448733 (N-(2-(4-((1H-indol-3-yl)methyl)piperazin-1-yl)-5- ...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)c(NC(=O)c2ccco2)c1 Show InChI InChI=1S/C25H23F3N4O2/c26-25(27,28)18-7-8-22(21(14-18)30-24(33)23-6-3-13-34-23)32-11-9-31(10-12-32)16-17-15-29-20-5-2-1-4-19(17)20/h1-8,13-15,29H,9-12,16H2,(H,30,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	74.9	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448714 (N-(2-(4-((1H-pyrazol-4-yl)methyl)piperazin-1-yl)-5...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cn[nH]c3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1 Show InChI InChI=1S/C25H23F3N6O2/c26-25(27,28)19-1-2-21(34-11-9-33(10-12-34)16-17-14-30-31-15-17)20(13-19)32-24(35)23-4-3-22(36-23)18-5-7-29-8-6-18/h1-8,13-15H,9-12,16H2,(H,30,31)(H,32,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75.9	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448592 (N-(2-(4-(thiazol-4-ylmethyl)piperazin-1-yl)-5- (tr...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cscn3)CC2)c(NC(=O)c2ccco2)c1 Show InChI InChI=1S/C20H19F3N4O2S/c21-20(22,23)14-3-4-17(16(10-14)25-19(28)18-2-1-9-29-18)27-7-5-26(6-8-27)11-15-12-30-13-24-15/h1-4,9-10,12-13H,5-8,11H2,(H,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	79.8	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448706 (N-(2-(4-(oxazol-4-ylmethyl)piperazin-1-yl)-5-(trif...) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cocn3)CC2)c(NC(=O)c2cc[nH]n2)c1 Show InChI InChI=1S/C19H19F3N6O2/c20-19(21,22)13-1-2-17(16(9-13)25-18(29)15-3-4-24-26-15)28-7-5-27(6-8-28)10-14-11-30-12-23-14/h1-4,9,11-12H,5-8,10H2,(H,24,26)(H,25,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	83.1	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448545 (N-(2-(4-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)pip...) Show SMILES Cc1nnc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(o2)-c2ccncc2)C(F)(F)F)o1 Show InChI InChI=1S/C25H23F3N6O3/c1-16-31-32-23(36-16)15-33-10-12-34(13-11-33)20-3-2-18(25(26,27)28)14-19(20)30-24(35)22-5-4-21(37-22)17-6-8-29-9-7-17/h2-9,14H,10-13,15H2,1H3,(H,30,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	88.3	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair
SRSF protein kinase 1 (Homo sapiens (Human))	BDBM448665 (US10696661, Compound 20) Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3nccs3)CC2)c(NC(=O)c2ccco2)c1 Show InChI InChI=1S/C20H19F3N4O2S/c21-20(22,23)14-3-4-16(15(12-14)25-19(28)17-2-1-10-29-17)27-8-6-26(7-9-27)13-18-24-5-11-30-18/h1-5,10-12H,6-9,13H2,(H,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	104	n/a	n/a	n/a	n/a	n/a	n/a
Exonate Limited US Patent					Assay Description Screening of a series of molecules identified compounds (Compounds 5, 8, 16 to 18 and 43 of Table 3) that had improved potency against SRPK1 against ...				US Patent US10696661 (2020) BindingDB Entry DOI: 10.7270/Q23B635R
					More data for this Ligand-Target Pair

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