BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 79 hits of ic50 for UniProtKB: P29703   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50080764
PNG
((S)-2-({5-[(Benzyl-pyridin-3-yl-amino)-methyl]-2'-...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(Cc2ccccc2)c2cccnc2)cc1-c1ccccc1C)C(O)=O
Show InChI InChI=1S/C32H33N3O3S/c1-23-9-6-7-13-27(23)29-19-25(14-15-28(29)31(36)34-30(32(37)38)16-18-39-2)22-35(26-12-8-17-33-20-26)21-24-10-4-3-5-11-24/h3-15,17,19-20,30H,16,18,21-22H2,1-2H3,(H,34,36)(H,37,38)/t30-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 0.100n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against yeast farnesyltransferase

J Med Chem 44: 3117-24 (2001)


BindingDB Entry DOI: 10.7270/Q2VH5N43
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50067563
PNG
((S)-2-{[2'-Methyl-5-(pyridin-3-yloxymethyl)-biphen...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(COc2cccnc2)cc1-c1ccccc1C)C(O)=O
Show InChI InChI=1S/C25H26N2O4S/c1-17-6-3-4-8-20(17)22-14-18(16-31-19-7-5-12-26-15-19)9-10-21(22)24(28)27-23(25(29)30)11-13-32-2/h3-10,12,14-15,23H,11,13,16H2,1-2H3,(H,27,28)(H,29,30)/t23-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 0.400n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against yeast farnesyltransferase

J Med Chem 44: 3117-24 (2001)


BindingDB Entry DOI: 10.7270/Q2VH5N43
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50067584
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C21H27N3O3S2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27)/t15-,19+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 0.780n/an/an/an/a7.5n/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50072626
PNG
((S)-2-[2-({(S)-2-[2-(4-Cyano-benzylsulfanyl)-acety...)
Show SMILES CCC(C)[C@@H](CN(CC(=O)N[C@@H](CCSC)C(O)=O)Cc1cccc2ccccc12)NC(=O)CSCc1ccc(cc1)C#N
Show InChI InChI=1S/C34H42N4O4S2/c1-4-24(2)31(37-33(40)23-44-22-26-14-12-25(18-35)13-15-26)20-38(21-32(39)36-30(34(41)42)16-17-43-3)19-28-10-7-9-27-8-5-6-11-29(27)28/h5-15,24,30-31H,4,16-17,19-23H2,1-3H3,(H,36,39)(H,37,40)(H,41,42)/t24?,30-,31+/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 5.40n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against yeast farnesyltransferase

J Med Chem 44: 3117-24 (2001)


BindingDB Entry DOI: 10.7270/Q2VH5N43
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50104054
PNG
(4-Methylsulfanyl-2-{[5-(5-phenyl-furan-2-ylmethoxy...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(COCc2ccc(o2)-c2ccccc2)cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C30H29NO5S/c1-37-17-16-27(30(33)34)31-29(32)25-14-12-21(18-26(25)22-8-4-2-5-9-22)19-35-20-24-13-15-28(36-24)23-10-6-3-7-11-23/h2-15,18,27H,16-17,19-20H2,1H3,(H,31,32)(H,33,34)/t27-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 6n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against yeast farnesyltransferase

J Med Chem 44: 3117-24 (2001)


BindingDB Entry DOI: 10.7270/Q2VH5N43
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50104052
PNG
(2-{2-[(2-{2-[1-(4-Cyano-benzyl)-4,5-dihydro-1H-imi...)
Show SMILES CCC(C)[C@@H](CN(CC(=O)N[C@@H](CCSC)C(O)=O)Cc1cccc2ccccc12)NC(=O)CC1CN(Cc2ccc(cc2)C#N)C=N1 |c:49|
Show InChI InChI=1S/C37H46N6O4S/c1-4-26(2)34(41-35(44)18-31-22-43(25-39-31)20-28-14-12-27(19-38)13-15-28)23-42(24-36(45)40-33(37(46)47)16-17-48-3)21-30-10-7-9-29-8-5-6-11-32(29)30/h5-15,25-26,31,33-34H,4,16-18,20-24H2,1-3H3,(H,40,45)(H,41,44)(H,46,47)/t26?,31?,33-,34+/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 12n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against yeast farnesyltransferase

J Med Chem 44: 3117-24 (2001)


BindingDB Entry DOI: 10.7270/Q2VH5N43
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50104047
PNG
((E)-N-[3-Benzoyl-4-(2-p-tolyl-acetylamino)-phenyl]...)
Show SMILES Cc1ccc(CC(=O)Nc2ccc(NC(=O)\C=C\c3ccc(o3)-c3ccc(cc3)[N+]([O-])=O)cc2C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C35H27N3O6/c1-23-7-9-24(10-8-23)21-34(40)37-31-18-13-27(22-30(31)35(41)26-5-3-2-4-6-26)36-33(39)20-17-29-16-19-32(44-29)25-11-14-28(15-12-25)38(42)43/h2-20,22H,21H2,1H3,(H,36,39)(H,37,40)/b20-17+
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 35n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against yeast farnesyltransferase

J Med Chem 44: 3117-24 (2001)


BindingDB Entry DOI: 10.7270/Q2VH5N43
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103281
PNG
(1-(3-Benzoyl-4-diphenylacetylamino-phenylcarbamoyl...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)C(c2ccccc2)c2ccccc2)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C30H27N3O3S/c31-25(19-37)29(35)32-23-16-17-26(24(18-23)28(34)22-14-8-3-9-15-22)33-30(36)27(20-10-4-1-5-11-20)21-12-6-2-7-13-21/h1-18,25,27,37H,19,31H2,(H,32,35)(H,33,36)/p+1/t25-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 36n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103269
PNG
(1-{3-Benzoyl-4-[2-(4-bromo-phenyl)-acetylamino]-ph...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2ccc(Br)cc2)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C24H22BrN3O3S/c25-17-8-6-15(7-9-17)12-22(29)28-21-11-10-18(27-24(31)20(26)14-32)13-19(21)23(30)16-4-2-1-3-5-16/h1-11,13,20,32H,12,14,26H2,(H,27,31)(H,28,29)/p+1/t20-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 76n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103285
PNG
(1-[3-Benzoyl-4-(2-p-tolyl-acetylamino)-phenylcarba...)
Show SMILES Cc1ccc(CC(=O)Nc2ccc(NC(=O)[C@@H]([NH3+])CS)cc2C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C25H25N3O3S/c1-16-7-9-17(10-8-16)13-23(29)28-22-12-11-19(27-25(31)21(26)15-32)14-20(22)24(30)18-5-3-2-4-6-18/h2-12,14,21,32H,13,15,26H2,1H3,(H,27,31)(H,28,29)/p+1/t21-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 77n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103271
PNG
(1-(3-Benzoyl-4-phenylmethanesulfonylamino-phenylca...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NS(=O)(=O)Cc2ccccc2)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C23H23N3O4S2/c24-20(14-31)23(28)25-18-11-12-21(19(13-18)22(27)17-9-5-2-6-10-17)26-32(29,30)15-16-7-3-1-4-8-16/h1-13,20,26,31H,14-15,24H2,(H,25,28)/p+1/t20-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 85n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238364
PNG
(3-(4-(Methoxycarbonyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES COC(=O)c1ccc(cc1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C17H15NO4S2/c1-9(2)23-17-12(8-18)13(14(24-17)15(19)20)10-4-6-11(7-5-10)16(21)22-3/h4-7,9H,1-3H3,(H,19,20)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 85n/an/an/an/a7.5n/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103280
PNG
(1-(3-Benzoyl-4-p-tolylmethanesulfonylamino-phenylc...)
Show SMILES Cc1ccc(CS(=O)(=O)Nc2ccc(NC(=O)[C@@H]([NH3+])CS)cc2C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C24H25N3O4S2/c1-16-7-9-17(10-8-16)15-33(30,31)27-22-12-11-19(26-24(29)21(25)14-32)13-20(22)23(28)18-5-3-2-4-6-18/h2-13,21,27,32H,14-15,25H2,1H3,(H,26,29)/p+1/t21-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 100n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103262
PNG
(1-{3-Benzoyl-4-[2-(4-chloro-phenyl)-acetylamino]-p...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2ccc(Cl)cc2)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C24H22ClN3O3S/c25-17-8-6-15(7-9-17)12-22(29)28-21-11-10-18(27-24(31)20(26)14-32)13-19(21)23(30)16-4-2-1-3-5-16/h1-11,13,20,32H,12,14,26H2,(H,27,31)(H,28,29)/p+1/t20-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 105n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238353
PNG
(3-(4-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-3-5-10(16)6-4-9/h3-6,8H,1-2H3,(H,18,19)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 110n/an/an/an/a7.5n/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103274
PNG
(1-{3-Benzoyl-4-[2-(4-nitro-phenyl)-acetylamino]-ph...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2ccc(cc2)[N+]([O-])=O)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C24H22N4O5S/c25-20(14-34)24(31)26-17-8-11-21(19(13-17)23(30)16-4-2-1-3-5-16)27-22(29)12-15-6-9-18(10-7-15)28(32)33/h1-11,13,20,34H,12,14,25H2,(H,26,31)(H,27,29)/p+1/t20-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 115n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103261
PNG
(1-{3-Benzoyl-4-[2-(2,4-dichloro-phenyl)-acetylamin...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2ccc(Cl)cc2Cl)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C24H21Cl2N3O3S/c25-16-7-6-15(19(26)11-16)10-22(30)29-21-9-8-17(28-24(32)20(27)13-33)12-18(21)23(31)14-4-2-1-3-5-14/h1-9,11-12,20,33H,10,13,27H2,(H,28,32)(H,29,30)/p+1/t20-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 120n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238367
PNG
(3-(4-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-c...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(C)cc1
Show InChI InChI=1S/C16H15NO2S2/c1-9(2)20-16-12(8-17)13(14(21-16)15(18)19)11-6-4-10(3)5-7-11/h4-7,9H,1-3H3,(H,18,19)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 190n/an/an/an/a7.5n/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238361
PNG
(3-(4-Methoxyphenyl)-4-cyano-5-(isopropylthio)thiop...)
Show SMILES COc1ccc(cc1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C16H15NO3S2/c1-9(2)21-16-12(8-17)13(14(22-16)15(18)19)10-4-6-11(20-3)7-5-10/h4-7,9H,1-3H3,(H,18,19)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 250n/an/an/an/a7.5n/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238356
PNG
(3-(4-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(F)cc1
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-3-5-10(16)6-4-9/h3-6,8H,1-2H3,(H,18,19)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 270n/an/an/an/a7.5n/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238371
PNG
(3-(2-Naphthyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc2ccccc2c1
Show InChI InChI=1S/C19H15NO2S2/c1-11(2)23-19-15(10-20)16(17(24-19)18(21)22)14-8-7-12-5-3-4-6-13(12)9-14/h3-9,11H,1-2H3,(H,21,22)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 320n/an/an/an/a7.5n/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103270
PNG
(1-{3-Benzoyl-4-[2-(2,6-dichloro-phenyl)-acetylamin...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2c(Cl)cccc2Cl)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C24H21Cl2N3O3S/c25-18-7-4-8-19(26)16(18)12-22(30)29-21-10-9-15(28-24(32)20(27)13-33)11-17(21)23(31)14-5-2-1-3-6-14/h1-11,20,33H,12-13,27H2,(H,28,32)(H,29,30)/p+1/t20-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 340n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238374
PNG
(3-(3-Thienyl)-4-cyano-5-(isopropylthio)thiophene-2...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(Sc2ccsc2)c1C#N
Show InChI InChI=1S/C13H11NO2S4/c1-7(2)18-13-9(5-14)10(11(20-13)12(15)16)19-8-3-4-17-6-8/h3-4,6-7H,1-2H3,(H,15,16)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 350n/an/an/an/a7.5n/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103272
PNG
(1-[3-Benzoyl-4-(2-naphthalen-1-yl-acetylamino)-phe...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2cccc3ccccc23)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C28H25N3O3S/c29-24(17-35)28(34)30-21-13-14-25(23(16-21)27(33)19-8-2-1-3-9-19)31-26(32)15-20-11-6-10-18-7-4-5-12-22(18)20/h1-14,16,24,35H,15,17,29H2,(H,30,34)(H,31,32)/p+1/t24-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 380n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50104050
PNG
(5-Phenyl-pentanoic acid [3-benzoyl-4-(2-p-tolyl-ac...)
Show SMILES Cc1ccc(CC(=O)Nc2ccc(NC(=O)CCCCc3ccccc3)cc2C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C33H32N2O3/c1-24-16-18-26(19-17-24)22-32(37)35-30-21-20-28(23-29(30)33(38)27-13-6-3-7-14-27)34-31(36)15-9-8-12-25-10-4-2-5-11-25/h2-7,10-11,13-14,16-21,23H,8-9,12,15,22H2,1H3,(H,34,36)(H,35,37)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 390n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against yeast farnesyltransferase

J Med Chem 44: 3117-24 (2001)


BindingDB Entry DOI: 10.7270/Q2VH5N43
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103260
PNG
(1-[3-Benzoyl-4-(2-o-tolyl-acetylamino)-phenylcarba...)
Show SMILES Cc1ccccc1CC(=O)Nc1ccc(NC(=O)[C@@H]([NH3+])CS)cc1C(=O)c1ccccc1
Show InChI InChI=1S/C25H25N3O3S/c1-16-7-5-6-10-18(16)13-23(29)28-22-12-11-19(27-25(31)21(26)15-32)14-20(22)24(30)17-8-3-2-4-9-17/h2-12,14,21,32H,13,15,26H2,1H3,(H,27,31)(H,28,29)/p+1/t21-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 400n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103258
PNG
(1-{3-Benzoyl-4-[2-(2,3-dichloro-phenyl)-acetylamin...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2cccc(Cl)c2Cl)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C24H21Cl2N3O3S/c25-18-8-4-7-15(22(18)26)11-21(30)29-20-10-9-16(28-24(32)19(27)13-33)12-17(20)23(31)14-5-2-1-3-6-14/h1-10,12,19,33H,11,13,27H2,(H,28,32)(H,29,30)/p+1/t19-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 420n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50104055
PNG
(CHEMBL276748 | N-[3-Benzoyl-4-(2-p-tolyl-acetylami...)
Show SMILES Cc1ccc(CC(=O)Nc2ccc(NC(=O)\C=C\c3csc(n3)-c3ccc(cc3)[N+]([O-])=O)cc2C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C34H26N4O5S/c1-22-7-9-23(10-8-22)19-32(40)37-30-17-13-26(20-29(30)33(41)24-5-3-2-4-6-24)35-31(39)18-14-27-21-44-34(36-27)25-11-15-28(16-12-25)38(42)43/h2-18,20-21H,19H2,1H3,(H,35,39)(H,37,40)/b18-14+
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 455n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against yeast farnesyltransferase

J Med Chem 44: 3117-24 (2001)


BindingDB Entry DOI: 10.7270/Q2VH5N43
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238357
PNG
(3-(3-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(F)c1
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-4-3-5-10(16)6-9/h3-6,8H,1-2H3,(H,18,19)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 460n/an/an/an/a7.5n/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103277
PNG
(1-[3-Benzoyl-4-(2-naphthalen-2-yl-acetylamino)-phe...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2ccc3ccccc3c2)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C28H25N3O3S/c29-24(17-35)28(34)30-22-12-13-25(23(16-22)27(33)20-7-2-1-3-8-20)31-26(32)15-18-10-11-19-6-4-5-9-21(19)14-18/h1-14,16,24,35H,15,17,29H2,(H,30,34)(H,31,32)/p+1/t24-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 460n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103284
PNG
(1-{3-Benzoyl-4-[2-(3,4-dichloro-phenyl)-acetylamin...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2ccc(Cl)c(Cl)c2)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C24H21Cl2N3O3S/c25-18-8-6-14(10-19(18)26)11-22(30)29-21-9-7-16(28-24(32)20(27)13-33)12-17(21)23(31)15-4-2-1-3-5-15/h1-10,12,20,33H,11,13,27H2,(H,28,32)(H,29,30)/p+1/t20-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 480n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50104048
PNG
(CHEMBL106900 | N-[3-Benzoyl-4-(2-p-tolyl-acetylami...)
Show SMILES Cc1ccc(CC(=O)Nc2ccc(NC(=O)CCCc3ccccc3)cc2C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C32H30N2O3/c1-23-15-17-25(18-16-23)21-31(36)34-29-20-19-27(22-28(29)32(37)26-12-6-3-7-13-26)33-30(35)14-8-11-24-9-4-2-5-10-24/h2-7,9-10,12-13,15-20,22H,8,11,14,21H2,1H3,(H,33,35)(H,34,36)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 530n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against yeast farnesyltransferase

J Med Chem 44: 3117-24 (2001)


BindingDB Entry DOI: 10.7270/Q2VH5N43
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103276
PNG
(1-{3-Benzoyl-4-[2-(3,5-dichloro-phenyl)-acetylamin...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2cc(Cl)cc(Cl)c2)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C24H21Cl2N3O3S/c25-16-8-14(9-17(26)11-16)10-22(30)29-21-7-6-18(28-24(32)20(27)13-33)12-19(21)23(31)15-4-2-1-3-5-15/h1-9,11-12,20,33H,10,13,27H2,(H,28,32)(H,29,30)/p+1/t20-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 535n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103259
PNG
(1-[3-Benzoyl-4-(2-m-tolyl-acetylamino)-phenylcarba...)
Show SMILES Cc1cccc(CC(=O)Nc2ccc(NC(=O)[C@@H]([NH3+])CS)cc2C(=O)c2ccccc2)c1
Show InChI InChI=1S/C25H25N3O3S/c1-16-6-5-7-17(12-16)13-23(29)28-22-11-10-19(27-25(31)21(26)15-32)14-20(22)24(30)18-8-3-2-4-9-18/h2-12,14,21,32H,13,15,26H2,1H3,(H,27,31)(H,28,29)/p+1/t21-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 540n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103268
PNG
(1-{3-Benzoyl-4-[2-(4-methoxy-phenyl)-acetylamino]-...)
Show SMILES COc1ccc(CC(=O)Nc2ccc(NC(=O)[C@@H]([NH3+])CS)cc2C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C25H25N3O4S/c1-32-19-10-7-16(8-11-19)13-23(29)28-22-12-9-18(27-25(31)21(26)15-33)14-20(22)24(30)17-5-3-2-4-6-17/h2-12,14,21,33H,13,15,26H2,1H3,(H,27,31)(H,28,29)/p+1/t21-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 545n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103257
PNG
(1-[3-Benzoyl-4-(4-carboxy-butyrylamino)-phenylcarb...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)CCCC(O)=O)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C21H23N3O5S/c22-16(12-30)21(29)23-14-9-10-17(24-18(25)7-4-8-19(26)27)15(11-14)20(28)13-5-2-1-3-6-13/h1-3,5-6,9-11,16,30H,4,7-8,12,22H2,(H,23,29)(H,24,25)(H,26,27)/p+1/t16-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 550n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238359
PNG
(3-(4-(Trifluoromethyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H12F3NO2S2/c1-8(2)23-15-11(7-20)12(13(24-15)14(21)22)9-3-5-10(6-4-9)16(17,18)19/h3-6,8H,1-2H3,(H,21,22)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 580n/an/an/an/a7.5n/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238366
PNG
(3-Phenyl-4-cyano-5-(isopropylthio)thiophene-2-carb...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1
Show InChI InChI=1S/C15H13NO2S2/c1-9(2)19-15-11(8-16)12(13(20-15)14(17)18)10-6-4-3-5-7-10/h3-7,9H,1-2H3,(H,17,18)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 610n/an/an/an/a7.5n/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238365
PNG
(3-(3-(Methoxycarbonyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES COC(=O)c1cccc(c1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C17H15NO4S2/c1-9(2)23-17-12(8-18)13(14(24-17)15(19)20)10-5-4-6-11(7-10)16(21)22-3/h4-7,9H,1-3H3,(H,19,20)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 620n/an/an/an/a7.5n/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238373
PNG
(3-(3-Biphenyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C21H17NO2S2/c1-13(2)25-21-17(12-22)18(19(26-21)20(23)24)16-10-6-9-15(11-16)14-7-4-3-5-8-14/h3-11,13H,1-2H3,(H,23,24)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 640n/an/an/an/a7.5n/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103278
PNG
(1-[3-Benzoyl-4-(2-phenyl-propionylamino)-phenylcar...)
Show SMILES CC(C(=O)Nc1ccc(NC(=O)[C@@H]([NH3+])CS)cc1C(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H25N3O3S/c1-16(17-8-4-2-5-9-17)24(30)28-22-13-12-19(27-25(31)21(26)15-32)14-20(22)23(29)18-10-6-3-7-11-18/h2-14,16,21,32H,15,26H2,1H3,(H,27,31)(H,28,30)/p+1/t16?,21-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 650n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103287
PNG
(1-(3-Benzoyl-4-phenylacetylamino-phenylcarbamoyl)-...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2ccccc2)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C24H23N3O3S/c25-20(15-31)24(30)26-18-11-12-21(27-22(28)13-16-7-3-1-4-8-16)19(14-18)23(29)17-9-5-2-6-10-17/h1-12,14,20,31H,13,15,25H2,(H,26,30)(H,27,28)/p+1/t20-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 650n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103266
PNG
(1-[3-Benzoyl-4-(3-carboxy-propionylamino)-phenylca...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)CCC(O)=O)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C20H21N3O5S/c21-15(11-29)20(28)22-13-6-7-16(23-17(24)8-9-18(25)26)14(10-13)19(27)12-4-2-1-3-5-12/h1-7,10,15,29H,8-9,11,21H2,(H,22,28)(H,23,24)(H,25,26)/p+1/t15-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 700n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103283
PNG
(1-{3-Benzoyl-4-[2-(4-trifluoromethyl-phenyl)-acety...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)Cc2ccc(cc2)C(F)(F)F)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C25H22F3N3O3S/c26-25(27,28)17-8-6-15(7-9-17)12-22(32)31-21-11-10-18(30-24(34)20(29)14-35)13-19(21)23(33)16-4-2-1-3-5-16/h1-11,13,20,35H,12,14,29H2,(H,30,34)(H,31,32)/p+1/t20-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 725n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50104053
PNG
(CHEMBL329401 | N-[3-Benzoyl-4-(2-p-tolyl-acetylami...)
Show SMILES Cc1ccc(CC(=O)Nc2ccc(NC(=O)\C=C\c3ccc(o3)-c3ccc(Br)cc3)cc2C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C35H27BrN2O4/c1-23-7-9-24(10-8-23)21-34(40)38-31-18-15-28(22-30(31)35(41)26-5-3-2-4-6-26)37-33(39)20-17-29-16-19-32(42-29)25-11-13-27(36)14-12-25/h2-20,22H,21H2,1H3,(H,37,39)(H,38,40)/b20-17+
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 925n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against yeast farnesyltransferase

J Med Chem 44: 3117-24 (2001)


BindingDB Entry DOI: 10.7270/Q2VH5N43
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238375
PNG
(3-(1-Dibenzofuranyl)-4-cyano-5-(isopropylthio)thio...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2oc3ccccc3c12 |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;2.99,4.21,;3.89,5.45,;3.27,6.86,;1.73,7.02,;.83,8.27,;-.64,7.79,;-1.97,8.56,;-3.3,7.79,;-3.3,6.25,;-1.97,5.48,;-.64,6.25,;.83,5.77,)|
Show InChI InChI=1S/C21H15NO3S2/c1-11(2)26-21-14(10-22)18(19(27-21)20(23)24)13-7-5-9-16-17(13)12-6-3-4-8-15(12)25-16/h3-9,11H,1-2H3,(H,23,24)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.00E+3n/an/an/an/a7.5n/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50104049
PNG
(6-Phenyl-hexanoic acid [3-benzoyl-4-(2-p-tolyl-ace...)
Show SMILES Cc1ccc(CC(=O)Nc2ccc(NC(=O)CCCCCc3ccccc3)cc2C(=O)c2ccccc2)cc1
Show InChI InChI=1S/C34H34N2O3/c1-25-17-19-27(20-18-25)23-33(38)36-31-22-21-29(24-30(31)34(39)28-14-8-4-9-15-28)35-32(37)16-10-3-7-13-26-11-5-2-6-12-26/h2,4-6,8-9,11-12,14-15,17-22,24H,3,7,10,13,16,23H2,1H3,(H,35,37)(H,36,38)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against yeast farnesyltransferase

J Med Chem 44: 3117-24 (2001)


BindingDB Entry DOI: 10.7270/Q2VH5N43
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238370
PNG
(3-(1-Naphthyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2ccccc12 |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;2.99,4.21,;3.89,5.45,;3.27,6.86,;1.73,7.02,;1.11,8.43,;-.42,8.59,;-1.33,7.34,;-.7,5.94,;.83,5.77,)|
Show InChI InChI=1S/C19H15NO2S2/c1-11(2)23-19-15(10-20)16(17(24-19)18(21)22)14-9-5-7-12-6-3-4-8-13(12)14/h3-9,11H,1-2H3,(H,21,22)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.10E+3n/an/an/an/a7.5n/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50103282
PNG
(1-[3-Benzoyl-4-(3-phenyl-propionylamino)-phenylcar...)
Show SMILES [NH3+][C@@H](CS)C(=O)Nc1ccc(NC(=O)CCc2ccccc2)c(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C25H25N3O3S/c26-21(16-32)25(31)27-19-12-13-22(20(15-19)24(30)18-9-5-2-6-10-18)28-23(29)14-11-17-7-3-1-4-8-17/h1-10,12-13,15,21,32H,11,14,16,26H2,(H,27,31)(H,28,29)/p+1/t21-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.29E+3n/an/an/an/an/an/a



Philipps-Universität Marburg

Curated by ChEMBL


Assay Description
Inhibitory activity against farnesyltransferase.

J Med Chem 44: 2886-99 (2001)


BindingDB Entry DOI: 10.7270/Q2TQ60TB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238358
PNG
(3-(2-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1F |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;.83,5.77,;1.73,7.02,;3.27,6.86,;3.89,5.45,;2.99,4.21,;3.61,2.8,)|
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-10(7-17)12(13(21-15)14(18)19)9-5-3-4-6-11(9)16/h3-6,8H,1-2H3,(H,18,19)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.30E+3n/an/an/an/a7.5n/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 79 total )  |  Next  |  Last  >>
Jump to: