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Compile Data Set for Download or QSAR

Found 224 hits of ic50 for UniProtKB: P35439   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50134218
PNG
(CHEMBL3741652)
Show SMILES CCOC(=O)c1c(NC(=O)CC2SC(=N)NC2=O)sc2CC(CC)CCc12
Show InChI InChI=1S/C18H23N3O4S2/c1-3-9-5-6-10-11(7-9)26-16(14(10)17(24)25-4-2)20-13(22)8-12-15(23)21-18(19)27-12/h9,12H,3-8H2,1-2H3,(H,20,22)(H2,19,21,23)
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n/an/a 900n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat GluN1a/GluN2C receptor expressed in Xenopus laevis oocytes assessed as suppression of 100 uM glutamate and 30 u...

Bioorg Med Chem Lett 25: 5583-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.046
BindingDB Entry DOI: 10.7270/Q2BK1F61
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324399
PNG
((E)-4-(6-iodo-2-(3-nitrostyryl)-4-oxoquinazolin-3(...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(I)cc2c1=O
Show InChI InChI=1S/C23H14IN3O5/c24-16-7-10-20-19(13-16)22(28)26(17-8-5-15(6-9-17)23(29)30)21(25-20)11-4-14-2-1-3-18(12-14)27(31)32/h1-13H,(H,29,30)/b11-4+
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n/an/a 1.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324392
PNG
((E)-4-(6-Chloro-2-(3-nitrostyryl)-4-oxoquinazolin-...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(Cl)cc2c1=O
Show InChI InChI=1S/C23H14ClN3O5/c24-16-7-10-20-19(13-16)22(28)26(17-8-5-15(6-9-17)23(29)30)21(25-20)11-4-14-2-1-3-18(12-14)27(31)32/h1-13H,(H,29,30)/b11-4+
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n/an/a 2.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324404
PNG
((E)-4-(2-(3-Nitrostyryl)-4-oxo-6-phenylquinazolin-...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(cc2c1=O)-c1ccccc1
Show InChI InChI=1S/C29H19N3O5/c33-28-25-18-22(20-6-2-1-3-7-20)12-15-26(25)30-27(16-9-19-5-4-8-24(17-19)32(36)37)31(28)23-13-10-21(11-14-23)29(34)35/h1-18H,(H,34,35)/b16-9+
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n/an/a 2.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324428
PNG
((E)-3-(6-Iodo-2-(3-nitrostyryl)-4-oxoquinazolin-3(...)
Show SMILES OC(=O)c1cccc(c1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(I)cc2c1=O
Show InChI InChI=1S/C23H14IN3O5/c24-16-8-9-20-19(13-16)22(28)26(17-5-2-4-15(12-17)23(29)30)21(25-20)10-7-14-3-1-6-18(11-14)27(31)32/h1-13H,(H,29,30)/b10-7+
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n/an/a 2.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324426
PNG
((E)-4-(6-iodo-2-(4-nitrostyryl)-4-oxoquinazolin-3(...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccc(cc2)[N+]([O-])=O)nc2ccc(I)cc2c1=O
Show InChI InChI=1S/C23H14IN3O5/c24-16-6-11-20-19(13-16)22(28)26(17-9-4-15(5-10-17)23(29)30)21(25-20)12-3-14-1-7-18(8-2-14)27(31)32/h1-13H,(H,29,30)/b12-3+
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n/an/a 2.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324405
PNG
((E)-4-(2-(3-Nitrostyryl)-4-oxobenzo[g]quinazolin-3...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2cc3ccccc3cc2c1=O
Show InChI InChI=1S/C27H17N3O5/c31-26-23-15-19-5-1-2-6-20(19)16-24(23)28-25(13-8-17-4-3-7-22(14-17)30(34)35)29(26)21-11-9-18(10-12-21)27(32)33/h1-16H,(H,32,33)/b13-8+
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n/an/a 2.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324397
PNG
((E)-4-(6-Fluoro-2-(3-nitrostyryl)-4-oxoquinazolin-...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(F)cc2c1=O
Show InChI InChI=1S/C23H14FN3O5/c24-16-7-10-20-19(13-16)22(28)26(17-8-5-15(6-9-17)23(29)30)21(25-20)11-4-14-2-1-3-18(12-14)27(31)32/h1-13H,(H,29,30)/b11-4+
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n/an/a 2.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324398
PNG
((E)-4-(6-Bromo-2-(3-nitrostyryl)-4-oxoquinazolin-3...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(Br)cc2c1=O
Show InChI InChI=1S/C23H14BrN3O5/c24-16-7-10-20-19(13-16)22(28)26(17-8-5-15(6-9-17)23(29)30)21(25-20)11-4-14-2-1-3-18(12-14)27(31)32/h1-13H,(H,29,30)/b11-4+
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n/an/a 2.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50509842
PNG
(CHEMBL4468229)
Show SMILES CCN(CC)C(=O)Oc1ccc(cc1)C(=O)Nc1cccc(CCNS(=O)(=O)c2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C26H27ClFN3O5S/c1-3-31(4-2)26(33)36-21-10-8-19(9-11-21)25(32)30-20-7-5-6-18(16-20)14-15-29-37(34,35)22-12-13-24(28)23(27)17-22/h5-13,16-17,29H,3-4,14-15H2,1-2H3,(H,30,32)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...

ACS Med Chem Lett 10: 248-254 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00395
BindingDB Entry DOI: 10.7270/Q2G16441
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50509840
PNG
(CHEMBL4528294)
Show SMILES CCN(CC)C(=O)Oc1ccc(cc1)C(=O)Nc1cccc(CCNS(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C26H29N3O5S/c1-3-29(4-2)26(31)34-23-15-13-21(14-16-23)25(30)28-22-10-8-9-20(19-22)17-18-27-35(32,33)24-11-6-5-7-12-24/h5-16,19,27H,3-4,17-18H2,1-2H3,(H,28,30)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...

ACS Med Chem Lett 10: 248-254 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00395
BindingDB Entry DOI: 10.7270/Q2G16441
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324445
PNG
((E)-6-iodo-3-(2-methoxyphenyl)-2-(2-(pyridin-3-yl)...)
Show SMILES COc1ccccc1-n1c(\C=C\c2cccnc2)nc2ccc(I)cc2c1=O |(9.99,5.86,;9.99,4.32,;11.33,3.56,;12.66,4.34,;14.01,3.58,;14.01,2.04,;12.68,1.26,;11.34,2.03,;10.01,1.26,;10.02,-.29,;11.36,-1.06,;11.36,-2.6,;12.69,-3.36,;14.01,-2.58,;15.35,-3.34,;15.35,-4.89,;14.02,-5.66,;12.69,-4.9,;8.68,-1.07,;7.35,-.3,;6,-1.07,;4.67,-.3,;4.67,1.24,;3.34,2.01,;6,2.01,;7.34,1.24,;8.67,2.03,;8.66,3.57,)|
Show InChI InChI=1S/C22H16IN3O2/c1-28-20-7-3-2-6-19(20)26-21(11-8-15-5-4-12-24-14-15)25-18-10-9-16(23)13-17(18)22(26)27/h2-14H,1H3/b11-8+
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n/an/a 3.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324409
PNG
((E)-4-(2-(3-Nitrostyryl)-4-oxo-6-propylquinazolin-...)
Show SMILES CCCc1ccc2nc(\C=C\c3cccc(c3)[N+]([O-])=O)n(-c3ccc(cc3)C(O)=O)c(=O)c2c1
Show InChI InChI=1S/C26H21N3O5/c1-2-4-17-7-13-23-22(16-17)25(30)28(20-11-9-19(10-12-20)26(31)32)24(27-23)14-8-18-5-3-6-21(15-18)29(33)34/h3,5-16H,2,4H2,1H3,(H,31,32)/b14-8+
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n/an/a 3.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50509841
PNG
(CHEMBL4445076)
Show SMILES CCN(CC)C(=O)Oc1ccc(cc1)C(=O)Nc1cccc(CCNS(=O)(=O)c2cccnc2)c1
Show InChI InChI=1S/C25H28N4O5S/c1-3-29(4-2)25(31)34-22-12-10-20(11-13-22)24(30)28-21-8-5-7-19(17-21)14-16-27-35(32,33)23-9-6-15-26-18-23/h5-13,15,17-18,27H,3-4,14,16H2,1-2H3,(H,28,30)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...

ACS Med Chem Lett 10: 248-254 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00395
BindingDB Entry DOI: 10.7270/Q2G16441
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50509834
PNG
(CHEMBL4583491)
Show SMILES CCN(CC)C(=O)Oc1ccc(cc1)C(=O)Nc1cccc2cc[nH]c12
Show InChI InChI=1S/C20H21N3O3/c1-3-23(4-2)20(25)26-16-10-8-15(9-11-16)19(24)22-17-7-5-6-14-12-13-21-18(14)17/h5-13,21H,3-4H2,1-2H3,(H,22,24)
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n/an/a 3.70E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...

ACS Med Chem Lett 10: 248-254 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00395
BindingDB Entry DOI: 10.7270/Q2G16441
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324411
PNG
(4-(2-(3-Nitrostyryl)-4-oxo-6-styrylquinazolin-3(4H...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(\C=C\c3ccccc3)cc2c1=O
Show InChI InChI=1S/C31H21N3O5/c35-30-27-20-23(10-9-21-5-2-1-3-6-21)11-17-28(27)32-29(18-12-22-7-4-8-26(19-22)34(38)39)33(30)25-15-13-24(14-16-25)31(36)37/h1-20H,(H,36,37)/b10-9+,18-12+
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n/an/a 4.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324473
PNG
((E)-3-(2-methoxyphenyl)-2-(2-nitrostyryl)quinazoli...)
Show SMILES COc1ccccc1-n1c(\C=C\c2ccccc2[N+]([O-])=O)nc2ccccc2c1=O |(33.08,.19,;31.74,.96,;31.74,2.5,;33.07,3.27,;33.06,4.81,;31.73,5.58,;30.4,4.8,;30.4,3.27,;29.07,2.5,;29.08,.94,;30.41,.19,;30.42,-1.37,;31.76,-2.13,;33.07,-1.35,;34.41,-2.12,;34.42,-3.66,;33.09,-4.43,;31.75,-3.67,;30.42,-4.44,;29.08,-3.67,;30.42,-5.98,;27.74,.16,;26.4,.93,;25.05,.16,;23.72,.93,;23.72,2.47,;25.05,3.25,;26.39,2.48,;27.72,3.27,;27.71,4.81,)|
Show InChI InChI=1S/C23H17N3O4/c1-30-21-13-7-6-12-20(21)25-22(24-18-10-4-3-9-17(18)23(25)27)15-14-16-8-2-5-11-19(16)26(28)29/h2-15H,1H3/b15-14+
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n/an/a 4.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324410
PNG
((E)-4-(2-(3-nitrostyryl)-4-oxo-6-(thiophen-2-yl)qu...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccc(cc2c1=O)-c1cccs1
Show InChI InChI=1S/C27H17N3O5S/c31-26-22-16-19(24-5-2-14-36-24)9-12-23(22)28-25(13-6-17-3-1-4-21(15-17)30(34)35)29(26)20-10-7-18(8-11-20)27(32)33/h1-16H,(H,32,33)/b13-6+
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n/an/a 5.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324400
PNG
((E)-4-(6-Methyl-2-(3-nitrostyryl)-4-oxoquinazolin-...)
Show SMILES Cc1ccc2nc(\C=C\c3cccc(c3)[N+]([O-])=O)n(-c3ccc(cc3)C(O)=O)c(=O)c2c1
Show InChI InChI=1S/C24H17N3O5/c1-15-5-11-21-20(13-15)23(28)26(18-9-7-17(8-10-18)24(29)30)22(25-21)12-6-16-3-2-4-19(14-16)27(31)32/h2-14H,1H3,(H,29,30)/b12-6+
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n/an/a 5.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50165461
PNG
((S)-1-(4-Chloro-phenyl)-2-((S)-6,7-dimethoxy-2-met...)
Show SMILES COc1cc2CCN(C)[C@@H](C[C@H](O)c3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C20H24ClNO3/c1-22-9-8-14-10-19(24-2)20(25-3)11-16(14)17(22)12-18(23)13-4-6-15(21)7-5-13/h4-7,10-11,17-18,23H,8-9,12H2,1-3H3/t17-,18-/m0/s1
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n/an/a 5.29E+3n/an/an/an/an/an/a



Ludwig-Maximilians-Universität München

Curated by ChEMBL


Assay Description
Mean inhibitory concentration against rat N-methyl-D-aspartate (NMDA) glutamate receptor 1a/2C expressed in Xenopus oocytes

Bioorg Med Chem Lett 15: 2231-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.03.025
BindingDB Entry DOI: 10.7270/Q2VM4BR3
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324452
PNG
((E)-4-(6-Iodo-4-oxo-2-(2-(pyridin-3-yl)vinyl)quina...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccnc2)nc2ccc(I)cc2c1=O
Show InChI InChI=1S/C22H14IN3O3/c23-16-6-9-19-18(12-16)21(27)26(17-7-4-15(5-8-17)22(28)29)20(25-19)10-3-14-2-1-11-24-13-14/h1-13H,(H,28,29)/b10-3+
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n/an/a 6.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324408
PNG
((E)-4-(6-Isopropyl-2-(3-nitrostyryl)-4-oxoquinazol...)
Show SMILES CC(C)c1ccc2nc(\C=C\c3cccc(c3)[N+]([O-])=O)n(-c3ccc(cc3)C(O)=O)c(=O)c2c1
Show InChI InChI=1S/C26H21N3O5/c1-16(2)19-9-12-23-22(15-19)25(30)28(20-10-7-18(8-11-20)26(31)32)24(27-23)13-6-17-4-3-5-21(14-17)29(33)34/h3-16H,1-2H3,(H,31,32)/b13-6+
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n/an/a 6.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324401
PNG
((E)-4-(6-Methoxy-2-(3-nitrostyryl)-4-oxoquinazolin...)
Show SMILES COc1ccc2nc(\C=C\c3cccc(c3)[N+]([O-])=O)n(-c3ccc(cc3)C(O)=O)c(=O)c2c1
Show InChI InChI=1S/C24H17N3O6/c1-33-19-10-11-21-20(14-19)23(28)26(17-8-6-16(7-9-17)24(29)30)22(25-21)12-5-15-3-2-4-18(13-15)27(31)32/h2-14H,1H3,(H,29,30)/b12-5+
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n/an/a 6.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50531765
PNG
(CHEMBL4534780)
Show SMILES OC(=O)c1cc2cc(\C=C\c3ccc(cc3)[N+]([O-])=O)ccc2cc1O
Show InChI InChI=1S/C19H13NO5/c21-18-11-14-6-3-13(9-15(14)10-17(18)19(22)23)2-1-12-4-7-16(8-5-12)20(24)25/h1-11,21H,(H,22,23)/b2-1+
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n/an/a 6.50E+3n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...

Eur J Med Chem 164: 471-498 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.054
BindingDB Entry DOI: 10.7270/Q22J6GB9
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324453
PNG
((E)-3-(6-Iodo-4-oxo-2-(2-(pyridin-3-yl)vinyl)quina...)
Show SMILES OC(=O)c1cccc(c1)-n1c(\C=C\c2cccnc2)nc2ccc(I)cc2c1=O
Show InChI InChI=1S/C22H14IN3O3/c23-16-7-8-19-18(12-16)21(27)26(17-5-1-4-15(11-17)22(28)29)20(25-19)9-6-14-3-2-10-24-13-14/h1-13H,(H,28,29)/b9-6+
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n/an/a 7.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50531773
PNG
(CHEMBL4475740)
Show SMILES OC(=O)c1cc2cc(\C=C\c3cccc(c3)[N+]([O-])=O)ccc2cc1O
Show InChI InChI=1S/C19H13NO5/c21-18-11-14-7-6-13(8-15(14)10-17(18)19(22)23)5-4-12-2-1-3-16(9-12)20(24)25/h1-11,21H,(H,22,23)/b5-4+
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n/an/a 7.90E+3n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...

Eur J Med Chem 164: 471-498 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.054
BindingDB Entry DOI: 10.7270/Q22J6GB9
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324461
PNG
((E)-4-(2-(2-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccccc2[N+]([O-])=O)nc2ccccc2c1=O
Show InChI InChI=1S/C23H15N3O5/c27-22-18-6-2-3-7-19(18)24-21(14-11-15-5-1-4-8-20(15)26(30)31)25(22)17-12-9-16(10-13-17)23(28)29/h1-14H,(H,28,29)/b14-11+
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n/an/a 8.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324463
PNG
((E)-3-(2-(2-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)...)
Show SMILES OC(=O)c1cccc(c1)-n1c(\C=C\c2ccccc2[N+]([O-])=O)nc2ccccc2c1=O
Show InChI InChI=1S/C23H15N3O5/c27-22-18-9-2-3-10-19(18)24-21(13-12-15-6-1-4-11-20(15)26(30)31)25(22)17-8-5-7-16(14-17)23(28)29/h1-14H,(H,28,29)/b13-12+
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n/an/a 8.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50531766
PNG
(CHEMBL4472540)
Show SMILES OC(=O)c1cc2cc(\C=C\c3ccccc3[N+]([O-])=O)ccc2cc1O
Show InChI InChI=1S/C19H13NO5/c21-18-11-14-8-6-12(9-15(14)10-16(18)19(22)23)5-7-13-3-1-2-4-17(13)20(24)25/h1-11,21H,(H,22,23)/b7-5+
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n/an/a 8.20E+3n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...

Eur J Med Chem 164: 471-498 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.054
BindingDB Entry DOI: 10.7270/Q22J6GB9
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50509838
PNG
(CHEMBL4440270)
Show SMILES CCN(CC)C(=O)Oc1ccc(cc1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H20N2O3/c1-3-20(4-2)18(22)23-16-12-10-14(11-13-16)17(21)19-15-8-6-5-7-9-15/h5-13H,3-4H2,1-2H3,(H,19,21)
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n/an/a 8.60E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...

ACS Med Chem Lett 10: 248-254 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00395
BindingDB Entry DOI: 10.7270/Q2G16441
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324380
PNG
((E)-4-(2-(3-methoxystyryl)-4-oxoquinazolin-3(4H)-y...)
Show SMILES COc1cccc(\C=C\c2nc3ccccc3c(=O)n2-c2ccc(cc2)C(O)=O)c1
Show InChI InChI=1S/C24H18N2O4/c1-30-19-6-4-5-16(15-19)9-14-22-25-21-8-3-2-7-20(21)23(27)26(22)18-12-10-17(11-13-18)24(28)29/h2-15H,1H3,(H,28,29)/b14-9+
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n/an/a 9.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324396
PNG
((E)-4-(6,8-Dichloro-2-(4-nitrostyryl)-4-oxoquinazo...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccc(cc2)[N+]([O-])=O)nc2c(Cl)cc(Cl)cc2c1=O
Show InChI InChI=1S/C23H13Cl2N3O5/c24-15-11-18-21(19(25)12-15)26-20(10-3-13-1-6-17(7-2-13)28(32)33)27(22(18)29)16-8-4-14(5-9-16)23(30)31/h1-12H,(H,30,31)/b10-3+
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n/an/a 9.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324427
PNG
((E)-3-(6-Iodo-2-(4-nitrostyryl)-4-oxoquinazolin-3(...)
Show SMILES OC(=O)c1cccc(c1)-n1c(\C=C\c2ccc(cc2)[N+]([O-])=O)nc2ccc(I)cc2c1=O
Show InChI InChI=1S/C23H14IN3O5/c24-16-7-10-20-19(13-16)22(28)26(18-3-1-2-15(12-18)23(29)30)21(25-20)11-6-14-4-8-17(9-5-14)27(31)32/h1-13H,(H,29,30)/b11-6+
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n/an/a 9.00E+3n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50007024
PNG
(CHEMBL3237304)
Show SMILES COC(=O)c1ccc(cc1)C1N(CCc2cccc3ccccc23)C(=O)C(O)=C1C(C)=O |c:30|
Show InChI InChI=1S/C26H23NO5/c1-16(28)22-23(19-10-12-20(13-11-19)26(31)32-2)27(25(30)24(22)29)15-14-18-8-5-7-17-6-3-4-9-21(17)18/h3-13,23,29H,14-15H2,1-2H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as reduction in current response

J Med Chem 57: 2334-56 (2014)


Article DOI: 10.1021/jm401695d
BindingDB Entry DOI: 10.7270/Q2SB4786
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50180890
PNG
(CHEMBL3818694)
Show SMILES c1ccncc1.[H][C@@]12CC[C@]3([H])C[C@@H](CC[C@]3(C)[C@@]1([H])CC[C@@H](C)C2)OS(O)(=O)=O |r|
Show InChI InChI=1S/C16H28O4S.C5H5N/c1-11-3-6-15-12(9-11)4-5-13-10-14(20-21(17,18)19)7-8-16(13,15)2;1-2-4-6-5-3-1/h11-15H,3-10H2,1-2H3,(H,17,18,19);1-5H/t11-,12+,13-,14-,15+,16+;/m1./s1
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n/an/a 1.11E+4n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic

Curated by ChEMBL


Assay Description
Inhibition of recombinant rat GluN1a/GluN2C co-expressed in HEK293 cells assessed as suppression of glutamate-induced current by patch-clamp method

J Med Chem 59: 4724-39 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00079
BindingDB Entry DOI: 10.7270/Q28K7C05
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324383
PNG
((E)-4-(4-oxo-2-(3-(trifluoromethyl)styryl)quinazol...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)C(F)(F)F)nc2ccccc2c1=O
Show InChI InChI=1S/C24H15F3N2O3/c25-24(26,27)17-5-3-4-15(14-17)8-13-21-28-20-7-2-1-6-19(20)22(30)29(21)18-11-9-16(10-12-18)23(31)32/h1-14H,(H,31,32)/b13-8+
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n/an/a 1.20E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50509835
PNG
(CHEMBL4443031)
Show SMILES CCN(CC)C(=O)Oc1ccc(cc1)C(=O)Nc1ccc(CCNS(=O)(=O)c2cccnc2)cc1
Show InChI InChI=1S/C25H28N4O5S/c1-3-29(4-2)25(31)34-22-13-9-20(10-14-22)24(30)28-21-11-7-19(8-12-21)15-17-27-35(32,33)23-6-5-16-26-18-23/h5-14,16,18,27H,3-4,15,17H2,1-2H3,(H,28,30)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...

ACS Med Chem Lett 10: 248-254 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00395
BindingDB Entry DOI: 10.7270/Q2G16441
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324394
PNG
((E)-4-(8-Chloro-2-(3-nitrostyryl)-4-oxoquinazolin-...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2c(Cl)cccc2c1=O
Show InChI InChI=1S/C23H14ClN3O5/c24-19-6-2-5-18-21(19)25-20(12-7-14-3-1-4-17(13-14)27(31)32)26(22(18)28)16-10-8-15(9-11-16)23(29)30/h1-13H,(H,29,30)/b12-7+
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n/an/a 1.20E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324459
PNG
((E)-4-(2-(3-Nitrostyryl)-4-oxoquinazolin-3(4H)-yl)...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2ccccc2c1=O
Show InChI InChI=1S/C23H15N3O5/c27-22-19-6-1-2-7-20(19)24-21(13-8-15-4-3-5-18(14-15)26(30)31)25(22)17-11-9-16(10-12-17)23(28)29/h1-14H,(H,28,29)/b13-8+
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n/an/a 1.20E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324429
PNG
((E)-4-(6-Methoxy-2-(4-nitrostyryl)-4-oxoquinazolin...)
Show SMILES COc1ccc2nc(\C=C\c3ccc(cc3)[N+]([O-])=O)n(-c3ccc(cc3)C(O)=O)c(=O)c2c1
Show InChI InChI=1S/C24H17N3O6/c1-33-19-11-12-21-20(14-19)23(28)26(17-9-5-16(6-10-17)24(29)30)22(25-21)13-4-15-2-7-18(8-3-15)27(31)32/h2-14H,1H3,(H,29,30)/b13-4+
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n/an/a 1.30E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324433
PNG
((E)-4-(6-Iodo-4-oxo-2-styrylquinazolin-3(4H)-yl)be...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccccc2)nc2ccc(I)cc2c1=O
Show InChI InChI=1S/C23H15IN2O3/c24-17-9-12-20-19(14-17)22(27)26(18-10-7-16(8-11-18)23(28)29)21(25-20)13-6-15-4-2-1-3-5-15/h1-14H,(H,28,29)/b13-6+
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n/an/a 1.30E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50531772
PNG
(CHEMBL4593032)
Show SMILES OC(=O)c1cc2cc(\C=C\c3ccccc3)ccc2cc1O
Show InChI InChI=1S/C19H14O3/c20-18-12-15-9-8-14(7-6-13-4-2-1-3-5-13)10-16(15)11-17(18)19(21)22/h1-12,20H,(H,21,22)/b7-6+
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n/an/a 1.38E+4n/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat GluN1/GluN2C expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...

Eur J Med Chem 164: 471-498 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.054
BindingDB Entry DOI: 10.7270/Q22J6GB9
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324436
PNG
((E)-4-(2-(2-(naphthalen-2-yl)vinyl)-4-oxoquinazoli...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccc3ccccc3c2)nc2ccccc2c1=O
Show InChI InChI=1S/C27H18N2O3/c30-26-23-7-3-4-8-24(23)28-25(29(26)22-14-12-20(13-15-22)27(31)32)16-10-18-9-11-19-5-1-2-6-21(19)17-18/h1-17H,(H,31,32)/b16-10+
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n/an/a 1.40E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324417
PNG
((E)-4-(6,7-Dimethoxy-2-(3-nitrostyryl)-4-oxoquinaz...)
Show SMILES COC(=O)c1cccc(\C=C\c2nc3ccc(OC)cc3c(=O)n2-c2ccc(cc2)C(O)=O)c1
Show InChI InChI=1S/C26H20N2O6/c1-33-20-11-12-22-21(15-20)24(29)28(19-9-7-17(8-10-19)25(30)31)23(27-22)13-6-16-4-3-5-18(14-16)26(32)34-2/h3-15H,1-2H3,(H,30,31)/b13-6+
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n/an/a 1.50E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324382
PNG
((E)-4-(4-oxo-2-(4-(trifluoromethyl)styryl)quinazol...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccc(cc2)C(F)(F)F)nc2ccccc2c1=O
Show InChI InChI=1S/C24H15F3N2O3/c25-24(26,27)17-10-5-15(6-11-17)7-14-21-28-20-4-2-1-3-19(20)22(30)29(21)18-12-8-16(9-13-18)23(31)32/h1-14H,(H,31,32)/b14-7+
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n/an/a 1.50E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324455
PNG
((E)-4-(2-(4-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2ccc(cc2)[N+]([O-])=O)nc2ccccc2c1=O
Show InChI InChI=1S/C23H15N3O5/c27-22-19-3-1-2-4-20(19)24-21(14-7-15-5-10-18(11-6-15)26(30)31)25(22)17-12-8-16(9-13-17)23(28)29/h1-14H,(H,28,29)/b14-7+
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n/an/a 1.50E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324395
PNG
((E)-4-(6,8-Dichloro-2-(3-nitrostyryl)-4-oxoquinazo...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2c(Cl)cc(Cl)cc2c1=O
Show InChI InChI=1S/C23H13Cl2N3O5/c24-15-11-18-21(19(25)12-15)26-20(9-4-13-2-1-3-17(10-13)28(32)33)27(22(18)29)16-7-5-14(6-8-16)23(30)31/h1-12H,(H,30,31)/b9-4+
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n/an/a 1.60E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324393
PNG
((E)-4-(7-Chloro-2-(3-nitrostyryl)-4-oxoquinazolin-...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(c2)[N+]([O-])=O)nc2cc(Cl)ccc2c1=O
Show InChI InChI=1S/C23H14ClN3O5/c24-16-7-10-19-20(13-16)25-21(11-4-14-2-1-3-18(12-14)27(31)32)26(22(19)28)17-8-5-15(6-9-17)23(29)30/h1-13H,(H,29,30)/b11-4+
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n/an/a 1.60E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324381
PNG
((E)-4-(2-(2-methoxystyryl)-4-oxoquinazolin-3(4H)-y...)
Show SMILES COc1ccccc1\C=C\c1nc2ccccc2c(=O)n1-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C24H18N2O4/c1-30-21-9-5-2-6-16(21)12-15-22-25-20-8-4-3-7-19(20)23(27)26(22)18-13-10-17(11-14-18)24(28)29/h2-15H,1H3,(H,28,29)/b15-12+
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n/an/a 1.60E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2C


(RAT-Rattus norvegicus (Rat))		BDBM50324386
PNG
((E)-4-(2-(3-hydroxystyryl)-4-oxoquinazolin-3(4H)-y...)
Show SMILES OC(=O)c1ccc(cc1)-n1c(\C=C\c2cccc(O)c2)nc2ccccc2c1=O
Show InChI InChI=1S/C23H16N2O4/c26-18-5-3-4-15(14-18)8-13-21-24-20-7-2-1-6-19(20)22(27)25(21)17-11-9-16(10-12-17)23(28)29/h1-14,26H,(H,28,29)/b13-8+
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n/an/a 1.70E+4n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Antagonist activity at rat recombinant NR1-NR2C receptor expressed in Xenopus oocytes at holding potential of -40mV by two-electrode voltage-clamp el...

J Med Chem 53: 5476-90 (2010)


Article DOI: 10.1021/jm100027p
BindingDB Entry DOI: 10.7270/Q2DR2VQF
More data for this
Ligand-Target Pair
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