Found 54 hits of ic50 for UniProtKB: P11309 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM238767
(US9394297, 451)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC1(C)CC1)n(C)c2=O Show InChI InChI=1S/C20H21N5O2/c1-10-15-13(17(26)21-10)9-14(22-15)11-5-4-6-12-16(11)23-19(25(3)18(12)27)24-20(2)7-8-20/h4-6,9-10,22H,7-8H2,1-3H3,(H,21,26)(H,23,24)/t10-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50536094
(CHEMBL4541192)Show SMILES Cc1nc2cccc(-c3cc4C(=O)N[C@H](CCN)c4[nH]3)c2nc1NC(C)(C)C |r| Show InChI InChI=1S/C21H26N6O/c1-11-19(27-21(2,3)4)26-17-12(6-5-7-14(17)23-11)16-10-13-18(24-16)15(8-9-22)25-20(13)28/h5-7,10,15,24H,8-9,22H2,1-4H3,(H,25,28)(H,26,27)/t15-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50536095
(CHEMBL4587596)Show SMILES Cc1nc2ccc(F)c(-c3cc4c(CCNC4=O)[nH]3)c2nc1NC(C)(C)C Show InChI InChI=1S/C20H22FN5O/c1-10-18(26-20(2,3)4)25-17-14(23-10)6-5-12(21)16(17)15-9-11-13(24-15)7-8-22-19(11)27/h5-6,9,24H,7-8H2,1-4H3,(H,22,27)(H,25,26) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM238724
(US9394297, 405)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2c1nc(NC(C)(C)C)n(C)c2=O Show InChI InChI=1S/C20H22FN5O2/c1-9-15-11(17(27)22-9)8-13(23-15)14-12(21)7-6-10-16(14)24-19(25-20(2,3)4)26(5)18(10)28/h6-9,23H,1-5H3,(H,22,27)(H,24,25)/t9-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192574
(US9187486, 37 | US9187486, 39 | US9187486, 60)Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C23H23F2N7/c1-14-9-15(26)13-31(12-14)21-7-8-27-11-20(21)29-23-28-10-16-5-6-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-8,10-11,14-15H,9,12-13,26H2,1H3,(H,28,29)/t14-,15+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM238637
(US9394297, 297)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2nc(C)c(NC(C)(C)C)nc12 Show InChI InChI=1S/C20H22FN5O/c1-9-16-11(19(27)23-9)8-14(24-16)15-12(21)6-7-13-17(15)25-18(10(2)22-13)26-20(3,4)5/h6-9,24H,1-5H3,(H,23,27)(H,25,26)/t9-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM238664
(US9394297, 326)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2nc(C)c(NC(C)(C)C)nc12 Show InChI InChI=1S/C20H23N5O/c1-10-16-13(19(26)22-10)9-15(23-16)12-7-6-8-14-17(12)24-18(11(2)21-14)25-20(3,4)5/h6-10,23H,1-5H3,(H,22,26)(H,24,25)/t10-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50200531
(CHEMBL3950251)Show SMILES N[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C22H22F2N8O/c23-13-2-1-3-14(24)20(13)17-5-4-12-8-28-22(32(12)30-17)29-18-9-27-7-6-19(18)31-10-15(25)21(33)16(26)11-31/h1-9,15-16,21,33H,10-11,25-26H2,(H,28,29)/t15-,16+,21+ | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM238766
(US9394297, 450)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC(C)(C)C)n(C)c2=O Show InChI InChI=1S/C20H23N5O2/c1-10-15-13(17(26)21-10)9-14(22-15)11-7-6-8-12-16(11)23-19(24-20(2,3)4)25(5)18(12)27/h6-10,22H,1-5H3,(H,21,26)(H,23,24)/t10-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM238672
(US9394297, 334)Show SMILES Cc1nc2cccc(-c3cc4C(=O)NCc4[nH]3)c2nc1NC(C)(C)C Show InChI InChI=1S/C19H21N5O/c1-10-17(24-19(2,3)4)23-16-11(6-5-7-13(16)21-10)14-8-12-15(22-14)9-20-18(12)25/h5-8,22H,9H2,1-4H3,(H,20,25)(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192593
(US9187486, 65)Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C22H23FN8/c1-14-9-15(24)13-30(12-14)20-6-8-25-11-19(20)28-22-27-10-16-4-5-18(29-31(16)22)21-17(23)3-2-7-26-21/h2-8,10-11,14-15H,9,12-13,24H2,1H3,(H,27,28)/t14-,15+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192642
(US9187486, 87)Show SMILES C[C@@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C23H23F2N7/c1-14-5-6-15(26)13-31(14)21-9-10-27-12-20(21)29-23-28-11-16-7-8-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-4,7-12,14-15H,5-6,13,26H2,1H3,(H,28,29)/t14-,15+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM238665
(US9394297, 327)Show SMILES C[C@@H]1NC(=O)c2cc([nH]c12)-c1cccc2nc(C)c(NC(C)(C)C)nc12 Show InChI InChI=1S/C20H23N5O/c1-10-16-13(19(26)22-10)9-15(23-16)12-7-6-8-14-17(12)24-18(11(2)21-14)25-20(3,4)5/h6-10,23H,1-5H3,(H,22,26)(H,24,25)/t10-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM238662
(US9394297, 324)Show SMILES Cc1nc2cccc(-c3cc4C(=O)NC5(CC5)c4[nH]3)c2nc1NC(C)(C)C Show InChI InChI=1S/C21H23N5O/c1-11-18(25-20(2,3)4)24-16-12(6-5-7-14(16)22-11)15-10-13-17(23-15)21(8-9-21)26-19(13)27/h5-7,10,23H,8-9H2,1-4H3,(H,24,25)(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50536097
(CHEMBL4572195)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(N1CCCC1(C)C)n(C)c2=O |r| Show InChI InChI=1S/C22H25N5O2/c1-12-17-15(19(28)23-12)11-16(24-17)13-7-5-8-14-18(13)25-21(26(4)20(14)29)27-10-6-9-22(27,2)3/h5,7-8,11-12,24H,6,9-10H2,1-4H3,(H,23,28)/t12-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM238547
(US9394297, 193)Show SMILES Cc1nc2cccc(-c3cc4c(CCNC4=O)[nH]3)c2nc1NC(C)(C)C Show InChI InChI=1S/C20H23N5O/c1-11-18(25-20(2,3)4)24-17-12(6-5-7-15(17)22-11)16-10-13-14(23-16)8-9-21-19(13)26/h5-7,10,23H,8-9H2,1-4H3,(H,21,26)(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50200533
(CHEMBL3904539)Show SMILES N[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C21H22FN9O/c22-13-2-1-6-26-19(13)16-4-3-12-8-27-21(31(12)29-16)28-17-9-25-7-5-18(17)30-10-14(23)20(32)15(24)11-30/h1-9,14-15,20,32H,10-11,23-24H2,(H,27,28)/t14-,15+,20+ | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50536098
(CHEMBL4587256)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(NC(C)(C)CO)n(C)c2=O |r| Show InChI InChI=1S/C20H23N5O3/c1-10-15-13(17(27)21-10)8-14(22-15)11-6-5-7-12-16(11)23-19(25(4)18(12)28)24-20(2,3)9-26/h5-8,10,22,26H,9H2,1-4H3,(H,21,27)(H,23,24)/t10-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 127 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192640
(US9187486, 85)Show SMILES C[C@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C23H23F2N7/c1-14-5-6-15(26)13-31(14)21-9-10-27-12-20(21)29-23-28-11-16-7-8-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-4,7-12,14-15H,5-6,13,26H2,1H3,(H,28,29)/t14-,15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 142 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM238706
(US9394297, 370)Show SMILES Cc1nc2ccc(F)c(-c3cc4c(CCNC4=O)[nH]3)c2nc1NC(C)(C)CO Show InChI InChI=1S/C20H22FN5O2/c1-10-18(26-20(2,3)9-27)25-17-14(23-10)5-4-12(21)16(17)15-8-11-13(24-15)6-7-22-19(11)28/h4-5,8,24,27H,6-7,9H2,1-3H3,(H,22,28)(H,25,26) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 143 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM238707
(US9394297, 371)Show SMILES Cc1nc2ccc(F)c(-c3cc4c(cc[nH]c4=O)[nH]3)c2nc1NC(C)(C)C Show InChI InChI=1S/C20H20FN5O/c1-10-18(26-20(2,3)4)25-17-14(23-10)6-5-12(21)16(17)15-9-11-13(24-15)7-8-22-19(11)27/h5-9,24H,1-4H3,(H,22,27)(H,25,26) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 148 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50536092
(CHEMBL4589855)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1nc(N(C)C(C)(C)C)n(C)c2=O |r| Show InChI InChI=1S/C21H25N5O2/c1-11-16-14(18(27)22-11)10-15(23-16)12-8-7-9-13-17(12)24-20(25(5)19(13)28)26(6)21(2,3)4/h7-11,23H,1-6H3,(H,22,27)/t11-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 167 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192648
(US9187486, 100)Show SMILES C[C@@H]1CCN(C[C@H]1N)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C23H23F2N7/c1-14-8-10-31(13-18(14)26)21-7-9-27-12-20(21)29-23-28-11-15-5-6-19(30-32(15)23)22-16(24)3-2-4-17(22)25/h2-7,9,11-12,14,18H,8,10,13,26H2,1H3,(H,28,29)/t14-,18-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 212 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192586
(US9187486, 54)Show SMILES C[C@@H]1[C@@H](N)CCCN1c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C23H23F2N7/c1-14-18(26)6-3-11-31(14)21-9-10-27-13-20(21)29-23-28-12-15-7-8-19(30-32(15)23)22-16(24)4-2-5-17(22)25/h2,4-5,7-10,12-14,18H,3,6,11,26H2,1H3,(H,28,29)/t14-,18+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 221 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192645
(US9187486, 96)Show SMILES C[C@@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C22H23FN8/c1-14-4-5-15(24)13-30(14)20-8-10-25-12-19(20)28-22-27-11-16-6-7-18(29-31(16)22)21-17(23)3-2-9-26-21/h2-3,6-12,14-15H,4-5,13,24H2,1H3,(H,27,28)/t14-,15+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 258 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192577
(US9187486, 40)Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C21H21FN8/c22-16-4-1-8-25-20(16)17-6-5-15-11-26-21(30(15)28-17)27-18-12-24-9-7-19(18)29-10-2-3-14(23)13-29/h1,4-9,11-12,14H,2-3,10,13,23H2,(H,26,27)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 286 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192539
(US9187486, 1)Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C22H21F2N7/c23-16-4-1-5-17(24)21(16)18-7-6-15-11-27-22(31(15)29-18)28-19-12-26-9-8-20(19)30-10-2-3-14(25)13-30/h1,4-9,11-12,14H,2-3,10,13,25H2,(H,27,28)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 403 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM238771
(US9394297, 455)Show SMILES C[C@H]1NC(=O)c2c(Cl)c([nH]c12)-c1cccc2nc(C)c(NC(C)(C)C)nc12 Show InChI InChI=1S/C20H22ClN5O/c1-9-15-13(19(27)23-9)14(21)17(24-15)11-7-6-8-12-16(11)25-18(10(2)22-12)26-20(3,4)5/h6-9,24H,1-5H3,(H,23,27)(H,25,26)/t9-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 407 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192571
(US9187486, 33 | US9187486, 61)Show SMILES C[C@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C23H23F2N7/c1-14-9-15(26)13-31(12-14)21-7-8-27-11-20(21)29-23-28-10-16-5-6-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-8,10-11,14-15H,9,12-13,26H2,1H3,(H,28,29)/t14-,15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 522 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192546
(US9187486, 8)Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1nccs1 |r| Show InChI InChI=1S/C19H20N8S/c20-13-2-1-8-26(12-13)17-5-6-21-11-16(17)24-19-23-10-14-3-4-15(25-27(14)19)18-22-7-9-28-18/h3-7,9-11,13H,1-2,8,12,20H2,(H,23,24)/t13-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 602 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192604
(US9187486, 78)Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1Cl |r| Show InChI InChI=1S/C21H21ClN8/c22-16-4-1-8-25-20(16)17-6-5-15-11-26-21(30(15)28-17)27-18-12-24-9-7-19(18)29-10-2-3-14(23)13-29/h1,4-9,11-12,14H,2-3,10,13,23H2,(H,26,27)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 620 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192582
(US9187486, 48)Show SMILES N[C@H]1C[C@@H](F)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C22H20F3N7/c23-13-8-14(26)12-31(11-13)20-6-7-27-10-19(20)29-22-28-9-15-4-5-18(30-32(15)22)21-16(24)2-1-3-17(21)25/h1-7,9-10,13-14H,8,11-12,26H2,(H,28,29)/t13-,14+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 983 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50536099
(CHEMBL4546373)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccc2c1N=C(NC(C)(C)C)N(C)S2(=O)=O |r,t:19| Show InChI InChI=1S/C19H23N5O3S/c1-10-15-12(17(25)20-10)9-13(21-15)11-7-6-8-14-16(11)22-18(23-19(2,3)4)24(5)28(14,26)27/h6-10,21H,1-5H3,(H,20,25)(H,22,23)/t10-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50536091
(CHEMBL4527131)Show SMILES Cc1nc2cccc(-c3cc4CNC(=O)c4s3)c2nc1NC(C)(C)C Show InChI InChI=1S/C19H20N4OS/c1-10-17(23-19(2,3)4)22-15-12(6-5-7-13(15)21-10)14-8-11-9-20-18(24)16(11)25-14/h5-8H,9H2,1-4H3,(H,20,24)(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192553
(US9187486, 15)Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ccccc1F |r| Show InChI InChI=1S/C22H22FN7/c23-18-6-2-1-5-17(18)19-8-7-16-12-26-22(30(16)28-19)27-20-13-25-10-9-21(20)29-11-3-4-15(24)14-29/h1-2,5-10,12-13,15H,3-4,11,14,24H2,(H,26,27)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM238645
(US9394297, 305)Show SMILES Cc1nc2cccc(-c3cc4c(CCCNC4=O)[nH]3)c2nc1NC(C)(C)C Show InChI InChI=1S/C21H25N5O/c1-12-19(26-21(2,3)4)25-18-13(7-5-8-16(18)23-12)17-11-14-15(24-17)9-6-10-22-20(14)27/h5,7-8,11,24H,6,9-10H2,1-4H3,(H,22,27)(H,25,26) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50536096
(CHEMBL4530924)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1nccc2c1nc(NC(C)(C)C)n(C)c2=O |r| Show InChI InChI=1S/C19H22N6O2/c1-9-13-11(16(26)21-9)8-12(22-13)15-14-10(6-7-20-15)17(27)25(5)18(23-14)24-19(2,3)4/h6-9,22H,1-5H3,(H,21,26)(H,23,24)/t9-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192592
(US9187486, 64)Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ccccn1 |r| Show InChI InChI=1S/C21H22N8/c22-15-4-3-11-28(14-15)20-8-10-23-13-19(20)26-21-25-12-16-6-7-18(27-29(16)21)17-5-1-2-9-24-17/h1-2,5-10,12-13,15H,3-4,11,14,22H2,(H,25,26)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192550
(US9187486, 12)Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ccc(F)cc1F |r| Show InChI InChI=1S/C22H21F2N7/c23-14-3-5-17(18(24)10-14)19-6-4-16-11-27-22(31(16)29-19)28-20-12-26-8-7-21(20)30-9-1-2-15(25)13-30/h3-8,10-12,15H,1-2,9,13,25H2,(H,27,28)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50536100
(CHEMBL4522524)Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccn2c1nc(NC(C)(C)C)c(C)c2=O |r| Show InChI InChI=1S/C20H23N5O2/c1-10-16(24-20(3,4)5)23-17-12(7-6-8-25(17)19(10)27)14-9-13-15(22-14)11(2)21-18(13)26/h6-9,11,22,24H,1-5H3,(H,21,26)/t11-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192632
(US9187486, 55)Show SMILES C[C@H]1[C@@H](N)CCCN1c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C23H23F2N7/c1-14-18(26)6-3-11-31(14)21-9-10-27-13-20(21)29-23-28-12-15-7-8-19(30-32(15)23)22-16(24)4-2-5-17(22)25/h2,4-5,7-10,12-14,18H,3,6,11,26H2,1H3,(H,28,29)/t14-,18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192542
(US9187486, 4)Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ccccc1Cl |r| Show InChI InChI=1S/C22H22ClN7/c23-18-6-2-1-5-17(18)19-8-7-16-12-26-22(30(16)28-19)27-20-13-25-10-9-21(20)29-11-3-4-15(24)14-29/h1-2,5-10,12-13,15H,3-4,11,14,24H2,(H,26,27)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM50536093
(CHEMBL4514782)Show SMILES Cc1nc2cccc(-c3cc4C(=O)NCc4s3)c2nc1NC(C)(C)C Show InChI InChI=1S/C19H20N4OS/c1-10-17(23-19(2,3)4)22-16-11(6-5-7-13(16)21-10)14-8-12-15(25-14)9-20-18(12)24/h5-8H,9H2,1-4H3,(H,20,24)(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192646
(US9187486, 98)Show SMILES C[C@H]1CCN(C[C@H]1N)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C23H23F2N7/c1-14-8-10-31(13-18(14)26)21-7-9-27-12-20(21)29-23-28-11-15-5-6-19(30-32(15)23)22-16(24)3-2-4-17(22)25/h2-7,9,11-12,14,18H,8,10,13,26H2,1H3,(H,28,29)/t14-,18+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192600
(US9187486, 73)Show SMILES N[C@H]1CCCN(C1)c1ccccc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C23H22F2N6/c24-17-6-3-7-18(25)22(17)20-11-10-16-13-27-23(31(16)29-20)28-19-8-1-2-9-21(19)30-12-4-5-15(26)14-30/h1-3,6-11,13,15H,4-5,12,14,26H2,(H,27,28)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM238534
(US9394297, 174)Show SMILES Cc1nc2cccc(-c3cc4C(=O)NCCn4c3)c2nc1NC(C)(C)C Show InChI InChI=1S/C20H23N5O/c1-12-18(24-20(2,3)4)23-17-14(6-5-7-15(17)22-12)13-10-16-19(26)21-8-9-25(16)11-13/h5-7,10-11H,8-9H2,1-4H3,(H,21,26)(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192557
(US9187486, 19)Show SMILES O[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C22H20F2N6O/c23-16-4-1-5-17(24)21(16)18-7-6-14-11-26-22(30(14)28-18)27-19-12-25-9-8-20(19)29-10-2-3-15(31)13-29/h1,4-9,11-12,15,31H,2-3,10,13H2,(H,26,27)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.81E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192549
(US9187486, 11)Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ccc(Cl)cc1Cl |r| Show InChI InChI=1S/C22H21Cl2N7/c23-14-3-5-17(18(24)10-14)19-6-4-16-11-27-22(31(16)29-19)28-20-12-26-8-7-21(20)30-9-1-2-15(25)13-30/h3-8,10-12,15H,1-2,9,13,25H2,(H,27,28)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM192570
(US9187486, 32)Show SMILES N[C@H]1CCC[C@H](C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C23H22F2N6/c24-18-5-2-6-19(25)22(18)20-8-7-16-12-28-23(31(16)30-20)29-21-13-27-10-9-17(21)14-3-1-4-15(26)11-14/h2,5-10,12-15H,1,3-4,11,26H2,(H,28,29)/t14-,15+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1/pim-2/pim-3
(Homo sapiens (Human)) | BDBM238728
(US9394297, 409)Show SMILES Cc1nc2cccc(-c3cc4C(=O)NC5(CCOCC5)c4[nH]3)c2nc1NC(C)(C)C Show InChI InChI=1S/C23H27N5O2/c1-13-20(27-22(2,3)4)26-18-14(6-5-7-16(18)24-13)17-12-15-19(25-17)23(28-21(15)29)8-10-30-11-9-23/h5-7,12,25H,8-11H2,1-4H3,(H,26,27)(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m... |
J Med Chem 59: 6407-30 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00610
BindingDB Entry DOI: 10.7270/Q2125X4G |
More data for this
Ligand-Target Pair | |
Search and Browse
