BindingDB PrimarySearch

Found 15 hits of ec50 for monomerid = 50081701
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50081701 (3-[2-(dimethylamino)ethyl]-1H-indol-4-ol \| 4-hydro...) Show SMILES CN(C)CCc1c[nH]c2cccc(O)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.30	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by...				J Nat Prod 83: 461-467 (2020) Article DOI: 10.1021/acs.jnatprod.9b01061 BindingDB Entry DOI: 10.7270/Q2RX9GM1
Usona Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50081701 (3-[2-(dimethylamino)ethyl]-1H-indol-4-ol \| 4-hydro...) Show SMILES CN(C)CCc1c[nH]c2cccc(O)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.30	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by...				J Nat Prod 83: 461-467 (2020) Article DOI: 10.1021/acs.jnatprod.9b01061 BindingDB Entry DOI: 10.7270/Q2RX9GM1
Usona Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50081701 (3-[2-(dimethylamino)ethyl]-1H-indol-4-ol \| 4-hydro...) Show SMILES CN(C)CCc1c[nH]c2cccc(O)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.5	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at 5-HT2A receptor (unknown origin) by calcium flux assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00129 BindingDB Entry DOI: 10.7270/Q23T9N3F
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50081701 (3-[2-(dimethylamino)ethyl]-1H-indol-4-ol \| 4-hydro...) Show SMILES CN(C)CCc1c[nH]c2cccc(O)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.5	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00577 BindingDB Entry DOI: 10.7270/Q2Z89H7T
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Mus musculus (Mouse))	BDBM50081701 (3-[2-(dimethylamino)ethyl]-1H-indol-4-ol \| 4-hydro...) Show SMILES CN(C)CCc1c[nH]c2cccc(O)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9.80	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by...				J Nat Prod 83: 461-467 (2020) Article DOI: 10.1021/acs.jnatprod.9b01061 BindingDB Entry DOI: 10.7270/Q2RX9GM1
Usona Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Mus musculus (Mouse))	BDBM50081701 (3-[2-(dimethylamino)ethyl]-1H-indol-4-ol \| 4-hydro...) Show SMILES CN(C)CCc1c[nH]c2cccc(O)c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9.90	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by...				J Nat Prod 83: 461-467 (2020) Article DOI: 10.1021/acs.jnatprod.9b01061 BindingDB Entry DOI: 10.7270/Q2RX9GM1
Usona Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50081701 (3-[2-(dimethylamino)ethyl]-1H-indol-4-ol \| 4-hydro...) Show SMILES CN(C)CCc1c[nH]c2cccc(O)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a
Organix Inc. Curated by ChEMBL					Assay Description Effective concentration required for accumulation of [3H]-inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determi...				Bioorg Med Chem Lett 15: 4555-9 (2005) Article DOI: 10.1016/j.bmcl.2005.06.104 BindingDB Entry DOI: 10.7270/Q2PZ58B5
Organix Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50081701 (3-[2-(dimethylamino)ethyl]-1H-indol-4-ol \| 4-hydro...) Show SMILES CN(C)CCc1c[nH]c2cccc(O)c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
Organix Inc. Curated by ChEMBL					Assay Description Effective concentration required for accumulation of [3H]-inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determi...				Bioorg Med Chem Lett 15: 4555-9 (2005) Article DOI: 10.1016/j.bmcl.2005.06.104 BindingDB Entry DOI: 10.7270/Q2PZ58B5
Organix Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50081701 (3-[2-(dimethylamino)ethyl]-1H-indol-4-ol \| 4-hydro...) Show SMILES CN(C)CCc1c[nH]c2cccc(O)c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	58	n/a	n/a	n/a	n/a
Organix Inc. Curated by ChEMBL					Assay Description Effective concentration required for accumulation of [3H]-inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor de...				Bioorg Med Chem Lett 15: 4555-9 (2005) Article DOI: 10.1016/j.bmcl.2005.06.104 BindingDB Entry DOI: 10.7270/Q2PZ58B5
Organix Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50081701 (3-[2-(dimethylamino)ethyl]-1H-indol-4-ol \| 4-hydro...) Show SMILES CN(C)CCc1c[nH]c2cccc(O)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	75	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]-ketanserin from human 5-HT2A receptor incubated for 90 mins by scintillation counting analysis				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00467 BindingDB Entry DOI: 10.7270/Q2TT4VR2
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50081701 (3-[2-(dimethylamino)ethyl]-1H-indol-4-ol \| 4-hydro...) Show SMILES CN(C)CCc1c[nH]c2cccc(O)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	75	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]-ketanserin from human 5-HT2A receptor incubated for 90 mins by scintillation counting analysis				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00467 BindingDB Entry DOI: 10.7270/Q2TT4VR2
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50081701 (3-[2-(dimethylamino)ethyl]-1H-indol-4-ol \| 4-hydro...) Show SMILES CN(C)CCc1c[nH]c2cccc(O)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00352 BindingDB Entry DOI: 10.7270/Q2CC14Q8
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50081701 (3-[2-(dimethylamino)ethyl]-1H-indol-4-ol \| 4-hydro...) Show SMILES CN(C)CCc1c[nH]c2cccc(O)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a
TBA					Assay Description i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2 4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followed by 0.2 ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K077JM
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50081701 (3-[2-(dimethylamino)ethyl]-1H-indol-4-ol \| 4-hydro...) Show SMILES CN(C)CCc1c[nH]c2cccc(O)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00128 BindingDB Entry DOI: 10.7270/Q2KD22Z5
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50081701 (3-[2-(dimethylamino)ethyl]-1H-indol-4-ol \| 4-hydro...) Show SMILES CN(C)CCc1c[nH]c2cccc(O)c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Tested for its ability to activate phospholipase C by quantification of IP3 at cloned rat 5-hydroxytryptamine 2A receptor				J Med Chem 46: 3526-35 (2003) Article DOI: 10.1021/jm030064v BindingDB Entry DOI: 10.7270/Q20P0ZC1
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair