Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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11-beta-hydroxysteroid dehydrogenase type 2 (Homo sapiens (Human)) | BDBM50233538 (18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human 11beta-HSD2 | Eur J Med Chem 65: 403-14 (2013) Article DOI: 10.1016/j.ejmech.2013.05.010 BindingDB Entry DOI: 10.7270/Q2JS9RV7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase type 2 (Homo sapiens (Human)) | BDBM50233538 (18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human 11beta-HSD2 overexpressed in microsomal fraction of HEK293 cells using [3H]-cortisol as substrate by scintillation proximity assa... | J Nat Prod 78: 330-4 (2015) Article DOI: 10.1021/np500896n BindingDB Entry DOI: 10.7270/Q2930VWF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase type 2 (Homo sapiens (Human)) | BDBM50233538 (18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China. Curated by ChEMBL | Assay Description Inhibition of full-length human 11beta-HSD2 expressed in HEK293 microsomal fraction using [3H]cortisone as substrate after 2 hr by scintillation prox... | Eur J Med Chem 135: 324-338 (2017) Article DOI: 10.1016/j.ejmech.2017.04.059 BindingDB Entry DOI: 10.7270/Q2CF9SK2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase type 2 (Homo sapiens (Human)) | BDBM50233538 (18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 257 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Natural Resources and Applied Life Sciences Curated by ChEMBL | Assay Description Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-3H]-cortisol to cortisone by scintillation c... | Bioorg Med Chem 18: 7522-41 (2010) Article DOI: 10.1016/j.bmc.2010.08.046 BindingDB Entry DOI: 10.7270/Q2PR7W7Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase type 2 (Homo sapiens (Human)) | BDBM50233538 (18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 257 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Technology Curated by ChEMBL | Assay Description Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [1,2,6,7-[3H]cortisol to cortisone after 10 mins by scintillation... | Bioorg Med Chem 19: 1866-80 (2011) Article DOI: 10.1016/j.bmc.2011.02.005 BindingDB Entry DOI: 10.7270/Q2VD6ZR7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase type 2 (Rattus norvegicus) | BDBM50233538 (18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Technology Curated by ChEMBL | Assay Description Inhibition of rat renal 11beta-HSD2 | Bioorg Med Chem 19: 1866-80 (2011) Article DOI: 10.1016/j.bmc.2011.02.005 BindingDB Entry DOI: 10.7270/Q2VD6ZR7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
11-beta-hydroxysteroid dehydrogenase type 2 (Rattus norvegicus) | BDBM50233538 (18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Vienna University of Technology Curated by ChEMBL | Assay Description Inhibition of rat renal 11beta-HSD2 in rat liver assessed as inhibition of cortisone production | Bioorg Med Chem 18: 433-54 (2010) Article DOI: 10.1016/j.bmc.2009.10.036 BindingDB Entry DOI: 10.7270/Q2BP02W3 | |||||||||||
More data for this Ligand-Target Pair |