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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 (Homo sapiens (Human)) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
UMR C8076 (CNRS) Curated by ChEMBL | Assay Description Binding affinity towards cloned human 5-hydroxytryptamine 4E receptor expressed in C6 glial cells using [3H]-GR-113,808 as radioligand | J Med Chem 46: 2606-20 (2003) Article DOI: 10.1021/jm0307887 BindingDB Entry DOI: 10.7270/Q2H131DJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (RAT) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.07 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS-BIOCIS Curated by ChEMBL | Assay Description Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatal membranes by [3H]-GR 113808 displacement. | J Med Chem 40: 1755-61 (1997) Article DOI: 10.1021/jm960853v BindingDB Entry DOI: 10.7270/Q2NS0T0C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (RAT) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article | 1.07 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity against 5-hydroxytryptamine 4 receptor using [3H]-GR-113,808 as radioligand in rat striatum | Bioorg Med Chem Lett 4: 1433-1436 (1994) Article DOI: 10.1016/S0960-894X(01)80508-4 BindingDB Entry DOI: 10.7270/Q2G160RF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (RAT) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS-BIOCIS Curated by ChEMBL | Assay Description Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand | J Med Chem 40: 608-21 (1997) Article DOI: 10.1021/jm960320m BindingDB Entry DOI: 10.7270/Q2T72J36 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (Homo sapiens (Human)) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Paris-Sud Curated by ChEMBL | Assay Description Binding affinity to YFP fused 5HT4 receptor expressed in CHO cells | J Med Chem 50: 4482-92 (2007) Article DOI: 10.1021/jm070552t BindingDB Entry DOI: 10.7270/Q2251K0C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (Homo sapiens (Human)) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 3.69 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Paris-Sud Curated by PDSP Ki Database | J Neurochem 70: 2252-61 (1998) Article DOI: 10.1046/j.1471-4159.1998.70062252.x BindingDB Entry DOI: 10.7270/Q2Z036PW | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (Homo sapiens (Human)) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 3.69 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM Curated by ChEMBL | Assay Description Binding affinity was determined against cloned 5-hydroxytryptamine 4D receptor isoform expressed in COS-7 cells | J Med Chem 43: 3761-9 (2000) BindingDB Entry DOI: 10.7270/Q2CC0ZXH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (Homo sapiens (Human)) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Paris-Sud Curated by ChEMBL | Assay Description Displacement of [3H]GR-113808 from human 5HT4e receptor expressed in C6 cells | J Med Chem 50: 4482-92 (2007) Article DOI: 10.1021/jm070552t BindingDB Entry DOI: 10.7270/Q2251K0C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (Homo sapiens (Human)) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 5 | -47.4 | n/a | n/a | 51 | n/a | n/a | 7.4 | 25 |
CNRS | Assay Description Radioligand binding studies were performed in buffer contains test compound, [3H]-GR113808, and receptor C6 glial cell membrane preparation. Nonspeci... | J Med Chem 52: 2214-25 (2009) Article DOI: 10.1021/jm801327q BindingDB Entry DOI: 10.7270/Q2QF8R6F | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (Homo sapiens (Human)) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Paris XI Curated by ChEMBL | Assay Description Binding affinity for 5-HT4 receptor using [3H]-GR-113,808 | J Med Chem 48: 6220-8 (2005) Article DOI: 10.1021/jm050234z BindingDB Entry DOI: 10.7270/Q22N51V9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (Homo sapiens (Human)) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM Curated by ChEMBL | Assay Description Binding affinity was determined against cloned 5-hydroxytryptamine 4E receptor isoform expressed in C6 glial cells incubated with 0.2 nM [3H]-GR-113,... | J Med Chem 43: 3761-9 (2000) BindingDB Entry DOI: 10.7270/Q2CC0ZXH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (Homo sapiens (Human)) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Paris-Sud Curated by ChEMBL | Assay Description Binding affinity to Rluc fused 5HT4 receptor expressed in CHO cells | J Med Chem 50: 4482-92 (2007) Article DOI: 10.1021/jm070552t BindingDB Entry DOI: 10.7270/Q2251K0C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (Homo sapiens (Human)) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 7.98 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Paris-Sud Curated by PDSP Ki Database | J Neurochem 70: 2252-61 (1998) Article DOI: 10.1046/j.1471-4159.1998.70062252.x BindingDB Entry DOI: 10.7270/Q2Z036PW | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (Homo sapiens (Human)) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 7.98 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM Curated by ChEMBL | Assay Description Binding affinity was determined against cloned 5-hydroxytryptamine 4C receptor isoform expressed in COS-7 cells | J Med Chem 43: 3761-9 (2000) BindingDB Entry DOI: 10.7270/Q2CC0ZXH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (Homo sapiens (Human)) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM Curated by ChEMBL | Assay Description Binding affinity was determined against cloned 5-hydroxytryptamine 4A receptor isoform expressed in COS-7 cells | J Med Chem 43: 3761-9 (2000) BindingDB Entry DOI: 10.7270/Q2CC0ZXH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (Homo sapiens (Human)) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Paris-Sud Curated by PDSP Ki Database | J Neurochem 70: 2252-61 (1998) Article DOI: 10.1046/j.1471-4159.1998.70062252.x BindingDB Entry DOI: 10.7270/Q2Z036PW | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (Homo sapiens (Human)) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 10.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM Curated by ChEMBL | Assay Description Binding affinity was determined against cloned 5-hydroxytryptamine 4B receptor isoform expressed in COS-7 cells | J Med Chem 43: 3761-9 (2000) BindingDB Entry DOI: 10.7270/Q2CC0ZXH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (Homo sapiens (Human)) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 10.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Paris-Sud Curated by PDSP Ki Database | J Neurochem 70: 2252-61 (1998) Article DOI: 10.1046/j.1471-4159.1998.70062252.x BindingDB Entry DOI: 10.7270/Q2Z036PW | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (RAT) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description 5-hydroxytryptamine 4 receptor agonist activity was determined by the relaxation of the carbachol-contracted rat esophageal tunica muscularis mucosae | Bioorg Med Chem Lett 4: 1433-1436 (1994) Article DOI: 10.1016/S0960-894X(01)80508-4 BindingDB Entry DOI: 10.7270/Q2G160RF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (GUINEA PIG) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
CNRS-BIOCIS Curated by ChEMBL | Assay Description 5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an... | J Med Chem 40: 608-21 (1997) Article DOI: 10.1021/jm960320m BindingDB Entry DOI: 10.7270/Q2T72J36 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (GUINEA PIG) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description 5-hydroxytryptamine 4 receptor agonist activity as increased response to electrical stimulation in guinea pig ileum | Bioorg Med Chem Lett 4: 1433-1436 (1994) Article DOI: 10.1016/S0960-894X(01)80508-4 BindingDB Entry DOI: 10.7270/Q2G160RF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (Homo sapiens (Human)) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd. Curated by ChEMBL | Assay Description Agonist activity at human 5HT4e receptor expressed in CHO cells assessed as cAMP level after 4 hrs by luciferase reporter gene assay | Eur J Med Chem 103: 289-301 (2015) Article DOI: 10.1016/j.ejmech.2015.08.051 BindingDB Entry DOI: 10.7270/Q20C4ZST | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 4 (GUINEA PIG) | BDBM29526 (2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
Suven Life Sciences Ltd. Curated by ChEMBL | Assay Description Agonist activity at 5-HT4 receptor in guinea pig ileum assessed as increase in response to electrical stimulation | Eur J Med Chem 103: 289-301 (2015) Article DOI: 10.1016/j.ejmech.2015.08.051 BindingDB Entry DOI: 10.7270/Q20C4ZST | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
