Found 4 hits Enz. Inhib. hit(s) with Target = 'ATP-sensitive inward rectifier potassium channel 1' and Ligand = 'BDBM50235196' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
ATP-sensitive inward rectifier potassium channel 1
(Homo sapiens (Human)) | BDBM50235196
(CHEMBL4064760)Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2)c2cnc(cn2)S(C)(=O)=O)CC1 |r| Show InChI InChI=1S/C24H30N4O5S/c1-16-17(3-4-18-19(16)14-33-23(18)30)20(29)13-27-8-5-24(6-9-27)7-10-28(15-24)21-11-26-22(12-25-21)34(2,31)32/h3-4,11-12,20,29H,5-10,13-15H2,1-2H3/t20-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck& Co. Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human ROMK expressed in CHO cells by electrophysiology method |
Bioorg Med Chem Lett 27: 1109-1114 (2017)
Article DOI: 10.1016/j.bmcl.2016.10.032
BindingDB Entry DOI: 10.7270/Q2T43WC8 |
More data for this
Ligand-Target Pair | |
ATP-sensitive inward rectifier potassium channel 1
(Rattus norvegicus (Rat)) | BDBM50235196
(CHEMBL4064760)Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2)c2cnc(cn2)S(C)(=O)=O)CC1 |r| Show InChI InChI=1S/C24H30N4O5S/c1-16-17(3-4-18-19(16)14-33-23(18)30)20(29)13-27-8-5-24(6-9-27)7-10-28(15-24)21-11-26-22(12-25-21)34(2,31)32/h3-4,11-12,20,29H,5-10,13-15H2,1-2H3/t20-/m0/s1 | UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck& Co. Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by thallium flux assay |
Bioorg Med Chem Lett 27: 1109-1114 (2017)
Article DOI: 10.1016/j.bmcl.2016.10.032
BindingDB Entry DOI: 10.7270/Q2T43WC8 |
More data for this
Ligand-Target Pair | |
ATP-sensitive inward rectifier potassium channel 1
(Homo sapiens (Human)) | BDBM50235196
(CHEMBL4064760)Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2)c2cnc(cn2)S(C)(=O)=O)CC1 |r| Show InChI InChI=1S/C24H30N4O5S/c1-16-17(3-4-18-19(16)14-33-23(18)30)20(29)13-27-8-5-24(6-9-27)7-10-28(15-24)21-11-26-22(12-25-21)34(2,31)32/h3-4,11-12,20,29H,5-10,13-15H2,1-2H3/t20-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck& Co. Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human ROMK expressed in HEK293 cells after 30 mins by thallium flux assay |
Bioorg Med Chem Lett 27: 1109-1114 (2017)
Article DOI: 10.1016/j.bmcl.2016.10.032
BindingDB Entry DOI: 10.7270/Q2T43WC8 |
More data for this
Ligand-Target Pair | |
ATP-sensitive inward rectifier potassium channel 1
(Homo sapiens (Human)) | BDBM50235196
(CHEMBL4064760)Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2)c2cnc(cn2)S(C)(=O)=O)CC1 |r| Show InChI InChI=1S/C24H30N4O5S/c1-16-17(3-4-18-19(16)14-33-23(18)30)20(29)13-27-8-5-24(6-9-27)7-10-28(15-24)21-11-26-22(12-25-21)34(2,31)32/h3-4,11-12,20,29H,5-10,13-15H2,1-2H3/t20-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Patents
Similars
| US Patent
| n/a | n/a | 44.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description
Assay Protocol: The ROMK channel functional thallium flux assay was performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells were ... |
US Patent US9751881 (2017)
BindingDB Entry DOI: 10.7270/Q26M38ZP |
More data for this
Ligand-Target Pair | |
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