BindingDB PrimarySearch

Found 17 hits Enz. Inhib. hit(s) with Target = 'Alpha-1D adrenergic receptor' and Ligand = 'BDBM29568'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM29568 (CHEMBL2 \| PRAZOSIN \| PRAZOSIN HYDROCHLORIDE \| [3H]...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institut de Recherches Servier, Centre de Recherches de Croissy Curated by PDSP K_i Database									Synapse 35: 79-95 (2000) Article DOI: 10.1002/(SICI)1098-2396(200002)35:2<79::AID-SYN1>3.0.CO;2-X BindingDB Entry DOI: 10.7270/Q2XK8D4N
					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM29568 (CHEMBL2 \| PRAZOSIN \| PRAZOSIN HYDROCHLORIDE \| [3H]...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	0.170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Displacement of [3H]prazosin from human recombinant adrenergic alpha-1D receptor expressed in CHO cell membranes incubated for 60 mins				J Med Chem 63: 433-439 (2020) Article DOI: 10.1021/acs.jmedchem.9b01465 BindingDB Entry DOI: 10.7270/Q2P55RW6
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Rattus norvegicus (Rat))	BDBM29568 (CHEMBL2 \| PRAZOSIN \| PRAZOSIN HYDROCHLORIDE \| [3H]...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Displacement of [3H]prazosin (0.3 nM) from rat Alpha-1D adrenergic receptor expressed in CHO cells				J Med Chem 46: 265-83 (2003) Article DOI: 10.1021/jm020938y BindingDB Entry DOI: 10.7270/Q2TB17MV
H. Lundbeck A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM29568 (CHEMBL2 \| PRAZOSIN \| PRAZOSIN HYDROCHLORIDE \| [3H]...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Compound was tested for binding affinity utilizing cloned receptor binding assays by using [125 I]HEAT as radioligand to the human Alpha-1D adrenergi...				J Med Chem 41: 1205-8 (1998) Article DOI: 10.1021/jm980053f BindingDB Entry DOI: 10.7270/Q2XG9Q72
Merck & Co. Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM29568 (CHEMBL2 \| PRAZOSIN \| PRAZOSIN HYDROCHLORIDE \| [3H]...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	0.224	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Alma Mater Studiorum-University of Bologna Curated by ChEMBL					Assay Description Displacement of [3H]prazosin from human alpha1D adrenoceptor expressed in CHO cell membranes after 30 mins				Eur J Med Chem 136: 259-269 (2017) Article DOI: 10.1016/j.ejmech.2017.05.003 BindingDB Entry DOI: 10.7270/Q2W95CQN
					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM29568 (CHEMBL2 \| PRAZOSIN \| PRAZOSIN HYDROCHLORIDE \| [3H]...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	0.224	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bologna Curated by ChEMBL					Assay Description Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi				J Med Chem 46: 4895-903 (2003) Article DOI: 10.1021/jm030952q BindingDB Entry DOI: 10.7270/Q2ZK5KDG
University of Bologna Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM29568 (CHEMBL2 \| PRAZOSIN \| PRAZOSIN HYDROCHLORIDE \| [3H]...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PubMed	0.230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Istituto Chimico Farmaceutico e Tossicologico Curated by ChEMBL					Assay Description Binding affinity towards human cloned alpha1d-adrenoceptor using [3H]-prazosin as radioligand				J Med Chem 44: 2403-10 (2001) BindingDB Entry DOI: 10.7270/Q2WS8SHW
					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM29568 (CHEMBL2 \| PRAZOSIN \| PRAZOSIN HYDROCHLORIDE \| [3H]...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	0.290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università di Milano Curated by ChEMBL					Assay Description The compound was tested for binding affinity on [3H]- prazosin as specific ligand on Human cloned alpha-1D adrenergic receptor in CHO cells				J Med Chem 42: 173-7 (1999) Article DOI: 10.1021/jm981006q BindingDB Entry DOI: 10.7270/Q22J6B05
Università di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Rattus norvegicus (Rat))	BDBM29568 (CHEMBL2 \| PRAZOSIN \| PRAZOSIN HYDROCHLORIDE \| [3H]...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Compound was evaluated for its ability to displace [125I]-HEAT binding from rat Alpha-1D adrenergic receptor				J Med Chem 41: 1205-8 (1998) Article DOI: 10.1021/jm980053f BindingDB Entry DOI: 10.7270/Q2XG9Q72
Merck & Co. Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM29568 (CHEMBL2 \| PRAZOSIN \| PRAZOSIN HYDROCHLORIDE \| [3H]...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Synaptic Pharmaceutical Corporation Curated by ChEMBL					Assay Description In vitro binding affinity against alpha-1D adrenergic receptor of human liver microsomes.				J Med Chem 42: 4778-93 (1999) BindingDB Entry DOI: 10.7270/Q2930SCW
Synaptic Pharmaceutical Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM29568 (CHEMBL2 \| PRAZOSIN \| PRAZOSIN HYDROCHLORIDE \| [3H]...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Synaptic Pharmaceutical Corporation Curated by ChEMBL					Assay Description Ability to displace [3H]prazosin from cloned human Alpha-1D adrenergic receptor				J Med Chem 38: 1579-81 (1995) BindingDB Entry DOI: 10.7270/Q25Q4WRJ
Synaptic Pharmaceutical Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM29568 (CHEMBL2 \| PRAZOSIN \| PRAZOSIN HYDROCHLORIDE \| [3H]...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PubMed	0.320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Binding affinity against Alpha-1D adrenergic receptor, from human clones.				J Med Chem 38: 3415-44 (1995) BindingDB Entry DOI: 10.7270/Q20G3J6W
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM29568 (CHEMBL2 \| PRAZOSIN \| PRAZOSIN HYDROCHLORIDE \| [3H]...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PubMed	0.330	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Synaptic Pharmaceutical Corporation Curated by ChEMBL					Assay Description Binding affinity against human Alpha-1D adrenergic receptor (h alpha-1d)				Bioorg Med Chem Lett 9: 2843-8 (1999) BindingDB Entry DOI: 10.7270/Q2NK3FJ2
Synaptic Pharmaceutical Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM29568 (CHEMBL2 \| PRAZOSIN \| PRAZOSIN HYDROCHLORIDE \| [3H]...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	0.380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by PDSP K_i Database									J Pharmacol Exp Ther 302: 58-65 (2002) Article DOI: 10.1124/jpet.302.1.58 BindingDB Entry DOI: 10.7270/Q2PG1Q9R
Emory University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Rattus norvegicus (Rat))	BDBM29568 (CHEMBL2 \| PRAZOSIN \| PRAZOSIN HYDROCHLORIDE \| [3H]...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	0.790	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					Assay Description Binding affinity against Alpha-1D adrenergic receptor, from rat clones.				J Med Chem 38: 3415-44 (1995) BindingDB Entry DOI: 10.7270/Q20G3J6W
SmithKline Beecham Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Rattus norvegicus (Rat))	BDBM29568 (CHEMBL2 \| PRAZOSIN \| PRAZOSIN HYDROCHLORIDE \| [3H]...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Camerino Curated by ChEMBL					Assay Description Compound was tested for binding affinity against cloned Alpha-1D adrenergic receptor from rat brain.				J Med Chem 39: 4602-7 (1996) Article DOI: 10.1021/jm960510x BindingDB Entry DOI: 10.7270/Q29W0J6P
University of Camerino Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Rattus norvegicus (Rat))	BDBM29568 (CHEMBL2 \| PRAZOSIN \| PRAZOSIN HYDROCHLORIDE \| [3H]...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a
Universidade Federal do Rio de Janeiro Curated by ChEMBL					Assay Description Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hr				Eur J Med Chem 46: 3000-12 (2011) Article DOI: 10.1016/j.ejmech.2011.04.032 BindingDB Entry DOI: 10.7270/Q2M32WVZ
Universidade Federal do Rio de Janeiro Curated by ChEMBL					More data for this Ligand-Target Pair