Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'COP9 signalosome complex subunit 5' and Ligand = 'BDBM224012'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
COP9 signalosome complex subunit 5 (Homo sapiens (Human))	BDBM224012 (Capzimin | US10005735, Compound 12) Show SMILES Sc1cccc2cc(cnc12)C(=O)NCCc1nccs1 Show InChI InChI=1S/C15H13N3OS2/c19-15(17-5-4-13-16-6-7-21-13)11-8-10-2-1-3-12(20)14(10)18-9-11/h1-3,6-9,20H,4-5H2,(H,17,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...				Bioorg Med Chem 17: 8086-92 (2009) BindingDB Entry DOI: 10.7270/Q22R3V09
					More data for this Ligand-Target Pair
COP9 signalosome complex subunit 5 (Homo sapiens (Human))	BDBM224012 (Capzimin | US10005735, Compound 12) Show SMILES Sc1cccc2cc(cnc12)C(=O)NCCc1nccs1 Show InChI InChI=1S/C15H13N3OS2/c19-15(17-5-4-13-16-6-7-21-13)11-8-10-2-1-3-12(20)14(10)18-9-11/h1-3,6-9,20H,4-5H2,(H,17,19)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	7.5	n/a
California Institute of Technology					Assay Description Csn5 activity was measured using purified CSN complex and the fluorescent substrate OGNedd8–SCFSkp2, in which a unique cysteine engineered into ...				Nat Chem Biol 13: 486-493 (2017) Article DOI: 10.1038/nchembio.2326 BindingDB Entry DOI: 10.7270/Q24J0D0B
					More data for this Ligand-Target Pair