| Reaction Details |
|---|
 | Report a problem with these data |
| Target | COP9 signalosome complex subunit 5 |
|---|
| Ligand | BDBM224012 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | In Vitro Csn5 Activity Assay |
|---|
| pH | 7.5±0 |
|---|
| IC50 | 3.0e+4±n/a nM |
|---|
| Citation |  Li, J; Yakushi, T; Parlati, F; Mackinnon, AL; Perez, C; Ma, Y; Carter, KP; Colayco, S; Magnuson, G; Brown, B; Nguyen, K; Vasile, S; Suyama, E; Smith, LH; Sergienko, E; Pinkerton, AB; Chung, TDY; Palmer, AE; Pass, I; Hess, S; Cohen, SM; Deshaies, RJ Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol13:486-493 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| COP9 signalosome complex subunit 5 |
|---|
| Name: | COP9 signalosome complex subunit 5 |
|---|
| Synonyms: | COP9 signalosome complex subunit 5 (Csn5) | COPS5 | CSN5 | CSN5_HUMAN | JAB1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 37578.39 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q92905 |
|---|
| Residue: | 334 |
|---|
| Sequence: | MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISAL
ALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAY
IENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGK
VNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLEL
LWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKL
AKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS
|
|
|
|---|
| BDBM224012 |
|---|
| n/a |
|---|
| Name | BDBM224012 |
|---|
| Synonyms: | Capzimin | US10005735, Compound 12 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H13N3OS2 |
|---|
| Mol. Mass. | 315.413 |
|---|
| SMILES | Sc1cccc2cc(cnc12)C(=O)NCCc1nccs1 |
|---|
| Structure | 
|
|---|
Search and Browse
