Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(1A) dopamine receptor (Sus scrofa) | BDBM50033116 ((1R,3S)-3-Adamantan-1-yl-1-aminomethyl-isochroman-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.ejmech.2020.113073 BindingDB Entry DOI: 10.7270/Q2FT8R1H | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
D(1A) dopamine receptor (Homo sapiens (Human)) | BDBM50033116 ((1R,3S)-3-Adamantan-1-yl-1-aminomethyl-isochroman-...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells | J Med Chem 38: 3445-7 (1995) BindingDB Entry DOI: 10.7270/Q26M37G0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
D(1A) dopamine receptor (RAT) | BDBM50033116 ((1R,3S)-3-Adamantan-1-yl-1-aminomethyl-isochroman-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand | J Med Chem 40: 1585-99 (1997) Article DOI: 10.1021/jm970038v BindingDB Entry DOI: 10.7270/Q2Z89D2B | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
D(1A) dopamine receptor (Homo sapiens (Human)) | BDBM50033116 ((1R,3S)-3-Adamantan-1-yl-1-aminomethyl-isochroman-...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1 | J Med Chem 38: 3445-7 (1995) BindingDB Entry DOI: 10.7270/Q26M37G0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
D(1A) dopamine receptor (RAT) | BDBM50033116 ((1R,3S)-3-Adamantan-1-yl-1-aminomethyl-isochroman-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 5.10 | n/a | n/a | n/a | n/a |
University of North Carolina Curated by ChEMBL | Assay Description Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional acti... | J Med Chem 39: 285-96 (1996) Article DOI: 10.1021/jm9502100 BindingDB Entry DOI: 10.7270/Q2NZ86Q3 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |