Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA (cytosine-5)-methyltransferase 3A (Homo sapiens (Human)) | BDBM50430056 (CHEMBL2336409 | SGI-1027) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
M. V. Lomonosov Moscow State University Curated by ChEMBL | Assay Description Inhibition of human C-terminal DNMT3A (623 to 908 residues) using 5'-biotin labeled oligonucleotide as substrate measured after 1 hr | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.127296 BindingDB Entry DOI: 10.7270/Q2BR8WQH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA (cytosine-5)-methyltransferase 3A (Homo sapiens (Human)) | BDBM50430056 (CHEMBL2336409 | SGI-1027) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS-Pierre Fabre Curated by ChEMBL | Assay Description Inhibition of His6-tagged human recombinant DNMT3a expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-bio... | J Med Chem 58: 2569-83 (2015) Article DOI: 10.1021/jm500843d BindingDB Entry DOI: 10.7270/Q24T6M36 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA (cytosine-5)-methyltransferase 3A (Homo sapiens (Human)) | BDBM50430056 (CHEMBL2336409 | SGI-1027) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 900 | n/a | n/a | n/a | n/a |
Unit£ de Service et de Recherche CNRS-Pierre Fabre n£3388 Curated by ChEMBL | Assay Description Inhibition of human C-terminal DNMT3A after 1 hr by fluorescence assay | Bioorg Med Chem 23: 5946-53 (2015) Article DOI: 10.1016/j.bmc.2015.06.066 BindingDB Entry DOI: 10.7270/Q2P270X8 | |||||||||||
More data for this Ligand-Target Pair |