Found 13 hits Enz. Inhib. hit(s) with Target = 'Dihydrofolate reductase' and Ligand = 'BDBM50405962' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dihydrofolate reductase
(Escherichia coli) | BDBM50405962
(CHEMBL19772)Show InChI InChI=1S/C11H11FN4/c12-9-3-1-2-7(5-9)4-8-6-15-11(14)16-10(8)13/h1-3,5-6H,4H2,(H4,13,14,15,16) | MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet 
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 588 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uniroyal Chemical Co., Inc.
Curated by ChEMBL
| Assay Description
Inhibition constant against binding of Escherichia coli dihydrofolate reductase |
J Med Chem 31: 1396-406 (1988)
BindingDB Entry DOI: 10.7270/Q2P55QQJ |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Escherichia coli) | BDBM50405962
(CHEMBL19772)Show InChI InChI=1S/C11H11FN4/c12-9-3-1-2-7(5-9)4-8-6-15-11(14)16-10(8)13/h1-3,5-6H,4H2,(H4,13,14,15,16) | MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 589 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Compound is evaluated for the inhibition of dihydrofolate reductase from Escherichia coli |
J Med Chem 24: 538-44 (1981)
BindingDB Entry DOI: 10.7270/Q2GF0WQM |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Salmonella enterica subsp. enterica serovar Typhi) | BDBM50405962
(CHEMBL19772)Show InChI InChI=1S/C11H11FN4/c12-9-3-1-2-7(5-9)4-8-6-15-11(14)16-10(8)13/h1-3,5-6H,4H2,(H4,13,14,15,16) | PDB
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 589 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pomona College
Curated by ChEMBL
| Assay Description
Inhibitory activity against Escherichia coli dihydrofolate reductase |
J Med Chem 34: 46-54 (1991)
BindingDB Entry DOI: 10.7270/Q2X92CH4 |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Escherichia coli) | BDBM50405962
(CHEMBL19772)Show InChI InChI=1S/C11H11FN4/c12-9-3-1-2-7(5-9)4-8-6-15-11(14)16-10(8)13/h1-3,5-6H,4H2,(H4,13,14,15,16) | MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 589 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Beijing Medical University
Curated by ChEMBL
| Assay Description
Apparent inhibitory (log 1/Ki) activity against Escherichia coli dihydrofolate reductase |
J Med Chem 31: 366-70 (1988)
BindingDB Entry DOI: 10.7270/Q2BV7JTC |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Escherichia coli) | BDBM50405962
(CHEMBL19772)Show InChI InChI=1S/C11H11FN4/c12-9-3-1-2-7(5-9)4-8-6-15-11(14)16-10(8)13/h1-3,5-6H,4H2,(H4,13,14,15,16) | MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 589 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli (expressed as log 1/Kiapp) |
J Med Chem 25: 777-84 (1982)
BindingDB Entry DOI: 10.7270/Q2WH2S6T |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM50405962
(CHEMBL19772)Show InChI InChI=1S/C11H11FN4/c12-9-3-1-2-7(5-9)4-8-6-15-11(14)16-10(8)13/h1-3,5-6H,4H2,(H4,13,14,15,16) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
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CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.2 | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2. |
J Med Chem 25: 435-40 (1982)
BindingDB Entry DOI: 10.7270/Q2DF6TDD |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM50405962
(CHEMBL19772)Show InChI InChI=1S/C11H11FN4/c12-9-3-1-2-7(5-9)4-8-6-15-11(14)16-10(8)13/h1-3,5-6H,4H2,(H4,13,14,15,16) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
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CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.2 | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against bovine liver dihydrofolate reductase at pH 7.2. |
J Med Chem 25: 435-40 (1982)
BindingDB Entry DOI: 10.7270/Q2DF6TDD |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Bos taurus (Cattle)) | BDBM50405962
(CHEMBL19772)Show InChI InChI=1S/C11H11FN4/c12-9-3-1-2-7(5-9)4-8-6-15-11(14)16-10(8)13/h1-3,5-6H,4H2,(H4,13,14,15,16) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of dihydrofolate reductase from bovine liver |
J Med Chem 24: 538-44 (1981)
BindingDB Entry DOI: 10.7270/Q2GF0WQM |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Lactobacillus casei) | BDBM50405962
(CHEMBL19772)Show InChI InChI=1S/C11H11FN4/c12-9-3-1-2-7(5-9)4-8-6-15-11(14)16-10(8)13/h1-3,5-6H,4H2,(H4,13,14,15,16) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pomona College
Curated by ChEMBL
| Assay Description
Inhibitory activity against Lactobacillus casei dihydrofolate reductase |
J Med Chem 32: 1895-905 (1989)
BindingDB Entry DOI: 10.7270/Q2QR4ZB9 |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Lactobacillus casei) | BDBM50405962
(CHEMBL19772)Show InChI InChI=1S/C11H11FN4/c12-9-3-1-2-7(5-9)4-8-6-15-11(14)16-10(8)13/h1-3,5-6H,4H2,(H4,13,14,15,16) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against dihydrofolate reductase (DHFR) from Lactobacillus casei (expressed as log 1/Kiapp) |
J Med Chem 25: 777-84 (1982)
BindingDB Entry DOI: 10.7270/Q2WH2S6T |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405962
(CHEMBL19772)Show InChI InChI=1S/C11H11FN4/c12-9-3-1-2-7(5-9)4-8-6-15-11(14)16-10(8)13/h1-3,5-6H,4H2,(H4,13,14,15,16) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.2 | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against chicken dihydrofolate reductase at pH 7.2. |
J Med Chem 25: 435-40 (1982)
BindingDB Entry DOI: 10.7270/Q2DF6TDD |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405962
(CHEMBL19772)Show InChI InChI=1S/C11H11FN4/c12-9-3-1-2-7(5-9)4-8-6-15-11(14)16-10(8)13/h1-3,5-6H,4H2,(H4,13,14,15,16) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pomona College
Curated by ChEMBL
| Assay Description
Inhibitory activity against chicken liver dihydrofolate reductase |
J Med Chem 32: 1895-905 (1989)
BindingDB Entry DOI: 10.7270/Q2QR4ZB9 |
More data for this
Ligand-Target Pair | |
Dihydrofolate reductase
(Gallus gallus (Chicken)) | BDBM50405962
(CHEMBL19772)Show InChI InChI=1S/C11H11FN4/c12-9-3-1-2-7(5-9)4-8-6-15-11(14)16-10(8)13/h1-3,5-6H,4H2,(H4,13,14,15,16) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.2 | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibitory activity against chicken dihydrofolate reductase at pH 7.2. |
J Med Chem 25: 435-40 (1982)
BindingDB Entry DOI: 10.7270/Q2DF6TDD |
More data for this
Ligand-Target Pair | |
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