Compile Data Set for Download or QSAR

Found 10 hits Enz. Inhib. hit(s) with Target = 'Dopamine beta-hydroxylase' and Ligand = 'BDBM50014968'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014968 (1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...) Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1 Show InChI InChI=1S/C10H10N2OS/c13-9-3-1-8(2-4-9)7-12-6-5-11-10(12)14/h1-6,13H,7H2,(H,11,14)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	55	n/a	n/a	n/a	n/a	n/a	n/a	4.5	n/a
TBA Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of Dopamine beta hydroxylase at pH 4.5				J Med Chem 29: 2465-72 (1987) BindingDB Entry DOI: 10.7270/Q2BR8R5P
					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014968 (1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...) Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1 Show InChI InChI=1S/C10H10N2OS/c13-9-3-1-8(2-4-9)7-12-6-5-11-10(12)14/h1-6,13H,7H2,(H,11,14)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	55	n/a	n/a	n/a	n/a	n/a	n/a	4.5	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity towards Dopamine beta hydroxylase using tyramine substrate at pH 4.5 in the absence of fumarate				J Med Chem 29: 887-9 (1986) BindingDB Entry DOI: 10.7270/Q2JH3K55
					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014968 (1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...) Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1 Show InChI InChI=1S/C10H10N2OS/c13-9-3-1-8(2-4-9)7-12-6-5-11-10(12)14/h1-6,13H,7H2,(H,11,14)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	344	n/a	n/a	n/a	n/a	n/a	n/a	6.6	n/a
TBA Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of Dopamine beta hydroxylase at pH 6.6				J Med Chem 29: 2465-72 (1987) BindingDB Entry DOI: 10.7270/Q2BR8R5P
					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Rattus norvegicus)	BDBM50014968 (1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...) Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1 Show InChI InChI=1S/C10H10N2OS/c13-9-3-1-8(2-4-9)7-12-6-5-11-10(12)14/h1-6,13H,7H2,(H,11,14)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.57E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois Curated by ChEMBL					Assay Description Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally				J Med Chem 33: 274-81 (1990) BindingDB Entry DOI: 10.7270/Q26Q1ZD2
					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Homo sapiens (Human))	BDBM50014968 (1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...) Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1 Show InChI InChI=1S/C10H10N2OS/c13-9-3-1-8(2-4-9)7-12-6-5-11-10(12)14/h1-6,13H,7H2,(H,11,14)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.57E+3	n/a	n/a	n/a	n/a	n/a	n/a
Molecular Simulations Inc Curated by ChEMBL					Assay Description Inhibition of dopamine beta hydroxylase				J Med Chem 38: 2091-102 (1995) BindingDB Entry DOI: 10.7270/Q2W37XH8
					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Homo sapiens (Human))	BDBM50014968 (1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...) Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1 Show InChI InChI=1S/C10H10N2OS/c13-9-3-1-8(2-4-9)7-12-6-5-11-10(12)14/h1-6,13H,7H2,(H,11,14)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.57E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard University Curated by ChEMBL					Assay Description Inhibition of dopamine beta-hydroxylase (DbetaH) enzyme				J Med Chem 40: 4360-71 (1998) Article DOI: 10.1021/jm970488n BindingDB Entry DOI: 10.7270/Q2BZ6784
					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Rattus norvegicus)	BDBM50014968 (1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...) Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1 Show InChI InChI=1S/C10H10N2OS/c13-9-3-1-8(2-4-9)7-12-6-5-11-10(12)14/h1-6,13H,7H2,(H,11,14)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Dopamine beta hydroxylase in spontaneously hypertensive rats; Value ranges from 1.3-4.6				J Med Chem 30: 1309-13 (1987) BindingDB Entry DOI: 10.7270/Q2MC8Z0M
					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014968 (1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...) Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1 Show InChI InChI=1S/C10H10N2OS/c13-9-3-1-8(2-4-9)7-12-6-5-11-10(12)14/h1-6,13H,7H2,(H,11,14)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Dopamine beta hydroxylase.				J Med Chem 29: 2465-72 (1987) BindingDB Entry DOI: 10.7270/Q2BR8R5P
					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014968 (1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...) Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1 Show InChI InChI=1S/C10H10N2OS/c13-9-3-1-8(2-4-9)7-12-6-5-11-10(12)14/h1-6,13H,7H2,(H,11,14)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014968 (1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...) Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1 Show InChI InChI=1S/C10H10N2OS/c13-9-3-1-8(2-4-9)7-12-6-5-11-10(12)14/h1-6,13H,7H2,(H,11,14)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory Concentration against bovine Dopamine beta hydroxylase (DBH); Range is between (1.3-4.6)				J Med Chem 30: 486-94 (1987) BindingDB Entry DOI: 10.7270/Q2FJ2FSM
					More data for this Ligand-Target Pair